Nicolas DELSUC


Chargé de Recherche CNRS

ENS – Département de chimie
24 rue Lhomond, 75005 Paris

Phone: +33 144322424
Office: E037a

Our website:


Short bio

I have been trained in chemistry at Bordeaux University. I did a PhD from 2004 to 2007 in supramolecular chemistry under the supervision of Dr. Ivan Huc. I worked on the development of proteomimetic structures using abiotic foldamers. I then obtained a fellowship from the Japan Society for the Promotion of Sciences (JSPS) to join the group of Prof. Itaru Hamachi at Kyoto University where I worked on new peptidyl receptors for peptide recognition. In 2009, I came back to France as temporary lecturer (ATER) at the Laboratoire des Biomolécules (LBM, UMR 7203), where I worked with Prof. Philippe Karoyan to develop foldamers based on proline derivatives. I have been appointed as CNRS researcher in 2010 and joined the group of Clotilde Policar at the LBM. I first worked on the conjugation of bioactive molecules with peptide to enhance their penetration and bioavaibality as well on the development of multimodal metal-based probes. Now I want to combine peptide and metal ions to synergistically take advantages of the properties of both classes of molecules by developing new peptidyl metalloprobes and metallodrugs.

Education and professional experience

  • Sept 2020-2022: Assitant Professor associate. ENS
  • Oct 2010-now: Associate researcher. Laboratoire des BioMolécules, UMR7203 CNRS-SU-ENS. In the Inorganic Cellular Chemistry group within the team 1.
  • Sept 2009-Sept 2010: Teaching assistant. Laboratoire des BioMolécules, UMR7203 UPMC-ENS. In the group of P. Karoyan, « Conception of enzyme mimics with foldamers »
  • Nov 2007-Jul 2009: Post-doctoral fellow of the JSPS. Kyoto University, Japan. In the group of I. Hamachi. « Development of molecular receptors for specific peptides recognition »
  • Oct 2004-Oct 2007: PhD in Organic chemistry, Bordeaux1 University under the supervision of I. Huc. »Development of proteomimetic tertiary structures with aromatic oligoamide foldamers »
  • Sept 2005- Sept 2007: M.Sc. in Organic chemistry, Bordeaux1 University

Research interests

  • Development of peptidyl metal complexes mimicking metalloenzymes
  • Development of metal-centered probes for bio-imaging or diagnostic

Awards and distinctions

  • 2016: ANR JCJC
  • 2007: JSPS Postodoctoral Fellowship

Supervised PhD and post-doctoral students

  • Current: Nader Balbali (2023-)
  • Formers: Gabrielle Schanne (2019-2022), Martha Zoumpoulaki (2017-2021), Koudedja Coulibaly (2017-2020), Amandine Vincent (2016-2019), Emilie Mathieu (2014-2017), Sarah Hostachy (2012-2015), May Lee Low (2011-2014, cotutelle with Malaysia), Anne-Sophie Bernard (2010-2014)


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Cellular evaluation of superoxide dismutase mimics as catalytic drugs: Challenges and opportunities Article de journal

Gabrielle Schanne; Sylvie Demignot; Clotilde Policar; Nicolas Delsuc

Coordination Chemistry Reviews, 514 , p. 215906, 2024, ISSN: 0010-8545.

Piezoelectric and microfluidic tuning of an infrared cavity for vibrational polariton studies Article de journal

Wei Wang; Jaime de la Fuente Diez; Nicolas Delsuc; Juan Peng; Riccardo Spezia; Rodolphe Vuilleumier; Yong Chen

Lab Chip, p. -, 2024.

Metal complexes in cells: from design of catalytic antioxidants to imaging metal ions and designing metal-based probes in X-ray fluorescence and IR-imaging, a multidisciplinary collaborative journey in bioinorganic chemistry and inorganic chemical biology Article de journal

Clotilde Policar; Nicolas Delsuc; Hél`ene Charlotte Bertrand

Comptes Rendus. Chimie, 2024, (Online first).


Ruthenium(II) polypyridyl complexes as emerging photosensitisers for antibacterial photodynamic therapy Article de journal

Ng Xiao Ying; Fong Kar Wai; Kiew Lik Voon; Katrina Chung Pooi Yin; Liew Yun Khoon; Nicolas Delsuc; Mohd Zulkefeli; Low May Lee

Journal of Inorganic Biochemistry, p. 112425, 2023, ISSN: 0162-0134.

Engineering Peptidyl and Protein Glutathione Peroxidase Mimics Book Chapter

Nicolas Delsuc

Peptide and Protein Engineering for Biotechnological and Therapeutic Applications, Chapitre Chapter 6, p. 247-278, WORLD SCIENTIFIC, 2023.


Cellular Detection of a Mitochondria Targeted Brominated Vinyl Triphenylamine Optical Probe (TP−Br) by X-Ray Fluorescence Microscopy Article de journal

Sounderya Nagarajan; Florent Poyer; Laura Fourmois; Delphine Naud-Martin; Kadda Medjoubi; Andrea Somogyi; Gabrielle Schanne; Lucas Henry; Nicolas Delsuc; Clotilde Policar; Helene C Bertrand; Florence Mahuteau-Betzer

Chemistry – A European Journal, 28 (15), p. e202104424, 2022.

Inertness of Superoxide Dismutase Mimics Mn(II) Complexes Based on an Open-Chain Ligand, Bioactivity, and Detection in Intestinal Epithelial Cells Article de journal

Gabrielle Schanne; Martha Zoumpoulaki; Géraldine Gazzah; Amandine Vincent; Hugues Preud’homme; Ryszard Lobinski; Sylvie Demignot; Philippe Seksik; Nicolas Delsuc; Clotilde Policar

Oxidative Medicine and Cellular Longevity, 2022 , p. e3858122, 2022, ISSN: 1942-0900, (Publisher: Hindawi).

SOD mimics: From the tool box of the chemists to cellular studies Article de journal

Clotilde Policar; Jean Bouvet; Hélène C Bertrand; Nicolas Delsuc

Current Opinion in Chemical Biology, 67 , p. 102109, 2022, ISSN: 1367-5931.

Deciphering the Metal Speciation in Low-Molecular-Weight Complexes by IMS-MS: Application to the Detection of Manganese Superoxide Dismutase Mimics in Cell Lysates Article de journal

Martha Zoumpoulaki; Gabrielle Schanne; Nicolas Delsuc; Hugues Preud'homme; Elodie Quévrain; Nicolas Eskenazi; Géraldine Gazzah; Regis Guillot; Philippe Seksik; Joelle Vinh; Ryszard Lobinski; Clotilde Policar

Angewandte Chemie International Edition, n/a (n/a), p. e202203066, 2022.

Improvement of Peptidyl Copper Complexes Mimicking Catalase: A Subtle Balance between Thermodynamic Stability and Resistance towards H2O2 Degradation Article de journal

Yaqine Ben Hadj Hammouda; Koudedja Coulibaly; Alimatou Bathily; Magdalene Teoh Sook Han; Clotilde Policar; Nicolas Delsuc

Molecules, 27 (17), 2022, ISSN: 1420-3049.


A di-Copper Peptidyl Complex Mimics the Activity of Catalase, a Key Antioxidant Metalloenzyme Article de journal

Koudedja Coulibaly; Marion Thauvin; Adyn Melenbacher; Clara Testard; Evangelina Trigoni; Amandine Vincent; Martin J Stillman; Sophie Vriz; Clotilde Policar; Nicolas Delsuc

Inorganic Chemistry, 60 (13), p. 9309-9319, 2021.

Rhenium carbonyl complexes bearing methylated triphenylphosphonium cations as antibody-free mitochondria trackers for X-ray fluorescence imaging Article de journal

Gabrielle Schanne; Lucas Henry; How Chee Ong; Andrea Somogyi; Kadda Medjoubi; Nicolas Delsuc; Clotilde Policar; Felipe García; Helene C Bertrand

Inorg. Chem. Front., 8 , p. 3905-3915, 2021.

Evaluation of the compounds commonly known as superoxide dismutase and catalase mimics in cellular models Article de journal

Amandine Vincent; Marion Thauvin; Elodie Quévrain; Emilie Mathieu; Sarah Layani; Philippe Seksik; Ines Batinic-Haberle; Sophie Vriz; Clotilde Policar; Nicolas Delsuc

Journal of Inorganic Biochemistry, p. 111431, 2021, ISSN: 0162-0134.


An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase Article de journal

Amandine Vincent; Jennifer Rodon Fores; Elodie Tauziet; Elodie Quévrain; Ágnes Dancs; Amandine Conte-Daban; Anne-Sophie Bernard; Philippe Pelupessy; Koudedja Coulibaly; Philippe Seksik; Christelle Hureau; Katalin Selmeczi; Clotilde Policar; Nicolas Delsuc

Chem. Commun., 56 , p. 399-402, 2020.

Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese(ii) superoxide dismutase mimic complex Article de journal

Emilie Mathieu; Anne-Sophie Bernard; Elodie Quévrain; Martha Zoumpoulaki; Sébastien Iriart; Caroline Lung-Soong; Barry Lai; Kadda Medjoubi; Lucas Henry; Sounderya Nagarajan; Florent Poyer; Andreas Scheitler; Ivana Ivanović-Burmazović; Sergio Marco; Andrea Somogyi; Philippe Seksik; Nicolas Delsuc; Clotilde Policar

Chem. Commun., p. -, 2020.

Anti-inflammatory activity of superoxide dismutase mimics functionalized with cell-penetrating peptides Article de journal

Emilie Mathieu; Anne-Sophie Bernard; Vincent H Y Ching; Andrea Somogyi; Kadda Medjoubi; Jennifer Rodon Fores; Hélène C Bertrand; Amandine Vincent; Sylvain Trépout; Jean-Luc Guerquin-Kern; Andreas Scheitler; Ivana Ivanović-Burmazović; Philippe Seksik; Nicolas Delsuc; Clotilde Policar

Dalton Trans., 49 , p. 2323-2330, 2020.

Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites Article de journal

Nicolas Debons; Dounia Dems; Christophe Hélary; Sylvain Le Grill; Lise Picaut; Flore Renaud; Nicolas Delsuc; Marie-Claire Schanne-Klein; Thibaud Coradin; Carole Aimé

Biomater. Sci., 8 , p. 569-576, 2020.

Recent Emergence of Rhenium(I) Tricarbonyl Complexes as Photosensitisers for Cancer Therapy Article de journal

Hui Shan Liew; Chun-Wai Mai; Mohd Zulkefeli; Thiagarajan Madheswaran; Lik Voon Kiew; Nicolas Delsuc; May Lee Low

Molecules, 25 (18), 2020, ISSN: 1420-3049.


Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins Article de journal

S Hostachy; M Masuda; T Miki; I Hamachi; S Sagan; O Lequin; K Medjoubi; A Somogyi; N Delsuc; C Policar

Chemical Science, 9 (19), p. 4483–4487, 2018.

Labeling of Hyaluronic Acids with a Rhenium-tricarbonyl Tag and Percutaneous Penetration Studied by Multimodal Imaging Article de journal

L Henry; N Delsuc; C Laugel; F Lambert; C Sandt; S Hostachy; A -S Bernard; H C Bertrand; L Grimaud; A Baillet-Guffroy; C Policar

Bioconjugate Chemistry, 29 (4), p. 987–991, 2018.

A Metallo Pro-Drug to Target CuII in the Context of Alzheimer's Disease Article de journal

A Conte-Daban; V Ambike; R Guillot; N Delsuc; C Policar; C Hureau

Chemistry - A European Journal, 24 (20), p. 5095–5099, 2018.


Re(I) carbonyl complexes: Multimodal platforms for inorganic chemical biology Article de journal

S Hostachy; C Policar; N Delsuc

Coordination Chemistry Reviews, 351 , p. 172–188, 2017.

A Cell-Penetrant Manganese Superoxide Dismutase (MnSOD) Mimic Is Able to Complement MnSOD and Exerts an Antiinflammatory Effect on Cellular and Animal Models of Inflammatory Bowel Diseases Article de journal

E Mathieu; A -S Bernard; N Delsuc; E Quévrain; G Gazzah; B Lai; F Chain; P Langella; M Bachelet; J Masliah; P Seksik; C Policar

Inorganic Chemistry, 56 (5), p. 2545–2555, 2017.

A host-guest system based on collagen-like triple-helix hybridization Article de journal

N Delsuc; S Uchinomiya; A Ojida; I Hamachi

Chemical Communications, 53 (51), p. 6856–6859, 2017.

An All-in-One Molecule for the One-Step Synthesis of Functional Hybrid Silica Particles with Tunable Sizes Article de journal

J Graffion; D Dems; M Demirelli; T Coradin; N Delsuc; C Aimé

European Journal of Inorganic Chemistry, 2017 (43), p. 5047–5051, 2017.


Photophysical properties of single core multimodal probe for imaging (SCoMPI) in a membrane model and in cells Article de journal

S Hostachy; J -M Swiecicki; C Sandt; N Delsuc; C Policar

Dalton Transactions, 45 (7), p. 2791–2795, 2016.

New insight into the structural, electrochemical and biological aspects of macroacyclic Cu(II) complexes derived from S-substituted dithiocarbazate schiff bases Article de journal

M L Low; L Maigre; M I M Tahir; E R T Tiekink; P Dorlet; R Guillot; T B Ravoof; R Rosli; J -M Pagès; C Policar; N Delsuc; K A Crouse

European Journal of Medicinal Chemistry, 120 , p. 1–12, 2016.

Bioinspired superoxide-dismutase mimics: The effects of functionalization with cationic polyarginine peptides Article de journal

H Y V Ching; I Kenkel; N Delsuc; E Mathieu; I Ivanović-Burmazović; C Policar

Journal of Inorganic Biochemistry, 160 , p. 172–179, 2016.


Synthesis, characterization and biological activity of Cu(II), Zn(II) and Re(I) complexes derived from S-benzyldithiocarbazate and 3-acetylcoumarin Article de journal

M L Low; G Paulus; P Dorlet; R Guillot; R Rosli; N Delsuc; K A Crouse; C Policar

BioMetals, 28 (3), p. 553–566, 2015.

An easy-to-detect nona-arginine peptide for epidermal targeting Article de journal

S Clède; N Delsuc; C Laugel; F Lambert; C Sandt; A Baillet-Guffroy; C Policar

Chemical Communications, 51 (13), p. 2687–2689, 2015.

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