Controversies concerning the use of phytoestrogens in menopause management: Bioavailability and metabolism

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TitleControversies concerning the use of phytoestrogens in menopause management: Bioavailability and metabolism
Publication TypeJournal Article
Year of Publication2010
Authorsde Cremoux, P, This P, Leclercq G, Jacquot Y
JournalMaturitas
Volume65
Issue4
Pagination334-339
Date PublishedApr
ISBN Number0378-5122
Accession NumberISI:000276434900008
Abstract

It has been proposed that the use of phytoestrogens (PE) in menopausal therapy could be beneficial to woman health, particularly with respect to hot flushes. Indeed, PE may compensate the lack of endogenous 17 beta-estradiol occurring during menopause. However, therapeutic benefits remain questionable, as highlighted by recent publications. Indeed, data are often subjected to controversy since a number of exogenous and endogenous factors influencing the responsiveness of patients are not sufficiently taken into account. In the present paper, we will discuss the role of bioavailability and metabolism in the instability of individual response to PE. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

URL<Go to ISI>://000276434900008
DOI10.1016/j.maturitas.2009.12.019
Short TitleControversies concerning the use of phytoestrogens in menopause management: Bioavailability and metabolism
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