Blaise DUMAT

Chargé de Recherche CNRS – CNRS Research Associate

Laboratoire des Biomolécules
UMR7203
ENS – Département de chimie
24 rue Lhomond, 75005 Paris

Email: blaise.dumat@ens.psl.eu
Phone: +33 144323335
Office: E048

Education and professional experience

  • Since 2017: CNRS research associate in the Laboratoire des Biomolécules UMR7203 at the ENS chemistry department
  • 2015 – 2016: Assistant Professor (ATER) at University Paris Descartes
  • 2013 – 2015: Postdoctoral researcher in the group of Pr. Marcus Wilhelmsson at Chalmers University (Gothenburg, Sweden)
  • 2012: PhD in Chemistry from University Paris Sud under the supervision of Dr. Marie-Paule Teulade-Fichou and Dr. Florence Mahuteau-Betzer at Institut Curie
  • 2008: MSc and chemical engineering degree from Chimie Paristech

Research projects

My research aims at developing new fluorescent probes as tools to study biological processes. To that end, we develop functional probes whose emission can be specifically triggered by biological analytes or proteins. The research work combines organic synthesis, biochemistry (interaction studies) and biophysics (optical spectroscopies, microscopy).

  • Fluorescent calcium probes (ANR JCJC DIPimaging 2019-2022)
  • Targeted fluorescent emulsion for probing phagocytosis (in collaboration with Jean-Maurice Mallet (LBM) and Jacques Fattaccioli (PASTEUR lab UMR8640))

Supervised students and post-doctoral researchers

Current
Justine Coïs (PhD student ; since Oct. 2021) in co-supervision with J-M Mallet (LBM) and Vincent Vialou (IPBS UMR8246)
Sophie Michelis (PhD student ; since Oct. 2021) in co-supervision with J-M Mallet (LBM)

Past
Dr. Sylvestre Bachollet (postdoc ANR ; Dec. 2018- May 2021)
Yuriy Shpinov (M2 intern ; February – June 2020)
Charles-Henri Buffet (M2 intern ; February – June 2020) in co-supervision with JM Mallet
Nadjib Khene (M1 intern ; April – July 2019)

Publications

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2020

Fluorogenic Protein Probes with Red and Near‐Infrared Emission for Genetically Targeted Imaging** Article de journal

Sylvestre P J T Bachollet; Cyril Addi; Nicolas Pietrancosta; Jean-Maurice Mallet; Blaise Dumat

Chemistry – A European Journal, 26 (63), p. 14467–14473, 2020, ISSN: 0947-6539.

2019

Mannose-Coated Fluorescent Lipid Microparticles for Specific Cellular Targeting and Internalization via Glycoreceptor-Induced Phagocytosis Article de journal

Blaise Dumat; Lorraine Montel; Léa Pinon; Pascal Matton; Laurent Cattiaux; Jacques Fattaccioli; Jean-Maurice Mallet

ACS Applied Bio Materials, 2 , p. 5118-5126, 2019, ISSN: 2576-6422.

2018

Synthesis, Oligonucleotide Incorporation and Fluorescence Properties in DNA of a Bicyclic Thymine Analogue Article de journal

Christopher P Lawson; Anders F Füchtbauer; Moa S Wranne; Tristan Giraud; Thomas Floyd; Blaise Dumat; Nicolai K Andersen; Afaf H. El-Sagheer; Tom Brown; Henrik Gradén; Marcus L Wilhelmsson; Morten Grøtli

Scientific Reports, 8 (1), p. 1-9, 2018, ISSN: 4159801831897.

2017

Toward Complete Sequence Flexibility of Nucleic Acid Base Analogue FRET Article de journal

Moa S Wranne; Anders Foller Füchtbauer; Blaise Dumat; Mattias Bood; Afaf H El-Sagheer; Tom Brown; Henrik Gradén; Morten Grøtli; Marcus L Wilhelmsson

Journal of the American Chemical Society, 139 (27), p. 9271-9280, 2017.

2016

Studying Z-DNA and B- to Z-DNA Transitions Using a Cytosine Analogue FRET-Pair Article de journal

Blaise Dumat; Anders Foller Larsen; Marcus L Wilhelmsson

Nucleic Acids Research, 44 (11), p. e101-e101, 2016.

Influence of the Oxazole Ring Connection on the Fluorescence of Oxazoyl-Triphenylamine Biphotonic DNA Probes Article de journal

Blaise Dumat; Elodie Faurel-Paul; Pauline Fornarelli; Nicolas Saettel; Germain Metgé; Céline Fiorini-Debuisschert; Fabrice Charra; Florence Mahuteau-Betzer; Marie-Paule Teulade-Fichou

Organic & Biomolecular Chemistry, 14 (1), p. 358-370, 2016.

Mitochondria-Targeted Triphenylamine Derivatives Activatable by Two-Photon Excitation for Triggering and Imaging Cell Apoptosis Article de journal

Rahima Chennoufi; Houcine Bougherara; Nathalie Gagey-Eilstein; Blaise Dumat; Etienne Henry; Frédéric Subra; Stéphanie Bury-Moné; Florence Mahuteau-Betzer; Patrick Tauc; Marie-Paule Teulade-Fichou; Eric Deprez

Scientific Reports, 6 (January), p. 21458-21458, 2016.

2015

Development of Bright Fluorescent Quadracyclic Adenine Analogues: TDDFT-Calculation Supported Rational Design Article de journal

Anders Foller Larsen; Blaise Dumat; Moa S Wranne; Christopher P Lawson; Søren Preus; Mattias Bood; Henrik Gradén; L Marcus Wilhelmsson; Morten Grøtli

Scientific Reports, 5 , p. 12653-12653, 2015.

Second-Generation Fluorescent Quadracyclic Adenine Analogues: Environment-Responsive Probes with Enhanced Brightness Article de journal

Blaise Dumat; Mattias Bood; Moa S Wranne; Christopher P Lawson; Anders Foller Larsen; Søren Preus; Jens Streling; Henrik Gradén; Eric Wellner; Morten Grøtli; Marcus L Wilhelmsson

Chemistry - A European Journal, 21 (10), p. 4039-4048, 2015.

Differential Behaviour of Cationic Triphenylamine Derivatives in Fixed and Living Cells: Triggering and Imaging Cell Death Article de journal

R Chennoufi; H Bougherara; N Gagey-Eilstein; B Dumat; E Henry; F Subra; F Mahuteau-Betzer; P Tauc; M -P Teulade-Fichou; E Deprez

Chemical Communications, 51 (80), p. 14881-14884, 2015.

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