Physical and Biological Chemistry of Living Matter


Our activities

… in a nutshell

The study of Living Matter drives our activity, both as a source of molecules and processes to be studied and harnessed, and as a motivation to introduce methodological developments in chemistry and new molecular tools. We in particular aim at controlling and analyzing the dynamics of biomolecules involved in networks of chemical reactions and interactions, up to in vivo. We also push forward bio-assisted chemistry, exploiting living microorganisms as engineered chemical factories. Our projects involving perturbing/imaging cells or taming micro-organisms are of interest for diagnostic, medical applications, or bioproduction.

More precisely, our activities are organized along two research axes:
Control and analysis of the dynamics of biomolecules
Bio-assisted chemistry

(follow the links to know more)

News from us

A Fluorescent False Neurotransmitter as a Dual Electrofluorescent Probe for Secretory Cell Models

RNA is a critical element for the sizing and the composition of phase-separated RNA–protein condensates

Ultrafast oxidation of a tyrosine by proton-coupled electron transfer promotes light activation of an animal-like cryptochrome

A split fluorescent reporter with rapid and reversible complementation

Nanoparticle-based local translation reveals mRNA as a translation-coupled scaffold with anchoring function

Ultrafast photoinduced flavin dynamics in the unusual active site of the tRNA methyltransferase TrmFO

Investigation of photocurrents resulting from a living unicellular algae suspension with quinones over time

Prix de l’Instrumentation – 2018

Actin-Network Architecture Regulates Microtubule Dynamics

Delocalized hole transport coupled to sub-ns tryptophanyl deprotonation promotes photoreduction of class II photolyases

Taming Nickel-Catalyzed Suzuki-Miyaura Coupling: A Mechanistic Focus on Boron-to-Nickel Transmetalation

Nomination Institut Universitaire de France

A novel diarylethene-based photoswitchable chelator for reversible release and capture of Ca2+ in aqueous media

Electrochemical switching fluorescence emission in rhodamine derivatives

Resonant out-of-phase fluorescence microscopy and remote imaging overcome spectral limitations

Dynamic multicolor protein labeling in living cells

Redesigning the QA binding site of Photosystem II allows reduction of exogenous quinones

Photoinduced Chromophore Hydration in the Fluorescent Protein Dreiklang Is Triggered by Ultrafast Excited-State Proton Transfer Coupled to a Low-Frequency Vibration

Selective Electrochemical Bleaching of the Outer Leaflet of Fluorescently Labeled Giant Liposomes

Interview Arnaud GAUTIER, a chemical biologist !