Peptides, Glycoconjugates and Metals in Biology

@article{https://doi.org/10.1002/anie.202521718,
title = {Organoplatinum(II) J-Aggregates with Prolonged Triplet Lifetimes for Enhanced Photodynamic and Photocatalytic Therapy},
author = {Dan Li and Xiuyang Wang and Tao Jin and Xun Wang and Hanqiang Wang and Hongbiao Ma and Xintong Lin and Li Wei and Bruno Lazarevski and Zhi Chen and Weiwen Yin and Zhigang Wang and Clotilde Policar and Oliver S Wenger and Huaiyi Huang and Pingyu Zhang},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202521718},
doi = {https://doi.org/10.1002/anie.202521718},
year = {2026},
date = {2026-01-01},
journal = {Angewandte Chemie International Edition},
volume = {n/a},
number = {n/a},
pages = {e21718},
abstract = {Abstract J-aggregates have demonstrated superior phototherapeutic performance compared to their monomeric counterparts. However, the underlying mechanisms for this enhancement are not fully understood. In this work, we report two near-infrared (NIR)-emissive organoplatinum(II) complexes, Pt-2TPE and Pt-2TPA, which self-assemble into J-aggregates via Pt-Pt and π-π stacking interactions. Theoretical calculations reveal that J-aggregates possess lower LUMO energy levels and reduced singlet\textendashtriplet energy gaps compared to their monomers, indicating enhanced electron-accepting ability and more efficient intersystem crossing (ISC). Transient absorption spectroscopy confirmed a dramatically prolonged triplet excited-state lifetime in Pt-2TPA J-aggregates (5.8 µs) versus the monomer (123 ns). The efficient oxygen quenching of this long-lived triplet excited-state verified enhanced triplet-state population and sensitization in the J-aggregates. Consequently, the J-aggregates efficiently generate Type I/II reactive oxygen species (ROS) and catalyze NADH oxidation under red light, leading to effective eradication of B16-F10 cells under both normoxic and hypoxic conditions. Furthermore, a biotin-modified nanoformulation (Biotin@Pt-2TPA) exhibits excellent tumor accumulation and tumor growth suppression in vivo. This work provides a strategy to enhance the efficacy of photodynamic and photocatalytic therapy of platinum(II) complexes.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{cuza2025angleb,
title = {Angle-dependent spin crossover properties in polymorphic iron (ii) complexes based on pyridine--triazole derivatives},
author = {Emmelyne Cuza and Nicolas Delsuc and Jer{^o}me Marrot and William Shepard and Clotilde Policar and Christian Serre and Antoine Tissot},
year = {2025},
date = {2025-01-01},
journal = {Dalton Transactions},
volume = {54},
number = {15},
pages = {6274--6280},
publisher = {Royal Society of Chemistry},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{Cois2024c,
title = {Locally activated semisynthetic fluorescent biosensors for imaging cellular biochemistry},
author = {Justine Co\"{i}s and Blaise Dumat},
url = {https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.365/},
doi = {10.5802/crchim.365},
issn = {1878-1543},
year = {2025},
date = {2025-01-01},
journal = {Comptes Rendus. Chimie},
volume = {28},
pages = {61-78},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{cuza2025angle,
title = {Angle-dependent spin crossover properties in polymorphic iron (ii) complexes based on pyridine--triazole derivatives},
author = {Emmelyne Cuza and Nicolas Delsuc and Jer{^o}me Marrot and William Shepard and Clotilde Policar and Christian Serre and Antoine Tissot},
year = {2025},
date = {2025-01-01},
journal = {Dalton Transactions},
volume = {54},
number = {15},
pages = {6274--6280},
publisher = {Royal Society of Chemistry},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{https://doi.org/10.1002/anie.202422644,
title = {Kinetic Redox Shotgun Proteomics Reveals Specific Lipopolysaccharide Effects on Intestinal Epithelial Cells, Mitigated by a Mn Superoxide Dismutase Mimic},
author = {Martha Zoumpoulaki and Giovanni Chiappetta and Jean Bouvet and Namita-Raju John and Gabrielle Schanne and Pauline Gehan and Samuel Diebolt and Shakir Shakir and Elodie Qu\'{e}vrain and Emilie Mathieu and Sylvie Demignot and Philippe Seksik and Nicolas Delsuc and Joelle Vinh and Clotilde Policar},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202422644},
doi = {https://doi.org/10.1002/anie.202422644},
year = {2025},
date = {2025-01-01},
journal = {Angewandte Chemie International Edition},
volume = {n/a},
number = {n/a},
pages = {e202422644},
abstract = {Abstract Overproduction of reactive oxygen species and antioxidant superoxide dismutases (SOD1, SOD2) dysregulation contribute to chronic inflammation such as generated in inflammatory bowel diseases (IBD). A kinetic redox shotgun proteomic strategy (OcSILAC for Oxidized cysteine Stable Isotope Labelling by Amino acids in Cell culture) was used to explore the lipopolysaccharide (LPS) effects including LPS-induced oxidation and inflammation cascades on a dedicated intestinal epithelial cell line (HT29-MD2) together with the potential mitigating role of a Mn-based SOD-mimic Mn1. While LPS induced transient oxidative damages at early times (15 min), cells incubated with Mn1 showed, in this time frame, a significantly reduced cysteine oxidation, highlighting Mn1 antioxidant properties. Over time, cysteine oxidation of LPS-treated cells was counteracted by an overexpression of antioxidant proteins (SOD1, NQO1) and a late (6 h) preponderant increase in SOD2 level. Mn1, when co-incubated with LPS, attenuated the level of most LPS-modified proteins, that is, proteins involved in the inflammatory response. Our results highlight Mn1 as a potentially effective antioxidant and anti-inflammatory agent to consider in the treatment of IBD, as well as a useful tool for exploring the interconnection between oxidative stress and inflammation.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}