Blaise DUMAT

Chargé de Recherche CNRS – CNRS Research Associate

Laboratoire des Biomolécules
ENS – Département de chimie
24 rue Lhomond, 75005 Paris

Phone: +33 144323335
Office: E045

Education and professional experience

  • Since 2017: CNRS research associate in the Laboratoire des Biomolécules UMR7203 at the ENS chemistry department
  • 2015 – 2016: Assistant Professor (ATER) at University Paris Descartes
  • 2013 – 2015: Postdoctoral researcher in the group of Pr. Marcus Wilhelmsson at Chalmers University (Gothenburg, Sweden)
  • 2012: PhD in Chemistry from University Paris Sud under the supervision of Dr. Marie-Paule Teulade-Fichou and Dr. Florence Mahuteau-Betzer at Institut Curie
  • 2008: MSc and chemical engineering degree from Chimie Paristech

Research projects

My research aims at developing new fluorescent probes as tools to study biological processes. To that end, we develop functional probes whose emission can be specifically triggered by biological analytes or proteins. The research work combines organic synthesis, biochemistry (interaction studies) and biophysics (optical spectroscopies, microscopy).

  • Hybrid chemogenetic probes and sensors (ANR JCJC DIPimaging 2019-2022)
  • Targeted fluorescent lipid mircroparticles for probing phagocytosis (in collaboration with Jean-Maurice Mallet (LBM), Jacques Fattaccioli (PASTEUR lab UMR8640) and Florence Niedergang (Institut Cochin))

Supervised students and post-doctoral researchers

Manon Wittwer (PhD student ; since Sept. 2023)
Dr. Carolina Chieffo (Postdoc; since Jan. 2023)
Justine Coïs (PhD student ; since Oct. 2021) in co-supervision with J-M Mallet (LBM) and Vincent Vialou (Neurosciences Paris Seine, UMR8246)
Sophie Michelis (PhD student ; since Oct. 2021) in co-supervision with J-M Mallet (LBM)

Manon Wittwer (M2 intern; Feb. – June 2023)
Louis Sanchez (M2 intern ; Feb. – June 2022)
Dr. Sylvestre Bachollet (postdoc ANR ; Dec. 2018- May 2021)
Yuriy Shpinov (M2 intern ; February – June 2020)
Charles-Henri Buffet (M2 intern ; February – June 2020) in co-supervision with JM Mallet
Nadjib Khene (M1 intern ; April – July 2019)


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Design of Bright Chemogenetic Reporters Based on the Combined Engineering of Fluorogenic Molecular Rotors and of the HaloTag Protein Article de journal

Justine Coïs; Sylvestre P J T Bachollet; Louis Sanchez; Nicolas Pietrancosta; Vincent Vialou; Jean-Maurice Mallet; Blaise Dumat

Chemistry – A European Journal, 2024, ISSN: 0947-6539.

FRET-Sensing of Multivalent Protein Binding at the Interface of Biomimetic Microparticles Functionalized with Fluorescent Glycolipids Article de journal

Sophie Michelis; Chiara Pompili; Florence Niedergang; Jacques Fattaccioli; Blaise Dumat; Jean-Maurice Mallet

ACS Applied Materials & Interfaces, 16 (8), p. 9669–9679, 2024, ISSN: 1944-8244.


Fluorogenic and Genetic Targeting of a Red-Emitting Molecular Calcium Indicator Article de journal

Sylvestre P J T Bachollet; Nicolas Pietrancosta; Jean-Maurice Mallet; Blaise Dumat

Chemical Communications, 2022.

An expanded palette of fluorogenic HaloTag probes with enhanced contrast for targeted cellular imaging Article de journal

Sylvestre P J T Bachollet; Yuriy Shpinov; Fanny Broch; Hela Benaissa; Arnaud Gautier; Nicolas Pietrancosta; Jean-Maurice Mallet; Blaise Dumat

Organic & Biomolecular Chemistry, 20 (17), p. 3619 - 3628, 2022, ISSN: 1477-0520.


Fluorogenic Protein Probes with Red and Near‐Infrared Emission for Genetically Targeted Imaging** Article de journal

Sylvestre P J T Bachollet; Cyril Addi; Nicolas Pietrancosta; Jean-Maurice Mallet; Blaise Dumat

Chemistry – A European Journal, 26 (63), p. 14467–14473, 2020, ISSN: 0947-6539.


Mannose-Coated Fluorescent Lipid Microparticles for Specific Cellular Targeting and Internalization via Glycoreceptor-Induced Phagocytosis Article de journal

Blaise Dumat; Lorraine Montel; Léa Pinon; Pascal Matton; Laurent Cattiaux; Jacques Fattaccioli; Jean-Maurice Mallet

ACS Applied Bio Materials, 2 , p. 5118-5126, 2019, ISSN: 2576-6422.


Synthesis, Oligonucleotide Incorporation and Fluorescence Properties in DNA of a Bicyclic Thymine Analogue Article de journal

Christopher P Lawson; Anders F Füchtbauer; Moa S Wranne; Tristan Giraud; Thomas Floyd; Blaise Dumat; Nicolai K Andersen; Afaf H. El-Sagheer; Tom Brown; Henrik Gradén; Marcus L Wilhelmsson; Morten Grøtli

Scientific Reports, 8 (1), p. 1-9, 2018, ISSN: 4159801831897.


Toward Complete Sequence Flexibility of Nucleic Acid Base Analogue FRET Article de journal

Moa S Wranne; Anders Foller Füchtbauer; Blaise Dumat; Mattias Bood; Afaf H El-Sagheer; Tom Brown; Henrik Gradén; Morten Grøtli; Marcus L Wilhelmsson

Journal of the American Chemical Society, 139 (27), p. 9271-9280, 2017.


Studying Z-DNA and B- to Z-DNA Transitions Using a Cytosine Analogue FRET-Pair Article de journal

Blaise Dumat; Anders Foller Larsen; Marcus L Wilhelmsson

Nucleic Acids Research, 44 (11), p. e101-e101, 2016.

Influence of the Oxazole Ring Connection on the Fluorescence of Oxazoyl-Triphenylamine Biphotonic DNA Probes Article de journal

Blaise Dumat; Elodie Faurel-Paul; Pauline Fornarelli; Nicolas Saettel; Germain Metgé; Céline Fiorini-Debuisschert; Fabrice Charra; Florence Mahuteau-Betzer; Marie-Paule Teulade-Fichou

Organic & Biomolecular Chemistry, 14 (1), p. 358-370, 2016.

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