Clotilde POLICAR

Professor, Ecole Normale Supérieure, PSL université Paris
Dean of the studies at the department of chemistry of ENS
Deputy director of the Laboratoire des BioMolécules (LBM), UMR7203, CNRS-PSL-SU
Scientific deputy director of the Institute of chemistry at CNRS (DAS-INC-CNRS), in charge of interdisciplinarity

ENS – Département de chimie
24 rue Lhomond, 75005 Paris, France

Email: clotilde.policar@ens.fr
Phone: +33 144322424
Office: E037

Short bio

Clotilde Policar was trained in organic, inorganic and physical chemistry and she then specialized in bio-inorganic chemistry. After a Ph.D. under the supervision of Dr. Daniel Mansuy and Dr. Isabelle Artaud at Paris-Sud 11 and Paris 5 universities on mimics of a metalloprotein (manganese peroxidase), she worked as a post-doctoral fellow on high-field electron paramagnetic resonance to characterize complexes mimicking the Mn cluster from the oxygen evolving center in the photosystem II with Dr. Sun Un and Dr. William Rutherford. She was then appointed assistant professor at Paris-Sud 11, where she dedicated her work to the development of Mn-complexes reproducing the activity of superoxide-dismutase (SOD). The initial focus was the spectroscopic characterization of Mn-OO adducts involved in the catalytic cycle for superoxide dismutation. She became an associate professor in 2005. Because the metalloproteins SODs are involved in the cellular protection against oxidative stress, the next step she took was to study these compounds in cellular models of oxidative stress. Since 2008, she has a professorship at the Ecole Normale Supérieure—Paris Sciences et Lettres, where she has set up a thematic group in bioinorganic chemistry or more precisely in inorganic biological and cellular chemistry. This emerging thematic is dedicated to the direct study of inorganic compounds in biological environments. Her main current interests focus, on the one hand, on the design of manganese-based anti-oxidants and their evaluation in cells. On the other, her group has initiated a new topic with the development of metal-based probes, including metal–carbonyl as multimodal bioprobes and that they validated as efficient IR-probe for bio-imaging.

Education and professional experience

  • Short CV
  • Detailed CV
  • Since 2019 (Sept)  Responsible of the two-year master programme in Chemistry and Life Science (parcours CSDV du master de chimie de Paris Centre)
    Since 2017              Member of the editorial board of Journal of Inorganic Biochemistry
    Since 2016              Deputy director of the Institut de Chimie du CNRS in charge of interdisciplinarity                                     (Directrice adjointe science DAS-INC)
    2015-2017              Member of the advisory board of Inorganic Chemistry (ACS)
    Since 2015              Deputy chair of the FrenchBIC   (French network in BioInorganic Chemistry, network of 25 laboratories)
    Since 2014 (Sept)  Dean of the studies, co-responsible for the international relationships
    Since 2014 (Jan)    Deputy director of the Research Unit LBM
    2008                         Nomination as a professor at the ENS
    2005-2008             Associate professor, Paris-Sud 11 university
    2005 (nov.)             Habilitation thesis, Paris-Sud 11 university
    1996-2005             Assistant professor, Paris-Sud 11 university
    Institut de Chimie Moléculaire et des Matériaux d’Orsay

Research interests

  • Bioinorganic chemistry
  • Superoxide dismutase mimics, superoxide, cellular models of oxidative stress, metal-based anti-oxidants
  • Metal-carbonyls as multimodal probes for imaging: IR-spectromicroscopy, micro X-ray fluorescence and classical fluorescence
  • Metals in biology: intracellular detection,  metal imaging

Awards, distinctions, scientific societies membership, and contracts

  • Elected member of the international council of the SBIC in October 2019.
  • Member of the Société chimique de France and of the FrenchBIC
  • Research contracts since 2008:
    -Research contract from FRM as PI (Fédération pour la recherche médicale, Appels Pionniers de la recherche Etudes Physico-chimiques innovantes pour la biologie et la médecine- 2016-2020)
    -Research fellowship from the Association François Aupetit (inflammatory bowel disease patients) obtained in 2015
    -ANR contracts (National Funding Agency) : one as a PI (MAGIC, 2015-2020) ; three ANR contracts as a partner (Take Care, PI M. Robert, 2011-13 ; Metabact, PI I. Artaud, 2011-13, and MnHFPELDOR, PI L. Tabares, 2012-2015,)
    -Paris-Sciences-Lettres research contract (PI, 2014-15)
    -CNRS-contract Interdisciplinary work (interface chemistry-physic-biology), support for risky research (2009)
    -Young researcher grant (ACI jeune chercheur) (2005-08)
    -Since 2008: more than 10 projects selected on synchrotron beamlines (SOLEIL, APS, Alladin).
  • 1997: first prize “Creation” for the French Ministry of Research for the project Le ticket d’Archimède (posters of popularisation of science in the Parisian Metro), project directed by C. Policar from 1995 to 1998.

Supervised students and post-doctorants

  • Formers (not available)
  • Currents:
    -Martha Zoumpoulaki, PhD since October 2017
    -Koudedja Coulibaly, PhD since October 2017
    -Antoine Hoste, PhD since October 2017

Teaching

  • Bioinorganic chemistry: M1-ENS and Sorbonne université;  master de chimie de Paris Centre, parcours chemistry and life science
  • Metals in biology: M2-master de chimie de Paris Centre, parcours chimie moléculaire
  • History of Sciences: organisation of the annual conference day « Journée Bram »

Significant publications

Graftable SCoMPIs enable the labeling and X-Ray fluorescence imaging of proteins, Sarah Hostachy, Marie Masuda, Takayuki Miki, Itaru Hamachi, Sandrine Sagan, Olivier Lequin, Kadda Medjoubi, Andrea Somogyi, Nicolas Delsuc and Clotilde Policar*, Chem. Sci. 2018 9, 4483-4487, doi 10.1039/C8SC00886H

A cell penetrant manganese SOD-mimic is able to complement MnSOD and exerts an anti-inflammatory effect on cellular and animal models of inflammatory bowel diseases, Emilie Mathieu, Anne-Sophie Bernard, Nicolas Delsuc, Elodie Quévrain, Géraldine Gazzah, Barry Lai, Florian Chain, Philippe Langella, Maria Bachelet, Joelle Masliah, Philippe Seksik, and Clotilde Policar*, Inorg Chem. 2017, 56, 2545-2555, IF 4.82 (2016), doi: dx.doi.org/10.1021/acs.inorgchem.6b02695

Entasis Through Hook-and-Loop Fastening in a Glycoligand with Cumulative Weak Forces Stabilizing CuI, Ludivine Garcia, Federico Cisnetti, Natacha Gillet, Régis Guillot, Magali Aumont-Niciase, Jean-Philip Piquemal, Michel Desmadril, François Lambert, Clotilde Policar*, J. Am. Chem. Soc., 2015, 137, 1141−1146, DOI: 10.1021/ja510259p,

A Rhenium tris-Carbonyl Derivative as a Single Core Multimodal Probe for Imaging (SCoMPI) Combining Infrared and Luminescent Properties, Sylvain Clède, François Lambert, Christophe Sandt, Zoher Gueroui, Matthieu Réfrégiers, Marie-Aude Plamont, Paul Dumas, Anne Vessières, Clotilde Policar*, Chem. Commun., 2012, 48, 7729–7731, doi : 10.1039/C2CC32163G,

Subcellular Imaging in the Mid-IR of a Metal-Carbonyl Moiety using Photothermal Induced Resonance, Clotilde Policar*, Jenny-Birgitta Waern, Marie-Aude Plamont, Sylvain Clède, Céline Mayet, Rui Prazeres, Jean-Michel Ortega, Anne Vessières, Alexandre Dazzi, Angew. Chem., Int. Ed., 2011, 50, 860-864; doi : 10.1002/anie.201003161, Highlighted with an inside cover.

Publications

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2018

Rhenium tricarbonyl complexes with arenethiolate axial ligands Article de journal

M He; H Y V Ching; C Policar; H C Bertrand

New Journal of Chemistry, 42 (14), p. 11312–11323, 2018.

Résumé | Liens

Macrophage-derived superoxide production and antioxidant response following skeletal muscle injury Article de journal

E Le Moal; G Juban; A S Bernard; T Varga; C Policar; B Chazaud; R Mounier

Free Radical Biology and Medicine, 120 , p. 33–40, 2018.

Résumé | Liens

A Metallo Pro-Drug to Target CuII in the Context of Alzheimer's Disease Article de journal

A Conte-Daban; V Ambike; R Guillot; N Delsuc; C Policar; C Hureau

Chemistry - A European Journal, 24 (20), p. 5095–5099, 2018.

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Labeling of Hyaluronic Acids with a Rhenium-tricarbonyl Tag and Percutaneous Penetration Studied by Multimodal Imaging Article de journal

L Henry; N Delsuc; C Laugel; F Lambert; C Sandt; S Hostachy; A -S Bernard; H C Bertrand; L Grimaud; A Baillet-Guffroy; C Policar

Bioconjugate Chemistry, 29 (4), p. 987–991, 2018.

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Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins Article de journal

S Hostachy; M Masuda; T Miki; I Hamachi; S Sagan; O Lequin; K Medjoubi; A Somogyi; N Delsuc; C Policar

Chemical Science, 9 (19), p. 4483–4487, 2018.

Résumé | Liens

Ferrocifens labelled with an infrared rhenium tricarbonyl tag: Synthesis, antiproliferative activity, quantification and nano IR mapping in cancer cells Article de journal

Y Wang; F Heinemann; S Top; A Dazzi; C Policar; L Henry; F Lambert; G Jaouen; M Salmain; A Vessieres

Dalton Transactions, 47 (29), p. 9824–9833, 2018.

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Clarifying the Copper Coordination Environment in a de Novo Designed Red Copper Protein Article de journal

K J Koebke; L Ruckthong; J L Meagher; E Mathieu; J Harland; A Deb; N Lehnert; C Policar; C Tard; J E Penner-Hahn; J A Stuckey; V L Pecoraro

Inorganic Chemistry, 57 (19), p. 12291–12302, 2018.

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2017

Synthesis of Homoditopic Ligands with an Incrementable Rodlike Backbone Article de journal

P Demay-Drouhard; L -M Chamoreau; R Guillot; C Policar; H C Bertrand

European Journal of Organic Chemistry, 2017 (1), p. 131–137, 2017.

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Rhenium Complexes Based on 2-Pyridyl-1,2,3-triazole Ligands: A New Class of CO2 Reduction Catalysts Article de journal

H Y V Ching; X Wang; M He; N Perujo Holland; R Guillot; C Slim; S Griveau; H C Bertrand; C Policar; F Bedioui; M Fontecave

Inorganic Chemistry, 56 (5), p. 2966–2976, 2017.

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Re(I) carbonyl complexes: Multimodal platforms for inorganic chemical biology Article de journal

S Hostachy; C Policar; N Delsuc

Coordination Chemistry Reviews, 351 , p. 172–188, 2017.

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A Cell-Penetrant Manganese Superoxide Dismutase (MnSOD) Mimic Is Able to Complement MnSOD and Exerts an Antiinflammatory Effect on Cellular and Animal Models of Inflammatory Bowel Diseases Article de journal

E Mathieu; A -S Bernard; N Delsuc; E Quévrain; G Gazzah; B Lai; F Chain; P Langella; M Bachelet; J Masliah; P Seksik; C Policar

Inorganic Chemistry, 56 (5), p. 2545–2555, 2017.

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2016

The Use of Mn(II) Bound to His-tags as Genetically Encodable Spin-Label for Nanometric Distance Determination in Proteins Article de journal

H Y V Ching; F C Mascali; H C Bertrand; E M Bruch; P Demay-Drouhard; R M Rasia; C Policar; L C Tabares; S Un

Journal of Physical Chemistry Letters, 7 (6), p. 1072–1076, 2016.

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RIDME spectroscopy on high-spin Mn2+ centers Article de journal

D Akhmetzyanov; H Y V Ching; V Denysenkov; P Demay-Drouhard; H C Bertrand; L C Tabares; C Policar; T F Prisner; S Un

Physical Chemistry Chemical Physics, 18 (44), p. 30857–30866, 2016.

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Photophysical properties of single core multimodal probe for imaging (SCoMPI) in a membrane model and in cells Article de journal

S Hostachy; J -M Swiecicki; C Sandt; N Delsuc; C Policar

Dalton Transactions, 45 (7), p. 2791–2795, 2016.

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New insight into the structural, electrochemical and biological aspects of macroacyclic Cu(II) complexes derived from S-substituted dithiocarbazate schiff bases Article de journal

M L Low; L Maigre; M I M Tahir; E R T Tiekink; P Dorlet; R Guillot; T B Ravoof; R Rosli; J -M Pagès; C Policar; N Delsuc; K A Crouse

European Journal of Medicinal Chemistry, 120 , p. 1–12, 2016.

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Monitoring bicosomes containing antioxidants in normal and irradiated skin Article de journal

E Fernández; S Hostachy; C Sandt; G Rodríguez; H C Bertrand; S Clède; M Cócera; A D L Maza; F Lambert; C Policar; O López

RSC Advances, 6 (76), p. 72559–72567, 2016.

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Human TTR conformation altered by rhenium tris-carbonyl derivatives Article de journal

L Ciccone; C Policar; E A Stura; W Shepard

Journal of Structural Biology, 195 (3), p. 353–364, 2016.

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Bioinspired superoxide-dismutase mimics: The effects of functionalization with cationic polyarginine peptides Article de journal

H Y V Ching; I Kenkel; N Delsuc; E Mathieu; I Ivanović-Burmazović; C Policar

Journal of Inorganic Biochemistry, 160 , p. 172–179, 2016.

Résumé | Liens

Bimodal X-ray and Infrared Imaging of an Organometallic Derivative of Praziquantel in Schistosoma mansoni Article de journal

S Clède; N Cowan; F Lambert; H C Bertrand; R Rubbiani; M Patra; J Hess; C Sandt; N Trcera; G Gasser; J Keiser; C Policar

ChemBioChem, 17 (11), p. 1004–1007, 2016.

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A Bis-Manganese(II)–DOTA Complex for Pulsed Dipolar Spectroscopy Article de journal

P Demay-Drouhard; H Y V Ching; D Akhmetzyanov; R Guillot; L C Tabares; H C Bertrand; C Policar

ChemPhysChem, p. 2066–2078, 2016.

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2015

Nanometric distance measurements between Mn(II)DOTA centers Article de journal

H Y Vincent Ching; P Demay-Drouhard; H C Bertrand; C Policar; L C Tabares; S Un

Physical Chemistry Chemical Physics, 17 (36), p. 23368–23377, 2015.

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Synthesis, characterization and biological activity of Cu(II), Zn(II) and Re(I) complexes derived from S-benzyldithiocarbazate and 3-acetylcoumarin Article de journal

M L Low; G Paulus; P Dorlet; R Guillot; R Rosli; N Delsuc; K A Crouse; C Policar

BioMetals, 28 (3), p. 553–566, 2015.

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Metal-carbonyl units for vibrational and luminescence imaging: Towards multimodality Article de journal

S Clède; C Policar

Chemistry - A European Journal, 21 (3), p. 942–958, 2015.

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An easy-to-detect nona-arginine peptide for epidermal targeting Article de journal

S Clède; N Delsuc; C Laugel; F Lambert; C Sandt; A Baillet-Guffroy; C Policar

Chemical Communications, 51 (13), p. 2687–2689, 2015.

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Fast magnetically driven electrodeposition of amorphous metal oxide water oxidation catalysts from carbon-coated metallic nanoparticles Article de journal

J Zhu; F Lambert; C Policar; F Mavré; B Limoges

Journal of Materials Chemistry A, 3 (31), p. 16190–16197, 2015.

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Entasis through Hook-and-Loop fastening in a glycoligand with cumulative weak forces stabilizing CuI Article de journal

L Garcia; F Cisnetti; N Gillet; R Guillot; M Aumont-Nicaise; J -P Piquemal; M Desmadril; F Lambert; C Policar

Journal of the American Chemical Society, 137 (3), p. 1141–1146, 2015.

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2014

Influence of the side-chain length on the cellular uptake and the cytotoxicity of rhenium triscarbonyl derivatives: A bimodal infrared and luminescence quantitative study Article de journal

S Clède; F Lambert; R Saint-Fort; M -A Plamont; H Bertrand; A Vessières; C Policar

Chemistry - A European Journal, 20 (28), p. 8714–8722, 2014.

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Electrochemical formation and reactivity of a manganese peroxo complex: Acid driven Ħ2O2 generation vs. O-O bond cleavage Article de journal

H Y V Ching; E Anxolabéhère-Mallart; H E Colmer; C Costentin; P Dorlet; T A Jackson; C Policar; M Robert

Chemical Science, 5 (6), p. 2304–2310, 2014.

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Conjugation of a new series of dithiocarbazate schiff base copper(II) complexes with vectors selected to enhance antibacterial activity Article de journal

M L Low; L Maigre; P Dorlet; R Guillot; J -M Pagès; K A Crouse; C Policar; N Delsuc

Bioconjugate Chemistry, 25 (12), p. 2269–2284, 2014.

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Apo-neocarzinostatin: A protein carrier for Cu(II) glycocomplexes and Cu(II) into U937 and HT29 cell lines Article de journal

L Garcia; S Franzoni; F Mussi; M Aumont-Niçaise; H Bertrand; M Desmadril; G Pelosi; A Buschini; C Policar

Journal of Inorganic Biochemistry, 135 , p. 40–44, 2014.

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