Hélène BERTRAND

Maître de conférences, Sorbonne Université

ENS – Département de chimie
24 rue Lhomond, 75005 Paris

Email: helene.bertrand@ens.psl.eu
Phone: +33 144322440
Office: E037b

Short bio

  • orcid.org/0000-0002-3841-022X
  • researcherID: A-5581-2015

Education and professional experience

  • Since Sept. 2017: Visiting Faculty at Nanyang Technological University (School of Physical and Mathematical Sciences, Division of Chemistry and Biological Chemistry, Group WK Leong) – Délégation CNRS (1 year full time 2017-2018, 1 year part time 2018-2019)
  • Since Sept. 2011: Assistant Professor at Sorbonne Université (Faculté Sciences et Ingénierie), Laboratoire des Biomolécules, UMR7203- Prime d’investissement en recherche depuis 2016.
  • April – August 2011: Postdoctoral research assistant – ISM UMR5255 – Institut Européen de Chimie et de Biologie (IECB), Bordeaux, France – Advisor: Prof. S. Quideau – Antiviral agents against Influenza A nucleoprotein
  • March 2009- March 2011: Postdoctoral research assistant – School of Pharmacy, University of London, UK – Advisor: Dr. G. Wells – Direct reversible inhibition of the Keap1-Nrf2 protein-protein interaction
  • Sept 2005- Oct 2008: PhD in molecular chemistry (Université P. et M. Curie UPMC) – PhD advisors: Dr. M.-P. Teulade-Fichou (Institut Curie) and Dr. D. Fichou (CEA) – Title: Hétérocycles aromatiques étendus: variations structurales pour l’auto- assemblage bi-dimensionnel et la reconnaissance d’ADN G-quadruplexe – Defense: 24 October 2008
  • 2001-2005: ESPCI – PSL, Paris (espci.fr) Master level degree in Science and Engineering
  • 2004-2005: Master II (organic and bioorganic chemistry), UPMC

Research interests

  • Bioorganic and bioinorganic chemistry, inorganic medicinal chemistry, protein-protein interactions, Re-tricarbonyl multimodal probes, intracellular detection, bioimaging, Mn(II) spin-labels, CO-releasing molecules

Awards and distinctions

  • Member of Société Chimique de France (SCF)
  • Member of the Society of Bioinorganic Chemistry (SBIC)
  • Member of Singaporean National Institute of Chemistry (SNIC) (2017-2020)
  • Member of Frenchbic (Groupe français de Chimie BioInorganique), directoire

Supervised students and post-doctorants

  • Co-supervision of 2 Postdoctoral researchers:
  • – Sept 2017- Feb 2019: Sounderya Nagarajan (PSL Chimie PINOT) Co-supervision F. Mahuteau-Betzer (CMIB, Institut Curie), ‘New multimodal Probes for Individual Organelle Targeting’
  • Oct 2018 – Oct 2019: Manon Isaac (ANR JCJC SATIN ‘Single-core Agents for Therapeutics and Imaging’)
  • Co-supervision of 3 PhD candidates:
  • 01 Oct 2012 – 31 Oct 2015: Paul Demay-Drouhard (Sorbonne Université SU, ED406), Co-supervision C. Policar, ‘Measuring Nanometer-Scale Distances by High-Field Pulsed Electron-Electron Double Resonance Using MnII Spin Labels’ (funding ANR MnHFPELDOR), defence 25/10/2015, now postdoc York University, Toronto, Canada
  • 08 Oct 2015 – 6 May 2019: Menglan He (SU, ED406), Co-supervision C. Policar, ‘Novel rhenium(I) tricarbonyl complexes towards catalytic, photophysical and biological applications’ (China Scholarship Council CSC funding)
  • Sept 2017 – : Antoine Hoste (PSL University, ED406), ‘Single-core Agents for Therapeutics and Imaging’ (ENS fellowship)
  • Supervision of 5 Master 2 (SU), 1 Master 1 (SU), 4 Erasmus Master 1 (Imperial College London, Heraklion university), 2 L3 (ENS), 2 L3 (SU, Paris Diderot), 3 Professional Licence (SU)

Organization

  • First ‘Singapore-Paris Chemical Biology Workshop’ (4-7 March 2019): Project supervisor, https://sites.google.com/view/spcb19/home, 3 days meeting gathering 40 invited speakers from Paris area and Singapore (NTU, NUS, A*STAR) on chemical biology research topics, NTU Campus (SPMS), 120 participants. Organizing committee: HC Bertrand (SU), MP Teulade-Fichou (Curie-PSL), WK Leong (NTU), B. Xing (NTU), A.T. Phan (NTU), B. I. Morinaka (NUS), Financial support from PSL University (ANR-10-IDEX-0001-02 PSL), Institut Curie, NTU School of Physical and Mathematical Sciences, Institute of Advanced Studies Singapore, TwistBioscience.
  • Journées de la Montagne Sainte Geneviève (2014-2018): Member of the organization committee, national one-day conference in organic and bioorganic chemistry, 200 participants
  • FrenchBic (2015 – ): Organization of the annual meeting (3 days, 90-100 participants, last edition 14-17 Octobre 2018 – Carry-le-Rouet), French Bioinorganic Chemistry group, national research network with 25 laboratories (http://frenchbic.cnrs.fr/)
  • Journées bibliographiques de l’Ecole doctorale (UPMC, 2013)
  • UMR seminars (LBM, 2014-2015): Member of the organization committee
  • ENS Chemistry department seminars (since 2017): Member of the organization committee

Teaching

  • Since 2011: Sorbonne Université, UFR Chimie (926), Première Année des Etudes de Santé (PAES), Parcours pré-doctoral ENS, 192h équivalent TD/an
  • PAES: TDs general and organic chemistry, UE (teaching unit) co-coordination (2015-2016)
  • Licence: lectures, TD and TP (lab work), organic chemistry, biological chemistry
  • Master (chemistry): lectures, TD, TP, supervision of literature study, jurys – organic, bioorganic and bioionorganic chemistry
  • Pre-doctoral cursus ENS: coordination and organization of the experimental teaching unit (L3, M1)
  • Dec 2015: Participation to the Prosfer program (Program of sino-french education for research, pre-doctoral training between French ENS and ECNU (East China Normal University)) as an invited professor: course ‘Biomolecules: targeting and recognition by metal complexes’, 20h, Shanghai
  • Jan-March 2017: Teaching module at Ecole Polytechnique -: ‘Metal complexes as therapeutic targets and agents’ – 28 h course at M1 level (CHI 581)

Significant publications

  • Peer-reviewed articles:
  1. Dilly S., Fotso A., Lejal N., Zedda G., Chebbo M., Rahman F., Companys S., Bertrand H.C., Vidic J., Noiray M., Alessi M.C., Tarus B., Quideau S., Riteau B., Slama-Schwok A., From naproxen repurposing to naproxen analogues and their antiviral activity against Influenza A virus; Med. Chem., 2018, 61 (16), 7202–7217 – DOI: 10.1021/acs.jmedchem.8b00557 (IF(2016/2017) 6.259)
  2. He M., Ching H.Y.V., Policar C., Bertrand H.C.*, Rhenium tricarbonyl complexes with arenethiolate axial ligands, New Journal of Chemistry, 2018, 42, 11312 – 11323 – DOI: 10.1039/C8NJ01960F (IF(2016/2017) 3.269)
  3. Panagiotakis S., Giannoudis E., Charisiadis A., Paravatou R., Lazaridi M.-E., Kandyli M., Ladomenou K., Angaridis P.A., Bertrand H.C.*, Sharma G.D.*, Coutsolelos A.G.* Increased Efficiency of Dye‐Sensitized Solar Cells by Incorporation of a π Spacer in Donor–Acceptor Zinc Porphyrins Bearing Cyanoacrylic Acid as an Anchoring Group, J. Inorg. Chem., 2018, 20-21, 2369-2379 – DOI: 10.1002/ejic.201800123 (IF(2016/2017) 2.444)
  4. Henry L., Delsuc N., Laugel C., Lambert F., Sandt C., Hostachy S., Bernard A.-S., Bertrand H.C., Grimaud L., Baillet-Guffroy A., Policar C. Labeling of Hyaluronic Acids with a Rhenium-tricarbonyl Tag and Percutaneous Penetration Studied by Multimodal Imaging, Bioconjugate Chem., 2018, 29(4), 987–991- DOI: 10.1021/acs.bioconjchem.7b00825 (IF(2016/2017) 4.818)
  5. Georgakopoulos N.D., Frison M., Alvarez M.S., Bertrand H.; Wells G., Campanella M. Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy, Scientific Reports, 2017, 7, 10303 – DOI:1038/s41598-017-07679-7 (IF 4.259)
  6. Charif R., Granotier-Beckers, C., Bertrand H.C., Poupon J., Segal-Bendirdjian E., Teulade-Fichou M.-P., Boussin F., Bombard S. Association of a platinum complex to a G-quadruplex ligand enhances the telomere disruption, Res. Toxicol. 2017, 30(8), 1629-1640 DOI: 10.1021/acs.chemrestox.7b00131 (IF 3.278)
  7. Ching H. Y. V., Wang X., He M., Perujo Holland N., Guillot R., Slim C., Griveau S., Bertrand H. C., Policar C., Bedioui F., Fontecave M. Rhenium Complexes Based on 2‑Pyridyl-1,2,3-triazole Ligands: A New Class of CO2 Reduction Catalysts, Chem. 2017, 56 (5), 2966-2976 – DOI: 10.1021/acs.inorgchem.6b03078 (IF 4.857)
  8. Kerr F., Sofola-Adesakin , Ivanov D.K., Gatliff J., Gomez Perez-Nievas B., Bertrand H.C., Martinez P., Callard R., Snoeren I., Cochemé H. M., Adcott J., Khericha M., Castillo-Quan J. I., Wells G., Noble W., Thornton J., Partridge L. Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease. PLoS Gen 2017, 13 (3):e1006593 – DOI: 10.1371/journal.pgen.1006593 (IF 6.661)
  9. Demay-Drouhard P., Chamoreau L.-M., Guillot R., Policar C., Bertrand H. C.* Synthesis of homoditopic ligands with an incrementable rodlike backbone, J. Org. Chem. 2017, 131-137 – DOI: 10.1002/ejoc.201601081 (IF 3.068)
  10. Akhmetzyanov D., Ching H. Y. V., Denysenkov V. P., Demay-Drouhard P., Bertrand H. C., Tabares L. C., Policar C., Prisner T., Un S., RIDME Spectroscopy on High-Spin Mn2+ Centers, Chem.Chem.Phys. 2016, 18, 30857-30866 – DOI: 10.1039/C6CP05239H (IF 4.449)
  11. Ferńandez E., Hostachy S., Sandt C., Rodŕıguez G., Bertrand H. C., Clède S., Ćocera M., de la Maza A., Lambert F., Policar C., Ĺopez O., Monitoring bicosomes containing antioxidants in normal and irradiated skin, RSC Adv., 2016, 6, 72559-72567 – DOI: 10.1039/c6ra11170j (IF 3.289)
  12. Kaminska K. K., Bertrand H. C., Tajima H., Stafford W. C., Cheng Q., Chen W., Wells G., Arner E., Chew E.-H., Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads, Oncotarget, 2016, 7(26), 40233-40251 – DOI: 10.18632/oncotarget.9579 (IF 5.008)
  13. Demay-Drouhard P., Ching H. Y. V., Akhmetzyanov D. Guillot R., Tabares L. C., Bertrand H. C.,* Policar C.*, A bis-Manganese(II)-DOTA complex for Pulsed Dipolar Spectroscopy, ChemPhysChem, 2016, 17 (13), 2066-78 – DOI: 10.1002/cphc.201600234 (IF 3.138)
  14. Ching H. Y. V., Mascali F. C., Bertrand H.C., Bruch E. M., Demay-Drouhard P., Rasia R. M., Policar C., Tabares L. C., Un S. The Use of Mn(II) Bound to His-tags as Genetically Encodable Spin-Label for Nanometric Distance Determination in Proteins. Phys. Chem. Lett., 2016, 7 (6), 1072–1076 – DOI: 10.1021/acs.jpclett.6b00362 (IF 8.539)
  15. Clède S., Cowan N., Lambert F., Bertrand H. C., Rubbiani R., Patra M., Hess J., Sandt C., Trcera N., Gasser G., Keiser J., Policar C. Bimodal X-ray and Infrared Imaging of an Organometallic Derivative of Praziquantel in Schistosoma Mansoni. ChemBioChem, 2016, 17 (11), 1004-1007 – DOI: 10.1002/cbic.201500688 (IF 2.850)
  16. Bertrand H. C., Schaap M., Baird L., Georgakopoulos N. D., Fowkes A., Thiollier C., Kachi H., Dinkova-Kostova A. T., Wells G. Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction. Med. Chem., 2015, 58 (18), pp 7186–7194 – DOI: 10.1021/acs.jmedchem.5b00602 (IF 5.589)
  17. Ching H. Y. V., Demay-Drouhard P., Bertrand H. C., Policar C., Tabares L. C., Un S. Nanometric distance measurements between Mn(II)DOTA centers. Chem.Chem.Phys., 2015, 17, 23368-23377 – DOI: 10.1039/c5cp03487f (IF 4.449)
  18. Tarus B., Bertrand H., Zedda G., Di Primo C., Quideau S., Slama-Schwok A. Structure-based design of novel naproxen derivatives targeting monomeric nucleoprotein of Influenza A virus. Biomol. Struct. Dyn., 2014, Nov 19, 1-14 – DOI: 10.1080/07391102.2014.979230 (IF 2.983)
  19. East A., Fagani F., Crosby J., Georgakopoulos N., Bertrand H., Schaap M., Fowkes A., Wells G., Campanella M. PMI: a novel, DYm independent, Mitophagy Inducer. Chemistry and Biology, 2014, 21, 1585-1596 – DOI: 10.1016/j.chembiol.2014.09.019 (IF 6.586)
  20. Bertrand H. C., Clède S., Guillot R., Lambert F., Policar C. Luminescence Modulations of Rhenium Tricarbonyl Complexes Induced by Structural Variations, Chem., 2014, 53 (12), 6204 – 6223 – DOI: 10.1021/ic5007007 (IF 4.794)
  21. Nagle A. A., Reddy S. A., Bertrand H., Tajima H., Dang T.-M., Wong S.-C., Hayes J. D., Wells G., Chew E.-H. 3-(2-Oxoethylidene)indolin-2-one derivatives activate Nrf2 and inhibit NF-kB: potential candidates for chemoprevention, ChemMedChem, 2014, 9 (8), 1763-1774 – DOI: 10.1002/cmdc.201402038 (IF 3.046)
  22. Clède S., Lambert F., Saint-Fort R., Plamont M.-A., Bertrand H., Vessières A., Policar C. Influence of the side chain length on the cellular uptake and the cytotoxicity of Rhenium tris-carbonyl derivatives: a bimodal infrared and luminescence quantitative study Eur. J., 2014, 20 (28), 8714-8722 – DOI: 10.1002/chem.201402471 (IF 5.73)
  23. Garcia L.; Franzoni S.; Mussi F.; Aumont-Niçaise M.; Bertrand H.; Desmadril M.; Pelosi G.; Buschini A.; Policar C. Apo-neocarzinostatin: a protein carrier for Cu(II) glycocomplexes and Cu(II) into U937 and HT29 cell lines, Inorg. Biochem., 2014, 135, 40-44. – DOI: 10.1016/j.jinorgbio.2014.02.006 (IF 3.44)
  24. Bertrand H., Guillot R., Teulade-Fichou M.-P., Fichou D. Synthesis, Properties, and Remarkable 2D Self-Assembly at the Liquid/Solid Interface of a Series of Triskele-Shaped 5,11,17-Triazatrinaphthylenes (TrisK). Eur. J., 2013, 19, 14654-14664 – DOI: 10.1002/chem.201300705 (IF 5.831)
  25. Hancock R.; Bertrand H. C.; Tsujita T.; Naz S.; El-Bakry A.; Laoruchupong J.; Hayes J. D.; Wells G.; Peptide inhibitors of the Keap1–Nrf2 protein–protein interaction. Free Rad. Biol. Med., 2012, 52 (2), 444-451 – DOI:10.1016/j.freeradbiomed.2011.10.486 (IF 5.423)
  26. Bertrand H.; Silly F.; Teulade-Fichou M.-P.; Tortech L.; Fichou D.; Locking the free-rotation of a prochiral star-shaped guest molecule inside a two-dimensional nanoporous network by introduction of chlorine atoms. Commun., 2011, 47 (36), 10091-10093   – DOI: 10.1039/c1cc12951a (IF 6.169)
  27. Bertrand H.; Granzhan A.; Monchaud D.; Saettel N.; Guillot R.; Clifford S.; Mergny J.-L.; Teulade-Fichou M.-P.; Recognition of G-Quadruplex DNA by Triangular Star-Shaped Compounds: With or Without Side Chains? Eur. J., 2011, 17 (16), 4529-4539   – DOI: 10.1002/chem.201002810 (IF 5.925)
  28. Bertrand H., Bombard S., Monchaud D., Talbot E., Guédin A., Mergny J.-L., Grünert R., Bednarsky P.J., Teulade-Fichou M.-P. Exclusive platination of loop adenines in the human telomeric G-quadruplex. Biomol. Chem. 2009, 7, 2864-2871 – DOI: 10.1039/b904599f (IF 3.762)
  29. Monchaud D., Allain C., Bertrand H., Smargiasso N., Rosu F., Gabelica V., De Cian A., Mergny J.-L., Teulade-Fichou M.-P. Ligands playing musical chairs with G-quadruplex DNA: A rapid and simple displacement assay for identifying selective G-quadruplex binders. Biochimie 2008, 90, 1207-1223 – DOI: 10.1016/j.biochi.2008.02.019 (IF 3.071)
  30. De Cian A., Grellier P., Mouray E., Depoix D., Bertrand H., Monchaud D., Teulade-Fichou M.-P., Mergny J.-L., Alberti P. Plasmodium Telomeric Sequences: Structure, Stability and Quadruplex Targeting by Small Compounds. ChemBioChem 2008, 9, 2730–2739 – DOI: 10.1002/cbic.200800330 (IF 3.322)
  31. Bertrand H., Bombard S., Monchaud D., Teulade-Fichou, M.-P. A platinum-quinacridine hybrid as a G-quadruplex ligand. Biol. Inorg. Chem. 2007, 12 (7), 1003-1014 – DOI: 10.1007/s00775-007-0273-3 (IF 3.325)
  32. Bertrand H., Monchaud D., de Cian A., Mergny J.-L., Teulade-Fichou, M.-P. The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes. Biomol. Chem. 2007, 5 (16), 2555-2559 – DOI: 10.1039/B708635K (IF 3.167)
  33. Lartia R., Bertrand H., Teulade-Fichou M.-P. Improved synthesis of quinacridine derivatives. Synlett 2006, 4, 610-614 – DOI: 10.1055/s-2006-932465 (IF 2.838)
  • Proceedings: Bertrand H., Bombard S., Monchaud D., Teulade-Fichou M.-P. New platinum(II) complexes targeting the loops of the human telomeric G-quadruplex. Nucleic Acids Symposium Series, 2008, 52, 163-164 – DOI: 10.1093/nass/nrn083
  • Patents:
  • –  Slama-Schowk A., Delmas B., Quideau S., Bertrand H., Tarus B., Antiviral compositions directed against the influenza virus nucleoprotein. 13/12/2012, WO2012143141 A3
  • – Policar C., Delsuc N., Lambert F., Bertrand H., Bernard A. S., Hostachy, S. Functionalizable molecular probe for X-ray fluorescence spectroscopy and multimodal imaging, 06/07/2015, application number 15175553.5 – 1408
  • e-book chapter: Biochemical assays and biophysical tools for inhibitor identification and validation. Fowkes A., Bertrand H., Wells G. In: Understanding and Exploiting Protein–Protein Interactions as Drug Targets, Unitec House, 2 Albert Place, London N3 1QB, UK (Future Science Ltd) 2013, Pages 104-116 eBook ISBN: 978-1-909453-46-3

Publications

33 Entrées « 1 de 2 »

2020

Anti-inflammatory activity of superoxide dismutase mimics functionalized with cell-penetrating peptides Article de journal

Emilie Mathieu; Anne-Sophie Bernard; Vincent H Y Ching; Andrea Somogyi; Kadda Medjoubi; Jennifer Rodon Fores; Hélène C Bertrand; Amandine Vincent; Sylvain Trépout; Jean-Luc Guerquin-Kern; Andreas Scheitler; Ivana Ivanović-Burmazović; Philippe Seksik; Nicolas Delsuc; Clotilde Policar

Dalton Trans., 49 , p. 2323-2330, 2020.

Résumé | Liens

2018

From Naproxen Repurposing to Naproxen Analogues and Their Antiviral Activity against Influenza A Virus Article de journal

Sébastien Dilly; Aurélien Fotso Fotso; Nathalie Lejal; Gloria Zedda; Mohamad Chebbo; Fryad Rahman; Simon Companys; Hélène C Bertrand; Jasmina Vidic; Magali Noiray; Marie-Christine Alessi; Bogdan Tarus; Stéphane Quideau; Béatrice Riteau; Anny Slama-Schwok

Journal of Medicinal Chemistry, 61 (16), p. 7202–7217, 2018, ISSN: 0022-2623.

Liens

Rhenium tricarbonyl complexes with arenethiolate axial ligands Article de journal

M He; H Y V Ching; C Policar; H C Bertrand

New Journal of Chemistry, 42 (14), p. 11312–11323, 2018.

Résumé | Liens

Labeling of Hyaluronic Acids with a Rhenium-tricarbonyl Tag and Percutaneous Penetration Studied by Multimodal Imaging Article de journal

L Henry; N Delsuc; C Laugel; F Lambert; C Sandt; S Hostachy; A -S Bernard; H C Bertrand; L Grimaud; A Baillet-Guffroy; C Policar

Bioconjugate Chemistry, 29 (4), p. 987–991, 2018.

Résumé | Liens

Increased Efficiency of Dye-Sensitized Solar Cells by Incorporation of a π Spacer in Donor–Acceptor Zinc Porphyrins Bearing Cyanoacrylic Acid as an Anchoring Group Article de journal

S Panagiotakis; E Giannoudis; A Charisiadis; R Paravatou; M -E Lazaridi; M Kandyli; K Ladomenou; P A Angaridis; H C Bertrand; G D Sharma; A G Coutsolelos

European Journal of Inorganic Chemistry, 2018 (20), p. 2369–2379, 2018.

Résumé | Liens

2017

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease Article de journal

Fiona Kerr; Oyinkan Sofola-Adesakin; Dobril K Ivanov; Jemma Gatliff; Beatriz Gomez Perez-Nievas; Hélène C Bertrand; Pedro Martinez; Rebecca Callard; Inge Snoeren; Helena M Cochemé; Jennifer Adcott; Mobina Khericha; Jorge Iván Castillo-Quan; Geoffrey Wells; Wendy Noble; Janet Thornton; Linda Partridge

PLOS Genetics, 13 (3), p. e1006593, 2017.

Résumé | Liens

Synthesis of Homoditopic Ligands with an Incrementable Rodlike Backbone Article de journal

P Demay-Drouhard; L -M Chamoreau; R Guillot; C Policar; H C Bertrand

European Journal of Organic Chemistry, 2017 (1), p. 131–137, 2017.

Résumé | Liens

Rhenium Complexes Based on 2-Pyridyl-1,2,3-triazole Ligands: A New Class of CO2 Reduction Catalysts Article de journal

H Y V Ching; X Wang; M He; N Perujo Holland; R Guillot; C Slim; S Griveau; H C Bertrand; C Policar; F Bedioui; M Fontecave

Inorganic Chemistry, 56 (5), p. 2966–2976, 2017.

Résumé | Liens

Association of a Platinum Complex to a G-Quadruplex Ligand Enhances Telomere Disruption Article de journal

R Charif; C Granotier-Beckers; H C Bertrand; J Poupon; E Ségal-Bendirdjian; M -P Teulade-Fichou; F D Boussin; S Bombard

Chemical Research in Toxicology, 30 (8), p. 1629–1640, 2017.

Résumé | Liens

Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy Article de journal

Nikolaos D Georgakopoulos; Michele Frison; Maria Soledad Alvarez; Hélène Bertrand; Geoff Wells; Michelangelo Campanella

Scientific Reports, 7 (1), p. 10303, 2017, ISSN: 2045-2322.

Résumé | Liens

2016

Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads Article de journal

Kamila K Kaminska; Helene C Bertrand; Hisashi Tajima; William C Stafford; Qing Cheng; Wan Chen; Geoffrey Wells; Elias S J Arner; Eng-Hui Chew

Oncotarget, 7 (26), p. 40233–40251, 2016, ISSN: 1949-2553.

Résumé | Liens

The Use of Mn(II) Bound to His-tags as Genetically Encodable Spin-Label for Nanometric Distance Determination in Proteins Article de journal

H Y V Ching; F C Mascali; H C Bertrand; E M Bruch; P Demay-Drouhard; R M Rasia; C Policar; L C Tabares; S Un

Journal of Physical Chemistry Letters, 7 (6), p. 1072–1076, 2016.

Résumé | Liens

RIDME spectroscopy on high-spin Mn2+ centers Article de journal

D Akhmetzyanov; H Y V Ching; V Denysenkov; P Demay-Drouhard; H C Bertrand; L C Tabares; C Policar; T F Prisner; S Un

Physical Chemistry Chemical Physics, 18 (44), p. 30857–30866, 2016.

Résumé | Liens

Monitoring bicosomes containing antioxidants in normal and irradiated skin Article de journal

E Fernández; S Hostachy; C Sandt; G Rodríguez; H C Bertrand; S Clède; M Cócera; A D L Maza; F Lambert; C Policar; O López

RSC Advances, 6 (76), p. 72559–72567, 2016.

Résumé | Liens

Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads Article de journal

K K Kaminska; H C Bertrand; H Tajima; W C Stafford; Q Cheng; W Chen; G Wells; E S J Arner; E -H Chew

Oncotarget, 7 (26), p. 40233–40251, 2016.

Résumé | Liens

Bimodal X-ray and Infrared Imaging of an Organometallic Derivative of Praziquantel in Schistosoma mansoni Article de journal

S Clède; N Cowan; F Lambert; H C Bertrand; R Rubbiani; M Patra; J Hess; C Sandt; N Trcera; G Gasser; J Keiser; C Policar

ChemBioChem, 17 (11), p. 1004–1007, 2016.

Résumé | Liens

A Bis-Manganese(II)–DOTA Complex for Pulsed Dipolar Spectroscopy Article de journal

P Demay-Drouhard; H Y V Ching; D Akhmetzyanov; R Guillot; L C Tabares; H C Bertrand; C Policar

ChemPhysChem, p. 2066–2078, 2016.

Résumé | Liens

2015

Structure-based design of novel naproxen derivatives targeting monomeric nucleoprotein of Influenza A virus Article de journal

Bogdan Tarus; Hélène Bertrand; Gloria Zedda; Carmelo Di Primo; Stéphane Quideau; Anny Slama-Schwok

Journal of biomolecular structure & dynamics, 33 (9), p. 1899–1912, 2015, ISSN: 1538-0254.

Résumé | Liens

Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1–Nrf2 Protein–Protein Interaction Article de journal

Hélène C Bertrand; Marjolein Schaap; Liam Baird; Nikolaos D Georgakopoulos; Adrian Fowkes; Clarisse Thiollier; Hiroko Kachi; Albena T Dinkova-Kostova; Geoff Wells

Journal of Medicinal Chemistry, 58 (18), p. 7186–7194, 2015, ISSN: 0022-2623.

Liens

Nanometric distance measurements between Mn(II)DOTA centers Article de journal

H Y Vincent Ching; P Demay-Drouhard; H C Bertrand; C Policar; L C Tabares; S Un

Physical Chemistry Chemical Physics, 17 (36), p. 23368–23377, 2015.

Résumé | Liens

2014

PMI: a $Delta$$Psi$m independent pharmacological regulator of mitophagy Article de journal

Daniel A East; Francesca Fagiani; James Crosby; Nikolaos D Georgakopoulos; Hélène Bertrand; Marjolein Schaap; Adrian Fowkes; Geoff Wells; Michelangelo Campanella

Chemistry & biology, 21 (11), p. 1585–1596, 2014, ISSN: 1879-1301.

Résumé | Liens

Influence of the side-chain length on the cellular uptake and the cytotoxicity of rhenium triscarbonyl derivatives: A bimodal infrared and luminescence quantitative study Article de journal

S Clède; F Lambert; R Saint-Fort; M -A Plamont; H Bertrand; A Vessières; C Policar

Chemistry - A European Journal, 20 (28), p. 8714–8722, 2014.

Résumé | Liens

Apo-neocarzinostatin: A protein carrier for Cu(II) glycocomplexes and Cu(II) into U937 and HT29 cell lines Article de journal

L Garcia; S Franzoni; F Mussi; M Aumont-Niçaise; H Bertrand; M Desmadril; G Pelosi; A Buschini; C Policar

Journal of Inorganic Biochemistry, 135 , p. 40–44, 2014.

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Luminescence modulations of rhenium tricarbonyl complexes induced by structural variations Article de journal

H C Bertrand; S Clède; R Guillot; F Lambert; C Policar

Inorganic Chemistry, 53 (12), p. 6204–6223, 2014.

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2013

Synthesis, Properties, and Remarkable 2 D Self-Assembly at the Liquid/Solid Interface of a Series of Triskele-Shaped 5,11,17-Triazatrinaphthylenes (TrisK) Article de journal

Hélène Bertrand; Régis Guillot; Marie-Paule Teulade-Fichou; Denis Fichou

Chemistry – A European Journal, 19 (43), p. 14654–14664, 2013, ISSN: 0947-6539.

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2011

Recognition of G-Quadruplex DNA by Triangular Star-Shaped Compounds: With or Without Side Chains? Article de journal

Hélène Bertrand; Anton Granzhan; David Monchaud; Nicolas Saettel; Régis Guillot; Sarah Clifford; Aurore Guédin; Jean-Louis Mergny; Marie-Paule Teulade-Fichou

Chemistry – A European Journal, 17 (16), p. 4529–4539, 2011, ISSN: 0947-6539.

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Locking the free-rotation of a prochiral star-shaped guest molecule inside a two-dimensional nanoporous network by introduction of chlorine atoms Article de journal

Hélène Bertrand; Fabien Silly; Marie-Paule Teulade-Fichou; Ludovic Tortech; Denis Fichou

Chemical Communications, 47 (36), p. 10091–10093, 2011, ISSN: 1359-7345.

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2009

Exclusive platination of loop adenines in the human telomeric G-quadruplex Article de journal

Hélène Bertrand; Sophie Bombard; David Monchaud; Eric Talbot; Aurore Guédin; Jean-Louis Mergny; Renate Grünert; Patrick J Bednarski; Marie-Paule Teulade-Fichou

Organic & Biomolecular Chemistry, 7 (14), p. 2864–2871, 2009, ISSN: 1477-0520.

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2008

Plasmodium Telomeric Sequences: Structure, Stability and Quadruplex Targeting by Small Compounds Article de journal

Anne De Cian; Philippe Grellier; Elisabeth Mouray; Delphine Depoix; Hélène Bertrand; David Monchaud; Marie-Paule Teulade-Fichou; Jean-Louis Mergny; Patrizia Alberti

ChemBioChem, 9 (16), p. 2730–2739, 2008, ISSN: 1439-4227.

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New platinum(II) complexes targeting the loops of the human telomeric G-quadruplex. Article de journal

Hélène Bertrand; Sophie Bombard; David Monchaud; Marie-Paule Teulade-Fichou

Nucleic Acids Symposium Series, 52 (1), p. 163–164, 2008, ISSN: 0261-3166.

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