Peptides, Glycoconjugates and Metals in Biology

Coordination: Jean-Maurice MALLET

The team Peptides, Glycoconjugates and Metals in Biology is constituted of organic and inorganic chemists who share skills, and know-hows to synthesize and study the reactivity of bioactive molecules, bioconjugates and functional nanoparticles.
Combining organic synthesis, spectroscopies (IR, UV-Vis absorption, fluorescence, X-fluorescence) electrochemistry and biology, the research of the team is aimed at deciphering the reactivity and properties of bioinspired constructs ranging from the molecular to the supramolecular and colloidal scales. Applications include the fundamental understanding of the (bio)catalytic activity of metals complexes, the study of biomolecular interactions (membrane, peptides, proteins and glycoconjugates) and cellular imaging using tailored fluorescent, IR or X-fluorescent probes.

Graduate school affiliation: ED 406: Molecular Chemistry Paris-Centre


Bioinorganic Chemistry Bioorganic Chemistry

Latest Publications


Design of Bright Chemogenetic Reporters Based on the Combined Engineering of Fluorogenic Molecular Rotors and of the HaloTag Protein Article de journal

Justine Coïs; Sylvestre P J T Bachollet; Louis Sanchez; Nicolas Pietrancosta; Vincent Vialou; Jean-Maurice Mallet; Blaise Dumat

Chemistry – A European Journal, 2024, ISSN: 0947-6539.

FRET-Sensing of Multivalent Protein Binding at the Interface of Biomimetic Microparticles Functionalized with Fluorescent Glycolipids Article de journal

Sophie Michelis; Chiara Pompili; Florence Niedergang; Jacques Fattaccioli; Blaise Dumat; Jean-Maurice Mallet

ACS Applied Materials & Interfaces, 16 (8), p. 9669–9679, 2024, ISSN: 1944-8244.

Cellular evaluation of superoxide dismutase mimics as catalytic drugs: Challenges and opportunities Article de journal

Gabrielle Schanne; Sylvie Demignot; Clotilde Policar; Nicolas Delsuc

Coordination Chemistry Reviews, 514 , p. 215906, 2024, ISSN: 0010-8545.

Metal complexes in cells: from design of catalytic antioxidants to imaging metal ions and designing metal-based probes in X-ray fluorescence and IR-imaging, a multidisciplinary collaborative journey in bioinorganic chemistry and inorganic chemical biology Article de journal

Clotilde Policar; Nicolas Delsuc; Hél`ene Charlotte Bertrand

Comptes Rendus. Chimie, 2024, (Online first).


An expanded palette of fluorogenic HaloTag probes with enhanced contrast for targeted cellular imaging Article de journal

Sylvestre P J T Bachollet; Yuriy Shpinov; Fanny Broch; Hela Benaissa; Arnaud Gautier; Nicolas Pietrancosta; Jean-Maurice Mallet; Blaise Dumat

Organic & Biomolecular Chemistry, 20 (17), p. 3619 - 3628, 2022, ISSN: 1477-0520.