You will find below the list of publications of all the members of the Peptides, Glycoconjugates and Metals in Biology research pole. For individual or theme-specific publications, please consult the research or the personal pages via the members list using the sidebar navigation tool.
2009 |
C Luccardini; A V Yakovlev; M Pasche; S Gaillard; D Li; F Rousseau; R Ly; U Becherer; J -M Mallet; A Feltz; M Oheim Cell Calcium, 46 (3), p. 226, 2009. @article{Luccardini:2009, title = {Corrigendum to "Measuring mitochondrial and cytoplasmic Ca2+ in EGFP expressing cells with a low-affinity Calcium Ruby and its dextran conjugate" [Cell Calcium 45 (3) (2008)] (DOI:10.1016/j.ceca.2008.11.007)}, author = {C Luccardini and A V Yakovlev and M Pasche and S Gaillard and D Li and F Rousseau and R Ly and U Becherer and J -M Mallet and A Feltz and M Oheim}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-69249210939&doi=10.1016%2fj.ceca.2009.06.001&partnerID=40&md5=143097f5472f89ad18112a20ea7d6a29}, doi = {10.1016/j.ceca.2009.06.001}, year = {2009}, date = {2009-01-01}, journal = {Cell Calcium}, volume = {46}, number = {3}, pages = {226}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Ab initio study of excitation energy transfer between quantum dots and dye molecules Article de journal H Tamura; J -M Mallet; M Oheim; I Burghardt Journal of Physical Chemistry C, 113 (18), p. 7548–7552, 2009. @article{Tamura:2009, title = {Ab initio study of excitation energy transfer between quantum dots and dye molecules}, author = {H Tamura and J -M Mallet and M Oheim and I Burghardt}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-67049113893&doi=10.1021%2fjp811042t&partnerID=40&md5=ad82f74e914be46d0dd01274201f4335}, doi = {10.1021/jp811042t}, year = {2009}, date = {2009-01-01}, journal = {Journal of Physical Chemistry C}, volume = {113}, number = {18}, pages = {7548--7552}, abstract = {We investigate excitation energy transfer between a semiconductor nanocrystal (NC) and an organic dye molecule, using ab initio calculations. The electronic coupling is evaluated based on the full Coulombic interaction between the NC and dye transition densities. We explore the effect of the NC-dye relative configurations on the electronic coupling, using a (CdSe)6 cluster and a rhodamine cation as a simplified model system. Our analysis demonstrates the limitations of the commonly used F\"{o}rster theory for the NC-dye system and highlights the importance of considering the full Coulombic interactions of donor and acceptor. We find that energy transfer involves several electronic states and can occur even from optically dark states of the NC. The consequences for larger NC-dye systems are discussed. © 2009 American Chemical Society.}, keywords = {}, pubstate = {published}, tppubtype = {article} } We investigate excitation energy transfer between a semiconductor nanocrystal (NC) and an organic dye molecule, using ab initio calculations. The electronic coupling is evaluated based on the full Coulombic interaction between the NC and dye transition densities. We explore the effect of the NC-dye relative configurations on the electronic coupling, using a (CdSe)6 cluster and a rhodamine cation as a simplified model system. Our analysis demonstrates the limitations of the commonly used Förster theory for the NC-dye system and highlights the importance of considering the full Coulombic interactions of donor and acceptor. We find that energy transfer involves several electronic states and can occur even from optically dark states of the NC. The consequences for larger NC-dye systems are discussed. © 2009 American Chemical Society. |
Measuring mitochondrial and cytoplasmic Ca2+ in EGFP expressing cells with a low-affinity Calcium Ruby and its dextran conjugate Article de journal C Luccardini; A V Yakovlev; M Pasche; S Gaillard; D Li; F Rousseau; R Ly; U Becherer; J -M Mallet; A Feltz; M Oheim Cell Calcium, 45 (3), p. 275–283, 2009. @article{Luccardini:2009a, title = {Measuring mitochondrial and cytoplasmic Ca2+ in EGFP expressing cells with a low-affinity Calcium Ruby and its dextran conjugate}, author = {C Luccardini and A V Yakovlev and M Pasche and S Gaillard and D Li and F Rousseau and R Ly and U Becherer and J -M Mallet and A Feltz and M Oheim}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-61649111725&doi=10.1016%2fj.ceca.2008.11.007&partnerID=40&md5=575fc8613aec2c8ecdd679859d3c5d1f}, doi = {10.1016/j.ceca.2008.11.007}, year = {2009}, date = {2009-01-01}, journal = {Cell Calcium}, volume = {45}, number = {3}, pages = {275--283}, abstract = {The limited choice and poor performance of red-emitting calcium (Ca2+) indicators have hampered microfluorometric measurements of the intracellular free Ca2+ concentration in cells expressing yellow- or green-fluorescent protein constructs. A long-wavelength Ca2+ indicator would also permit a better discrimination against cellular autofluorescence than the commonly used fluorescein-based probes. Here, we report an improved synthesis and characterization of Calcium Ruby, a red-emitting probe consisting of an extended rhodamine chromophore (578/602 nm peak excitation/emission) conjugated to BAPTA and having an additional NH2 linker arm. The low-affinity variant (KD,Ca ∼30 μM) with a chloride in meta position that was specifically designed for the detection of large and rapid Ca2+ transients. While Calcium Ruby is a mitochondrial Ca2+probe, its conjugation, via the NH2 tail, to a 10,000 MW dextran abolishes the sub-cellular compartmentalization and generates a cytosolic Ca2+ probe with an affinity matched to microdomain Ca2+ signals. As an example, we show depolarization-evoked Ca2+ signals triggering the exocytosis of individual chromaffin granules. Calcium Ruby should be of use in a wide range of applications involving dual- or triple labeling schemes or targeted sub-cellular Ca2+ measurements. © 2008 Elsevier Ltd. All rights reserved.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The limited choice and poor performance of red-emitting calcium (Ca2+) indicators have hampered microfluorometric measurements of the intracellular free Ca2+ concentration in cells expressing yellow- or green-fluorescent protein constructs. A long-wavelength Ca2+ indicator would also permit a better discrimination against cellular autofluorescence than the commonly used fluorescein-based probes. Here, we report an improved synthesis and characterization of Calcium Ruby, a red-emitting probe consisting of an extended rhodamine chromophore (578/602 nm peak excitation/emission) conjugated to BAPTA and having an additional NH2 linker arm. The low-affinity variant (KD,Ca ∼30 μM) with a chloride in meta position that was specifically designed for the detection of large and rapid Ca2+ transients. While Calcium Ruby is a mitochondrial Ca2+probe, its conjugation, via the NH2 tail, to a 10,000 MW dextran abolishes the sub-cellular compartmentalization and generates a cytosolic Ca2+ probe with an affinity matched to microdomain Ca2+ signals. As an example, we show depolarization-evoked Ca2+ signals triggering the exocytosis of individual chromaffin granules. Calcium Ruby should be of use in a wide range of applications involving dual- or triple labeling schemes or targeted sub-cellular Ca2+ measurements. © 2008 Elsevier Ltd. All rights reserved. |
2008 |
Materials Doping through Sol–Gel Chemistry: A Little Something Can Make a Big Difference Article de journal J -M Nedelec; L Courtheoux; E Jallot; C Kinowski; J Lao; P Laquerriere; C Mansuy; G Renaudin; S Turrell Journal of Sol-Gel Science and Technology, 46 (3), p. 259-271, 2008. @article{Nedelec:2008, title = {Materials Doping through Sol\textendashGel Chemistry: A Little Something Can Make a Big Difference}, author = {J -M Nedelec and L Courtheoux and E Jallot and C Kinowski and J Lao and P Laquerriere and C Mansuy and G Renaudin and S Turrell}, doi = {10.1007/s10971-007-1665-0}, year = {2008}, date = {2008-04-01}, journal = {Journal of Sol-Gel Science and Technology}, volume = {46}, number = {3}, pages = {259-271}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
P V -E Khoury; J -F Colombel; S Joossens; A Standaert-Vitse; M Collot; J Halfvarson; A Ayadi; C J Landers; S Vermeire; P Rutgeerts; S R Targan; M Chamaillard; J -M Mallet; B Sendid; D Poulain American Journal of Gastroenterology, 103 (4), p. 949–957, 2008. @article{Khoury:2008, title = {Detection of antisynthetic mannoside antibodies (AΣMA) reveals heterogeneity in the ASCA response of Crohn's disease patients and contributes to differential diagnosis, stratification, and prediction}, author = {P V -E Khoury and J -F Colombel and S Joossens and A Standaert-Vitse and M Collot and J Halfvarson and A Ayadi and C J Landers and S Vermeire and P Rutgeerts and S R Targan and M Chamaillard and J -M Mallet and B Sendid and D Poulain}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-41849115954&doi=10.1111%2fj.1572-0241.2007.01648.x&partnerID=40&md5=4294c5c9fa3805786e5a085466eac527}, doi = {10.1111/j.1572-0241.2007.01648.x}, year = {2008}, date = {2008-01-01}, journal = {American Journal of Gastroenterology}, volume = {103}, number = {4}, pages = {949--957}, abstract = {OBJECTIVES: Anti-S. cerevisiae mannan antibodies (ASCA) are human antibodies associated with Crohn's disease (CD) reacting with Saccharomyces cerevisiae (S. cerevisiae) mannan polymer. As mannan is a complex and variable repertoire of oligomannoses acting as epitopes, we chemically synthesized (Σ) two major oligomannose epitopes, Man α-1,3 Man α-1,2 Man (ΣMan3) and Man α-1,3 Man α-1,2 Man α-1,2 Man (ΣMan4), and then explored how antisynthetic mannoside antibodies (AΣMA) compare with ASCA as markers of CD. METHODS: The study involved different cohorts of CD and ulcerative colitis (UC) patients and healthy controls who had been studied previously in several medical centers in Europe, the United States, and North Africa to determine the clinical value of ASCA in terms of differential diagnosis, evolution of indeterminate colitis (IC), and serotype-phenotype correlations. The comparison of AΣMA and ASCA included a total of 1,365 subjects: 772 CD, 261 UC, 43 IC, and 289 controls. RESULTS: The specificity of AΣMA was similar to that of ASCA (89% vs 93%), although the sensitivity was lower (38% vs 55%). Unexpectedly, 24% of the CD patients who were negative for ASCA and/or other CD-associated serologic markers were positive for AΣMA. AΣMA were associated with colonic involvement in CD (odds ratio [OR] 1.609, 95% confidence interval [CI] 1.033-2.506}, keywords = {}, pubstate = {published}, tppubtype = {article} } OBJECTIVES: Anti-S. cerevisiae mannan antibodies (ASCA) are human antibodies associated with Crohn's disease (CD) reacting with Saccharomyces cerevisiae (S. cerevisiae) mannan polymer. As mannan is a complex and variable repertoire of oligomannoses acting as epitopes, we chemically synthesized (Σ) two major oligomannose epitopes, Man α-1,3 Man α-1,2 Man (ΣMan3) and Man α-1,3 Man α-1,2 Man α-1,2 Man (ΣMan4), and then explored how antisynthetic mannoside antibodies (AΣMA) compare with ASCA as markers of CD. METHODS: The study involved different cohorts of CD and ulcerative colitis (UC) patients and healthy controls who had been studied previously in several medical centers in Europe, the United States, and North Africa to determine the clinical value of ASCA in terms of differential diagnosis, evolution of indeterminate colitis (IC), and serotype-phenotype correlations. The comparison of AΣMA and ASCA included a total of 1,365 subjects: 772 CD, 261 UC, 43 IC, and 289 controls. RESULTS: The specificity of AΣMA was similar to that of ASCA (89% vs 93%), although the sensitivity was lower (38% vs 55%). Unexpectedly, 24% of the CD patients who were negative for ASCA and/or other CD-associated serologic markers were positive for AΣMA. AΣMA were associated with colonic involvement in CD (odds ratio [OR] 1.609, 95% confidence interval [CI] 1.033-2.506 |
M Collot; B Sendid; A Fievez; C Savaux; A Standaert-Vitse; M Tabouret; A S Drucbert; P M Danzé; D Poulain; J -M Mallet Journal of Medicinal Chemistry, 51 (19), p. 6201–6210, 2008. @article{Collot:2008, title = {Biotin sulfone as a new tool for synthetic oligosaccharide immobilization: Application to multiple analysis profiling and surface plasmonic analysis of anti-Candida albicans antibody reactivity against α and β (1→2) oligomannosides}, author = {M Collot and B Sendid and A Fievez and C Savaux and A Standaert-Vitse and M Tabouret and A S Drucbert and P M Danz\'{e} and D Poulain and J -M Mallet}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-53549134744&doi=10.1021%2fjm800099g&partnerID=40&md5=8fe7ec127f5de51b015a1e5e3beb840b}, doi = {10.1021/jm800099g}, year = {2008}, date = {2008-01-01}, journal = {Journal of Medicinal Chemistry}, volume = {51}, number = {19}, pages = {6201--6210}, abstract = {As a part of our glycoantigen synthetic program for diagnosis and basic analysis of yeast-related pathogenic mechanisms, a library of 1→2 oligomannosides suitable for immunoanalysis was prepared. The use of biotin sulfone, an oxidized form of biotin, offers a convenient solution for both oligosaccharide synthesis and immobilization on microspheres and surface plasmon resonance sensors. The application of this new strategy for the analysis of anti-Candida albicans antibody response through multiple-analyte profiling technology (Luminex) and with surface plasmonic analysis using biotin tagged synthetic oligosaccharides on avidin coated surfaces was validated using monoclonal antibodies. © 2008 American Chemical Society.}, keywords = {}, pubstate = {published}, tppubtype = {article} } As a part of our glycoantigen synthetic program for diagnosis and basic analysis of yeast-related pathogenic mechanisms, a library of 1→2 oligomannosides suitable for immunoanalysis was prepared. The use of biotin sulfone, an oxidized form of biotin, offers a convenient solution for both oligosaccharide synthesis and immobilization on microspheres and surface plasmon resonance sensors. The application of this new strategy for the analysis of anti-Candida albicans antibody response through multiple-analyte profiling technology (Luminex) and with surface plasmonic analysis using biotin tagged synthetic oligosaccharides on avidin coated surfaces was validated using monoclonal antibodies. © 2008 American Chemical Society. |
New thioglycoside derivatives for use in odourless synthesis of MUXF3 N-glycan fragments related to food allergens Article de journal M Collot; J Savreux; J -M Mallet Tetrahedron, 64 (7), p. 1523–1535, 2008. @article{Collot:2008a, title = {New thioglycoside derivatives for use in odourless synthesis of MUXF3 N-glycan fragments related to food allergens}, author = {M Collot and J Savreux and J -M Mallet}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-37649008067&doi=10.1016%2fj.tet.2007.11.002&partnerID=40&md5=5ef009049ab903c60716881332ff9bee}, doi = {10.1016/j.tet.2007.11.002}, year = {2008}, date = {2008-01-01}, journal = {Tetrahedron}, volume = {64}, number = {7}, pages = {1523--1535}, abstract = {Thioglycosides are valuable tools for complex oligosaccharides' constructions. They present precious advantages due to their stability and crystalline nature. However, their major drawbacks are the repulsive smell of thiols utilised as precursors and, often, their toxicity such as in case of the commonly employed thiophenol and thioethanol. The use of commercially available methyl tert-butyl phenyl thiol (MbpSH) avoids these problems and is compatible with gram scale synthesis of thioglycoside donors. In this paper, we describe that Mbp thioglycosides are useful and convenient precursors for odourless oligosaccharide synthesis and we further demonstrate, as a proof of their versatility, their use in the construction of most of the glycosidic linkages found in N-glycans. © 2007 Elsevier Ltd. All rights reserved.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Thioglycosides are valuable tools for complex oligosaccharides' constructions. They present precious advantages due to their stability and crystalline nature. However, their major drawbacks are the repulsive smell of thiols utilised as precursors and, often, their toxicity such as in case of the commonly employed thiophenol and thioethanol. The use of commercially available methyl tert-butyl phenyl thiol (MbpSH) avoids these problems and is compatible with gram scale synthesis of thioglycoside donors. In this paper, we describe that Mbp thioglycosides are useful and convenient precursors for odourless oligosaccharide synthesis and we further demonstrate, as a proof of their versatility, their use in the construction of most of the glycosidic linkages found in N-glycans. © 2007 Elsevier Ltd. All rights reserved. |
Synthetic sulfogalactosylceramide (sulfatide) and its use for the mass spectrometric quantitative urinary determination in metachromatic leukodystrophies Article de journal Y Cui; B Colsch; C Alonso; N Baumann; J -C Tabet; J -M Mallet; Y Zhang Glycoconjugate Journal, 25 (2), p. 147–155, 2008. @article{Cui:2008, title = {Synthetic sulfogalactosylceramide (sulfatide) and its use for the mass spectrometric quantitative urinary determination in metachromatic leukodystrophies}, author = {Y Cui and B Colsch and C Alonso and N Baumann and J -C Tabet and J -M Mallet and Y Zhang}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-39049149429&doi=10.1007%2fs10719-007-9067-7&partnerID=40&md5=f35d93ff6d2be81416a94170ff95d6a6}, doi = {10.1007/s10719-007-9067-7}, year = {2008}, date = {2008-01-01}, journal = {Glycoconjugate Journal}, volume = {25}, number = {2}, pages = {147--155}, abstract = {3-O-Sulfogalactosylceramides (sulfatides) accumulate in the genetic disease metachromatic leukodystrophy which is due to a defect in the catabolic enzyme, arylsulfatase A. Clinical diagnosis is usually confirmed by in vitro enzymatic deficiency of arylsulfatase A activity. The diagnosis may be complicated because of arylsulfatase A pseudo-deficiencies and another cause of MLD, sphingolipid activator B deficiency. As large quantities of sulfatides can be found in the urine in this disease, sulfatiduria appears as an extremely useful test. As recently enzyme replacement is underway, the quantitative determination, using an internal standard, appears particularly useful as a follow-up. Thus a non-physiological sulfatide was synthesized for this purpose, i.e. 3-O-sulfo-β-d-C17 galactosylceramide (3-O-Sulfo-d-Galactosyl- β1′→1-N-Heptadecanoyl-d-erythro-Sphingosine). It has been prepared through condensation of an azidosphingosine derivative with a protected d-galactopyranosyltrichloroacetimidate. Reduction of the azide was followed by acylation of a C-17 fatty acid. The key step was achieved by selective sulfation of the desired hydroxyl group on the sugar residue of the galactosylceramide using the stannylene methodology to give a 3′-sulfated beta-galactosyl C-17 ceramide. © 2007 Springer Science+Business Media, LLC.}, keywords = {}, pubstate = {published}, tppubtype = {article} } 3-O-Sulfogalactosylceramides (sulfatides) accumulate in the genetic disease metachromatic leukodystrophy which is due to a defect in the catabolic enzyme, arylsulfatase A. Clinical diagnosis is usually confirmed by in vitro enzymatic deficiency of arylsulfatase A activity. The diagnosis may be complicated because of arylsulfatase A pseudo-deficiencies and another cause of MLD, sphingolipid activator B deficiency. As large quantities of sulfatides can be found in the urine in this disease, sulfatiduria appears as an extremely useful test. As recently enzyme replacement is underway, the quantitative determination, using an internal standard, appears particularly useful as a follow-up. Thus a non-physiological sulfatide was synthesized for this purpose, i.e. 3-O-sulfo-β-d-C17 galactosylceramide (3-O-Sulfo-d-Galactosyl- β1′→1-N-Heptadecanoyl-d-erythro-Sphingosine). It has been prepared through condensation of an azidosphingosine derivative with a protected d-galactopyranosyltrichloroacetimidate. Reduction of the azide was followed by acylation of a C-17 fatty acid. The key step was achieved by selective sulfation of the desired hydroxyl group on the sugar residue of the galactosylceramide using the stannylene methodology to give a 3′-sulfated beta-galactosyl C-17 ceramide. © 2007 Springer Science+Business Media, LLC. |
Y Cui; B Colsch; C Afonso; N Baumann; J -C Tabet; J -M Mallet; Y Zhang Glycoconjugate Journal, 25 (2), p. 145, 2008. @article{Cui:2008a, title = {Synthetic sulfogalactosylceramide (sulfatide) and its use for the mass spectrometric quantitative urinary determination in metachromatic leukodystrophies (Glycoconjugate Journal DOI: 10.1007/s10719-007-9067-7)}, author = {Y Cui and B Colsch and C Afonso and N Baumann and J -C Tabet and J -M Mallet and Y Zhang}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-39049148424&doi=10.1007%2fs10719-007-9072-x&partnerID=40&md5=9f8557a960ae3a49662edfe49faf432f}, doi = {10.1007/s10719-007-9072-x}, year = {2008}, date = {2008-01-01}, journal = {Glycoconjugate Journal}, volume = {25}, number = {2}, pages = {145}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
2007 |
Concentration Effect on the Scintillation Properties of Sol–Gel Derived LuBO3 Doped with Eu3+ and Tb3+ Article de journal C Mansuy; J M Nedelec; C Dujardin; R Mahiou Optical Materials, 29 (6), p. 697-702, 2007. @article{Mansuy:2007, title = {Concentration Effect on the Scintillation Properties of Sol\textendashGel Derived LuBO3 Doped with Eu3+ and Tb3+}, author = {C Mansuy and J M Nedelec and C Dujardin and R Mahiou}, doi = {10.1016/j.optmat.2005.10.017}, year = {2007}, date = {2007-04-01}, journal = {Optical Materials}, volume = {29}, number = {6}, pages = {697-702}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Bis antennae amphiphilic cyclodextrins: the first examples Article de journal M Collot; M I Garcia-Moreno; C Fajolles; M Roux; L Mauclaire; J -M Mallet Tetrahedron Letters, 48 (48), p. 8566–8569, 2007. @article{Collot:2007, title = {Bis antennae amphiphilic cyclodextrins: the first examples}, author = {M Collot and M I Garcia-Moreno and C Fajolles and M Roux and L Mauclaire and J -M Mallet}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-35548995341&doi=10.1016%2fj.tetlet.2007.09.020&partnerID=40&md5=f8de7222a637eadc1c70bc14f4e98e1d}, doi = {10.1016/j.tetlet.2007.09.020}, year = {2007}, date = {2007-01-01}, journal = {Tetrahedron Letters}, volume = {48}, number = {48}, pages = {8566--8569}, abstract = {Methylated 6A,6D-diamino 6A,6D-dideoxy β-cyclodextrin 4 was coupled with three cholesterol substituted glutaric or succinic acids 5-7 to give amphiphilic cyclodextrins 1-3 with good yields. The succinic acid derivative 1, a typical member of this new family, has shown good compatibility with phosphatidyl choline monolayer and bilayer as confirmed by deuterium magnetic nuclear resonance (2H NMR). © 2007 Elsevier Ltd. All rights reserved.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Methylated 6A,6D-diamino 6A,6D-dideoxy β-cyclodextrin 4 was coupled with three cholesterol substituted glutaric or succinic acids 5-7 to give amphiphilic cyclodextrins 1-3 with good yields. The succinic acid derivative 1, a typical member of this new family, has shown good compatibility with phosphatidyl choline monolayer and bilayer as confirmed by deuterium magnetic nuclear resonance (2H NMR). © 2007 Elsevier Ltd. All rights reserved. |
Getting across the plasma membrane and beyond: Intracellular uses of colloidal semiconductor nanocrystals Article de journal C Luccardini; A Yakovlev; S Gaillard; M Van 'T Hoff; A P Alberola; J -M Mallet; W J Parak; A Feltz; M Oheim Journal of Biomedicine and Biotechnology, 2007 , 2007. @article{Luccardini:2007, title = {Getting across the plasma membrane and beyond: Intracellular uses of colloidal semiconductor nanocrystals}, author = {C Luccardini and A Yakovlev and S Gaillard and M Van 'T Hoff and A P Alberola and J -M Mallet and W J Parak and A Feltz and M Oheim}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-36949022046&doi=10.1155%2f2007%2f68963&partnerID=40&md5=06e26afc550ccd1aaa26858966dd1940}, doi = {10.1155/2007/68963}, year = {2007}, date = {2007-01-01}, journal = {Journal of Biomedicine and Biotechnology}, volume = {2007}, abstract = {Semiconductor nanocrystals (NCs) are increasingly being used as photoluminescen markers in biological imaging. Their brightness, large Stokes shift, and high photostability compared to organic fluorophores permit the exploration of biological phenomena at the single-molecule scale with superior temporal resolution and spatial precision. NCs have predominantly been used as extracellular markers for tagging and tracking membrane proteins. Successful internalization and intracellular labelling with NCs have been demonstrated for both fixed immunolabelled and live cells. However, the precise localization and subcellular compartment labelled are less clear. Generally, live cell studies are limited by the requirement of fairly invasive protocols for loading NCs and the relatively large size of NCs compared to the cellular machinery, along with the subsequent sequestration of NCs in endosomal/lysosomal compartments. For long-period observation the potential cytotoxicity of cytoplasmically loaded NCs must be evaluated. This review focuses on the challenges of intracellular uses of NCs. Copyright © 2007 Camilla Luccardini et al.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Semiconductor nanocrystals (NCs) are increasingly being used as photoluminescen markers in biological imaging. Their brightness, large Stokes shift, and high photostability compared to organic fluorophores permit the exploration of biological phenomena at the single-molecule scale with superior temporal resolution and spatial precision. NCs have predominantly been used as extracellular markers for tagging and tracking membrane proteins. Successful internalization and intracellular labelling with NCs have been demonstrated for both fixed immunolabelled and live cells. However, the precise localization and subcellular compartment labelled are less clear. Generally, live cell studies are limited by the requirement of fairly invasive protocols for loading NCs and the relatively large size of NCs compared to the cellular machinery, along with the subsequent sequestration of NCs in endosomal/lysosomal compartments. For long-period observation the potential cytotoxicity of cytoplasmically loaded NCs must be evaluated. This review focuses on the challenges of intracellular uses of NCs. Copyright © 2007 Camilla Luccardini et al. |
Weak calcium-mediated interactions between Lewis X-related trisaccharides studied by NMR measurements of residual dipolar couplings Article de journal G Nodet; L Poggi; D Abergel; C Gourmala; D Dong; Y Zhang; J -M Mallet; G Bodenhausen Journal of the American Chemical Society, 129 (29), p. 9080–9085, 2007. @article{Nodet:2007a, title = {Weak calcium-mediated interactions between Lewis X-related trisaccharides studied by NMR measurements of residual dipolar couplings}, author = {G Nodet and L Poggi and D Abergel and C Gourmala and D Dong and Y Zhang and J -M Mallet and G Bodenhausen}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-34547539474&doi=10.1021%2fja0711056&partnerID=40&md5=53aca08b440b69755694551b321f0625}, doi = {10.1021/ja0711056}, year = {2007}, date = {2007-01-01}, journal = {Journal of the American Chemical Society}, volume = {129}, number = {29}, pages = {9080--9085}, abstract = {The Lewis X (LeX) determinant, a trisaccharide with the carbohydrate sequence Galβ(1→4)-[Fucα(1→3)]GlcNAcβ, is believed to be responsible for Ca2+-mediated cell-cell interactions. In partly oriented phases composed of mixtures of penta(ethyleneglycol) monododecyl ether HO(CH2CH2O)5C 12H25 and n-hexanol in the presence of Ca2+ ions, the variation of the residual dipolar couplings 1DCH of various CiHi vectors in LeX as a function of the concentration of the trisaccharide demonstrates the existence of very weak LeX-Ca2+-LeX complexes in solution. Synthetic 3-, 4-, and 6-deoxy-LeX variants were also shown to form complexes in the presence of calcium ions, despite the replacement of one of their hydroxyl groups by hydrogen atoms. This is the first direct observation in solution of a calcium-mediated interaction between LeX molecules. © 2007 American Chemical Society.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The Lewis X (LeX) determinant, a trisaccharide with the carbohydrate sequence Galβ(1→4)-[Fucα(1→3)]GlcNAcβ, is believed to be responsible for Ca2+-mediated cell-cell interactions. In partly oriented phases composed of mixtures of penta(ethyleneglycol) monododecyl ether HO(CH2CH2O)5C 12H25 and n-hexanol in the presence of Ca2+ ions, the variation of the residual dipolar couplings 1DCH of various CiHi vectors in LeX as a function of the concentration of the trisaccharide demonstrates the existence of very weak LeX-Ca2+-LeX complexes in solution. Synthetic 3-, 4-, and 6-deoxy-LeX variants were also shown to form complexes in the presence of calcium ions, despite the replacement of one of their hydroxyl groups by hydrogen atoms. This is the first direct observation in solution of a calcium-mediated interaction between LeX molecules. © 2007 American Chemical Society. |
Synthesis and characterization of polymer-coated quantum dots with integrated acceptor dyes as FRET-based nanoprobes Article de journal M T Fernández-Arguelles; A Yakovlev; R A Sperling; C Luccardini; S Gaillard; A S Medel; J -M Mallet; J -C Brochon; A Feltz; M Oheim; W J Parak Nano Letters, 7 (9), p. 2613–2617, 2007. @article{Fernandez-Arguelles:2007, title = {Synthesis and characterization of polymer-coated quantum dots with integrated acceptor dyes as FRET-based nanoprobes}, author = {M T Fern\'{a}ndez-Arguelles and A Yakovlev and R A Sperling and C Luccardini and S Gaillard and A S Medel and J -M Mallet and J -C Brochon and A Feltz and M Oheim and W J Parak}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-34948824503&doi=10.1021%2fnl070971d&partnerID=40&md5=88762ac5c5ceee29bcbc970273ad38f4}, doi = {10.1021/nl070971d}, year = {2007}, date = {2007-01-01}, journal = {Nano Letters}, volume = {7}, number = {9}, pages = {2613--2617}, abstract = {A fluorescence resonance energy transfer pair consisting of a colloidal quantum dot donor and multiple organic fluorophores as acceptors is reported and the photophysics of the system is characterized. Most nanoparticle-based biosensors reported so far use the detection of specific changes of the donor/acceptor distance under the influence of analyte binding. Our nanoparticle design on the other hand leads to sensors that detect spectral changes of the acceptor (under the influence of analyte binding) at fixed donor/acceptor distance by the introduction of the acceptor into the polymer coating. This approach allows for short acceptor-donor separation and thus for high-energy transfer efficiencies. Advantageously, the binding properties of the hydrophilic polymer coating further allows for addition of polyethylene glycol) shells for improved colloidal stability. © 2007 American Chemical Society.}, keywords = {}, pubstate = {published}, tppubtype = {article} } A fluorescence resonance energy transfer pair consisting of a colloidal quantum dot donor and multiple organic fluorophores as acceptors is reported and the photophysics of the system is characterized. Most nanoparticle-based biosensors reported so far use the detection of specific changes of the donor/acceptor distance under the influence of analyte binding. Our nanoparticle design on the other hand leads to sensors that detect spectral changes of the acceptor (under the influence of analyte binding) at fixed donor/acceptor distance by the introduction of the acceptor into the polymer coating. This approach allows for short acceptor-donor separation and thus for high-energy transfer efficiencies. Advantageously, the binding properties of the hydrophilic polymer coating further allows for addition of polyethylene glycol) shells for improved colloidal stability. © 2007 American Chemical Society. |
Synthesis and characterization of a new red-emitting Ca2+ indicator, calcium ruby Article de journal S Gaillard; A Yakovlev; C Luccardini; M Oheim; A Feltz; J -M Mallet Organic Letters, 9 (14), p. 2629–2632, 2007. @article{Gaillard:2007, title = {Synthesis and characterization of a new red-emitting Ca2+ indicator, calcium ruby}, author = {S Gaillard and A Yakovlev and C Luccardini and M Oheim and A Feltz and J -M Mallet}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-34547421295&doi=10.1021%2fol070648h&partnerID=40&md5=56f662c27587a3b5ca14eb06961bb159}, doi = {10.1021/ol070648h}, year = {2007}, date = {2007-01-01}, journal = {Organic Letters}, volume = {9}, number = {14}, pages = {2629--2632}, abstract = {Equation Presented Calcium Ruby m-Cl (X = H}, keywords = {}, pubstate = {published}, tppubtype = {article} } Equation Presented Calcium Ruby m-Cl (X = H |
2006 |
Characterization of Sol-Gel Derived Scintillating LuBO3 Films Doped with Rare Earth Ions Article de journal C Mansuy; E Tomasella; R Mahiou; L Gengembre; J Grimblot; J M Nedelec Thin Solid Films, 515 (2), p. 666-669, 2006. @article{Mansuy:2006, title = {Characterization of Sol-Gel Derived Scintillating LuBO3 Films Doped with Rare Earth Ions}, author = {C Mansuy and E Tomasella and R Mahiou and L Gengembre and J Grimblot and J M Nedelec}, doi = {10.1016/j.tsf.2005.12.235}, year = {2006}, date = {2006-04-01}, journal = {Thin Solid Films}, volume = {515}, number = {2}, pages = {666-669}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Scintillation of Sol-Gel Derived Lutetium Orthophosphate Doped with Rare Earth Ions Article de journal C Mansuy; J M Nedelec; C Dujardin; R Mahiou Journal of Sol-Gel Science and Technology, 38 (1), p. 97-105, 2006. @article{Mansuy:2006a, title = {Scintillation of Sol-Gel Derived Lutetium Orthophosphate Doped with Rare Earth Ions}, author = {C Mansuy and J M Nedelec and C Dujardin and R Mahiou}, doi = {10.1007/s10971-005-5639-9}, year = {2006}, date = {2006-04-01}, journal = {Journal of Sol-Gel Science and Technology}, volume = {38}, number = {1}, pages = {97-105}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
2005 |
Preferential Site Substitution in Sol-Gel Derived Eu3+ Doped Lu2SiO5: A Combined Study by X-Ray Absorption and Luminescence Spectroscopies Article de journal C Mansuy; F Leroux; R Mahiou; J M Nedelec Journal of Materials Chemistry, 15 (38), p. 4129-4129, 2005. @article{Mansuy:2005, title = {Preferential Site Substitution in Sol-Gel Derived Eu3+ Doped Lu2SiO5: A Combined Study by X-Ray Absorption and Luminescence Spectroscopies}, author = {C Mansuy and F Leroux and R Mahiou and J M Nedelec}, doi = {10.1039/b504303d}, year = {2005}, date = {2005-04-01}, journal = {Journal of Materials Chemistry}, volume = {15}, number = {38}, pages = {4129-4129}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Structural and Scintillation Properties of Spray Coated Lutetium Borate Films Doped with Ce3+ and Eu3+ Article de journal G Chadeyron-Bertrand; D Boyer; C Dujardin; C Mansuy; R Mahiou Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 229 (2), p. 232-239, 2005. @article{Chadeyron-Bertrand:2005, title = {Structural and Scintillation Properties of Spray Coated Lutetium Borate Films Doped with Ce3+ and Eu3+}, author = {G {Chadeyron-Bertrand} and D Boyer and C Dujardin and C Mansuy and R Mahiou}, doi = {10.1016/j.nimb.2004.11.029}, year = {2005}, date = {2005-04-01}, journal = {Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms}, volume = {229}, number = {2}, pages = {232-239}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
New 1-amino-1-deoxy- and 2-amino-2-deoxy-polyhydroxyazepanes: Synthesis and inhibition of glycosidases Article de journal H Li; Y Blériot; J -M Mallet; E Rodriguez-Garcia; P Vogel; Y Zhang; P Sinaÿ Tetrahedron Asymmetry, 16 (2), p. 313–319, 2005. @article{Li:2005, title = {New 1-amino-1-deoxy- and 2-amino-2-deoxy-polyhydroxyazepanes: Synthesis and inhibition of glycosidases}, author = {H Li and Y Bl\'{e}riot and J -M Mallet and E Rodriguez-Garcia and P Vogel and Y Zhang and P Sina\"{y}}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-13144257750&doi=10.1016%2fj.tetasy.2004.12.005&partnerID=40&md5=9f267914f02732d547571d52723916a4}, doi = {10.1016/j.tetasy.2004.12.005}, year = {2005}, date = {2005-01-01}, journal = {Tetrahedron Asymmetry}, volume = {16}, number = {2}, pages = {313--319}, abstract = {Eight new seven-membered ring iminoalditols, displaying an amino group and a hydroxymethyl group on the ring, have been synthesized from d-arabinose via epoxidation of a protected azacycloheptene and subsequent nucleophilic opening. Three of them show a potent glycosidase inhibition on amyloglucosidase and, to a lesser extend, on α-l-fucosidase. © 2004 Elsevier Ltd. All rights reserved.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Eight new seven-membered ring iminoalditols, displaying an amino group and a hydroxymethyl group on the ring, have been synthesized from d-arabinose via epoxidation of a protected azacycloheptene and subsequent nucleophilic opening. Three of them show a potent glycosidase inhibition on amyloglucosidase and, to a lesser extend, on α-l-fucosidase. © 2004 Elsevier Ltd. All rights reserved. |
R Chevalier; J Esnault; P Vandewalle; B Sendid; J -F Colombel; D Poulain; J -M Mallet Tetrahedron, 61 (32), p. 7669–7677, 2005. @article{Chevalier:2005, title = {Synthetic yeast oligomannosides as biological probes: α-{D}-Manp (1→3) α-{D}-Manp (1→2) α-{D}-Manp and α-{D}-Manp (1→3) α-{D}-Manp (1→2) α-{D}-Manp (1→2) α-{D}-Manp as Crohn's disease markers}, author = {R Chevalier and J Esnault and P Vandewalle and B Sendid and J -F Colombel and D Poulain and J -M Mallet}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-21844454495&doi=10.1016%2fj.tet.2005.05.098&partnerID=40&md5=fce097411ee007e7bd0665e3abe8ec88}, doi = {10.1016/j.tet.2005.05.098}, year = {2005}, date = {2005-01-01}, journal = {Tetrahedron}, volume = {61}, number = {32}, pages = {7669--7677}, abstract = {The anti-Saccharomyces cerevisiae antibodies (ASCA) are markers for Crohn's disease used for diagnostic, phenotypic characterization and sero-epidemiological studies. Antibody detection is made by different immunoenzymatic tests using S. cerevisiae mannans which are both complex and poorly standardized antigens. Here we construct the major discriminating epitopes comprised within this antigen. When coupled to linker arm and a peptidic carrier to functionalize microtiter plates, they were able to discriminate serological responses between Crohn's disease and ulcerative colitis, another form of inflammatory bowel disease. © 2005 Elsevier Ltd. All rights reserved.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The anti-Saccharomyces cerevisiae antibodies (ASCA) are markers for Crohn's disease used for diagnostic, phenotypic characterization and sero-epidemiological studies. Antibody detection is made by different immunoenzymatic tests using S. cerevisiae mannans which are both complex and poorly standardized antigens. Here we construct the major discriminating epitopes comprised within this antigen. When coupled to linker arm and a peptidic carrier to functionalize microtiter plates, they were able to discriminate serological responses between Crohn's disease and ulcerative colitis, another form of inflammatory bowel disease. © 2005 Elsevier Ltd. All rights reserved. |
An alternative high yielding and highly stereoselective method for preparing an α-Neu5NAc-(2,6)-Đ-GalN3 building block suitable for further glycosylation Article de journal N Laurent; D Lafont; P Boullanger; J M Mallet Carbohydrate Research, 340 (11), p. 1885–1892, 2005. @article{Laurent:2005, title = {An alternative high yielding and highly stereoselective method for preparing an α-Neu5NAc-(2,6)-{D}-GalN3 building block suitable for further glycosylation}, author = {N Laurent and D Lafont and P Boullanger and J M Mallet}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-22044438685&doi=10.1016%2fj.carres.2005.05.007&partnerID=40&md5=bbb1c959301bf68c607bbacdd4a91608}, doi = {10.1016/j.carres.2005.05.007}, year = {2005}, date = {2005-01-01}, journal = {Carbohydrate Research}, volume = {340}, number = {11}, pages = {1885--1892}, abstract = {This paper deals with new approaches to α-Neu5NAc-(2,6)-D-GalN 3 building blocks, suitable as glycosylation donors. The major improvement, by comparison with the results of the literature, lies in the glycosylation step of a new D-galactosamine acceptor (tert-butyldimethylsilyl 3-O-acetyl-2-azido-2-deoxy-β-D-galactopyranoside) with O-methyl-S- [methyl(5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D- galacto-non-2-ulopyranosyl)onate] dithiocarbonate as the N-acetylneuraminic acid donor. The reaction affords the expected disaccharide in high yield (85%) and a complete α-Neu5NAc stereoselectivity. A subsequent oxidation step, eliminating the glycal by-product allows an easier purification. Afterwards, the tert-butyldimethylsilyl disaccharide can be transformed into a donor, after cleavage of the anomeric group in smooth conditions. © 2005 Elsevier Ltd. All rights reserved.}, keywords = {}, pubstate = {published}, tppubtype = {article} } This paper deals with new approaches to α-Neu5NAc-(2,6)-D-GalN 3 building blocks, suitable as glycosylation donors. The major improvement, by comparison with the results of the literature, lies in the glycosylation step of a new D-galactosamine acceptor (tert-butyldimethylsilyl 3-O-acetyl-2-azido-2-deoxy-β-D-galactopyranoside) with O-methyl-S- [methyl(5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D- galacto-non-2-ulopyranosyl)onate] dithiocarbonate as the N-acetylneuraminic acid donor. The reaction affords the expected disaccharide in high yield (85%) and a complete α-Neu5NAc stereoselectivity. A subsequent oxidation step, eliminating the glycal by-product allows an easier purification. Afterwards, the tert-butyldimethylsilyl disaccharide can be transformed into a donor, after cleavage of the anomeric group in smooth conditions. © 2005 Elsevier Ltd. All rights reserved. |
2004 |
LUMINIX : synth`ese, caractérisation et mise en forme de luminophores denses pour la tomographie X : application `a un syst`eme de réalité augmentée Article de journal C Mansuy; G Chadeyron; J M Nedelec; R Mahiou; C Dujardin; J Mugnier; C Leluyer; B Peuchot; A Tanguy ITBM-RBM, 25 (5), p. 246-249, 2004. @article{Mansuy:2004, title = {LUMINIX : synth`ese, caract\'{e}risation et mise en forme de luminophores denses pour la tomographie X : application `a un syst`eme de r\'{e}alit\'{e} augment\'{e}e}, author = {C Mansuy and G Chadeyron and J M Nedelec and R Mahiou and C Dujardin and J Mugnier and C Leluyer and B Peuchot and A Tanguy}, doi = {10.1016/j.rbmret.2004.09.001}, year = {2004}, date = {2004-04-01}, journal = {ITBM-RBM}, volume = {25}, number = {5}, pages = {246-249}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Scintillation of Sol?Gel Derived Lutetium Orthoborate Doped with Ce3+ Ions Article de journal C Mansuy; J M Nedelec; C Dujardin; R Mahiou Journal of Sol-Gel Science and Technology, 32 (1-3), p. 253-258, 2004. @article{Mansuy:2004b, title = {Scintillation of Sol?Gel Derived Lutetium Orthoborate Doped with Ce3+ Ions}, author = {C Mansuy and J M Nedelec and C Dujardin and R Mahiou}, doi = {10.1007/s10971-004-5797-1}, year = {2004}, date = {2004-04-01}, journal = {Journal of Sol-Gel Science and Technology}, volume = {32}, number = {1-3}, pages = {253-258}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Can small complex chains be treated as polymers? Article de journal C Gourier; F Pincet; T Le Bouar; Y Zhang; J Esnault; J -M Mallet; P Sinay; E Perez Macromolecules, 37 (23), p. 8778–8784, 2004. @article{Gourier:2004, title = {Can small complex chains be treated as polymers?}, author = {C Gourier and F Pincet and T Le Bouar and Y Zhang and J Esnault and J -M Mallet and P Sinay and E Perez}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-9744221290&doi=10.1021%2fma035905m&partnerID=40&md5=d6ed638dc00ca565963349bf76d733fe}, doi = {10.1021/ma035905m}, year = {2004}, date = {2004-01-01}, journal = {Macromolecules}, volume = {37}, number = {23}, pages = {8778--8784}, abstract = {The interactions of supramolecular systems often depend on small and complex molecules. It is tempting though dangerous to apply polymer theory to these molecules that are normally considered to be too small to be polymers and too large to be rigid. Here, forces and adhesions between surfaces bearing several types of such molecules with both flexible and rigid parts are measured. The force/distance profiles follow closely the description given by polymer theory. It is shown for a wide variety of systems containing these molecules that if one obtains an effective radius of gyration Rg of the molecules, polymer theory can be used to predict their adhesion energy. Conversely, if the adhesion energy for bilayers containing such small and complex molecules is measured, polymer theory allows to deduce the effective Rg of the molecule.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The interactions of supramolecular systems often depend on small and complex molecules. It is tempting though dangerous to apply polymer theory to these molecules that are normally considered to be too small to be polymers and too large to be rigid. Here, forces and adhesions between surfaces bearing several types of such molecules with both flexible and rigid parts are measured. The force/distance profiles follow closely the description given by polymer theory. It is shown for a wide variety of systems containing these molecules that if one obtains an effective radius of gyration Rg of the molecules, polymer theory can be used to predict their adhesion energy. Conversely, if the adhesion energy for bilayers containing such small and complex molecules is measured, polymer theory allows to deduce the effective Rg of the molecule. |
The first chemical synthesis of a cyclodextrin heteroduplex Article de journal O Bistri; T Lecourt; J -M Mallet; M Sollogoub; P Sinay Chemistry and Biodiversity, 1 (1), p. 129–137, 2004. @article{Bistri:2004, title = {The first chemical synthesis of a cyclodextrin heteroduplex}, author = {O Bistri and T Lecourt and J -M Mallet and M Sollogoub and P Sinay}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-2942665271&doi=10.1002%2fcbdv.200490004&partnerID=40&md5=ad582455447fd435a213c6ecba42ad90}, doi = {10.1002/cbdv.200490004}, year = {2004}, date = {2004-01-01}, journal = {Chemistry and Biodiversity}, volume = {1}, number = {1}, pages = {129--137}, abstract = {The synthesis of the first heteroduplex of cyclodextrin (CD) 11, i.e., a compound in which the two primary rims of α- and β-CDs are doubly connected, was achieved. The selected strategy involved a Sonogashira coupling of propargylated β-CD 6 and iodo-alkenyl α-CD 4 to singly connect the two CDs. A ring-closing metathesis (RCM) of the heterodimer 9 afforded the second bridge, final deprotection and reductions giving acces to 11.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The synthesis of the first heteroduplex of cyclodextrin (CD) 11, i.e., a compound in which the two primary rims of α- and β-CDs are doubly connected, was achieved. The selected strategy involved a Sonogashira coupling of propargylated β-CD 6 and iodo-alkenyl α-CD 4 to singly connect the two CDs. A ring-closing metathesis (RCM) of the heterodimer 9 afforded the second bridge, final deprotection and reductions giving acces to 11. |
The first synthesis of substituted azepanes mimicking monosaccharides: A new class of potent glycosidase inhibitors Article de journal H Li; Y Blériot; C Chantereau; J -M Mallet; M Sollogoub; Y Zhang; E Rodríguez-García; P Vogel; J Jiménez-Barbero; P Sinaÿ Organic and Biomolecular Chemistry, 2 (10), p. 1492–1499, 2004. @article{Li:2004c, title = {The first synthesis of substituted azepanes mimicking monosaccharides: A new class of potent glycosidase inhibitors}, author = {H Li and Y Bl\'{e}riot and C Chantereau and J -M Mallet and M Sollogoub and Y Zhang and E Rodr\'{i}guez-Garc\'{i}a and P Vogel and J Jim\'{e}nez-Barbero and P Sina\"{y}}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-3342907221&doi=10.1039%2fb402542c&partnerID=40&md5=404b626d021add2666c0dde80a2186c5}, doi = {10.1039/b402542c}, year = {2004}, date = {2004-01-01}, journal = {Organic and Biomolecular Chemistry}, volume = {2}, number = {10}, pages = {1492--1499}, abstract = {The synthesis of the first examples of seven-membered ring iminoalditols, molecules displaying an extra hydroxymethyl substituent on their seven-membered ring compared to the previously reported polyhydroxylated azepanes, has been achieved from D-arabinose in 10 steps using RCM of a protected N-allyl-aminohexenitol as a key step. While the (2R,3R,4R)-2-hydroxymethyl-3,4- dihydroxy-azepane 10, a seven-membered ring analogue of fagomine, is a weak inhibitor of glycosidases, the (2R,3R,4R,5S,6S)-2-hydroxymethyl-3,4,5,6- tetrahydroxy-azepane 9 selectively inhibits green coffee bean α-galactosidase in the low micromolar range (Ki = 2.2 μM) despite a D-gluco relative configuration.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The synthesis of the first examples of seven-membered ring iminoalditols, molecules displaying an extra hydroxymethyl substituent on their seven-membered ring compared to the previously reported polyhydroxylated azepanes, has been achieved from D-arabinose in 10 steps using RCM of a protected N-allyl-aminohexenitol as a key step. While the (2R,3R,4R)-2-hydroxymethyl-3,4- dihydroxy-azepane 10, a seven-membered ring analogue of fagomine, is a weak inhibitor of glycosidases, the (2R,3R,4R,5S,6S)-2-hydroxymethyl-3,4,5,6- tetrahydroxy-azepane 9 selectively inhibits green coffee bean α-galactosidase in the low micromolar range (Ki = 2.2 μM) despite a D-gluco relative configuration. |
2003 |
A New Sol-Gel Route to Lu 2 SiO 5 (LSO) Scintillator: Powders and Thin Films Article de journal C Mansuy; R Mahiou; J M Nedelec Chemistry of Materials, 15 (17), p. 3242-3244, 2003. @article{Mansuy:2003, title = {A New Sol-Gel Route to Lu 2 SiO 5 (LSO) Scintillator: Powders and Thin Films}, author = {C Mansuy and R Mahiou and J M Nedelec}, doi = {10.1021/cm034412t}, year = {2003}, date = {2003-04-01}, journal = {Chemistry of Materials}, volume = {15}, number = {17}, pages = {3242-3244}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Sol–Gel Derived YPO4 and LuPO4 Phosphors, a Spectroscopic Study Article de journal J M Nedelec; C Mansuy; R Mahiou Journal of Molecular Structure, 651-653 , p. 165-170, 2003. @article{Nedelec:2003, title = {Sol\textendashGel Derived YPO4 and LuPO4 Phosphors, a Spectroscopic Study}, author = {J M Nedelec and C Mansuy and R Mahiou}, doi = {10.1016/S0022-2860(03)00104-2}, year = {2003}, date = {2003-04-01}, journal = {Journal of Molecular Structure}, volume = {651-653}, pages = {165-170}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
An efficient preparation of 6I,IV dihydroxy permethylated β-cyclodextrin Article de journal T Lecourt; J -M Mallet; P Sinaÿ Carbohydrate Research, 338 (22), p. 2417–2419, 2003. @article{Lecourt:2003, title = {An efficient preparation of 6I,IV dihydroxy permethylated β-cyclodextrin}, author = {T Lecourt and J -M Mallet and P Sina\"{y}}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0142138718&doi=10.1016%2fS0008-6215%2803%2900359-8&partnerID=40&md5=7c7710ff4cf2ac5b6eef919297d23ae4}, doi = {10.1016/S0008-6215(03)00359-8}, year = {2003}, date = {2003-01-01}, journal = {Carbohydrate Research}, volume = {338}, number = {22}, pages = {2417--2419}, abstract = {We report on a straightforward synthesis of 2I-VII,3 I-VII,6II,III,V-VII-nonadeca-O-methylcyclomaltoheptaose, a methylated β-cyclodextrin derivative bearing two 6I,IV hydroxyl groups, from its easily available benzylated counterpart. © 2003 Elsevier Ltd. All rights reserved.}, keywords = {}, pubstate = {published}, tppubtype = {article} } We report on a straightforward synthesis of 2I-VII,3 I-VII,6II,III,V-VII-nonadeca-O-methylcyclomaltoheptaose, a methylated β-cyclodextrin derivative bearing two 6I,IV hydroxyl groups, from its easily available benzylated counterpart. © 2003 Elsevier Ltd. All rights reserved. |