Peptides, Glycoconjugates and Metals in Biology

Coordination: Jean-Maurice MALLET

The team Peptides, Glycoconjugates and Metals in Biology is constituted of organic and inorganic chemists who share skills, and know-hows to synthesize and study the reactivity of bioactive molecules, bioconjugates and functional nanoparticles.
Combining organic synthesis, spectroscopies (IR, UV-Vis absorption, fluorescence, X-fluorescence) electrochemistry and biology, the research of the team is aimed at deciphering the reactivity and properties of bioinspired constructs ranging from the molecular to the supramolecular and colloidal scales. Applications include the fundamental understanding of the (bio)catalytic activity of metals complexes, the study of biomolecular interactions (membrane, peptides, proteins and glycoconjugates) and cellular imaging using tailored fluorescent, IR or X-fluorescent probes.

Graduate school affiliation: ED 406: Molecular Chemistry Paris-Centre

Research

Bioinorganic Chemistry Bioorganic Chemistry

Latest Publications

2025

Kinetic Redox Shotgun Proteomics Reveals Specific Lipopolysaccharide Effects on Intestinal Epithelial Cells, Mitigated by a Mn Superoxide Dismutase Mimic Article de journal

Martha Zoumpoulaki; Giovanni Chiappetta; Jean Bouvet; Namita-Raju John; Gabrielle Schanne; Pauline Gehan; Samuel Diebolt; Shakir Shakir; Elodie Quévrain; Emilie Mathieu; Sylvie Demignot; Philippe Seksik; Nicolas Delsuc; Joelle Vinh; Clotilde Policar

Angewandte Chemie International Edition, n/a (n/a), p. e202422644, 2025.

Harnessing Cyanine‐like Properties to Develop Bright Fluorogenic Probes Based on Viscosity‐Sensitive Molecular Rotors Article de journal

Blaise Dumat; Carolina Chieffo

Chemistry – A European Journal, 31 , p. e202404077, 2025, ISSN: 0947-6539.

Locally activated semisynthetic fluorescent biosensors for imaging cellular biochemistry Article de journal

Justine Coïs; Blaise Dumat

Comptes Rendus. Chimie, 28 , p. 61-78, 2025, ISSN: 1878-1543.

Angle dependance Spin Crossover properties in polymorphic Iron(II) complexes based on pyridine-triazole derivatives Article de journal

Emmelyne Cuza; Nicolas DELSUC; Jérome Marrot; William E Shepard; Clotilde Policar; Christian Serre; Antoine Tissot

Dalton Trans., p. -, 2025.

SOD mimics delivered to the gut using lactic acid bacteria mitigate the colitis symptoms in a mouse model of Inflammatory Bowel Diseases Article de journal

Gabrielle Schanne; Amandine Vincent; Florian Chain; Pauline Ruffié; Célia Carbonne; Elodie Quévrain; Emilie Mathieu; Alice Balfourier; Luis G Bermúdez-Humarán; Philippe Langella; Sophie Thenet; Véronique Carrière; Nassim Hammoudi; Magali Svreck; Sylvie Demignot; Philippe Seksik; Clotilde Policar; Nicolas Delsuc

Free Radical Research, p. 1–16, 2025, (PMID: 40079422).