Bio - Françcois Lambert

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François Lambert

Assistant Professor, Laboratoire des BioMolécules
ENS, Department of Chemistry, 24 rue Lhomond

Present position:


LABORATORY: Laboratoire des BioMolécules (LBM),
UMR-CNRS 7203, Univ. Pierre et Marie Curie, Chemistry department, Ecole Normale Supérieure

Education and career:

Since 2009   Laboratoire des Biomolécules, Group Metals in Biology (LBM),
Metal complexes with biological activity and metal-centered bio-probes
1991-2009    Assistant professor
 Paris-Sud 11 university
 Laboratoire Institut de Chimie Moléculaire et des Matériaux d’Orsay
(Dir. Pr. Jean-Jacques Girerd),
UMR8182, Group Chimie Bioorganique et Bioinorganique (LCBB, dir. Pr. Jean-Pierre Mahy)
Metal complexes with biological activity
1990-1991 Post-doctoral studies, Utrecht university, Synthesis of cuprate catalysts.
  Supervision: Pr. G. van Koten       
  Chiral Copper(I) Arenethiolate Catalysts for the Enantioselective conjugate addition
1990 PhD in organic chemistry organometallic (organozinc-compounds)
  Supervision: Pr. J. Villieras
Preparation, Structure and Reactivity of organozincic allylic substituted compounds.Selective
Preparation of alpha-methylene gamma-butyrolactones

Research keywords:

Organic Chemistry, Organometallic Chemistry including M(CO) luminescent and IR probes, Inorganic Chemistry,
Bioinorganic Chemistry, Ligand synthesis, Transition Metal Complexes, Magnetism,
Electrochemical Systems, Intracellular detection, biophysics, IR-Spectromicroscopy


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  1. Luminescence Modulations of Rhenium Tricarbonyl Complexes Induced by Structural Variations; Hélène C. Bertrand,* Sylvain Clède, Régis Guillot, François Lambert, and Clotilde Policar, Inorg. Chem., 2014 , 53, 6204−6223; doi: 1021/ic5007007
  2. Influence of the Side Chain Length on the Cellular Uptake and the Cytotoxicity of Rhenium TriCarbonyl Derivatives: a Bimodal Infrared and Luminescence Quantitative Study; Sylvain Clède, François Lambert, Rénette Saint-Fort, Marie-Aude Plamont, Hélène Bertrand, Anne Vessières, Clotilde Policar* Chem. Eur. J., 2014 , 20, 8714-8722 doi: 10.1002/chem.201402471R1
  3. Detection of an Estrogen Derivative in Two Breast Cancer Cell Lines using a Single Core Multimodal Probe for Imaging (SCoMPI) Imaged by a Panel of Luminescent and Vibrational Techniques, Sylvain Clède, François Lambert, Christophe Sandt, Slavka Kascakova, Miriam Unger, Etienne Harté, Marie-Aude Plamont, Rénette Saint-Fort, Ariane Deniset-Besseau, Zoher Gueroui, Carol Hirschmugl, Sophie Lecomte, Alexandre Dazzi, Anne Vessières, Clotilde Policar, Analyst, 2013, 138, 5627 – 5638 DOI: 10.1039/c3an00807j
  4. Toward optimal spatial and spectral quality in widefield infrared spectromicroscopy of IR labelled single cells, Eric C. Mattson, Miriam Unger, Sylvain Clède, François Lambert, Clotilde Policar, Asher Imtiaz, Roshan D'Souza and Carol J. Hirschmugl, Analyst, 2013, 138, 5610–5618 DOI: 10.1039/c3an00383c
  5. Synchrotron Radiation FTIR Detection of a Metal-Carbonyl Tamoxifen Analog. Correlation with Luminescence Microscopy to Study its Subcellular Distribution, Sylvain Clède, François Lambert, Christophe Sandt, Zoher Gueroui, Nicolas Delsuc, Paul Dumas, Anne Vessières, Clotilde Policar, Biotechnology Advances (IF=7.6 et 5-year IF=9.0), 2013, 31, 393-395, DOI: 10.1016/j.biotechadv.2012.01.023, invited article to the Multimodal imaging special edition
  6. A Rhenium tris-Carbonyl Derivative as a Single Core Multimodal Probe for Imaging (SCoMPI) Combining Infrared and Luminescent Properties, Sylvain Clède, François Lambert, Christophe Sandt, Zoher Gueroui, Matthieu Réfrégiers, Marie-Aude Plamont, Paul Dumas, Anne Vessières, Clotilde Policar, Chem. Commun., 2012, 48, 7729–7731, DOI: 10.1039/C2CC32163G
  7. Metal Complexation of a d-Ribose-based Ligand Decoded by Experimental and Theoretical Studies, Federico Cisnetti, Jean-Didier Maréchal, Magali Nicaise, Régis Guillot, Michel Desmadril, François Lambert, Clotilde Policar, Eur. J. Inorg. Chem., 2012, 3308-3319 , doi : 10.1002/ejic.201200322
  8. Glycosiderophores: Synthesis of Tris-Hydroxamate Siderophores Based on a Galactose or Glycero Central Scaffold, Fe(III) Complexation Studies, Christelle Neff, François Bellot, Jenny-Birgitta Waern, François Lambert, Jérémy Brandel, Guy Serratrice, François Gaboriau, Clotilde Policar, J. Inorg. Biochem., 2012, 112, 59-67, DOI: 10.1016/j.jinorgbio.2012.02.030
  9. Intrinsically Fluorescent Glycoligands To Study Metal Selectivity, Ludivine Garcia, Stéphane Maisonneuve, Jennifer Oudinet-Sin Marcu, Régis Guillot, François Lambert, Juan Xie, and Clotilde Policar, Inorg. Chem., 2011, 50, 11353-11362, DOI: 10.1021/ic200897v
  10. Sugars to Control Ligand Shape in Metal Complexes: Conformationally Constrained Glycoligands with a Predetermination of Stereochemistry and a Structural Control, Ludivine Garcia, Stéphane Maisonneuve, Juan Xie, Régis Guillot, Pierre Dorlet, Eric Rivière, Michel Desmadril, François Lambert et Clotilde Policar, Inorg. Chem. 2010, 49, 7282-7288, doi : 10.1021/ic1002379
  11. Electrochemical functionalization of carbon surfaces by aromatic azide or alkyne molecules: a versatile platform for click chemistry David Evrard, François Lambert, Clotilde Policar, Véronique Balland, Benoît Limoges Chem. Eur. J., 2008, 14, 9286-9291
  12. Synthesis and crystal structures of two transition metal complexes based on functionalised 1,5-anhydro-2-deoxy-D-galactitol and methyl 2-deoxy-a-D-galactopyranose Federico Cisnetti, Régis Guillot, Nada Ibrahim, François Lambert, Michel Thérisod, Clotilde Policar, Carbohydr. Res. 2008, 343, 530-535
  13. A new pentadentate ligand forms both a di- and a mono-nuclear Mn(II) complex : electrochemical, spectroscopic and superoxide dismutase activity studies Federico Cisnetti, Anne-Sophie Lefèvre, Régis Guillot, François Lambert, Guillaume Blain, Elodie Anxolabéhère-Mallart, Clotilde Polica*, Eur. J. Inorg. Chem., 2007, 4472-4480
  14. Diaqua[methyl-4-O-benzyl-2,3,6-tri-O-(2-picolyl)-a-d-mannopyranoside] cobalt(II) bis(perchlorate) monohydrate: partial coordination of a ligand derived from d-mannose Federico Cisnetti, Régis Guillot, Michel Thérisod, Clotilde Policar*, Acta Cryst C63, 2007, m201-m203
  15. N-centered ligands Mn complexes series and superoxide. Part 2. Reactivity in anhydrous medium. SOD-like activity in aqueous medium correlated to Mn(II)/Mn(III) redox potentials. Stéphanie Durot, Clotilde Policar, Federico Cisnetti, François Lambert, Jean-Philippe Renault, Giorgio Pelosi, Guillaume Blain, Hafsa Korri-Youssoufi, Jean-Pierre Mahy, Eur. J. Inorg. Chem., 2005, 14, 3513-3523.
  16. A pulse radiolysis study of superoxide radical catalytic dismutation by a manganese(II) complex with a N-tripodal ligand. Stéphanie Durot, François Lambert, Jean-Philippe Renault, Clotilde Policar, Eur. J. Inorg. Chem., 2005, 2789-2793. Cover picture on editor’s demand : allegory of bio-inorganic chemistry
  17. Imidazole and imidazolate iron complexes : on the way for tuning 3D-structural characteristics and reactivity. Redox interconversions controlled by protonation state. François Lambert, Clotilde Policar, Stéphanie Durot , Michèle Cesario, Lu Yuwei, Hafsa Korri-Youssoufi, Bineta Keita, Louis Nadjo, Inorg. Chem., 2004, 43, 4178-4188.
  18. Unusual efficiency of a non-heme iron complex as catalyst for the hydroxylation of aromatic compounds by hydrogen peroxide: comparison with iron porphyrins.  Bartoli, Jean-Francois; Lambert, Francois; Morgenstern-Badarau, Irene; Battioni, Pierrette; Mansuy, Daniel. Comptes Rendus Chimie (2002),  5(4), 263-266.
  19. New Mn(II) complexes with N/O coordination sphere from tripodal N-centered ligands. Characterization from solid state to solution and reaction with superoxide in non-aqueous and aqueous medium. Clotilde Policar, Stéphanie Durot, François Lambert, Michèle Cesario, Florence Ramiandrasoa, Irène Morgenstern-Badarau. Eur. J. Inorg. Chem., 2001, 1807-1818.
  20. A polymeric, layered bimetallic imidazolate network Mn(II) Fe(III). Crystal structure and magnetic properties. François Lambert,* Jean-Philippe Renault, Clotilde Policar, Irène Morgenstern-Badarau and Michèle Cesario. Chem. Commun., 2000, 35-36.
  21. An inorganic helix [Mn(IPG)(MeOH)]n[PF6]n : structural and magnetic properties of a syn-anti carboxylato-bridges manganese(II) chain involving a tetradentate ligand. Clotilde Policar, François Lambert, Michèle Cesario, Irène Morgenstern-Badarau. Eur. J. Inorg. Chem., 1999, 2201-2208.
  22. Sterically hindered iron(II) complex of a new tripodal polyimidazole ligand: structure and reactivity toward superoxide. Morgenstern-Badarau, Irene; Lambert, Francois; Deroche, Alain; Cesario, Michele; Guilhem, Jean; Keita, Bineta; Nadjo, Louis. Inorganica Chimica Acta (1998), 275-276(1,2), 234-241.
  23. Selective Metal-Assisted Oxidative Cleavage of a C-N Bond: Synthesis and Characterization of the Mononuclear Iron(III) [Fe(BPG)Cl2] Complex and Its Two [Fe(BPA)Cl3] and [Fe(BPE)Cl3] Derivatives. Rodriguez, Marie-Carmen; Lambert, Francois; Morgenstern-Badarau, Irene; Cesario, Michele; Guilhem, Jean; Keita, Bineta; Nadjo, Louis. Inorganic Chemistry (1997), 36(16), 3525-3531.
  24.  {Tris[4-(2-pyridyl)-3-aza-3-butenyl]amine}iron(II) bis(hexafluorophosphate), [Fe(py3tren)](PF6)2. Boubekeur, Kamal; Deroche, Alain; Lambert, Francois; Morgenstern-Badarau, Irene. Acta Crystallographica, Section C: Crystal Structure Communications (1995), C51(11), 2244-2246.
  25.  Arenethiolatocopper(I) complexes as homogeneous catalysts for Michael addition réactions. Van Klaveren, Mayra; Lambert, Francois; Eijkelkamp, Desiree J. F. M.; Grove, David M.; van Koten, Gerard. Tetrahedron Letters (1994),  35(33), 6135-6138.
  26.  On the way to chiral copper(I) arenethiolate catalysts for the enantioselective conjugate addition of methyllithium and methylmagnesium iodide to benzylideneacetone. Lambert, Francois; Knotter, D. Martin; Janssen, Maurits D.; Van Klaveren, Mayra; Boersma, Jaap; Van Koten, Gerard ; Tetrahedron Asymmetry  (1991), 2(11), 1097-1100.
  27. Preparation and study of new derivatives of organozinc allyl functionality. Lambert, Francois; Kirschleger, Bernard; Villieras, Jean. Journal of Organometallic Chemistry (1991), 405(3),  273-286.
  28. Reactivity of γ-substituted β-functional allylzinc compounds.  Preparation of β- and γ-substituted α-methylene-γ-butyrolactones. Lambert, Francois; Kirschleger, Bernard; Villieras, Jean ; Journal of Organometallic Chemistry (1991),  406(1-2), 71-86.
  29. High yield synthesis of α-propargylic acrylic ester:  a general access to α-substituted acrylic esters. Queignec, Rene; Kirschleger, Bernard; Lambert, Francois; Aboutaj, Mohammed. Synthetic Communications (1988), 18(11), 1213-23.