Peptides, Glycoconjugates and Metals in Biology

PGMB

Coordination: Dr. Laurence Grimaud

The team Peptides, Glycoconjugates and Metals in Biology is constituted of organic and inorganic chemists who share skills, and know-hows to synthesize and study the reactivity of bioactive molecules, bioconjugates and functional nanoparticles.
Combining organic synthesis, spectroscopies (IR, UV-Vis absorption, fluorescence, X-fluorescence) electrochemistry and biology, the research of the team is aimed at deciphering the reactivity and properties of bioinspired constructs ranging from the molecular to the supramolecular and colloidal scales. Applications include the fundamental understanding of the (bio)catalytic activity of metals complexes, the study of biomolecular interactions (membrane, peptides, proteins and glycoconjugates) and cellular imaging using tailored fluorescent, IR or X-fluorescent probes.

Graduate school affiliation: ED 406: Molecular Chemistry Paris-Centre

Research

Bioinorganic Chemistry Bioorganic Chemistry

Latest Publications

2022

Improvement of Peptidyl Copper Complexes Mimicking Catalase: A Subtle Balance between Thermodynamic Stability and Resistance towards H2O2 Degradation Article de journal

Yaqine Ben Hadj Hammouda; Koudedja Coulibaly; Alimatou Bathily; Magdalene Teoh Sook Han; Clotilde Policar; Nicolas Delsuc

Molecules, 27 (17), 2022, ISSN: 1420-3049.

Fluorogenic and Genetic Targeting of a Red-Emitting Molecular Calcium Indicator Article de journal

Sylvestre P J T Bachollet; Nicolas Pietrancosta; Jean-Maurice Mallet; Blaise Dumat

Chemical Communications, 2022.

An expanded palette of fluorogenic HaloTag probes with enhanced contrast for targeted cellular imaging Article de journal

Sylvestre P J T Bachollet; Yuriy Shpinov; Fanny Broch; Hela Benaissa; Arnaud Gautier; Nicolas Pietrancosta; Jean-Maurice Mallet; Blaise Dumat

Organic & Biomolecular Chemistry, 20 (17), p. 3619 - 3628, 2022, ISSN: 1477-0520.

Inertness of Superoxide Dismutase Mimics Mn(II) Complexes Based on an Open-Chain Ligand, Bioactivity, and Detection in Intestinal Epithelial Cells Article de journal

Gabrielle Schanne; Martha Zoumpoulaki; Géraldine Gazzah; Amandine Vincent; Hugues Preud’homme; Ryszard Lobinski; Sylvie Demignot; Philippe Seksik; Nicolas Delsuc; Clotilde Policar

Oxidative Medicine and Cellular Longevity, 2022 , p. e3858122, 2022, ISSN: 1942-0900, (Publisher: Hindawi).

Deciphering the Metal Speciation in Low-Molecular-Weight Complexes by IMS-MS: Application to the Detection of Manganese Superoxide Dismutase Mimics in Cell Lysates Article de journal

Martha Zoumpoulaki; Gabrielle Schanne; Nicolas Delsuc; Hugues Preud'homme; Elodie Quévrain; Nicolas Eskenazi; Géraldine Gazzah; Regis Guillot; Philippe Seksik; Joelle Vinh; Ryszard Lobinski; Clotilde Policar

Angewandte Chemie International Edition, n/a (n/a), p. e202203066, 2022.