2009
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Interplay of Interactions Governing the Dynamic Conversions of Acyclic and Macrocyclic Helicates Article de journal Victoria E. Campbell; Xavier de Hatten; Nicolas Delsuc; Brice Kauffmann; Ivan Huc; Jonathan R. Nitschke Chemistry - A European Journal, 15 (25), p. 6138–6142, 2009, ISSN: 09476539, 15213765. @article{campbell_interplay_2009,
title = {Interplay of Interactions Governing the Dynamic Conversions of Acyclic and Macrocyclic Helicates},
author = {Victoria E. Campbell and Xavier de Hatten and Nicolas Delsuc and Brice Kauffmann and Ivan Huc and Jonathan R. Nitschke},
url = {http://doi.wiley.com/10.1002/chem.200900693},
doi = {10.1002/chem.200900693},
issn = {09476539, 15213765},
year = {2009},
date = {2009-01-01},
urldate = {2018-02-18},
journal = {Chemistry - A European Journal},
volume = {15},
number = {25},
pages = {6138--6142},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Helical Aromatic Oligoamide Foldamers as Organizational Scaffolds for Photoinduced Charge Transfer Article de journal Martin Wolffs; Nicolas Delsuc; Dirk Veldman; Nguyễn Vân Anh; René M Williams; Stefan C J Meskers; René A J Janssen; Ivan Huc; Albertus P H J Schenning Journal of the American Chemical Society, 131 (13), p. 4819–4829, 2009, ISSN: 0002-7863, 1520-5126. @article{wolffs_helical_2009,
title = {Helical Aromatic Oligoamide Foldamers as Organizational Scaffolds for Photoinduced Charge Transfer},
author = {Martin Wolffs and Nicolas Delsuc and Dirk Veldman and Nguyễn V\^{a}n Anh and Ren\'{e} M Williams and Stefan C J Meskers and Ren\'{e} A J Janssen and Ivan Huc and Albertus P H J Schenning},
url = {http://pubs.acs.org/doi/abs/10.1021/ja809367u},
doi = {10.1021/ja809367u},
issn = {0002-7863, 1520-5126},
year = {2009},
date = {2009-01-01},
urldate = {2018-02-18},
journal = {Journal of the American Chemical Society},
volume = {131},
number = {13},
pages = {4819--4829},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
2008
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Plasmodium Telomeric Sequences: Structure, Stability and Quadruplex Targeting by Small Compounds Article de journal Anne De Cian; Philippe Grellier; Elisabeth Mouray; Delphine Depoix; Hélène Bertrand; David Monchaud; Marie-Paule Teulade-Fichou; Jean-Louis Mergny; Patrizia Alberti ChemBioChem, 9 (16), p. 2730–2739, 2008, ISSN: 1439-4227. @article{DeCian2008,
title = {Plasmodium Telomeric Sequences: Structure, Stability and Quadruplex Targeting by Small Compounds},
author = {Anne {De Cian} and Philippe Grellier and Elisabeth Mouray and Delphine Depoix and H\'{e}l{\`{e}}ne Bertrand and David Monchaud and Marie-Paule Teulade-Fichou and Jean-Louis Mergny and Patrizia Alberti},
url = {https://doi.org/10.1002/cbic.200800330},
doi = {10.1002/cbic.200800330},
issn = {1439-4227},
year = {2008},
date = {2008-11-01},
journal = {ChemBioChem},
volume = {9},
number = {16},
pages = {2730--2739},
publisher = {John Wiley & Sons, Ltd},
abstract = {Abstract The increasing resistance of Plasmodium falciparum to the most commonly used antimalarial drugs makes it necessary to identify new therapeutic targets. The telomeres of the parasite could constitute an attractive target. They are composed of repetitions of a degenerate motif (5?GGGTTYA3?, where Y is T or C), different from the human one (5?GGGTTA3?). In this report we investigate the possibility of targeting Plasmodium telomeres with G-quadruplex ligands. Through solution hybridisation assays we provide evidence of the existence of a telomeric 3? G-overhang in P. falciparum genomic DNA. Through UV spectroscopy studies we demonstrate that stable G-quadruplex structures are formed at physiological temperature by sequences composed of the degenerate Plasmodium telomeric motif. Through a FRET melting assay we show stabilisation of Plasmodium telomeric G-quadruplexes by a variety of ligands. Many of the tested ligands display strong quadruplex versus duplex selectivity, but show little discrimination between human and Plasmodium telomeric quadruplexes.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract The increasing resistance of Plasmodium falciparum to the most commonly used antimalarial drugs makes it necessary to identify new therapeutic targets. The telomeres of the parasite could constitute an attractive target. They are composed of repetitions of a degenerate motif (5?GGGTTYA3?, where Y is T or C), different from the human one (5?GGGTTA3?). In this report we investigate the possibility of targeting Plasmodium telomeres with G-quadruplex ligands. Through solution hybridisation assays we provide evidence of the existence of a telomeric 3? G-overhang in P. falciparum genomic DNA. Through UV spectroscopy studies we demonstrate that stable G-quadruplex structures are formed at physiological temperature by sequences composed of the degenerate Plasmodium telomeric motif. Through a FRET melting assay we show stabilisation of Plasmodium telomeric G-quadruplexes by a variety of ligands. Many of the tested ligands display strong quadruplex versus duplex selectivity, but show little discrimination between human and Plasmodium telomeric quadruplexes. |
New platinum(II) complexes targeting the loops of the human telomeric G-quadruplex. Article de journal Hélène Bertrand; Sophie Bombard; David Monchaud; Marie-Paule Teulade-Fichou Nucleic Acids Symposium Series, 52 (1), p. 163–164, 2008, ISSN: 0261-3166. @article{Bertrand2008,
title = {New platinum(II) complexes targeting the loops of the human telomeric G-quadruplex.},
author = {H\'{e}l{\`{e}}ne Bertrand and Sophie Bombard and David Monchaud and Marie-Paule Teulade-Fichou},
url = {https://doi.org/10.1093/nass/nrn083},
doi = {10.1093/nass/nrn083},
issn = {0261-3166},
year = {2008},
date = {2008-09-01},
journal = {Nucleic Acids Symposium Series},
volume = {52},
number = {1},
pages = {163--164},
abstract = {Two novel series of platinum(II) complexes have been designed and shown to interact with the human telomeric G-quadruplex-DNA via different binding modes: i- terpyridine-platinum (Pt-tpy) complexes covalently interact with quadruplex-DNA via selective platination of adenine residues of the loops, their interaction being driven by the aromatic surface of the ligand; ii- platinum-quinacridine hybrid (Pt-MPQ) interacts with quadruplex-DNA via a dual noncovalent/covalent binding mode, targeting preferentially guanines constitutive of external G-quartets. Therefore, platinum complexes presented herein constitute potential agents for irreversible trapping of G-quadruplex. DNA.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Two novel series of platinum(II) complexes have been designed and shown to interact with the human telomeric G-quadruplex-DNA via different binding modes: i- terpyridine-platinum (Pt-tpy) complexes covalently interact with quadruplex-DNA via selective platination of adenine residues of the loops, their interaction being driven by the aromatic surface of the ligand; ii- platinum-quinacridine hybrid (Pt-MPQ) interacts with quadruplex-DNA via a dual noncovalent/covalent binding mode, targeting preferentially guanines constitutive of external G-quartets. Therefore, platinum complexes presented herein constitute potential agents for irreversible trapping of G-quadruplex. DNA. |
A caged retinoic acid for one- and two-photon excitation in zebrafish embryos Article de journal P Neveu; I Aujard; C Benbrahim; T Le Saux; J -F Allemand; S Vriz; D Bensimon; L Jullien Angewandte Chemie - International Edition, 47 (20), p. 3744–3746, 2008. @article{Neveu:2008,
title = {A caged retinoic acid for one- and two-photon excitation in zebrafish embryos},
author = {P Neveu and I Aujard and C Benbrahim and T Le Saux and J -F Allemand and S Vriz and D Bensimon and L Jullien},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-45549089482&doi=10.1002%2fanie.200800037&partnerID=40&md5=320b837fbef96180278af6d16a13797a},
doi = {10.1002/anie.200800037},
year = {2008},
date = {2008-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {47},
number = {20},
pages = {3744--3746},
abstract = {(Chemical Equation Presented) Escaping the cage: Retinoic acid (RA), a crucial signaling molecule for the embryogenesis of vertebrates, can be photoreleased from a simple caged derivative (cRA) upon illumination. In zebrafish embryos, cRA causes RA-induced phenotypes with one- and two-photon excitation (see picture), which opens a route to the noninvasive generation of controlled RA concentration patterns in vivo. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
(Chemical Equation Presented) Escaping the cage: Retinoic acid (RA), a crucial signaling molecule for the embryogenesis of vertebrates, can be photoreleased from a simple caged derivative (cRA) upon illumination. In zebrafish embryos, cRA causes RA-induced phenotypes with one- and two-photon excitation (see picture), which opens a route to the noninvasive generation of controlled RA concentration patterns in vivo. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA. |
Metal-Directed Dynamic Formation of Tertiary Structure in Foldamer Assemblies: Orienting Helices at an Angle Article de journal Nicolas Delsuc; Marie Hutin; Victoria E. Campbell; Brice Kauffmann; Jonathan R. Nitschke; Ivan Huc Chemistry - A European Journal, 14 (24), p. 7140–7143, 2008, ISSN: 09476539, 15213765. @article{delsuc_metal-directed_2008,
title = {Metal-Directed Dynamic Formation of Tertiary Structure in Foldamer Assemblies: Orienting Helices at an Angle},
author = {Nicolas Delsuc and Marie Hutin and Victoria E. Campbell and Brice Kauffmann and Jonathan R. Nitschke and Ivan Huc},
url = {http://doi.wiley.com/10.1002/chem.200800988},
doi = {10.1002/chem.200800988},
issn = {09476539, 15213765},
year = {2008},
date = {2008-01-01},
urldate = {2018-02-18},
journal = {Chemistry - A European Journal},
volume = {14},
number = {24},
pages = {7140--7143},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Kinetics of Helix-Handedness Inversion: Folding and Unfolding in Aromatic Amide Oligomers Article de journal Nicolas Delsuc; Takahiro Kawanami; Julien Lefeuvre; Atsuomi Shundo; Hirotaka Ihara; Makoto Takafuji; Ivan Huc ChemPhysChem, 9 (13), p. 1882–1890, 2008, ISSN: 14394235, 14397641. @article{delsuc_kinetics_2008,
title = {Kinetics of Helix-Handedness Inversion: Folding and Unfolding in Aromatic Amide Oligomers},
author = {Nicolas Delsuc and Takahiro Kawanami and Julien Lefeuvre and Atsuomi Shundo and Hirotaka Ihara and Makoto Takafuji and Ivan Huc},
url = {http://doi.wiley.com/10.1002/cphc.200800310},
doi = {10.1002/cphc.200800310},
issn = {14394235, 14397641},
year = {2008},
date = {2008-01-01},
urldate = {2018-02-18},
journal = {ChemPhysChem},
volume = {9},
number = {13},
pages = {1882--1890},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
2007
|
The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes Article de journal Hélène Bertrand; David Monchaud; Anne De Cian; Régis Guillot; Jean-Louis Mergny; Marie-Paule Teulade-Fichou Organic & Biomolecular Chemistry, 5 (16), p. 2555–2559, 2007, ISSN: 1477-0520. @article{Bertrand2007,
title = {The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes},
author = {H\'{e}l{\`{e}}ne Bertrand and David Monchaud and Anne {De Cian} and R\'{e}gis Guillot and Jean-Louis Mergny and Marie-Paule Teulade-Fichou},
url = {http://dx.doi.org/10.1039/B708635K},
doi = {10.1039/B708635K},
issn = {1477-0520},
year = {2007},
date = {2007-01-01},
journal = {Organic & Biomolecular Chemistry},
volume = {5},
number = {16},
pages = {2555--2559},
publisher = {The Royal Society of Chemistry},
abstract = {A family of terpyridine metallo-organic complexes has been designed and its recognition properties of G-quadruplex-DNA investigated. The series combines easy synthetic access and good affinity\textendashselectivity ratio for quadruplex-DNA. Our study also highlights that the geometry of the metal center strongly governs the ability of the compounds to discriminate quadruplex from duplex-DNA.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
A family of terpyridine metallo-organic complexes has been designed and its recognition properties of G-quadruplex-DNA investigated. The series combines easy synthetic access and good affinity–selectivity ratio for quadruplex-DNA. Our study also highlights that the geometry of the metal center strongly governs the ability of the compounds to discriminate quadruplex from duplex-DNA. |
A platinum–quinacridine hybrid as a G-quadruplex ligand Article de journal Hélène Bertrand; Sophie Bombard; David Monchaud; Marie-Paule Teulade-Fichou JBIC Journal of Biological Inorganic Chemistry, 12 (7), p. 1003–1014, 2007, ISSN: 1432-1327. @article{Bertrand2007a,
title = {A platinum\textendashquinacridine hybrid as a G-quadruplex ligand},
author = {H\'{e}l{\`{e}}ne Bertrand and Sophie Bombard and David Monchaud and Marie-Paule Teulade-Fichou},
url = {https://doi.org/10.1007/s00775-007-0273-3},
doi = {10.1007/s00775-007-0273-3},
issn = {1432-1327},
year = {2007},
date = {2007-01-01},
journal = {JBIC Journal of Biological Inorganic Chemistry},
volume = {12},
number = {7},
pages = {1003--1014},
abstract = {A novel platinum\textendashquinacridine hybrid, comprising a monofunctional Pt moiety and a G-quadruplex ligand (mono-para-quinacridine or MPQ), has been synthesized and shown to interact with quadruplex DNA via a dual noncovalent/covalent binding mode. Denaturing gel electrophoresis was used to separate the various platination products of 22AG (an oligonucleotide that mimics the human telomeric repeat) by Pt-MPQ, and it was shown that two platinated adducts are highly stable quadruplex structures. Dimethylsulfate/piperidine treatment and 3′-exonuclease digestion of the isolated adducts allowed us to precisely determine the platination pattern of 22AG by Pt-MPQ, which displays three main sites G2, G10 and G22. Data presented herein support the hypothesis that Pt-MPQ traps preferentially the antiparallel structure of the 22AG quadruplex. Finally, the kinetics of Pt-MPQ platination using a construct containing both quadruplex DNA and a duplex DNA parts provide the first insights into the Pt-MPQ preference for quadruplex DNA over duplex DNA.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
A novel platinum–quinacridine hybrid, comprising a monofunctional Pt moiety and a G-quadruplex ligand (mono-para-quinacridine or MPQ), has been synthesized and shown to interact with quadruplex DNA via a dual noncovalent/covalent binding mode. Denaturing gel electrophoresis was used to separate the various platination products of 22AG (an oligonucleotide that mimics the human telomeric repeat) by Pt-MPQ, and it was shown that two platinated adducts are highly stable quadruplex structures. Dimethylsulfate/piperidine treatment and 3′-exonuclease digestion of the isolated adducts allowed us to precisely determine the platination pattern of 22AG by Pt-MPQ, which displays three main sites G2, G10 and G22. Data presented herein support the hypothesis that Pt-MPQ traps preferentially the antiparallel structure of the 22AG quadruplex. Finally, the kinetics of Pt-MPQ platination using a construct containing both quadruplex DNA and a duplex DNA parts provide the first insights into the Pt-MPQ preference for quadruplex DNA over duplex DNA. |
Proteomorphous Objects from Abiotic Backbones Article de journal Nicolas Delsuc; Jean-Michel Léger; Stéphane Massip; Ivan Huc Angewandte Chemie International Edition, 46 (1-2), p. 214–217, 2007, ISSN: 14337851, 15213773. @article{delsuc_proteomorphous_2007,
title = {Proteomorphous Objects from Abiotic Backbones},
author = {Nicolas Delsuc and Jean-Michel L\'{e}ger and St\'{e}phane Massip and Ivan Huc},
url = {http://doi.wiley.com/10.1002/anie.200603390},
doi = {10.1002/anie.200603390},
issn = {14337851, 15213773},
year = {2007},
date = {2007-01-01},
urldate = {2018-02-18},
journal = {Angewandte Chemie International Edition},
volume = {46},
number = {1-2},
pages = {214--217},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
The Herringbone Helix: A Noncanonical Folding in Aromatic−Aliphatic Peptides Article de journal Nicolas Delsuc; Frédéric Godde; Brice Kauffmann; Jean-Michel Léger; Ivan Huc Journal of the American Chemical Society, 129 (37), p. 11348–11349, 2007, ISSN: 0002-7863, 1520-5126. @article{delsuc_herringbone_2007,
title = {The Herringbone Helix: A Noncanonical Folding in Aromatic−Aliphatic Peptides},
author = {Nicolas Delsuc and Fr\'{e}d\'{e}ric Godde and Brice Kauffmann and Jean-Michel L\'{e}ger and Ivan Huc},
url = {http://pubs.acs.org/doi/abs/10.1021/ja074285s},
doi = {10.1021/ja074285s},
issn = {0002-7863, 1520-5126},
year = {2007},
date = {2007-01-01},
urldate = {2018-02-18},
journal = {Journal of the American Chemical Society},
volume = {129},
number = {37},
pages = {11348--11349},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
2006
|
Improved Synthesis of Quinacridine Derivatives Article de journal Rémy Lartia; Hélène Bertrand; Marie-Paule Teulade-Fichou Synlett, 2006 (04), p. 610–614, 2006, ISSN: 0936-5214. @article{Lartia2006,
title = {Improved Synthesis of Quinacridine Derivatives},
author = {R\'{e}my Lartia and H\'{e}l{\`{e}}ne Bertrand and Marie-Paule Teulade-Fichou},
doi = {10.1055/s-2006-932465},
issn = {0936-5214},
year = {2006},
date = {2006-01-01},
journal = {Synlett},
volume = {2006},
number = {04},
pages = {610--614},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Vibrational circular dichroism and ab initio structure elucidation of an aromatic foldamer Article de journal Thierry Buffeteau; Laurent Ducasse; Legiso Poniman; Nicolas Delsuc; Ivan Huc Chemical Communications, (25), p. 2714, 2006, ISSN: 1359-7345, 1364-548X. @article{buffeteau_vibrational_2006,
title = {Vibrational circular dichroism and ab initio structure elucidation of an aromatic foldamer},
author = {Thierry Buffeteau and Laurent Ducasse and Legiso Poniman and Nicolas Delsuc and Ivan Huc},
url = {http://xlink.rsc.org/?DOI=b604462j},
doi = {10.1039/b604462j},
issn = {1359-7345, 1364-548X},
year = {2006},
date = {2006-01-01},
urldate = {2018-02-18},
journal = {Chemical Communications},
number = {25},
pages = {2714},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
2005
|
Probing helix propensity of monomers within a helical oligomer Article de journal Christel Dolain; Jean-Michel Léger; Nicolas Delsuc; Heinz Gornitzka; Ivan Huc Proceedings of the National Academy of Sciences of the United States of America, 102 (45), p. 16146–16151, 2005. @article{dolain_probing_2005,
title = {Probing helix propensity of monomers within a helical oligomer},
author = {Christel Dolain and Jean-Michel L\'{e}ger and Nicolas Delsuc and Heinz Gornitzka and Ivan Huc},
year = {2005},
date = {2005-01-01},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
volume = {102},
number = {45},
pages = {16146--16151},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
