Nicolas DELSUC

Chargé de Recherche CNRS – Maître de conférence attaché à l’ENS

ENS – Département de chimie
24 rue Lhomond, 75005 Paris

Phone: +33 144322424
Office: E037a

Our website:


Short bio

I have been trained in chemistry at Bordeaux University. I did a PhD from 2004 to 2007 in supramolecular chemistry under the supervision of Dr. Ivan Huc. I worked on the development of proteomimetic structures using abiotic foldamers. I then obtained a fellowship from the Japan Society for the Promotion of Sciences (JSPS) to join the group of Prof. Itaru Hamachi at Kyoto University where I worked on new peptidyl receptors for peptide recognition. In 2009, I came back to France as temporary lecturer (ATER) at the Laboratoire des Biomolécules (LBM, UMR 7203), where I worked with Prof. Philippe Karoyan to develop foldamers based on proline derivatives. I have been appointed as CNRS researcher in 2010 and joined the group of Clotilde Policar at the LBM. I first worked on the conjugation of bioactive molecules with peptide to enhance their penetration and bioavaibality as well on the development of multimodal metal-based probes. Now I want to combine peptide and metal ions to synergistically take advantages of the properties of both classes of molecules by developing new peptidyl metalloprobes and metallodrugs.

Education and professional experience

  • Sept 2020-2022: Assitant Professor associate. ENS
  • Oct 2010-now: Associate researcher. Laboratoire des BioMolécules, UMR7203 CNRS-SU-ENS. In the Inorganic Cellular Chemistry group within the team 1.
  • Sept 2009-Sept 2010: Teaching assistant. Laboratoire des BioMolécules, UMR7203 UPMC-ENS. In the group of P. Karoyan, « Conception of enzyme mimics with foldamers »
  • Nov 2007-Jul 2009: Post-doctoral fellow of the JSPS. Kyoto University, Japan. In the group of I. Hamachi. « Development of molecular receptors for specific peptides recognition »
  • Oct 2004-Oct 2007: PhD in Organic chemistry, Bordeaux1 University under the supervision of I. Huc. »Development of proteomimetic tertiary structures with aromatic oligoamide foldamers »
  • Sept 2005- Sept 2007: M.Sc. in Organic chemistry, Bordeaux1 University

Research interests

  • Development of peptidyl metal complexes mimicking metalloenzymes
  • Development of metal-centered probes for bio-imaging or diagnostic

Awards and distinctions

  • 2016: ANR JCJC
  • 2007: JSPS Postodoctoral Fellowship

Supervised PhD and post-doctoral students

  • Current:
  • Formers: Gabrielle Schanne (2019-2022), Martha Zoumpoulaki (2017-2021), Koudedja Coulibaly (2017-2020), Amandine Vincent (2016-2019), Emilie Mathieu (2014-2017), Sarah Hostachy (2012-2015), May Lee Low (2011-2014, cotutelle with Malaysia), Anne-Sophie Bernard (2010-2014)


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Synchrotron radiation FTIR detection of a metal-carbonyl tamoxifen analog. Correlation with luminescence microscopy to study its subcellular distribution Article de journal

S Clède; F Lambert; C Sandt; Z Gueroui; N Delsuc; P Dumas; A Vessières; C Policar

Biotechnology Advances, 31 (3), p. 393–395, 2013.


Relative helix-helix conformations in branched aromatic oligoamide foldamers Article de journal

N Delsuc; S Massip; J -M Léger; B Kauffmann; I Huc

Journal of the American Chemical Society, 133 (9), p. 3165–3172, 2011.


Cascading transformations within a dynamic self-assembled system Article de journal

Victoria E Campbell; Xavier de Hatten; Nicolas Delsuc; Brice Kauffmann; Ivan Huc; Jonathan R Nitschke

Nature Chemistry, 2 (8), p. 684–687, 2010, ISSN: 1755-4349.


Helical Aromatic Oligoamide Foldamers as Organizational Scaffolds for Photoinduced Charge Transfer Article de journal

Martin Wolffs; Nicolas Delsuc; Dirk Veldman; Nguyễn Vân Anh; René M Williams; Stefan C J Meskers; René A J Janssen; Ivan Huc; Albertus P H J Schenning

Journal of the American Chemical Society, 131 (13), p. 4819–4829, 2009, ISSN: 0002-7863, 1520-5126.

Interplay of Interactions Governing the Dynamic Conversions of Acyclic and Macrocyclic Helicates Article de journal

Victoria E. Campbell; Xavier de Hatten; Nicolas Delsuc; Brice Kauffmann; Ivan Huc; Jonathan R. Nitschke

Chemistry - A European Journal, 15 (25), p. 6138–6142, 2009, ISSN: 09476539, 15213765.


Kinetics of Helix-Handedness Inversion: Folding and Unfolding in Aromatic Amide Oligomers Article de journal

Nicolas Delsuc; Takahiro Kawanami; Julien Lefeuvre; Atsuomi Shundo; Hirotaka Ihara; Makoto Takafuji; Ivan Huc

ChemPhysChem, 9 (13), p. 1882–1890, 2008, ISSN: 14394235, 14397641.

Metal-Directed Dynamic Formation of Tertiary Structure in Foldamer Assemblies: Orienting Helices at an Angle Article de journal

Nicolas Delsuc; Marie Hutin; Victoria E. Campbell; Brice Kauffmann; Jonathan R. Nitschke; Ivan Huc

Chemistry - A European Journal, 14 (24), p. 7140–7143, 2008, ISSN: 09476539, 15213765.


The Herringbone Helix: A Noncanonical Folding in Aromatic−Aliphatic Peptides Article de journal

Nicolas Delsuc; Frédéric Godde; Brice Kauffmann; Jean-Michel Léger; Ivan Huc

Journal of the American Chemical Society, 129 (37), p. 11348–11349, 2007, ISSN: 0002-7863, 1520-5126.

Proteomorphous Objects from Abiotic Backbones Article de journal

Nicolas Delsuc; Jean-Michel Léger; Stéphane Massip; Ivan Huc

Angewandte Chemie International Edition, 46 (1-2), p. 214–217, 2007, ISSN: 14337851, 15213773.


Vibrational circular dichroism and ab initio structure elucidation of an aromatic foldamer Article de journal

Thierry Buffeteau; Laurent Ducasse; Legiso Poniman; Nicolas Delsuc; Ivan Huc

Chemical Communications, (25), p. 2714, 2006, ISSN: 1359-7345, 1364-548X.


Probing helix propensity of monomers within a helical oligomer Article de journal

Christel Dolain; Jean-Michel Léger; Nicolas Delsuc; Heinz Gornitzka; Ivan Huc

Proceedings of the National Academy of Sciences of the United States of America, 102 (45), p. 16146–16151, 2005.


A di-Copper Peptidyl Complex Mimics the Activity of Catalase, a Key Antioxidant Metalloenzyme Article de journal

Koudedja Coulibaly; Marion Thauvin; Adyn Melenbacher; Clara Testard; Evangelia Trigoni; Amandine Vincent; Martin J Stillman; Sophie Vriz; Clotilde Policar; Nicolas Delsuc

Inorganic Chemistry, 0 (0), p. null, 0000, (PMID: 34109781).

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