Coordination: Jean-Maurice MALLET
The team Peptides, Glycoconjugates and Metals in Biology is constituted of organic and inorganic chemists who share skills, and know-hows to synthesize and study the reactivity of bioactive molecules, bioconjugates and functional nanoparticles.
Combining organic synthesis, spectroscopies (IR, UV-Vis absorption, fluorescence, X-fluorescence) electrochemistry and biology, the research of the team is aimed at deciphering the reactivity and properties of bioinspired constructs ranging from the molecular to the supramolecular and colloidal scales. Applications include the fundamental understanding of the (bio)catalytic activity of metals complexes, the study of biomolecular interactions (membrane, peptides, proteins and glycoconjugates) and cellular imaging using tailored fluorescent, IR or X-fluorescent probes.
Graduate school affiliation: ED 406: Molecular Chemistry Paris-Centre
Research
Latest Publications
2025
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SOD mimics delivered to the gut using lactic acid bacteria mitigate the colitis symptoms in a mouse model of Inflammatory Bowel Diseases Article de journal Gabrielle Schanne; Amandine Vincent; Florian Chain; Pauline Ruffié; Célia Carbonne; Elodie Quévrain; Emilie Mathieu; Alice Balfourier; Luis G Bermúdez-Humarán; Philippe Langella; Sophie Thenet; Véronique Carrière; Nassim Hammoudi; Magali Svreck; Sylvie Demignot; Philippe Seksik; Clotilde Policar; Nicolas Delsuc Free Radical Research, p. 1–16, 2025, (PMID: 40079422). @article{Schanne13032025,
title = {SOD mimics delivered to the gut using lactic acid bacteria mitigate the colitis symptoms in a mouse model of Inflammatory Bowel Diseases},
author = {Gabrielle Schanne and Amandine Vincent and Florian Chain and Pauline Ruffi\'{e} and C\'{e}lia Carbonne and Elodie Qu\'{e}vrain and Emilie Mathieu and Alice Balfourier and Luis G Berm\'{u}dez-Humar\'{a}n and Philippe Langella and Sophie Thenet and V\'{e}ronique Carri\`{e}re and Nassim Hammoudi and Magali Svreck and Sylvie Demignot and Philippe Seksik and Clotilde Policar and Nicolas Delsuc},
url = {https://doi.org/10.1080/10715762.2025.2478121},
doi = {10.1080/10715762.2025.2478121},
year = {2025},
date = {2025-01-01},
journal = {Free Radical Research},
pages = {1--16},
publisher = {Taylor & Francis},
note = {PMID: 40079422},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
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Angle-dependent spin crossover properties in polymorphic iron (ii) complexes based on pyridine--triazole derivatives Article de journal Emmelyne Cuza; Nicolas Delsuc; Jer^ome Marrot; William Shepard; Clotilde Policar; Christian Serre; Antoine Tissot Dalton Transactions, 54 (15), p. 6274–6280, 2025. @article{cuza2025angle,
title = {Angle-dependent spin crossover properties in polymorphic iron (ii) complexes based on pyridine--triazole derivatives},
author = {Emmelyne Cuza and Nicolas Delsuc and Jer{^o}me Marrot and William Shepard and Clotilde Policar and Christian Serre and Antoine Tissot},
year = {2025},
date = {2025-01-01},
journal = {Dalton Transactions},
volume = {54},
number = {15},
pages = {6274--6280},
publisher = {Royal Society of Chemistry},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
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Kinetic Redox Shotgun Proteomics Reveals Specific Lipopolysaccharide Effects on Intestinal Epithelial Cells, Mitigated by a Mn Superoxide Dismutase Mimic Article de journal Martha Zoumpoulaki; Giovanni Chiappetta; Jean Bouvet; Namita-Raju John; Gabrielle Schanne; Pauline Gehan; Samuel Diebolt; Shakir Shakir; Elodie Quévrain; Emilie Mathieu; Sylvie Demignot; Philippe Seksik; Nicolas Delsuc; Joelle Vinh; Clotilde Policar Angewandte Chemie International Edition, n/a (n/a), p. e202422644, 2025. @article{https://doi.org/10.1002/anie.202422644,
title = {Kinetic Redox Shotgun Proteomics Reveals Specific Lipopolysaccharide Effects on Intestinal Epithelial Cells, Mitigated by a Mn Superoxide Dismutase Mimic},
author = {Martha Zoumpoulaki and Giovanni Chiappetta and Jean Bouvet and Namita-Raju John and Gabrielle Schanne and Pauline Gehan and Samuel Diebolt and Shakir Shakir and Elodie Qu\'{e}vrain and Emilie Mathieu and Sylvie Demignot and Philippe Seksik and Nicolas Delsuc and Joelle Vinh and Clotilde Policar},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202422644},
doi = {https://doi.org/10.1002/anie.202422644},
year = {2025},
date = {2025-01-01},
journal = {Angewandte Chemie International Edition},
volume = {n/a},
number = {n/a},
pages = {e202422644},
abstract = {Abstract Overproduction of reactive oxygen species and antioxidant superoxide dismutases (SOD1, SOD2) dysregulation contribute to chronic inflammation such as generated in inflammatory bowel diseases (IBD). A kinetic redox shotgun proteomic strategy (OcSILAC for Oxidized cysteine Stable Isotope Labelling by Amino acids in Cell culture) was used to explore the lipopolysaccharide (LPS) effects including LPS-induced oxidation and inflammation cascades on a dedicated intestinal epithelial cell line (HT29-MD2) together with the potential mitigating role of a Mn-based SOD-mimic Mn1. While LPS induced transient oxidative damages at early times (15 min), cells incubated with Mn1 showed, in this time frame, a significantly reduced cysteine oxidation, highlighting Mn1 antioxidant properties. Over time, cysteine oxidation of LPS-treated cells was counteracted by an overexpression of antioxidant proteins (SOD1, NQO1) and a late (6 h) preponderant increase in SOD2 level. Mn1, when co-incubated with LPS, attenuated the level of most LPS-modified proteins, that is, proteins involved in the inflammatory response. Our results highlight Mn1 as a potentially effective antioxidant and anti-inflammatory agent to consider in the treatment of IBD, as well as a useful tool for exploring the interconnection between oxidative stress and inflammation.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract Overproduction of reactive oxygen species and antioxidant superoxide dismutases (SOD1, SOD2) dysregulation contribute to chronic inflammation such as generated in inflammatory bowel diseases (IBD). A kinetic redox shotgun proteomic strategy (OcSILAC for Oxidized cysteine Stable Isotope Labelling by Amino acids in Cell culture) was used to explore the lipopolysaccharide (LPS) effects including LPS-induced oxidation and inflammation cascades on a dedicated intestinal epithelial cell line (HT29-MD2) together with the potential mitigating role of a Mn-based SOD-mimic Mn1. While LPS induced transient oxidative damages at early times (15 min), cells incubated with Mn1 showed, in this time frame, a significantly reduced cysteine oxidation, highlighting Mn1 antioxidant properties. Over time, cysteine oxidation of LPS-treated cells was counteracted by an overexpression of antioxidant proteins (SOD1, NQO1) and a late (6 h) preponderant increase in SOD2 level. Mn1, when co-incubated with LPS, attenuated the level of most LPS-modified proteins, that is, proteins involved in the inflammatory response. Our results highlight Mn1 as a potentially effective antioxidant and anti-inflammatory agent to consider in the treatment of IBD, as well as a useful tool for exploring the interconnection between oxidative stress and inflammation. |
Angle-dependent spin crossover properties in polymorphic iron (ii) complexes based on pyridine--triazole derivatives Article de journal Emmelyne Cuza; Nicolas Delsuc; Jer^ome Marrot; William Shepard; Clotilde Policar; Christian Serre; Antoine Tissot Dalton Transactions, 54 (15), p. 6274–6280, 2025. @article{cuza2025angleb,
title = {Angle-dependent spin crossover properties in polymorphic iron (ii) complexes based on pyridine--triazole derivatives},
author = {Emmelyne Cuza and Nicolas Delsuc and Jer{^o}me Marrot and William Shepard and Clotilde Policar and Christian Serre and Antoine Tissot},
year = {2025},
date = {2025-01-01},
journal = {Dalton Transactions},
volume = {54},
number = {15},
pages = {6274--6280},
publisher = {Royal Society of Chemistry},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Locally activated semisynthetic fluorescent biosensors for imaging cellular biochemistry Article de journal Justine Coïs; Blaise Dumat Comptes Rendus. Chimie, 28 , p. 61-78, 2025, ISSN: 1878-1543. @article{Cois2024c,
title = {Locally activated semisynthetic fluorescent biosensors for imaging cellular biochemistry},
author = {Justine Co\"{i}s and Blaise Dumat},
url = {https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.365/},
doi = {10.5802/crchim.365},
issn = {1878-1543},
year = {2025},
date = {2025-01-01},
journal = {Comptes Rendus. Chimie},
volume = {28},
pages = {61-78},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
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Bioinorganic Chemistry
Bioorganic Chemistry