Jean-Maurice MALLET

Directeur de recherche CNRS

ENS – Département de chimie
24 rue Lhomond, 75005 Paris
Email: Jean-maurice.mallet@ens.psl.eu
Phone: +33 144323390
Office: E048

Short bio

Education and professional experience

1980 Student at Ecole Normale Supérieure (45 rue d’Ulm, Paris), 1980 S,
1983 Agregation de chimie
1983-85 Chemistry and physics teacher at Tevfik Fikret lise at Ankara, Turkey
1985-1988 PhD thesis at Université Paris VI (supervisor: Prof. Marc Julia)
« Elimination reaction in terpenic serie, Taft constants of phosphoric ester. New methods for the preparation of tert butyl ethers and esters.
1985-1987 Teaching assistant /Agrégé préparateur à l’ENS
1987-now CNRS researcher:
Chargé de Recherche CNRS (URA 1686/ UMR 8642) (1987-2001)
Directeur de Recherche CNRS (2001, 2nd class) (2012, 1st class)

Research interests

  • Chemical biology
  • Synthetic oligosaccharides, and conjugates:
    Glycosylation methods using thioglycosides –
    Synthesis of oligosaccharides and glycoconjugates, multivalent systems
  • Peptides and glycopeptides, mimotopes, antigenic peptides
  • Fluorescent and fluorogenic probes for subcellular imaging, (1 and 2 photons): design and cell vectorisation.
  • Functional Micro and nanoparticles: nanogels, gold NP, microdroplet

Supervised students and post-doctorants

  • PhD Thesis
    • Laure L’Haridon  (2012-2015)
    • Pascal Matton  (2014-2017) Codir J Fattaccioli
    • Agathe Peyrottes (2016-2019)   Codir   JP Grill
    • Roxane Ornstein  (2016-2019)
    • Antonio Mazoleni (2017-2020)   Codir A M Papini, univ Florence
    • Agathe Brudo (2018-2021) codir  C Mansuy
    • Yutong Li (2020-2023)

Last publications ( 2018-2020)

  1. Fluorogenic protein probes with red or near-infrared emission for genetically targeted live-cell imaging;
    Sylvestre P. J. T. Bachollet,; Cyril Addi, Nicolas Pietrancosta; Jean-Maurice Mallet, Blaise Dumat
    Chemistry 2020 10.1002/chem.2020029
  2. Hyper-glucosylated adhesin derived peptides as antigenic probes in multiple sclerosis: structure optimisation and immunological evaluationAntonio Mazzoleni, Feliciana Real-Fernandez , Maud Larregola , Olivier Lequin , Anna Maria Papini , Jean-Maurice Mallet* , Paolo Rovero* J Pept. Sci, 2020, DOI:10.1002/psc.3281
  3. A microenvironment-sensitive coumarin-labeled peptide for the assessment of lipid-peptide interactions.Francisco Mura, Daniel Zúñiga-Núñez, Solange Lavielle, Jean-Maurice Mallet, Pascal Matton, Pablo Barrías, Denis Fuentealba, and Alexis Aspée, Dye and pigments,176, 2020,108234. DOI:10.1016/j.dyepig.2020.108234
  4. Glycoreplica peptides to investigate molecular mechanisms of immune-mediated physiological versus pathological conditions A Mazzoleni, P Rovero, J-M Mallet, A M Papini Arch Biochem Biophys, 2019; 663,44-53. doi: 10.1016/j.abb.2018.12.030.
  5. Inter-kingdom effect on epithelial cells of the N-Acyl homoserine lactone 3-oxo-C12:2, a major quorum-sensing molecule from gut microbiota -C Landman, J-P Grill, J- M Mallet, P Marteau, L Humbert, Eric Le Balc’h, M-A Maubert, K Perez, W Chaara, L Brot, L Beaugerie, H Sokol, S Thenet, D Rainteau, P Seksik, E Quévrain PLOS ONE, 2018 10.1371/journal.pone.0202587
  6. New branched amino acids for very high affinity dendrimeric DC-sign ligands L Cattiaux, V Porkolab; F Fieschi, J-M Mallet, Bioorg Med Chem. 2018, 26, 1006-1015
  7. Redox-controlled fluorescence modulation in rhodamine derivatives; M Čížková, L Cattiaux, J-M Mallet, E Labbé, O Buriez, Electrochimica Acta 260 (2018) 589-597
  8. A diarylethene-based photoswitchable chelator for reversible release and capture of calcium ions in aqueous media -N Dozova, G Pousse, B Barnych, J-M Mallet*, J Cossy*, Be Valeur*, P Plaza* J Photochem Photobiol A: Chemistry; 2018, 10.1016/j.jphotochem.2018.04.029
  9. Redox switchable rhodamine-ferrocene dyad: exploring imaging possibilities in cells M Čížková, L Cattiaux, J Pandard, M Guille-Collignon, F Lemaître, Jérôme Delacotte, J-M Mallet, E Labbé, O Buriez, Electrochem Commun 2018, 10.1016/j.elecom.2018.10.009

Publications (2012-2020)

  1. Biological and Biophysical Properties of Galactose and/or Tryptophan containing Cell-Penetrating Peptides Pascaline Lécorché, Astrid Walrant, Fabienne Burlina, Laurence Dutot, Sandrine Sagan, Jean-Maurice Mallet, Bernard Desbat, Gérard Chassaing, Isabel D. Alves, Solange Lavielle BBA – Biomembranes 1818, 2012, 448–457 doi:10.1016/j.bbamem.2011.12.003
  2. Biotin-sulfone tagged oligomannosides as immunogens for eliciting antibodies against specific mannan epitopes  G Despras, R Robert, B Sendid, E Machez, D Poulain, J-M Mallet: Bioorg Med. Chem. 2012, 1817–1831; doi: 10.1016/j.bmc.2011.12.048
  3. Monogalactopyranosides of fluorescein and fluorescein methyl ester: Synthesis, enzymatic hydrolysis by biotinylated -galactosidase and determination of translational diffusion coefficient P K. Mandal, L Cattiaux, D Bensimon, J-M Mallet,  Carbohydr Res, 2012, 358,40-46; doi: 10.1016/j.carres.2012.05.017
  4. Bile acid profiling in human biological samples: Comparison of extraction procedures and application to normal and cholestatic patients  Humbert L, Maubert MA, Wolf C, Duboc H, Mahé M, Farabos D, Seksik P, Mallet JM, Trugnan G, Masliah J, Rainteau D.  J Chromatogr B Analyt Technol Biomed Life Sci. 2012, 899,165-45; doi: 10.1016/j.jchromb.2012.05.01
  5. Plasticity of the β-trefoil protein fold in the recognition and control of invertebrate predators and parasites by a fungal defence system.  Schubert M, Bleuler-Martinez S, Butschi A, Wälti MA, Egloff P, Stutz K, Yan S, Collot, M, Mallet JM, Wilson IB, Hengartner MO, Aebi M, Allain FH, Künzler M.  PLoS Pathog. 2012 :e1002706. see annotations; doi:10.1371/journal.ppat.1002706
  6. Calcium Rubies: a family of red-emitting functionalizable indicators for two-photon lifetime-based Ca2+ imaging Mayeul Collot, Christina Loukou, Aleksey V. Yakovlev, Christian D. Wilms, Dongdong Li, Alexis Evrard, Alsu Zamaleeva, Laurent Bourdieu, Jean-François Léger, Nicole Ropert, Jens Eilers, Martin Oheim, Anne Feltz, Jean-Maurice Mallet J Am Chem Soc. 2012, 34,14923-31; doi: 10.1021/ja304018d
  7. Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases H Duboc, S Rajca, D Rainteau, Benarous D, M Maubert, E Quevrain, G Thomas, V Barbu, L Humbert, G Despras, C Bridonneau, F Dumetz, J-P Grill, J Masliah, L Beaugerie, J Cosnes, O Chazouillères, R Poupon, C Wolf, J-M Mallet; P Langella, G Trugnan, H Sokol, P Seksik Gut 2013;62:531-539, doi:10.1136/gutjnl-2012-302578
  8. Toward libraries of biotinylated chondroitin sulfate analogs: from synthesis to in vivo studies G Despras, C Bernard, A Perrot, L Cattiaux, A Prochiantz, H Lortat-Jacob, J-M Mallet; Chemistry Eur J 2013, 531–540, doi: 10.1002/chem.201202173
  9. Unexpected Remote Effect in Red Fluorescent Sensors Based on extended APTRA M Collot, A Lasoroski, A Zamaleeva, A Feltz, R Vuillemier, J-M Mallet Tetrahedron, 2013, 69, 10482-10487, doi : 1016/j.tet.2013.09.073
  10. Mantyl tagged oligo α (1-> 2) mannosides as Candida Albicans β-mannosyltransferases substrates: a comparison between synthetic strategies M Pourcelot, L Cattiaux, G Sfihi-Loualia, E Fabre, F Krzewinsky, C Fradin, B Coddeville, E Maes, D Poulain, F Delplace, Y Guérardel, J-M Mallet RSC Adv., 2013, 3 (44), 22560 – 22571, doi:10.1039/C3RA43340D
  11. Characterization of the recombinant Candida albicans β-1,2 mannosyltransferase Bmt1 involved in the initiation of β-mannosylation of the yeast cell-wall phosphopeptidomannanE Fabre, G Sfihi-Loualia, M Pourcelot, B Coddeville, F Krzewinski, J Bouckaert, E Maes, R Dubois, C Fradin, J.-M Mallet, D Poulain, F Delplace,Y Guérardel Biochem J. 2014, 347‑360, doi:10.1042/BJ20131012
  12. Carbohydrate based dendrimers L L’Haridon, J-M Mallet Carbohydrate Chemistry 2014 40, 257-269; Eds: A Pilar Rauter, T Lindhorst, C Albrechts, Y Queneau ISBN-13 : 9781849739658 doi: 10.1039/9781849739986-00257
  13. New red-fluorescent calcium indicators for opto-genetics, photoactivation and multi-color imaging Martin Oheim, Marcel van ’t Hoff, Anne Feltz, Alsu Zamaleeva, Jean-Maurice Mallet and Mayeul Collot,  BBA-Molecular Cell Res 2014, 2284-306, doi:10.1016/j.bbamcr.2014.03.010
  14. Cell-penetrating nanobiosensors for pointillistic intracellular Ca2+-transient detection
    Alsu I. Zamaleeva, Mayeul Collot, Eloi Bahembera, Celine Tisseyre, Philippe Rostaing, Aleksey V. Yakovlev, Martin Oheim,, Michel De Waard,, Jean-Maurice Mallet, Anne Feltz  Nanolett, 2014,14(6) 2994-3001. doi: 10.1021/nl500733g.
  15. Glaser Oxidative Coupling on Peptides: Stabilization of β Turn Structure via a 1,3-Butadiyne Constrain Nicolas Auberger, Margherita Di Pisa, Maud Larregola, Gérard Chassaing, Elisa Peroni, Solange Lavielle, Anna-Maria Papini, Olivier Lequin, Jean- Maurice Mallet  Bioorg Med Chem 22, 2014, 6924-6932, doi 10.1016/j.bmc.2014.10.026
  16. Red Emitting Calcium Sensor Formed upon Functionalisable Click Chemistry Mayeul Collot Christian Wilms, Jean-Maurice Mallet,  RSC Adv., 2015, 5, 6993 doi 1039/C4RA12858C
  17. Calcium dynamics of astrocyte processes during neurovascular couplingYo Otsu, Kiri Couchman, Declan Lyons, Mayeul Collot, Jean-Maurice Mallet, Franck W. Pfrieger, D. Bergles, S. Charpak  Nature Neuroscience, 2015, 210-218. doi: 10.1038/nn.3906.
  18. A new method for the determination of the nitrogen content of nitrocellulose based on the molar ratio of nitrite-to-nitrate ions released after alkaline hydrolysis Elodie Alinat, Nathalie Delaunay, Xavier Archer, Jean-Maurice Mallet, Pierre Gareil,  J Hazard Mat. 2015, 286, 92–99, doi:10.1016/j.jhazmat.2014.12.032
  19. CaRuby-Nano: a Novel High Affinity Calcium Probe for Dual Color Imaging Mayeul Collot, Christian D Wilms, Asma Bentkhayet, Païkan Marcaggi, Kiri Couchman, Serge Charpak Stéphane Dieudonné, Michael Häusser, Anne Feltz, Jean-Maurice Mallet eLIFE 2015;4:e05808. DOI: 10.7554/eLife.05808
  20. Antibody Recognition in Multiple Sclerosis and Rett Syndrome Using a Collection of Linear and Cyclic N-Glucosylated Antigenic Probes Feliciana Real Fernández, Margherita Di Pisa, Giada Rossi, Nicolas Auberger, Olivier Lequin, Maud Larregola, Amina Benhora, Christelle Mansuy, Gerard Chassaing, Francesco Lolli, Joussef Hayek, Solange Lavielle, Paolo Rovero, Jean-Maurice Mallet, Anna Maria Papini Biopolymers, 2015, 104(5):560-76. DOI: 10.1002/bip.22677
  21. H-Rubies, a New Family of Red Emitting Fluorescent pH Sensors for Living Cells,
    Guillaume Despras, Alsu Zamaleeva, Céline Tisseyre, Joao Gamelas Magalhaes, Charlotte Garner, Michel De Waard, Sebastian Amigorena, Anne Feltz, Jean-Maurice Mallet, Mayeul Collot,  Chemical Science, 2015, 6, 5928-5937, DOI: 10.1039/c5sc01113b
  22. Towards cellular imaging of Ca2+ and H+ microdomains  Alsu I. Zamaleeva, Despras Guillaume, Camilla Luccardini, Mayeul Collot, Martin Oheim, Michel De Waard, Jean-Maurice Mallet, Anne Feltz Sensors, 2015, 15, 24662-24680; doi:10.3390/s150924662
  23. Beta1,2 Mannosyltransferases 1 and 3 Participate in Yeast and Hyphae O-and N-Linked Mannosylation and Alter Candida albicans Fitness during Infection Flavie Courjol, Thierry Jouault, Céline Mille, Rebecca Hall, Emmanuel Maes, Boualem Sendid, Jean Maurice Mallet, Yann Guerardel, Neil A.R. Gow, Daniel Poulain, Chantal Fradin Open Forum Infect Dis. 2015 Sep 10;2 (3):ofv116. doi: 10.1093/ofid/ofv116.
  24. Characterization of the recombinant Candida albicans β-1,2 mannosyltransferase Bmt3p involved in the β-mannosylation of cell-wall phosphopeptidomannan Ghenima Sfihi-Loualia, Thomas Hurtaux, Emeline Fabre, Anaïs Mée, Marilyne Pourcelot, Emmanuel Maes, Julie Bouckaert, Frédéric Krzewinski, Chantal Fradin, Jean-Maurice Mallet, Boualem Sendid, Daniel Poulain, Florence Delplace and Yann GuérardelGlycobiology, 2016, 26 (2): 203-214.doi 10.1093/glycob/cwv094
  25. Hexagonal-shaped chondroitin sulfate self-assemblies have exalted anti-HSV-2 activity
    Aurélia Galus, Jean-Maurice Mallet, David Lembo, Valeria Cagno, Madeleine Djabourov,, Hugues Lortat-Jacob, Kawthar Bouchemal,  Carbohydr Polym, 2016 ;136:113-20. doi:10.1016/j.carbpol.2015.08.054
  26. Formation and investigation of 6-cysteinyl amino ß-cyclodextrin self-assembled monolayers Viliam Kolivoska, Romana Sokolova, Jana Kocabova, Christina Loukou, Jean-Maurice Mallet, Magdalena Hromadova Monatshefte fuer Chemie 2016, 147, 45-51 DOI:10.1007/s00706- 015-1609-2
  27. Multi-stage mass spectrometry analysis of sugar-conjugated beta-turn structures to be used as probes in autoimmune diseases , Chiara Giangrande, Nicolas Auberger, Jean-Maurice Mallet, Solange Lavielle, Anna Maria Papini, Joelle Vinh, J Am Soc Mass Spectrom, 2016, 735-47 doi:10.1007/s13361-015-1321-9
  28. Candida albicans β-1,2 mannosyl transferase Bmt3: preparation and evaluation of a β(1,2),α(1,2)- tetramannosyl fluorescent substrate , Laurent Cattiaux, Anaïs Mée, Marilyne Pourcelot, Ghenima Sfihi-Loualia, Thomas Hurtaux, Emmanuel Maes, Chantal Fradin, Thierry Jouault, Emeline Fabre, Florence Delplace, Yann Guérardel, Jean-Maurice Mallet,  Bioorg Med Chem, 2016, 24, 1362-8. doi 10.1016/j.bmc.2016.02.008
  29. Evaluation of monovalent and multivalent iminosugars to modulate Candida albicans b-1,2 mannosyltransferase CaBmt1 and CaBmt3 enzyme activities Thomas Hurtaux, Ghenima Sfihi-Loualia, Yoan Brissonnet, Julie Bouckaert, Jean-Maurice Mallet, Boualem Sendid, Florence Delplace, Emeline Fabre, Sébastien Gouin, Yann Guérardel Carbohydrate Res, 2016, 429, 123-7 doi: 10.1016/j.carres.2016.01.004
  30. The chirality change of the XPC- and Sfi1-derived peptides affects their binding capacity to centrin, Dora Grecu, Victor Paul Raj Irudayaraj, Juan Martinez-Sanz, Jean-Maurice Mallet, Liliane Assairi Peptides 2016, 78, 77-86 doi:10.1016/j.peptides.2016.02.005 2016
  31. Dimerization of the fungal defense lectin CCL2 is essential for its toxicity against nematodes Silvia Bleuler-Martinez, Katrin Stutz, Ramon Sieber, Mayeul Collot, Jean-Maurice Mallet, Michael Hengartner, Mario Schubert, Annabelle Varrot and Markus Künzler Glycobiology, 2017, 27,486-500. doi: 10.1093/glycob/cww113
  32. Supramolecular chitosan micro-platelets synergistically enhance anti-Candida albicans activity of amphotericin B deoxycholate using an immunocompetent murine model, Kawthar Bouchemal ; Christian Bories; Martina Bombardi; Philippe Loiseau; Valérie Rouffiac; Audrey Solgadi; Jean-Maurice Mallet; Gilles Ponchel; Tiphany Grisin  Pharmaceutical Research, 2017, 34, 1067–1082 doi:10.1007/s11095-017-2117-3
  33. A secondary structure element in a wide range of fucosylated glyco-epitopes Thomas Aeschbacher, Mirko Zierke, Martin Smieško, Mayeul Collot, Jean-Maurice Mallet, Beat Ernst, Frédéric H.-T. Allain, Mario Schubert,  Chemistry 2017, 11598–11610, 10.1002/chem.201701866
  34. The inhibition of tyrosinase by some aryl butenes: a desired activity or a side effect to avoid E Ketata, A Neifar, W Mihoubi, P Pigeon, H Gouzi, J-M Mallet, S Top, G Kumar Gupta, G Jaouen, A Gargouri, M El Arbi  Journal of Organometallic Chemistry, 848, 2017, 133-141; 10.1016/j.jorganchem.2017.07.031
  35. Redox-controlled fluorescence modulation in rhodamine derivatives Martina Čížková, Laurent Cattiaux, Jean-Maurice Mallet, Eric Labbé, Olivier Buriez,  Electrochimica acta 260, 2018, 589-597, 10.1016/j.electacta.2017.12.104
  36. New branched amino acids for very high affinity dendrimeric DC-sign ligands ; Laurent Cattiaux, Vanessa Porkolab; Franck Fieschi, Jean-Maurice Mallet, Bioorg Biomed Chem, 2018, 10.1016/j.bmc.2017.12.036
  37. Protecting group strategies towards sulfated glycosaminoglycans ; Hélène Ledru, Pascal Matton, Jean-Maurice Mallet and Chrystel Lopin-Bon;Chapter 10 in Protecting Groups in Carbohydrate Chemistry ed/ Sebastien Vidal Wiley, 2018 ISBN: 978-3-527-34010-1
  38. A diarylethene-based photoswitchable chelator for reversible release and capture of calcium ions in aqueous media; Nadia Dozova, Guillaume Pousse, Bogdan Barnych, Jean-Maurice Mallet*, Janine Cossy*, Bernard Valeur*, Pascal Plaza*;Journal of Photochemistry and Photobiology A: Chemistry; 2018, 10.1016/j.jphotochem.2018.04.029
  39. Inter-kingdom effect on epithelial cells of the N-Acyl homoserine lactone 3-oxo-C12:2, a major quorum-sensing molecule from gut microbiota; Cécilia Landman, Jean-Pierre Grill, Jean-Maurice Mallet, Philippe Marteau, Lydie Humbert, Eric Le Balc’h, Marie-Anne Maubert, Kevin Perez, Wahiba Chaara, Loic Brot, Laurent Beaugerie, Harry Sokol, Sophie Thenet, Dominique Rainteau, Philippe Seksik, Elodie Quévrain; PLOS ONE, 20181371/journal.pone.0202587
  40. Redox switchable rhodamine-ferrocene dyad: exploring imaging possibilities in cells ,Martina Čížková, Laurent Cattiaux, Justine Pandard, Manon Guille-Collignon, Frédéric Lemaître, Jérôme Delacotte, Jean-Maurice Mallet, Eric Labbé, Olivier Buriez,  Electrochemistry Communications 2018, 10.1016/j.elecom.2018.10.009
  41. Glycoreplica peptides to investigate molecular mechanisms of immune-mediated physiological versus pathological conditions Antonio Mazzoleni, Paolo Rovero, Jean-Maurice Mallet, Anna Maria Papini Archives of Biochemistry and Biophysics, 2019 ; 663: 44-53. doi: 10.1016/j.abb.2018.12.030.
  42. Mannose-coated fluorescent lipid particles to decipher glycoreceptor-induced phagocytosis , B Dumat, L. Montel, L. Pinon, P. Matton, L. Cattiaux, J. Fattaccioli, J.-M. Mallet ACS Applied Bio Materials, 2019, doi 10.1021/acsabm.9b00793,
  43. A microenvironment-sensitive coumarin-labeled peptide for the assessment of lipid-peptide interactions. Francisco Mura, Daniel Zúñiga-Núñez, Solange Lavielle, Jean-Maurice Mallet, Pascal Matton, Pablo Barrías, Denis Fuentealba, and Alexis Aspée, Dye and pigments,176, 2020,108234. DOI:10.1016/j.dyepig.2020.108234
  44. Hyper-glucosylated adhesin derived peptides as antigenic probes in multiple sclerosis: structure optimisation and immunological evaluation Antonio Mazzoleni, Feliciana Real-Fernandez , Maud Larregola , Olivier Lequin , Anna Maria Papini , Jean-Maurice Mallet* , Paolo Rovero* J Pept. Sci, 2020, DOI:10.1002/psc.3281
  45. Fluorogenic protein probes with red or near-infrared emission for genetically targeted live-cell imaging; Sylvestre P. J. T. Bachollet,; Cyril Addi, Nicolas Pietrancosta; Jean-Maurice Mallet, Blaise Dumat Chemistry 10.1002/chem.202002911