Nicolas DELSUC

Chargé de Recherche

ENS – Département de chimie
24 rue Lhomond, 75005 Paris

Email: nicolas.delsuc@ens.psl.eu
Phone: +33 144322424
Office: E037a

Short bio

I have been trained in chemistry at Bordeaux University. I did a PhD from 2004 to 2007 in supramolecular chemistry under the supervision of Dr. Ivan Huc. I worked on the development of proteomimetic structures using abiotic foldamers. I then obtained a fellowship from the Japan Society for the Promotion of Sciences (JSPS) to join the group of Prof. Itaru Hamachi at Kyoto University where I worked on new peptidyl receptors for peptide recognition. In 2009, I came back to France as temporary lecturer (ATER) at the Laboratoire des Biomolécules (LBM, UMR 7203), where I worked with Prof. Philippe Karoyan to develop foldamers based on proline derivatives. I have been appointed as CNRS researcher in 2010 and joined the group of Clotilde Policar at the LBM. I first worked on the conjugation of bioactive molecules with peptide to enhance their penetration and bioavaibality as well on the development of multimodal metal-based probes. Now I want to combine peptide and metal ions to synergistically take advantages of the properties of both classes of molecules by developing new peptidyl metalloprobes and metallodrugs.

Education and professional experience

  • Oct 2010-now: Associate researcher. Laboratoire des BioMolécules, UMR7203 CNRS-SU-ENS. In the Inorganic Cellular Chemistry group within the team 1.
  • Sept 2009-Sept 2010: Teaching assistant. Laboratoire des BioMolécules, UMR7203 UPMC-ENS. In the group of P. Karoyan, « Conception of enzyme mimics with foldamers »
  • Nov 2007-Jul 2009: Post-doctoral fellow of the JSPS. Kyoto University, Japan. In the group of I. Hamachi. « Development of molecular receptors for specific peptides recognition »
  • Oct 2004-Oct 2007: PhD in Organic chemistry, Bordeaux1 University under the supervision of I. Huc. »Development of proteomimetic tertiary structures with aromatic oligoamide foldamers »
  • Sept 2005- Sept 2007: M.Sc. in Organic chemistry, Bordeaux1 University

Research interests

  • Development of peptidyl metal complexes mimicking metalloenzymes
  • Development of metal-centered probes for bio-imaging or diagnostic

Awards and distinctions

  • 2016: ANR JCJC
  • 2007: JSPS Postodcotoral Fellowship

Supervised PhD and post-doctoral students

  • Current: Gabrielle Schanne (2019), Koudedja Coulibaly (2017), Martha Zoumpoulaki (2017),
  • formers: Amandine Vincent (2016-2019), Emilie Mathieu (2014-2017), Sarah Hostachy (2012-2015), May Lee Low (2011-2014, cotutelle with Malaysia), Anne-Sophie Bernard (2010-2014)

Publications

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2020

An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase Article de journal

Amandine Vincent; Jennifer Rodon Fores; Elodie Tauziet; Elodie Quévrain; Ágnes Dancs; Amandine Conte-Daban; Anne-Sophie Bernard; Philippe Pelupessy; Koudedja Coulibaly; Philippe Seksik; Christelle Hureau; Katalin Selmeczi; Clotilde Policar; Nicolas Delsuc

Chem. Commun., 56 , p. 399-402, 2020.

Résumé | Liens

Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese(ii) superoxide dismutase mimic complex Article de journal

Emilie Mathieu; Anne-Sophie Bernard; Elodie Quévrain; Martha Zoumpoulaki; Sébastien Iriart; Caroline Lung-Soong; Barry Lai; Kadda Medjoubi; Lucas Henry; Sounderya Nagarajan; Florent Poyer; Andreas Scheitler; Ivana Ivanović-Burmazović; Sergio Marco; Andrea Somogyi; Philippe Seksik; Nicolas Delsuc; Clotilde Policar

Chem. Commun., p. -, 2020.

Résumé | Liens

Anti-inflammatory activity of superoxide dismutase mimics functionalized with cell-penetrating peptides Article de journal

Emilie Mathieu; Anne-Sophie Bernard; Vincent H Y Ching; Andrea Somogyi; Kadda Medjoubi; Jennifer Rodon Fores; Hélène C Bertrand; Amandine Vincent; Sylvain Trépout; Jean-Luc Guerquin-Kern; Andreas Scheitler; Ivana Ivanović-Burmazović; Philippe Seksik; Nicolas Delsuc; Clotilde Policar

Dalton Trans., 49 , p. 2323-2330, 2020.

Résumé | Liens

Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites Article de journal

Nicolas Debons; Dounia Dems; Christophe Hélary; Sylvain Le Grill; Lise Picaut; Flore Renaud; Nicolas Delsuc; Marie-Claire Schanne-Klein; Thibaud Coradin; Carole Aimé

Biomater. Sci., 8 , p. 569-576, 2020.

Résumé | Liens

Recent Emergence of Rhenium(I) Tricarbonyl Complexes as Photosensitisers for Cancer Therapy Article de journal

Hui Shan Liew; Chun-Wai Mai; Mohd Zulkefeli; Thiagarajan Madheswaran; Lik Voon Kiew; Nicolas Delsuc; May Lee Low

Molecules, 25 (18), 2020, ISSN: 1420-3049.

Résumé | Liens

2018

A Metallo Pro-Drug to Target CuII in the Context of Alzheimer's Disease Article de journal

A Conte-Daban; V Ambike; R Guillot; N Delsuc; C Policar; C Hureau

Chemistry - A European Journal, 24 (20), p. 5095–5099, 2018.

Résumé | Liens

Labeling of Hyaluronic Acids with a Rhenium-tricarbonyl Tag and Percutaneous Penetration Studied by Multimodal Imaging Article de journal

L Henry; N Delsuc; C Laugel; F Lambert; C Sandt; S Hostachy; A -S Bernard; H C Bertrand; L Grimaud; A Baillet-Guffroy; C Policar

Bioconjugate Chemistry, 29 (4), p. 987–991, 2018.

Résumé | Liens

Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins Article de journal

S Hostachy; M Masuda; T Miki; I Hamachi; S Sagan; O Lequin; K Medjoubi; A Somogyi; N Delsuc; C Policar

Chemical Science, 9 (19), p. 4483–4487, 2018.

Résumé | Liens

2017

Re(I) carbonyl complexes: Multimodal platforms for inorganic chemical biology Article de journal

S Hostachy; C Policar; N Delsuc

Coordination Chemistry Reviews, 351 , p. 172–188, 2017.

Résumé | Liens

An All-in-One Molecule for the One-Step Synthesis of Functional Hybrid Silica Particles with Tunable Sizes Article de journal

J Graffion; D Dems; M Demirelli; T Coradin; N Delsuc; C Aimé

European Journal of Inorganic Chemistry, 2017 (43), p. 5047–5051, 2017.

Résumé | Liens

A host-guest system based on collagen-like triple-helix hybridization Article de journal

N Delsuc; S Uchinomiya; A Ojida; I Hamachi

Chemical Communications, 53 (51), p. 6856–6859, 2017.

Résumé | Liens

A Cell-Penetrant Manganese Superoxide Dismutase (MnSOD) Mimic Is Able to Complement MnSOD and Exerts an Antiinflammatory Effect on Cellular and Animal Models of Inflammatory Bowel Diseases Article de journal

E Mathieu; A -S Bernard; N Delsuc; E Quévrain; G Gazzah; B Lai; F Chain; P Langella; M Bachelet; J Masliah; P Seksik; C Policar

Inorganic Chemistry, 56 (5), p. 2545–2555, 2017.

Résumé | Liens

2016

Photophysical properties of single core multimodal probe for imaging (SCoMPI) in a membrane model and in cells Article de journal

S Hostachy; J -M Swiecicki; C Sandt; N Delsuc; C Policar

Dalton Transactions, 45 (7), p. 2791–2795, 2016.

Résumé | Liens

New insight into the structural, electrochemical and biological aspects of macroacyclic Cu(II) complexes derived from S-substituted dithiocarbazate schiff bases Article de journal

M L Low; L Maigre; M I M Tahir; E R T Tiekink; P Dorlet; R Guillot; T B Ravoof; R Rosli; J -M Pagès; C Policar; N Delsuc; K A Crouse

European Journal of Medicinal Chemistry, 120 , p. 1–12, 2016.

Résumé | Liens

Bioinspired superoxide-dismutase mimics: The effects of functionalization with cationic polyarginine peptides Article de journal

H Y V Ching; I Kenkel; N Delsuc; E Mathieu; I Ivanović-Burmazović; C Policar

Journal of Inorganic Biochemistry, 160 , p. 172–179, 2016.

Résumé | Liens

2015

Synthesis, characterization and biological activity of Cu(II), Zn(II) and Re(I) complexes derived from S-benzyldithiocarbazate and 3-acetylcoumarin Article de journal

M L Low; G Paulus; P Dorlet; R Guillot; R Rosli; N Delsuc; K A Crouse; C Policar

BioMetals, 28 (3), p. 553–566, 2015.

Résumé | Liens

An easy-to-detect nona-arginine peptide for epidermal targeting Article de journal

S Clède; N Delsuc; C Laugel; F Lambert; C Sandt; A Baillet-Guffroy; C Policar

Chemical Communications, 51 (13), p. 2687–2689, 2015.

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2014

Conjugation of a new series of dithiocarbazate schiff base copper(II) complexes with vectors selected to enhance antibacterial activity Article de journal

M L Low; L Maigre; P Dorlet; R Guillot; J -M Pagès; K A Crouse; C Policar; N Delsuc

Bioconjugate Chemistry, 25 (12), p. 2269–2284, 2014.

Résumé | Liens

From IR-Spectromicroscopy using AFM-IR and SR-FTIR to Bimodal Spectromicroscopy using SCoMPIs - Single Core Multimodal Probe for Imaging Article de journal

C Policar; C Sylvain; F Lambert; N Delsuc; C Sandt; P Dumas; M Refregiers; M Plamont; A Vessieres; Z Gueroui; A Dazzi

Journal of Biological Inorganic Chemistry, 19 , p. S182-S182, 2014, ISSN: 0949-8257.

Liens

Anti-oxidant Mn-complexes: evaluation in cellular models of oxidative stress Article de journal

Clotilde Policar; Anne-Sophie Bernard; Nicolas Delsuc; Geraldine Gazzah; Manon Guille; Frederic Lemaitre; Christian Amatore; Maria Bachelet; Joelle Masliah

Journal of Biological Inorganic Chemistry, 19 , p. S739-S740, 2014, (Times Cited: 0 2 12th European Biological Inorganic Chemistry Conference (EuroBIC) Aug 24-28, 2014 Zurich, SWITZERLAND Univ Zurich).

2013

Synchrotron radiation FTIR detection of a metal-carbonyl tamoxifen analog. Correlation with luminescence microscopy to study its subcellular distribution Article de journal

S Clède; F Lambert; C Sandt; Z Gueroui; N Delsuc; P Dumas; A Vessières; C Policar

Biotechnology Advances, 31 (3), p. 393–395, 2013.

Résumé | Liens

Homooligomers of substituted prolines and β-prolines: Syntheses and secondary structure investigation Article de journal

C Caumes; N Delsuc; R B Azza; I Correia; F Chemla; F Ferreira; L Carlier; A P Luna; R Moumné; O Lequin; P Karoyan

New Journal of Chemistry, 37 (5), p. 1312–1319, 2013.

Résumé | Liens

3-substituted prolines: From synthesis to structural applications, from peptides to foldamers Article de journal

C Mothes; C Caumes; A Guez; H Boullet; T Gendrineau; S Darses; N Delsuc; R Moumné; B Oswald; O Lequin; P Karoyan

Molecules, 18 (2), p. 2307–2327, 2013.

Résumé | Liens

2011

Relative helix-helix conformations in branched aromatic oligoamide foldamers Article de journal

N Delsuc; S Massip; J -M Léger; B Kauffmann; I Huc

Journal of the American Chemical Society, 133 (9), p. 3165–3172, 2011.

Résumé | Liens

2010

Cascading transformations within a dynamic self-assembled system Article de journal

Victoria E Campbell; Xavier de Hatten; Nicolas Delsuc; Brice Kauffmann; Ivan Huc; Jonathan R Nitschke

Nature Chemistry, 2 (8), p. 684–687, 2010, ISSN: 1755-4349.

Résumé | Liens

2009

Interplay of Interactions Governing the Dynamic Conversions of Acyclic and Macrocyclic Helicates Article de journal

Victoria E. Campbell; Xavier de Hatten; Nicolas Delsuc; Brice Kauffmann; Ivan Huc; Jonathan R. Nitschke

Chemistry - A European Journal, 15 (25), p. 6138–6142, 2009, ISSN: 09476539, 15213765.

Liens

Helical Aromatic Oligoamide Foldamers as Organizational Scaffolds for Photoinduced Charge Transfer Article de journal

Martin Wolffs; Nicolas Delsuc; Dirk Veldman; Nguyễn Vân Anh; René M Williams; Stefan C J Meskers; René A J Janssen; Ivan Huc; Albertus P H J Schenning

Journal of the American Chemical Society, 131 (13), p. 4819–4829, 2009, ISSN: 0002-7863, 1520-5126.

Liens

2008

Metal-Directed Dynamic Formation of Tertiary Structure in Foldamer Assemblies: Orienting Helices at an Angle Article de journal

Nicolas Delsuc; Marie Hutin; Victoria E. Campbell; Brice Kauffmann; Jonathan R. Nitschke; Ivan Huc

Chemistry - A European Journal, 14 (24), p. 7140–7143, 2008, ISSN: 09476539, 15213765.

Liens

Kinetics of Helix-Handedness Inversion: Folding and Unfolding in Aromatic Amide Oligomers Article de journal

Nicolas Delsuc; Takahiro Kawanami; Julien Lefeuvre; Atsuomi Shundo; Hirotaka Ihara; Makoto Takafuji; Ivan Huc

ChemPhysChem, 9 (13), p. 1882–1890, 2008, ISSN: 14394235, 14397641.

Liens

2007

Proteomorphous Objects from Abiotic Backbones Article de journal

Nicolas Delsuc; Jean-Michel Léger; Stéphane Massip; Ivan Huc

Angewandte Chemie International Edition, 46 (1-2), p. 214–217, 2007, ISSN: 14337851, 15213773.

Liens

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