Mathilde LEPOITEVIN

Assistant professor, École Normale Supérieure

ENS – Département de chimie
24 rue Lhomond, 75005 Paris

Email: mathilde.lepoitevin@ens.fr
Phone: +33 144.322.460
Office: E024

Short bio

    • Since September 2018, Mathilde Lepoitevin is an assistant professor in Chemistry at Ecole Normale Superieure, in the Porous Materials Institute of Paris.
      During her bachelor’s she began to work on proteins interaction with materials. Before finishing that degree, she was admitted to the Materials for Energy Storage and Conversion (MESC) Master with a scholarship. While working on her master’s thesis, she was granted a PhD fellowship by Montpellier University (Fr), under the supervision of Dr. Balme and Dr. Bechelany. Her PhD work consisted in developing and designing single solid state nanopores to mimic biological channels and to investigate either bio-macromolecules translocation or to functionalize the nanopore to mimic stimuli-dependent ion channels. During her PhD, she was the recipient of a travel grant from the “Chaire Total” for a short-term stay collaboration work with Dr. Dumee group at Deakin University (Australia).
      In January 2017, she started working as a postdoctoral research fellow, at Brown University (Providence (RI), USA), under the guidance of Pr. D. Stein. There, she developed and demonstrated a new kind of ion source capable of efficiently transferring single amino acid ions from liquid into a mass spectrometer. Her results indicate a feasible path to single-molecule protein sequencing through a combination of a single-ion source and mass spectrometry.She has co-authored more than 20 papers in peer-reviewed journals.[Google scholar] and her work has been presented in 15 international conferences and 8 invited seminars. She has been the recipient of best PhD award from the “pole chimie Balard” in 2017.

        My research at IMAP focuses on Metal Organic Frameworks for two types of biological applications, (i) nanoMOFs systems for controlled drug release, (ii) the design of hybrid biosensors. The main objective is to develop new tools for the biomedical field, based on nanoMOFs and their associated composites, in a variety of designs and shaping. Regardless the application, this requires the development of new methods for modifying the surface of nanoMOFs to improve their stability, but also to regulate biological material (protein, DNA, etc.) / material interactions.
        [LinkedIn]
        .

Education and professional experience

Research interests

  • Nanopore, Biosensor, Nano-electrochemistry, Material Science

Awards and distinctions

Supervised students and post-doctorants

      • 3 Postdoctoral fellows: Francesca GAMBASSI(2023-2024), Charlotte de BLOIS (2023-2024), Ben SLATER (2021), Javier PEREZ (2019-2021)
      • 4 PhD Students: Xiling SONG (2023-2027), Shaokang JIANG (2021), Zhihao YU (2020-2024), Xin MA (2018-2022)
      • 11 MSc Students: Ximena LUNA GONZALEZ (2024), Leyth SAGLIO (2023), Wouter NIJENHUIS (2023), Thomas MCCLYMONT (2023), Ana Laure CORIA GUTIERREZ (2022), Anna STEVENSON (2020-2021), Narjis EL AMRAOUI (2020), Yutong LI (2020), Andrea FELLONI (2019-2020), Hanna SZAPARY (2017-2018), Marie LEMOUEL (2014)
      • 7 BSc Students: Bilal LAKHRISSI (2023), Paul ROBERT (2022), Marie BILLAUD (2021), Louise DELAURENTI (2020), Gabriel GOUJON (2020), Alban SIMMONOT (2019), Charles BUI (2017-2018), Paulius GAIGALAS (2016), Bastien JAMILLOUX (2015)
      • Xin MA, Master Chemistry and Life Science, PSL, Nov. 2018 – Nov. 2022
      • My-An TRAN, Magistère de Physico-Chimie Moléculaire, Université Paris-Saclay Feb. 2019 – July 2019
      • Andrea FELLONI, M.S. in Nanostructured Materials Engineering, Politecnico di Milano, March 2019 – Feb 2020

Teaching

Significant publications

Publications

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2023

Polymer--metal--organic framework self-assembly (PMOFSA) as a robust one-step method to generate well-dispersed hybrid nanoparticles in water Article de journal

Kun Li; Zhihao Yu; Iurii Dovgaliuk; Clémence Le Coeur; Viviane Lütz-Bueno; Eric Leroy; Blandine Brissault; Yoann Rancourt de Mimerand; Mathilde Lepoitevin; Christian Serre; others

Chemical Communications, 59 (33), p. 4923–4926, 2023.

Metal-Organic Frameworks as Phototherapeutic Systems for Antimicrobial Treatment Article de journal

YU Zhihao; Theotim LUCAS; ZHAO Heng; Florence GAZEAU; Mathilde LEPOITEVIN; Christian SERRE

Photodiagnosis and Photodynamic Therapy, 41 , p. 103376, 2023.

NanoMOFs with Encapsulated Photosensitizer: Accumulation in Chlamydia Trachomatis Inclusions and Antimicrobial Effects Article de journal

Xiaoli Qi; Ekaterina Grafskaia; Zhihao Yu; Ningfei Shen; Elena Fedina; Alexander Masyutin; Maria Erokhina; Mathilde Lepoitevin; Vassili Lazarev; Nailya Zigangirova; others

bioRxiv, p. 2023–04, 2023.

Detection and discrimination of nanoparticles using bullet shape nanopores coated with PEG Article de journal

Saly Charles-Achille; Nathan Meyer; Imad Abrao-Nemeir; Mathilde Lepoitevin; Joan Torrent; Jean-Marc Janot; Sébastien Balme

Journal of Electroanalytical Chemistry, 939 , p. 117447, 2023.

Metal-Organic Framework-Based Nanomedicines for the Treatment of Intracellular Bacterial Infections Article de journal

Xiaoli Qi; Ningfei Shen; Aya Al Othman; Alexandre Mezentsev; Anastasia Permyakova; Zhihao Yu; Mathilde Lepoitevin; Christian Serre; Mikhail Durymanov

Pharmaceutics, 15 (5), p. 1521, 2023.

Combining iontronic, chromatography and nanopipette for A$beta$42 aggregates detection and separation Article de journal

Mathilde Moderne; Imad Abrao-Nemeir; Nathan Meyer; Jun Du; Saly Charles-Achille; Jean-Marc Janot; Joan Torrent; Mathilde Lepoitevin; Sebastien Balme

Analytica Chimica Acta, 1275 , p. 341587, 2023.

Methylene Blue-Loaded NanoMOFs: Accumulation in Chlamydia Trachomatis Inclusions and Light/Dark Antibacterial Effects Article de journal

Xiaoli Qi; Ekaterina Grafskaia; Zhihao Yu; Ningfei Shen; Elena Fedina; Alexander Masyutin; Maria Erokhina; Mathilde Lepoitevin; Vassili Lazarev; Nailya Zigangirova; others

ACS Infectious Diseases, 9 (8), p. 1558–1569, 2023.

How defects impact the in vitro behavior of iron carboxylate MOF nanoparticles Article de journal

Xin Ma; Zhihao Yu; Farid Nouar; Iurii Dovgaliuk; Gilles Patriarche; Nicolas Sadovnik; Marco Daturi; Jean-Marc Gren`eche; Mathilde Lepoitevin; Christian Serre

Chemistry of Materials, 36 (1), p. 167–182, 2023.

2022

Combining ionic diode, resistive pulse and membrane for detection and separation of anti-CD44 antibody Article de journal

Imad Abrao-Nemeir; Oumaima Zaki; Nathan Meyer; Mathilde Lepoitevin; Joan Torrent; Jean-Marc Janot; Sebastien Balme

Journal of Membrane Science, 649 , p. 120391, 2022.

Nanopore ion sources deliver single amino acid and peptide ions directly into high vacuum Article de journal

Nicholas Drachman; Mathilde Lepoitevin; Hannah Szapary; Benjamin Wiener; William Maulbetsch; Derek Stein

2022.

2021

A nanopore ion source delivers single amino acid and peptide ions directly into the gas phase Article de journal

Nicholas Drachman; Mathilde LePoitevin; Hannah Szapary; Benjamin Wiener; William Maulbetsch; Derek Stein

bioRxiv, 2021.

Metal–organic frameworks towards bio-medical applications Article de journal

Xin Ma; Mathilde Lepoitevin; Christian Serre

Mater. Chem. Front., 5 , p. 5573-5594, 2021.

Metal--organic frameworks towards bio-medical applications Article de journal

Xin Ma; Mathilde Lepoitevin; Christian Serre

Materials Chemistry Frontiers, 5 (15), p. 5573–5594, 2021.

Metal--organic frameworks towards bio-medical applications Article de journal

Xin Ma; Mathilde Lepoitevin; Christian Serre

Materials Chemistry Frontiers, 5 (15), p. 5573–5594, 2021.

Metal--organic frameworks towards bio-medical applications Article de journal

Xin Ma; Mathilde Lepoitevin; Christian Serre

Materials Chemistry Frontiers, 5 (15), p. 5573–5594, 2021.

Metal--organic frameworks towards bio-medical applications Article de journal

Xin Ma; Mathilde Lepoitevin; Christian Serre

Materials Chemistry Frontiers, 5 (15), p. 5573–5594, 2021.

Metal--organic frameworks towards bio-medical applications Article de journal

Xin Ma; Mathilde Lepoitevin; Christian Serre

Materials Chemistry Frontiers, 5 (15), p. 5573–5594, 2021.

A nanopore ion source delivers single amino acid and peptide ions directly into the gas phase Article de journal

Nicholas Drachman; Mathilde LePoitevin; Hannah Szapary; Benjamin Wiener; William Maulbetsch; Derek Stein

BioRxiv, p. 2021–08, 2021.

Detection of amyloid-$beta$ fibrils using track-etched nanopores: Effect of geometry and crowding Article de journal

Nathan Meyer; Nicolas Arroyo; Jean-Marc Janot; Mathilde Lepoitevin; Anna Stevenson; Imad Abrao Nemeir; Veronique Perrier; Daisy Bougard; Maxime Belondrade; Didier Cot; others

ACS sensors, 6 (10), p. 3733–3743, 2021.

Solid-state and polymer nanopores for protein sensing: A review Article de journal

Nathan Meyer; Imad Abrao-Nemeir; Jean-Marc Janot; Joan Torrent; Mathilde Lepoitevin; Sebastien Balme

Advances in colloid and interface science, 298 , p. 102561, 2021.

2020

Machine Learning to Improve the Sensing of Biomolecules by Conical Track-Etched Nanopore Article de journal

Nathan Meyer; Jean-Marc Janot; Mathilde Lepoitevin; Micha"el Smietana; Jean-Jacques Vasseur; Joan Torrent; Sebastien Balme

Biosensors, 10 (10), p. 140, 2020.

Single-Molecule Sensitivity in Mass Spectrometry Using Nanoscale Ion Sources Article de journal

Nicholas Drachman; Mathilde LePoitevin; Benjamin Wiener; Derek Stein

Bulletin of the American Physical Society, 65 , 2020.

Single-Molecule Sensitivity in Mass Spectrometry Using Nanoscale Ion Sources Article de journal

Nicholas Drachman; Mathilde LePoitevin; Benjamin Wiener; Derek Stein

Bulletin of the American Physical Society, 65 , 2020.

Machine learning to improve the sensing of biomolecules by conical track-etched nanopore Article de journal

Nathan Meyer; Jean-Marc Janot; Mathilde Lepoitevin; Micha"el Smietana; Jean-Jacques Vasseur; Joan Torrent; Sébastien Balme

Biosensors, 10 (10), p. 140, 2020.

2019

Development of a Mass Spectrometer for Sequencing Single Protein Molecules Article de journal

Benjamin Wiener; Nicholas Drachman; Mathilde LePoitevin; William Maulbetsch; Oliver Isik; Derek Stein

Bulletin of the American Physical Society, 2019.

2018

Combining Light-Gated and pH-Responsive Nanopore Based on PEG-Spiropyran Functionalization Article de journal

Tianji Ma; Martin Walko; Mathilde Lepoitevin; Jean-Marc Janot; Emmanuel Balanzat; Armagan Kocer; Sebastien Balme

Advanced Materials Interfaces, 5 (2), p. 1701051, 2018, ISSN: 2196-7350.

Impact of Polyelectrolyte Multilayers on the Ionic Current Rectification of Conical Nanopores Article de journal

Tianji Ma; Paulius Gaigalas; Mathilde Lepoitevin; Ieva Plikusiene; Mikhael Bechelany; Jean-Marc Janot; Emmanuel Balanzat; Sebastien Balme

Langmuir, 34 (11), p. 3405-3412, 2018, ISSN: 0743-7463.

Unexpected Ionic Transport Behavior in Hydrophobic and Uncharged Conical Nanopores Article de journal

Sebastien Balme; Fabien Picaud; Mathilde Lepoitevin; Mikhael Bechelany; Emmanuel Balanzat; Jean-Marc Janot

Faraday discussions, 210 , p. 69-85, 2018, ISSN: 1364-5498.

Combining Light-Gated and pH-Responsive Nanopore Based on PEG-Spiropyran Functionalization Article de journal

Tianji Ma; Martin Walko; Mathilde Lepoitevin; Jean-Marc Janot; Emmanuel Balanzat; Armagan Kocer; Sebastien Balme

Advanced Materials Interfaces, 5 (2), p. 1701051, 2018.

The Nanopore Mass Spectrometer Article de journal

Mathilde Lepoitevin; William Maulbetsch; Benjamin Wiener; Derek Stein

Biophysical Journal, 114 (3), p. 216a, 2018.

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