Physical and Biological Chemistry of Living Matter


Our activities

… in a nutshell

The study of Living Matter drives our activity, both as a source of molecules and processes to be studied and harnessed, and as a motivation to introduce methodological developments in chemistry and new molecular tools. We in particular aim at controlling and analyzing the dynamics of biomolecules involved in networks of chemical reactions and interactions, up to in vivo. We also push forward bio-assisted chemistry, exploiting living microorganisms as engineered chemical factories. Our projects involving perturbing/imaging cells or taming micro-organisms are of interest for diagnostic, medical applications, or bioproduction.

More precisely, our activities are organized along two research axes:
Control and analysis of the dynamics of biomolecules
Bio-assisted chemistry

(follow the links to know more)

News from us

Fluorescent proteins glow longer in the presence of infrared light
Active diffusion in oocytes nonspecifically centers large objects during prophase I and meiosis I
Self-Assembly of Magnetically-Functionalized Molecular Motors and Microtubules into Active Gels
A Fluorescent False Neurotransmitter as a Dual Electrofluorescent Probe for Secretory Cell Models
RNA is a critical element for the sizing and the composition of phase-separated RNA–protein condensates
Ultrafast oxidation of a tyrosine by proton-coupled electron transfer promotes light activation of an animal-like cryptochrome
A split fluorescent reporter with rapid and reversible complementation
Nanoparticle-based local translation reveals mRNA as a translation-coupled scaffold with anchoring function
Ultrafast photoinduced flavin dynamics in the unusual active site of the tRNA methyltransferase TrmFO
Investigation of photocurrents resulting from a living unicellular algae suspension with quinones over time
Prix de l’Instrumentation – 2018
Actin-Network Architecture Regulates Microtubule Dynamics
Delocalized hole transport coupled to sub-ns tryptophanyl deprotonation promotes photoreduction of class II photolyases
Taming Nickel-Catalyzed Suzuki-Miyaura Coupling: A Mechanistic Focus on Boron-to-Nickel Transmetalation
Nomination Institut Universitaire de France
A novel diarylethene-based photoswitchable chelator for reversible release and capture of Ca2+ in aqueous media
Electrochemical switching fluorescence emission in rhodamine derivatives
Resonant out-of-phase fluorescence microscopy and remote imaging overcome spectral limitations
Dynamic multicolor protein labeling in living cells
Redesigning the QA binding site of Photosystem II allows reduction of exogenous quinones