Bioinorganic chemistry

Our website :
Metals in Biology: Inorganic Biological and Cellular Chemistry :

Our personal webpages and resumes:

Hélène Bertrand:

Nicolas Delsuc:

Clotilde Policar:

Some news about our work:

Publications of the group:

(go back to the ENS-BIC website, publication page)

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SOD mimics: From the tool box of the chemists to cellular studies Article de journal

Clotilde Policar; Jean Bouvet; Hélène C Bertrand; Nicolas Delsuc

Current Opinion in Chemical Biology, 67 , p. 102109, 2022, ISSN: 1367-5931.


Rhenium carbonyl complexes bearing methylated triphenylphosphonium cations as antibody-free mitochondria trackers for X-ray fluorescence imaging Article de journal

Gabrielle Schanne; Lucas Henry; How Chee Ong; Andrea Somogyi; Kadda Medjoubi; Nicolas Delsuc; Clotilde Policar; Felipe García; Helene C Bertrand

Inorg. Chem. Front., 8 , p. 3905-3915, 2021.

Evaluation of the compounds commonly known as superoxide dismutase and catalase mimics in cellular models Article de journal

Amandine Vincent; Marion Thauvin; Elodie Quévrain; Emilie Mathieu; Sarah Layani; Philippe Seksik; Ines Batinic-Haberle; Sophie Vriz; Clotilde Policar; Nicolas Delsuc

Journal of Inorganic Biochemistry, p. 111431, 2021, ISSN: 0162-0134.

A di-Copper Peptidyl Complex Mimics the Activity of Catalase, a Key Antioxidant Metalloenzyme Article de journal

Koudedja Coulibaly; Marion Thauvin; Adyn Melenbacher; Clara Testard; Evangelina Trigoni; Amandine Vincent; Martin J Stillman; Sophie Vriz; Clotilde Policar; Nicolas Delsuc

Inorganic Chemistry, 60 (13), p. 9309-9319, 2021.


Anti-inflammatory activity of superoxide dismutase mimics functionalized with cell-penetrating peptides Article de journal

Emilie Mathieu; Anne-Sophie Bernard; Vincent H Y Ching; Andrea Somogyi; Kadda Medjoubi; Jennifer Rodon Fores; Hélène C Bertrand; Amandine Vincent; Sylvain Trépout; Jean-Luc Guerquin-Kern; Andreas Scheitler; Ivana Ivanović-Burmazović; Philippe Seksik; Nicolas Delsuc; Clotilde Policar

Dalton Trans., 49 , p. 2323-2330, 2020.

An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase Article de journal

Amandine Vincent; Jennifer Rodon Fores; Elodie Tauziet; Elodie Quévrain; Ágnes Dancs; Amandine Conte-Daban; Anne-Sophie Bernard; Philippe Pelupessy; Koudedja Coulibaly; Philippe Seksik; Christelle Hureau; Katalin Selmeczi; Clotilde Policar; Nicolas Delsuc

Chem. Commun., 56 , p. 399-402, 2020.

Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese(ii) superoxide dismutase mimic complex Article de journal

Emilie Mathieu; Anne-Sophie Bernard; Elodie Quévrain; Martha Zoumpoulaki; Sébastien Iriart; Caroline Lung-Soong; Barry Lai; Kadda Medjoubi; Lucas Henry; Sounderya Nagarajan; Florent Poyer; Andreas Scheitler; Ivana Ivanović-Burmazović; Sergio Marco; Andrea Somogyi; Philippe Seksik; Nicolas Delsuc; Clotilde Policar

Chem. Commun., p. -, 2020.

Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites Article de journal

Nicolas Debons; Dounia Dems; Christophe Hélary; Sylvain Le Grill; Lise Picaut; Flore Renaud; Nicolas Delsuc; Marie-Claire Schanne-Klein; Thibaud Coradin; Carole Aimé

Biomater. Sci., 8 , p. 569-576, 2020.

Recent Emergence of Rhenium(I) Tricarbonyl Complexes as Photosensitisers for Cancer Therapy Article de journal

Hui Shan Liew; Chun-Wai Mai; Mohd Zulkefeli; Thiagarajan Madheswaran; Lik Voon Kiew; Nicolas Delsuc; May Lee Low

Molecules, 25 (18), 2020, ISSN: 1420-3049.


Oxaliplatin-induced neuropathy: the preventive effect of a new super-oxide dismutase modulator Article de journal

Marie-Anne Guillaumot; Olivier Cerles; Hélène C Bertrand; Evelyne Benoit; Carole Nicco; Sandrine Chouzenoux; Alain Schmitt; Frédéric Batteux; Clotilde Policar; Romain Coriat

Oncotarget, 10 (60), p. 6418-6431, 2019, ISSN: 1949-2553.


From Naproxen Repurposing to Naproxen Analogues and Their Antiviral Activity against Influenza A Virus Article de journal

Sébastien Dilly; Aurélien Fotso Fotso; Nathalie Lejal; Gloria Zedda; Mohamad Chebbo; Fryad Rahman; Simon Companys; Hélène C Bertrand; Jasmina Vidic; Magali Noiray; Marie-Christine Alessi; Bogdan Tarus; Stéphane Quideau; Béatrice Riteau; Anny Slama-Schwok

Journal of Medicinal Chemistry, 61 (16), p. 7202–7217, 2018, ISSN: 0022-2623.

Rhenium tricarbonyl complexes with arenethiolate axial ligands Article de journal

M He; H Y V Ching; C Policar; H C Bertrand

New Journal of Chemistry, 42 (14), p. 11312–11323, 2018.

Macrophage-derived superoxide production and antioxidant response following skeletal muscle injury Article de journal

E Le Moal; G Juban; A S Bernard; T Varga; C Policar; B Chazaud; R Mounier

Free Radical Biology and Medicine, 120 , p. 33–40, 2018.

A Metallo Pro-Drug to Target CuII in the Context of Alzheimer's Disease Article de journal

A Conte-Daban; V Ambike; R Guillot; N Delsuc; C Policar; C Hureau

Chemistry - A European Journal, 24 (20), p. 5095–5099, 2018.

Labeling of Hyaluronic Acids with a Rhenium-tricarbonyl Tag and Percutaneous Penetration Studied by Multimodal Imaging Article de journal

L Henry; N Delsuc; C Laugel; F Lambert; C Sandt; S Hostachy; A -S Bernard; H C Bertrand; L Grimaud; A Baillet-Guffroy; C Policar

Bioconjugate Chemistry, 29 (4), p. 987–991, 2018.

Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins Article de journal

S Hostachy; M Masuda; T Miki; I Hamachi; S Sagan; O Lequin; K Medjoubi; A Somogyi; N Delsuc; C Policar

Chemical Science, 9 (19), p. 4483–4487, 2018.

Ferrocifens labelled with an infrared rhenium tricarbonyl tag: Synthesis, antiproliferative activity, quantification and nano IR mapping in cancer cells Article de journal

Y Wang; F Heinemann; S Top; A Dazzi; C Policar; L Henry; F Lambert; G Jaouen; M Salmain; A Vessieres

Dalton Transactions, 47 (29), p. 9824–9833, 2018.

Clarifying the Copper Coordination Environment in a de Novo Designed Red Copper Protein Article de journal

K J Koebke; L Ruckthong; J L Meagher; E Mathieu; J Harland; A Deb; N Lehnert; C Policar; C Tard; J E Penner-Hahn; J A Stuckey; V L Pecoraro

Inorganic Chemistry, 57 (19), p. 12291–12302, 2018.

Increased Efficiency of Dye-Sensitized Solar Cells by Incorporation of a π Spacer in Donor–Acceptor Zinc Porphyrins Bearing Cyanoacrylic Acid as an Anchoring Group Article de journal

S Panagiotakis; E Giannoudis; A Charisiadis; R Paravatou; M -E Lazaridi; M Kandyli; K Ladomenou; P A Angaridis; H C Bertrand; G D Sharma; A G Coutsolelos

European Journal of Inorganic Chemistry, 2018 (20), p. 2369–2379, 2018.


Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease Article de journal

Fiona Kerr; Oyinkan Sofola-Adesakin; Dobril K Ivanov; Jemma Gatliff; Beatriz Gomez Perez-Nievas; Hélène C Bertrand; Pedro Martinez; Rebecca Callard; Inge Snoeren; Helena M Cochemé; Jennifer Adcott; Mobina Khericha; Jorge Iván Castillo-Quan; Geoffrey Wells; Wendy Noble; Janet Thornton; Linda Partridge

PLOS Genetics, 13 (3), p. e1006593, 2017.

Synthesis of Homoditopic Ligands with an Incrementable Rodlike Backbone Article de journal

P Demay-Drouhard; L -M Chamoreau; R Guillot; C Policar; H C Bertrand

European Journal of Organic Chemistry, 2017 (1), p. 131–137, 2017.

Rhenium Complexes Based on 2-Pyridyl-1,2,3-triazole Ligands: A New Class of CO2 Reduction Catalysts Article de journal

H Y V Ching; X Wang; M He; N Perujo Holland; R Guillot; C Slim; S Griveau; H C Bertrand; C Policar; F Bedioui; M Fontecave

Inorganic Chemistry, 56 (5), p. 2966–2976, 2017.

Re(I) carbonyl complexes: Multimodal platforms for inorganic chemical biology Article de journal

S Hostachy; C Policar; N Delsuc

Coordination Chemistry Reviews, 351 , p. 172–188, 2017.

A Cell-Penetrant Manganese Superoxide Dismutase (MnSOD) Mimic Is Able to Complement MnSOD and Exerts an Antiinflammatory Effect on Cellular and Animal Models of Inflammatory Bowel Diseases Article de journal

E Mathieu; A -S Bernard; N Delsuc; E Quévrain; G Gazzah; B Lai; F Chain; P Langella; M Bachelet; J Masliah; P Seksik; C Policar

Inorganic Chemistry, 56 (5), p. 2545–2555, 2017.

Association of a Platinum Complex to a G-Quadruplex Ligand Enhances Telomere Disruption Article de journal

R Charif; C Granotier-Beckers; H C Bertrand; J Poupon; E Ségal-Bendirdjian; M -P Teulade-Fichou; F D Boussin; S Bombard

Chemical Research in Toxicology, 30 (8), p. 1629–1640, 2017.

An All-in-One Molecule for the One-Step Synthesis of Functional Hybrid Silica Particles with Tunable Sizes Article de journal

J Graffion; D Dems; M Demirelli; T Coradin; N Delsuc; C Aimé

European Journal of Inorganic Chemistry, 2017 (43), p. 5047–5051, 2017.

A host-guest system based on collagen-like triple-helix hybridization Article de journal

N Delsuc; S Uchinomiya; A Ojida; I Hamachi

Chemical Communications, 53 (51), p. 6856–6859, 2017.

Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy Article de journal

Nikolaos D Georgakopoulos; Michele Frison; Maria Soledad Alvarez; Hélène Bertrand; Geoff Wells; Michelangelo Campanella

Scientific Reports, 7 (1), p. 10303, 2017, ISSN: 2045-2322.


Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads Article de journal

Kamila K Kaminska; Helene C Bertrand; Hisashi Tajima; William C Stafford; Qing Cheng; Wan Chen; Geoffrey Wells; Elias S J Arner; Eng-Hui Chew

Oncotarget, 7 (26), p. 40233–40251, 2016, ISSN: 1949-2553.

The Use of Mn(II) Bound to His-tags as Genetically Encodable Spin-Label for Nanometric Distance Determination in Proteins Article de journal

H Y V Ching; F C Mascali; H C Bertrand; E M Bruch; P Demay-Drouhard; R M Rasia; C Policar; L C Tabares; S Un

Journal of Physical Chemistry Letters, 7 (6), p. 1072–1076, 2016.

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