Mathilde LEPOITEVIN

Assistant professor, École Normale Supérieure

ENS – Département de chimie
24 rue Lhomond, 75005 Paris

Email: mathilde.lepoitevin@ens.psl.eu
Phone: +33 144322460
Office: E024

Short bio

    Since September 2018, Mathilde Lepoitevin is an assistant professor in Chemistry at Ecole Normale Superieure, in the Porous Materials Institute of Paris.
    During her bachelor’s she began to work on proteins interaction with materials. Before finishing that degree, she was admitted to the Materials for Energy Storage and Conversion (MESC) Master with a scholarship. While working on her master’s thesis, she was granted a PhD fellowship by Montpellier University (Fr), under the supervision of Dr. Balme and Dr. Bechelany. Her PhD work consisted in developing and designing single solid state nanopores to mimic biological channels and to investigate either bio-macromolecules translocation or to functionalize the nanopore to mimic stimuli-dependent ion channels. During her PhD, she was the recipient of a travel grant from the “Chaire Total” for a short-term stay collaboration work with Dr. Dumee group at Deakin University (Australia).
    In January 2017, she started working as a postdoctoral research fellow, at Brown University (Providence (RI), USA), under the guidance of Pr. D. Stein. There, she developed and demonstrated a new kind of ion source capable of efficiently transferring single amino acid ions from liquid into a mass spectrometer. Her results indicate a feasible path to single-molecule protein sequencing through a combination of a single-ion source and mass spectrometry.
    She has co-authored 20 papers in peer-reviewed journals, and her work has been presented in 15 international conferences and 8 invited seminars. She has been the recipient of best PhD award from the “pole chimie Balard” in 2017.

Education and professional experience

Research interests

  • Nanopore, Biosensor, Nano-electrochemistry, Material Science

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Awards and distinctions

    • You can also list the membership to professional organizations (SCF, e.g.)

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Supervised students and post-doctorants

      • Xin MA, Master Chemistry and Life Science, PSL, Nov. 2018 – Nov. 2022
      • My-An TRAN, Magistère de Physico-Chimie Moléculaire, Université Paris-Saclay Feb. 2019 – July 2019
      • Andrea FELLONI, M.S. in Nanostructured Materials Engineering, Politecnico di Milano, March 2019 – Feb 2020

Teaching

Significant publications

Publications

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2019

Development of a Mass Spectrometer for Sequencing Single Protein Molecules Article de journal

Benjamin Wiener; Nicholas Drachman; Mathilde LePoitevin; William Maulbetsch; Oliver Isik; Derek Stein

Bulletin of the American Physical Society, 2019.

2018

Combining Light-Gated and pH-Responsive Nanopore Based on PEG-Spiropyran Functionalization Article de journal

Tianji Ma; Martin Walko; Mathilde Lepoitevin; Jean-Marc Janot; Emmanuel Balanzat; Armagan Kocer; Sebastien Balme

Advanced Materials Interfaces, 5 (2), p. 1701051, 2018, ISSN: 2196-7350.

Impact of Polyelectrolyte Multilayers on the Ionic Current Rectification of Conical Nanopores Article de journal

Tianji Ma; Paulius Gaigalas; Mathilde Lepoitevin; Ieva Plikusiene; Mikhael Bechelany; Jean-Marc Janot; Emmanuel Balanzat; Sebastien Balme

Langmuir, 34 (11), p. 3405-3412, 2018, ISSN: 0743-7463.

Unexpected Ionic Transport Behavior in Hydrophobic and Uncharged Conical Nanopores Article de journal

Sebastien Balme; Fabien Picaud; Mathilde Lepoitevin; Mikhael Bechelany; Emmanuel Balanzat; Jean-Marc Janot

Faraday discussions, 210 , p. 69-85, 2018, ISSN: 1364-5498.

2017

The Nanopore Mass Spectrometer Article de journal

Joseph Bush; William Maulbetsch; Mathilde Lepoitevin; Benjamin Wiener; Mirna Mihovilovic Skanata; Wooyoung Moon; Cole Pruitt; Derek Stein

Review of Scientific Instruments, 88 (11), p. 113307, 2017, ISSN: 0034-6748.

Liens

Diffusion Dynamics of Latex Nanoparticles Coated with ssDNA across a Single Nanopore Article de journal

Sébastien Balme; Mathilde Lepoitevin; Ludovic F Dumée; Mikhael Bechelany; Jean-Marc Janot

Soft matter, 13 (2), p. 496-502, 2017.

Discrimination of Polynucleotide Transport through a Highly Hydrophobic Uncharged Nanopore Article de journal

Fabien Picaud; Guillaume Paris; Tijani Gharbi; Mathilde Lepoitevin; Pierre-Eug`ene Coulon; Mikhael Bechelany; Jean Marc Janot; Sébastien Balme

The Journal of Physical Chemistry C, 121 (13), p. 7525-7532, 2017, ISSN: 1932-7447.

Structure and Antibacterial Activity Relationships of Native and Amyloid Fibril Lysozyme Loaded on Layered Double Hydroxide Article de journal

Zaineb Bouaziz; Laurence Soussan; Jean-Marc Janot; Mathilde Lepoitevin; Mikhael Bechelany; Mohamed Amine Djebbi; Abdesslem Ben Haj Amara; Sebastien Balme

Colloids and Surfaces B: Biointerfaces, 157 , p. 10-17, 2017, ISSN: 0927-7765.

Functionalization of Single Solid State Nanopores to Mimic Biological Ion Channels: A Review Article de journal

Mathilde Lepoitevin; Tianji Ma; Mikhael Bechelany; Jean-Marc Janot; Sebastien Balme

Advances in colloid and interface science, 250 , p. 195-213, 2017, ISSN: 0001-8686.

2016

Detection of Short ssDNA and dsDNA by Current-Voltage Measurements Using Conical Nanopores Coated with Al 2 O 3 by Atomic Layer Deposition Article de journal

Vidhyadevi Thangaraj; Mathilde Lepoitevin; Michael Smietana; Emmanuel Balanzat; Mikhael Bechelany; Jean-Marc Janot; Jean-Jacques Vasseur; Sivanesan Subramanian; Sebastien Balme

Microchimica Acta, 183 (3), p. 1011-1017, 2016, ISSN: 0026-3672.

Nanopore as a Sensor Based on Avidin-Biotin System Article de journal

Mathilde Lepoitevin; Mikhael Bechelany; Emmanuel Balanzat; Jean-Marc Janot; Sebastien Balme

Biophysical Journal, 110 (3), p. 337a, 2016, ISSN: 0006-3495.

Fast and Reversible Functionalization of a Single Nanopore Based on Layer-by-Layer Polyelectrolyte Self-Assembly for Tuning Current Rectification and Designing Sensors Article de journal

Mathilde Lepoitevin; Bastien Jamilloux; Mikhael Bechelany; Emmanuel Balanzat; Jean-Marc Janot; Sebastien Balme

RSC Advances, 6 (38), p. 32228-32233, 2016.

Investigation of Sodium Insertion–Extraction in Olivine Na x FePO 4 (0$łeq$ X$łeq$ 1) Using First-Principles Calculations Article de journal

A Saracibar; J Carrasco; D Saurel; M Galceran; B Acebedo; H Anne; M Lepoitevin; T Rojo; Casas M Cabanas

Physical Chemistry Chemical Physics, 18 (18), p. 13045-13051, 2016.

Biomimetic Solution against Dewetting in a Highly Hydrophobic Nanopore Article de journal

Fabien Picaud; Guillaume Paris; Tijani Gharbi; Sébastien Balme; Mathilde Lepoitevin; Vidhyadevi Tangaraj; Mikhael Bechelany; Jean Marc Janot; Emmanuel Balanzat; Franc cois Henn

Soft matter, 12 (22), p. 4903-4911, 2016.

Non-Fluorescence Label Protein Sensing with Track-Etched Nanopore Decorated by Avidin/Biotin System Article de journal

Mathilde Lepoitevin; Mikhael Bechelany; Emmanuel Balanzat; Jean-Marc Janot; Sebastien Balme

Electrochimica Acta, 211 , p. 611-618, 2016, ISSN: 0013-4686.

Influence of Adsorption on Proteins and Amyloid Detection by Silicon Nitride Nanopore Article de journal

Sébastien Balme; Pierre Eug`ene Coulon; Mathilde Lepoitevin; Beno^it Charlot; Naresh Yandrapalli; Cyril Favard; Delphine Muriaux; Mikhael Bechelany; Jean-Marc Janot

Langmuir, 32 (35), p. 8916-8925, 2016, ISSN: 0743-7463.

CONCEPTION D'UN NANOPORE UNIQUE POUR MIMER UN CANAL BIOLOGIQUE ET POUR LA DETECTION DE BIOMACROMOLECULES Article de journal

Mathilde Lepoitevin

2016.

2015

Combining a Sensor and a pH-Gated Nanopore Based on an Avidin–Biotin System Article de journal

Mathilde Lepoitevin; Gael Nguyen; Mikhael Bechelany; Emmanuel Balanzat; Jean-Marc Janot; Sebastien Balme

Chemical Communications, 51 (27), p. 5994-5997, 2015.

Influence of Nanopore Surface Charge and Magnesium Ion on Polyadenosine Translocation Article de journal

Mathilde Lepoitevin; Pierre Eug`ene Coulon; Mikhael Bechelany; Julien Cambedouzou; Jean-Marc Janot; Sebastien Balme

Nanotechnology, 26 (14), p. 144001, 2015, ISSN: 0957-4484.

Gold Nanoparticles for the Bare-Eye Based and Spectrophotometric Detection of Proteins, Polynucleotides and DNA Article de journal

Mathilde Lepoitevin; Marie Lemouel; Mikhael Bechelany; Jean-Marc Janot; Sebastien Balme

Microchimica Acta, 182 (5-6), p. 1223-1229, 2015, ISSN: 0026-3672.

Biological Channel Confinement in Nanostructured Nanopore Article de journal

Sébastien Balme; Mathilde Lepoitevin; Adib Abou-Chayaa; Mikhael Bechelany; Jean-Marc Janot; Emmanuel Balanzat

Biophysical Journal, 108 (2), p. 484a, 2015, ISSN: 0006-3495.

Nanopore Functionalization for Biological Channel Mimicking Article de journal

Mathilde Lepoitevin; Mikhael Bechelany; Jean-Marc Janot; Sebastien Balme

Science Letters, 4 , p. 188, 2015.

2014

BSA and Lysozyme Adsorption on Homoionic Montmorillonite: Influence of the Interlayer Cation Article de journal

Mathilde Lepoitevin; Maguy Jaber; Régis Guégan; Jean-Marc Janot; Philippe Dejardin; Francois Henn; Sébastien Balme

Applied Clay Science, 95 , p. 396-402, 2014, ISSN: 0169-1317.

Influence of Nanopore Surface Charge on Polycytosine Translocation. Physics, Chemistry and Applications of Nanostructures: Proceedings of International Conference Nanomeeting 2015 Article de journal

Mathilde Lepoitevin; Mikhael Bechelany; JM Janot; Sebastien Balme

2014.

Hybrid Biological/Artificial Nanopore Physics, Chemistry and Applications of Nanostructures: Proceedings of International Conference Nanomeeting 2015 Article de journal

Sebastien Balme; Mathilde Lepoitevin; Mikhael Bechelany; Jean-Marc Janot

2014.

2013

Structure, Orientation and Stability of Lysozyme Confined in Layered Materials Article de journal

Sébastien Balme; Régis Guégan; Jean-Marc Janot; Maguy Jaber; Mathilde Lepoitevin; Philippe Dejardin; Xavier Bourrat; Mikael Motelica-Heino

Soft Matter, 9 (11), p. 3188-3196, 2013.

Controlling Potassium Selectivity and Proton Blocking in a Hybrid Biological/Solid-State Polymer Nanoporous Membrane Article de journal

Sébastien Balme; Fabien Picaud; Sebastian Kraszewski; Philippe Déjardin; Jean Marc Janot; Mathilde Lepoitevin; Jhon Capomanes; Christophe Ramseyer; Franc cois Henn

Nanoscale, 5 (9), p. 3961-3968, 2013.

Controlling Ionic Selectivity in Bio-Inspired Systems: Potassium Selectivity and Proton Blocking in Hybrid Biological/Solid-State Polymer Nanopore Membrane Article de journal

Sébastien Balme; Fabien Picaud; S Kraszewski; P Dejardin; JM Janot; M Lepoitevin; J Campomanes; C Ramseyer; F Henn

Nanoscale, 5 , p. 3961-3968, 2013.

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Controlling Potassium Selectivity and Proton Blocking by Gramicidin A Confined inside Track-Etched Membrane Article de journal

M Lepoitevin; F Picaud; S Kraszewski; JM Janot; F Henn; S Balme

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Sodium Insertion-Extraction in the Olivine NaxFePO4 (0$łeq$ X$łeq$ 1) from First-Principles Calculations Article de journal

A Saracibar; J Carrascob; D Saurelb; M Galceranb; B Acebedob; H Anneb; M Lepoitevinb; T Rojoc; Casas M Cabanas

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