Fabien FERRAGE

Senior Scientist CNRS
Associate Professor ENS

Laboratoire des biomolécules UMR 7203
ENS – Département de chimie
24 rue Lhomond, 75005 Paris

Office: ES111

Short bio

Fabien Ferrage did his undergraduate studies at the Ecole Normale Supérieure and Université Pierre et Marie Curie in Chemistry and Molecular Biophysics. He joined Geoffrey Bodenhausen’s group at ENS for his master thesis and continued with his PhD, which he completed in 2002. He spent.a semester in Art Palmer’s lab at Columbia University in 2001. He joined David Cowburn’s team at the New York Structural Biology Center in 2003 as a postdoc. He was appointed associate scientist at the Centre National de la Recherche Scientifique (CNRS) in 2005 in Geoffrey Bodenhausen’s group. Between 2007 and 2009, he worked part-time at the New York Structural Biology Center, collaborating with David Cowburn and Ranajeet Ghose. In 2010-1011, he spent two years as a visiting scientist in the team of Aneel Aggarwal at Mount Sinai School of Medicine. He was appointed associate professor at ENS in 2015 and senior scientist at CNRS in 2016.

Research interests

His main focus is on NMR methodology particularly the development of new methods and instruments for the exploration of biomolecular dynamics by NMR relaxation. Among recent developments, he studies protein dynamics from low-magnetic field nuclear spin relaxation, by a technique called high-resolution relaxometry. He introduced recently, in a partnership with Bruker Biospin, two-field NMR spectroscopy, where moderately low and high magnetic fields are coupled in a single experiment. Current investigations shed light on the dynamics of protein side chains in folded proteins as well as motions in intrinsically disordered proteins.

Awards and distinctions

  • 2003 PhD prize form the Chemical Physics division from the French Chemical and Physical Societies.
  • 2003 Lavoisier fellowship form the French Minister of Foreign Affairs.
  • 2003 Nine Choucroun Prize from the Institut de Biologie Physico-Chimique.
  • 2004 Raymond Andrew Award from the Groupement Ampère.
  • 2011 Starting Grant of the European Research Council (ERC) 2012-2017.

Current Teaching

  • Scientific Communication in English (2014-), Master 1, Undergraduate education of the department of Chemistry at ENS, as well as Master Chemistry and Life Sciences.
  • Nuclear Magnetic Resonance, First year students in Chemistry, Ecole normale supérieure (2015-pres.).
  • Nuclear Magnetic Resonance Spectroscopy (2014-pres.), Master 1 Physical, analytical, and theoretical Chemistry, UE M1 4C303, Local Field Spectroscopy and Microscopy: Probes for Structure and Reactivity, Sorbonne Université.

Publications

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2020

Theoretical and computational framework for the analysis of the relaxation properties of arbitrary spin systems. Application to high-resolution relaxometry Article de journal

N Bolik-Coulon; P Kadeřávek; P Pelupessy; J-N Dumez; F Ferrage; S F Cousin

Journal of Magnetic Resonance, 313 , p. 106718, 2020.

Résumé | Liens

Boosting the resolution of low‐field 15N relaxation experiments on intrinsically disordered proteins with triple‐resonance NMR Article de journal

Z Jasenáková; V Zapletal; P Padrta; M Zachrdla; N Bolik-Coulon; T Marquardsen; J-M Tyburn; L Zidek; F Ferrage

Journal of Biomolecular NMR, 74 , p. 139, 2020.

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2019

Protein Dynamics from Accurate Low-Field Site-Specific Longitudinal and Transverse Nuclear Spin Relaxation Article de journal

P Kadeřávek; N Bolik-Coulon; S F Cousin; T Marquardsen; J-M Tyburn; J-N Dumez; F Ferrage

The Journal of Physical Chemistry Letters, 10 , p. 5917, 2019.

Liens

Experimental characterization of the dynamics of IDPs and IDRs by NMR Livre

N Bolik-Coulon; G Bouvignies; L Carlier; F Ferrage

2019, ISBN: 9780128163481.

Liens

Understanding the methyl-TROSY effect over a wide range of magnetic fields Article de journal

N Bolik-Coulon; S F Cousin; P Kadeřávek; J-N Dumez; F Ferrage

The Journal of Chemical Physics, 150 , p. 224202, 2019.

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2018

High-Resolution NMR of Folded Proteins in Hyperpolarized Physiological Solvents Article de journal

P Kadeřávek; F Ferrage; G Bodenhausen; D Kurzbach

Chemistry - A European Journal, 24 (51), p. 13418–13423, 2018.

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Time-Resolved Protein Side-Chain Motions Unraveled by High-Resolution Relaxometry and Molecular Dynamics Simulations Article de journal

S F Cousin; P Kadeřávek; N Bolik-Coulon; Y Gu; C Charlier; L Carlier; L Bruschweiler-Li; T Marquardsen; J -M Tyburn; R Brüschweiler; F Ferrage

Journal of the American Chemical Society, 140 (41), p. 13456–13465, 2018.

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Analysis of NMR Spin-Relaxation Data Using an Inverse Gaussian Distribution Function Article de journal

A Hsu; F Ferrage; A G Palmer III

Biophysical Journal, 115 (12), p. 2301–2309, 2018.

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Measuring Solvent Hydrogen Exchange Rates by Multifrequency Excitation 15N CEST: Application to Protein Phase Separation Article de journal

T Yuwen; A Bah; J P Brady; F Ferrage; G Bouvignies; L E Kay

Journal of Physical Chemistry B, 122 (49), p. 11206–11217, 2018.

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Determination of protein ps-ns motions by high-resolution relaxometry Livre

S F Cousin; P Kadeřávek; N Bolik-Coulon; F Ferrage

2018.

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2017

Ultra-wide range field-dependent measurements of the relaxivity of Gd1-x Eux VO4 nanoparticle contrast agents using a mechanical sample-shuttling relaxometer Article de journal

C -Y Chou; M Abdesselem; C Bouzigues; M Chu; A Guiga; T -H Huang; F Ferrage; T Gacoin; A Alexandrou; D Sakellariou

Scientific Reports, 7 , 2017.

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Structure and Dynamics of an Intrinsically Disordered Protein Region That Partially Folds upon Binding by Chemical-Exchange NMR Article de journal

C Charlier; G Bouvignies; P Pelupessy; A Walrant; R Marquant; M Kozlov; P De Ioannes; N Bolik-Coulon; S Sagan; P Cortes; A K Aggarwal; L Carlier; F Ferrage

Journal of the American Chemical Society, 139 (35), p. 12219–12227, 2017.

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Full Correlations across Broad NMR Spectra by Two-Field Total Correlation Spectroscopy Article de journal

P Kadeřávek; L Strouk; S F Cousin; C Charlier; G Bodenhausen; T Marquardsen; J -M Tyburn; P -A Bovier; F Engelke; W Maas; F Ferrage

ChemPhysChem, 18 (19), p. 2772–2776, 2017.

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2016

Sample Shuttling Relaxometry of Contrast Agents: NMRD Profiles above 1 Ŧ with a Single Device Article de journal

Y Gossuin; Z Serhan; L Sandiford; D Henrard; T Marquardsen; R T M de Rosales; D Sakellariou; F Ferrage

Applied Magnetic Resonance, 47 (3), p. 237–246, 2016.

Résumé | Liens

Protein dynamics from nuclear magnetic relaxation Article de journal

C Charlier; S F Cousin; F Ferrage

Chemical Society Reviews, 45 (9), p. 2410–2422, 2016.

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Nuclear overhauser spectroscopy of chiral CHD methylene groups Article de journal

R Augustyniak; J Stanek; H Colaux; G Bodenhausen; W Koźmiński; T Herrmann; F Ferrage

Journal of Biomolecular NMR, 64 (1), p. 27–37, 2016.

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Recovering Invisible Signals by Two-Field NMR Spectroscopy Article de journal

S F Cousin; P Kadeřávek; B Haddou; C Charlier; T Marquardsen; J -M Tyburn; P -A Bovier; F Engelke; W Maas; G Bodenhausen; P Pelupessy; F Ferrage

Angewandte Chemie - International Edition, 55 (34), p. 9886–9889, 2016.

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High-resolution two-field nuclear magnetic resonance spectroscopy Article de journal

S F Cousin; C Charlier; P Kadeřávek; T Marquardsen; J -M Tyburn; P -A Bovier; S Ulzega; T Speck; D Wilhelm; F Engelke; W Maas; D Sakellariou; G Bodenhausen; P Pelupessy; F Ferrage

Physical Chemistry Chemical Physics, 18 (48), p. 33187–33194, 2016.

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2015

Simple method for the generation of multiple homogeneous field volumes inside the bore of superconducting magnets Article de journal

C -Y Chou; F Ferrage; G Aubert; D Sakellariou

Scientific Reports, 5 , 2015.

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Identification of hydrophobic interfaces in protein-ligand complexes by selective saturation transfer NMR spectroscopy Article de journal

F Ferrage; K Dutta; D Cowburn

Molecules, 20 (12), p. 21992–21999, 2015.

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Distribution of Pico- and Nanosecond Motions in Disordered Proteins from Nuclear Spin Relaxation Article de journal

S N Khan; C Charlier; R Augustyniak; N Salvi; V Déjean; G Bodenhausen; O Lequin; P Pelupessy; F Ferrage

Biophysical Journal, 109 (5), p. 988–999, 2015.

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Cross-correlated relaxation measurements under adiabatic sweeps: Determination of local order in proteins Article de journal

P Kadeřávek; S Grutsch; N Salvi; M Tollinger; L Žídek; G Bodenhausen; F Ferrage

Journal of Biomolecular NMR, 63 (4), p. 353–365, 2015.

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2013

Nanosecond time scale motions in proteins revealed by high-resolution nmr relaxometry Article de journal

C Charlier; S N Khan; T Marquardsen; P Pelupessy; V Reiss; D Sakellariou; G Bodenhausen; F Engelke; F Ferrage

Journal of the American Chemical Society, 135 (49), p. 18665–18672, 2013.

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Side chain dynamics of carboxyl and carbonyl groups in the catalytic function of escherichia coli ribonuclease Ħ Article de journal

K A Stafford; F Ferrage; J -H Cho; A G Palmer

Journal of the American Chemical Society, 135 (48), p. 18024–18027, 2013.

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2012

Time scales of slow motions in ubiquitin explored by heteronuclear double resonance Article de journal

N Salvi; S Ulzega; F Ferrage; G Bodenhausen

Journal of the American Chemical Society, 134 (5), p. 2481–2484, 2012.

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Protein dynamics by 15n nuclear magnetic relaxation Livre

F Ferrage

2012.

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Structure and dynamics of the second CARD of human RIG-I provide mechanistic insights into regulation of RIG-I activation Article de journal

F Ferrage; K Dutta; E Nistal-Villán; J R Patel; M T Sánchez-Aparicio; P De Ioannes; A Buku; G G Aseguinolaza; A García-Sastre; A K Aggarwal

Structure, 20 (12), p. 2048–2061, 2012.

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Efficient determination of diffusion coefficients by monitoring transport during recovery delays in NMR Article de journal

R Augustyniak; F Ferrage; C Damblon; G Bodenhausen; P Pelupessy

Chemical Communications, 48 (43), p. 5307–5309, 2012.

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2011

Control of cross relaxation of multiple-quantum coherences induced by fast chemical exchange under heteronuclear double-resonance irradiation Article de journal

S Ulzega; N Salvi; T F Segawa; F Ferrage; G Bodenhausen

ChemPhysChem, 12 (2), p. 333–341, 2011.

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1H, 13C and 15N resonance assignment of a 114-residue fragment of Engrailed 2 homeoprotein, a partially disordered protein Article de journal

R Augustyniak; S Balayssac; F Ferrage; G Bodenhausen; O Lequin

Biomolecular NMR Assignments, 5 (2), p. 229–231, 2011.

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