Hélène BERTRAND

Maître de conférences (Associate Professor), Sorbonne Université

ENS – Département de chimie
24 rue Lhomond, 75005 Paris

Email: helene.bertrand@ens.psl.eu
Phone: +33 144322440
Office: E037b

Short bio

  • orcid.org/0000-0002-3841-022X
  • researcherID: A-5581-2015

Education and professional experience

  • Sept. 2011 – present: Assistant (2011-2019)/ Associate (2019-) Professor at Sorbonne Université (Faculté Sciences et Ingénierie), Laboratoire des Biomolécules, UMR7203
  • Sept. 2017 – Aug 2020: Visiting Faculty at Nanyang Technological University, Singapore (School of Physical and Mathematical Sciences, CCEB Division, Group WK Leong)
  • April – August 2011: Postdoctoral research assistant – ISM UMR5255 – Institut Européen de Chimie et de Biologie (IECB), Bordeaux, France – Advisor: Prof. S. Quideau – Antiviral agents against Influenza A nucleoprotein
  • March 2009- March 2011: Postdoctoral research assistant – School of Pharmacy, University of London, UK – Advisor: Dr. G. Wells – Direct reversible inhibition of the Keap1-Nrf2 protein-protein interaction
  • Sept 2005- Oct 2008: PhD in molecular chemistry (Université P. et M. Curie UPMC) – PhD advisors: Dr. M.-P. Teulade-Fichou (Institut Curie) and Dr. D. Fichou (CEA) – Title: Hétérocycles aromatiques étendus: variations structurales pour l’auto- assemblage bi-dimensionnel et la reconnaissance d’ADN G-quadruplexe – Defense: 24 October 2008
  • 2001-2005: ESPCI – PSL, Paris (espci.fr) Master level degree in Science and Engineering
  • 2004-2005: Master II research (organic and bioorganic chemistry), UPMC

Research interests

  • Bioorganic and bioinorganic chemistry, inorganic medicinal chemistry, Pt anticancer agents, protein-protein interactions, Re-tricarbonyl multimodal probes, intracellular detection, bioimaging, Mn(II) spin-labels, CO-releasing molecules

Memberships

  • Elected board member of the bioinorganic chemistry group of the Société Chimique de France (SCF) since dec. 2022
  • Member of Frenchbic (Groupe français de Chimie BioInorganique, http://frenchbic.cnrs.fr/)
  • Member of FrenchLab Singapore (French Researcher Community in Singapore, CNRS-Ambassade de France-French Chamber Singapore) (https://frenchlab.sg/)

Supervised students and post-doctorants

Postdoctoral researchers:

  • Sept 2017- Feb 2019: Sounderya Nagarajan (PSL Chimie PINOT) Co-supervision F. Mahuteau-Betzer (CMIB, Institut Curie), ‘New multimodal Probes for Individual Organelle Targeting’
  • Oct 2018 – Oct 2020: Manon Isaac (ANR JCJC SATIN ‘Single-core Agents for Therapeutics and Imaging’)
  • Jan 21 – Dec 21: Ramu Vadde (ANR JCJC SATIN ‘Single-core Agents for Therapeutics and Imaging’)
  • Feb 21 – Jan 22: Priya Ranjan Sahoo (Fondation de la Maison de la Chimie, Pt complexes as anticancer agents with reduced neurotoxicity)

PhD candidates:

  • Oct 2012 – Oct 2015: Paul Demay-Drouhard (Sorbonne Université SU), Co-supervision C. Policar, ‘Measuring Nanometer-Scale Distances by High-Field Pulsed Electron-Electron Double Resonance Using MnII Spin Labels’ (funding ANR MnHFPELDOR), defence 25/10/2015
  • Oct 2015 – May 2019: Menglan He (SU), Co-supervision C. Policar, ‘Novel rhenium(I) tricarbonyl complexes towards catalytic, photophysical and biological applications’ (China Scholarship Council CSC funding), defence 19/05/2019
  • Sept 2017 –  Nov 2020: Rose Hoste (PSL University), Design, synthesis and characterization of protein-protein inhibitors (ENS scholarship), defence 05/12/2022
  • Oct 2021 – : Alvaro Lopez-Sanchez (Sorbonne Université SU), Pt anticancer agents with reduced neurotoxicity (funding ED406)
  • Oct 2022 – : Caitlan Vervisch (Sorbonne Université SU), Impact of redox modulation of the intracellular fate of Pt anticancer drugs (funding Interdisciplinary Program in Cancerology)

Supervision of 8 Master 2 (SU), 2 Master 1 (SU), 5 Erasmus Master 1 (Imperial College London, Heraklion university), 2 L3 (ENS), 2 L3 (SU, Paris Diderot), 3 Professional Licence (SU)

Organization

Teaching

  • Since 2011: Sorbonne Université, UFR Chimie (926), Parcours accès santé spécifique (PASS), Parcours pré-doctoral ENS, 192h équivalent TD/an
    • PASS: general and organic chemistry
    • Licence: organic chemistry, biological chemistry, bioinorganic chemistry, pharmacology
    • Master (chemistry): organic, bioorganic and bioionorganic chemistry, drug discovery
    • Co-responsability of the Licence program ‘Sciences et Chinese Language’ (SU)
  • Dec 2015: Participation to the Prosfer program (Program of sino-french education for research, pre-doctoral training between French ENS and ECNU (East China Normal University)) as an invited professor: course ‘Biomolecules: targeting and recognition by metal complexes’, 20h, Shanghai
  • Jan-March 2017: Teaching module at Ecole Polytechnique -: ‘Metal complexes as therapeutic targets and agents’ – 28 h course at M1 level (CHI 581)

Significant publications

Peer-reviewed articles:

  • Prieux-Klotz C., Chédotal H., Zoumpoulaki M., Chouzenoux S., Chêne C., Lopez-Sanchez A., Thomas M., Ranjan Sahoo P., Policar C., Batteux F., Nicco C., Bertrand H.C., Coriat R., A new Manganese superoxide dismutase mimetic improves oxaliplatin induced neuropathy and global tolerance on mice, Int. J. Mol. Sci, 202223, 12938. https://doi.org/10.3390/ijms232112938
  • Nagarajan S.,* Poyer F., Fourmois L., Naud-Martin D., Medjoubi K., Somogyi A., Cucchiarini A., Henry L., Delsuc N., Policar C., Bertrand H. C.*, Mahuteau-Betzer F.*, Cellular Detection of a Mitochondria Targeted Brominated Vinyl Triphenylamine Optical Probe (TP−Br) by X-Ray Fluorescence Microscopy, Chem Eur J., 2022, 28 (15), e202104424, DOI: 10.1002/chem.202104424
  • Policar C., Bouvet J., Bertrand H. C., Delsuc N., SOD mimics: from the tool box of the chemists to cellular studies, Curr. Op. Chem. Biol., 2022, 67, 102109, DOI: 10.1016/j.cbpa.2021.102109
  • Schanne G, Henry L., Ong H. C., Somogyi A., Medjoubi K., Delsuc N., Policar C., Garcia F.*, Bertrand H. C.*, Rhenium carbonyl complexes bearing methylated triphenylphosphonium cations as antibody-free mitochondria trackers for X-ray fluorescence imaging, Inorg. Chem. Front., 2021, 8, 3905-3915, DOI: 10.1039/D1QI00542A
  • Paul Demay-Drouhard, H. Y. Vincent Ching, Christophe Decroos, Régis Guillot, Yun Li, Leandro C. Tabares, Clotilde Policar, Helene C. Bertrand, Sun Un, Understanding the g-tensors of perchlorotriphenylmethyl and Finland-type trityl radicals, Phys.Chem.Chem.Phys., 2020, 22, 20792, DOI: 10.1039/d0cp03626a
  • Mathieu E., Bernard A.-S., Ching H. Y. V., Somogyi A., Medjoubi K., Rodon Fores J., Bertrand H. C., Vincent A., Trepout S., Guerquin-Kern J.-L., Scheitler A., Ivanović-Burmazović I., Seksik P., Delsuc N., Policar C., Anti-inflammatory activity of superoxide dismutase mimics functionalized with cell-penetrating peptides, Dalton Trans. 2020, 49, 2323-2330, DOI: 10.1039/c9dt04619d
  • Guillaumot M.-A., Cerles O., Bertrand H. C., Benoit E., Nicco C., Chouzenoux S, Schmitt A., Batteux F., Policar C., Coriat R., Oxaliplatin-induced neuropathy: The preventive effect of a new Super-Oxide Dismutase modulator, Oncotarget, 2019, 10(60): 6418–6431, DOI: 10.18632/oncotarget.27248
  • Dilly S., Fotso A., Lejal N., Zedda G., Chebbo M., Rahman F., Companys S., Bertrand H.C., Vidic J., Noiray M., Alessi M.C., Tarus B., Quideau S., Riteau B., Slama-Schwok A., From naproxen repurposing to naproxen analogues and their antiviral activity against Influenza A virus; J. Med. Chem., 2018, 61 (16), 7202–7217 – DOI: 10.1021/acs.jmedchem.8b00557
  • He M., Ching H.Y.V., Policar C., Bertrand H.C.*, Rhenium tricarbonyl complexes with arenethiolate axial ligands, New J. Chem., 2018, 42, 11312 – 11323 – DOI: 10.1039/C8NJ01960F
  • Panagiotakis S., Giannoudis E., Charisiadis A., Paravatou R., Lazaridi M.-E., Kandyli M., Ladomenou K., Angaridis P.A., Bertrand H.C.*, Sharma G.D.*, Coutsolelos A.G.* Increased Efficiency of Dye‐Sensitized Solar Cells by Incorporation of a π Spacer in Donor–Acceptor Zinc Porphyrins Bearing Cyanoacrylic Acid as an Anchoring Group, Eur. J. Inorg. Chem., 2018, 20-21, 2369-2379 – DOI: 10.1002/ejic.201800123
  • Henry L., Delsuc N., Laugel C., Lambert F., Sandt C., Hostachy S., Bernard A.-S., Bertrand H.C., Grimaud L., Baillet-Guffroy A., Policar C. Labeling of Hyaluronic Acids with a Rhenium-tricarbonyl Tag and Percutaneous Penetration Studied by Multimodal Imaging, Bioconjugate Chem., 2018, 29(4), 987–991- DOI: 10.1021/acs.bioconjchem.7b00825
  • Georgakopoulos N.D., Frison M., Alvarez M.S., Bertrand H.; Wells G., Campanella M. Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy, Scientific Reports, 2017, 7, 10303 – DOI:1038/s41598-017-07679-7
  • Charif R., Granotier-Beckers, C., Bertrand H.C., Poupon J., Segal-Bendirdjian E., Teulade-Fichou M.-P., Boussin F., Bombard S. Association of a platinum complex to a G-quadruplex ligand enhances the telomere disruption, Chem. Res. Toxicol. 2017, 30(8), 1629-1640 DOI: 10.1021/acs.chemrestox.7b00131
  • Ching H. Y. V., Wang X., He M., Perujo Holland N., Guillot R., Slim C., Griveau S., Bertrand H. C., Policar C., Bedioui F., Fontecave M. Rhenium Complexes Based on 2‑Pyridyl-1,2,3-triazole Ligands: A New Class of CO2 Reduction Catalysts, Inorg. Chem. 2017, 56 (5), 2966-2976 – DOI: 10.1021/acs.inorgchem.6b03078
  • Kerr F., Sofola-Adesakin , Ivanov D.K., Gatliff J., Gomez Perez-Nievas B., Bertrand H.C., Martinez P., Callard R., Snoeren I., Cochemé H. M., Adcott J., Khericha M., Castillo-Quan J. I., Wells G., Noble W., Thornton J., Partridge L. Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease. PLoS Gen 2017, 13 (3):e1006593 – DOI: 10.1371/journal.pgen.1006593
  • Demay-Drouhard P., Chamoreau L.-M., Guillot R., Policar C., Bertrand H. C.* Synthesis of homoditopic ligands with an incrementable rodlike backbone, J. Org. Chem. 2017, 131-137 – DOI: 10.1002/ejoc.201601081
  • Akhmetzyanov D., Ching H. Y. V., Denysenkov V. P., Demay-Drouhard P., Bertrand H. C., Tabares L. C., Policar C., Prisner T., Un S., RIDME Spectroscopy on High-Spin Mn2+ Centers, Phys.Chem.Chem.Phys. 2016, 18, 30857-30866 – DOI: 10.1039/C6CP05239H
  • Ferńandez E., Hostachy S., Sandt C., Rodŕıguez G., Bertrand H. C., Clède S., Ćocera M., de la Maza A., Lambert F., Policar C., Ĺopez O., Monitoring bicosomes containing antioxidants in normal and irradiated skin, RSC Adv., 2016, 6, 72559-72567 – DOI: 10.1039/c6ra11170j
  • Kaminska K. K., Bertrand H. C., Tajima H., Stafford W. C., Cheng Q., Chen W., Wells G., Arner E., Chew E.-H., Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads, Oncotarget, 2016, 7(26), 40233-40251 – DOI: 10.18632/oncotarget.9579
  • Demay-Drouhard P., Ching H. Y. V., Akhmetzyanov D. Guillot R., Tabares L. C., Bertrand H. C.,* Policar C.*, A bis-Manganese(II)-DOTA complex for Pulsed Dipolar Spectroscopy, ChemPhysChem, 2016, 17 (13), 2066-78 – DOI: 10.1002/cphc.201600234
  • Ching H. Y. V., Mascali F. C., Bertrand H.C., Bruch E. M., Demay-Drouhard P., Rasia R. M., Policar C., Tabares L. C., Un S. The Use of Mn(II) Bound to His-tags as Genetically Encodable Spin-Label for Nanometric Distance Determination in Proteins. J. Phys. Chem. Lett., 2016, 7 (6), 1072–1076 – DOI: 10.1021/acs.jpclett.6b00362
  • Clède S., Cowan N., Lambert F., Bertrand H. C., Rubbiani R., Patra M., Hess J., Sandt C., Trcera N., Gasser G., Keiser J., Policar C. Bimodal X-ray and Infrared Imaging of an Organometallic Derivative of Praziquantel in Schistosoma Mansoni. ChemBioChem, 2016, 17 (11), 1004-1007 – DOI: 10.1002/cbic.201500688
  • Bertrand H. C., Schaap M., Baird L., Georgakopoulos N. D., Fowkes A., Thiollier C., Kachi H., Dinkova-Kostova A. T., Wells G. Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction. J. Med. Chem., 2015, 58 (18), pp 7186–7194 – DOI: 10.1021/acs.jmedchem.5b00602
  • Ching H. Y. V., Demay-Drouhard P., Bertrand H. C., Policar C., Tabares L. C., Un S. Nanometric distance measurements between Mn(II)DOTA centers. Phys. Chem.Chem.Phys., 2015, 17, 23368-23377 – DOI: 10.1039/c5cp03487f
  • Tarus B., Bertrand H., Zedda G., Di Primo C., Quideau S., Slama-Schwok A. Structure-based design of novel naproxen derivatives targeting monomeric nucleoprotein of Influenza A virus. J. Biomol. Struct. Dyn., 2014, Nov 19, 1-14 – DOI: 10.1080/07391102.2014.979230
  • East A., Fagani F., Crosby J., Georgakopoulos N., Bertrand H., Schaap M., Fowkes A., Wells G., Campanella M. PMI: a novel, DYm independent, Mitophagy Inducer. Chemistry and Biology, 2014, 21, 1585-1596 – DOI: 10.1016/j.chembiol.2014.09.019
  • Bertrand H. C., Clède S., Guillot R., Lambert F., Policar C. Luminescence Modulations of Rhenium Tricarbonyl Complexes Induced by Structural Variations, Inorg. Chem., 2014, 53 (12), 6204 – 6223 – DOI: 10.1021/ic5007007
  • Nagle A. A., Reddy S. A., Bertrand H., Tajima H., Dang T.-M., Wong S.-C., Hayes J. D., Wells G., Chew E.-H. 3-(2-Oxoethylidene)indolin-2-one derivatives activate Nrf2 and inhibit NF-kB: potential candidates for chemoprevention, ChemMedChem, 2014, 9 (8), 1763-1774 – DOI: 10.1002/cmdc.201402038
  • Clède S., Lambert F., Saint-Fort R., Plamont M.-A., Bertrand H., Vessières A., Policar C. Influence of the side chain length on the cellular uptake and the cytotoxicity of Rhenium tris-carbonyl derivatives: a bimodal infrared and luminescence quantitative study Chem. Eur. J., 2014, 20 (28), 8714-8722 – DOI: 10.1002/chem.201402471
  • Garcia L.; Franzoni S.; Mussi F.; Aumont-Niçaise M.; Bertrand H.; Desmadril M.; Pelosi G.; Buschini A.; Policar C. Apo-neocarzinostatin: a protein carrier for Cu(II) glycocomplexes and Cu(II) into U937 and HT29 cell lines, J. Inorg. Biochem., 2014, 135, 40-44. – DOI: 10.1016/j.jinorgbio.2014.02.006
  • Bertrand H., Guillot R., Teulade-Fichou M.-P., Fichou D. Synthesis, Properties, and Remarkable 2D Self-Assembly at the Liquid/Solid Interface of a Series of Triskele-Shaped 5,11,17-Triazatrinaphthylenes (TrisK). Chem. Eur. J., 2013, 19, 14654-14664 – DOI: 10.1002/chem.201300705
  • Hancock R.; Bertrand H. C.; Tsujita T.; Naz S.; El-Bakry A.; Laoruchupong J.; Hayes J. D.; Wells G.; Peptide inhibitors of the Keap1–Nrf2 protein–protein interaction. Free Rad. Biol. Med., 2012, 52 (2), 444-451 – DOI:10.1016/j.freeradbiomed.2011.10.486
  • Bertrand H.; Silly F.; Teulade-Fichou M.-P.; Tortech L.; Fichou D.; Locking the free-rotation of a prochiral star-shaped guest molecule inside a two-dimensional nanoporous network by introduction of chlorine atoms. Chem. Commun., 2011, 47 (36), 10091-10093   – DOI: 10.1039/c1cc12951a
  • Bertrand H.; Granzhan A.; Monchaud D.; Saettel N.; Guillot R.; Clifford S.; Mergny J.-L.; Teulade-Fichou M.-P.; Recognition of G-Quadruplex DNA by Triangular Star-Shaped Compounds: With or Without Side Chains? Chem. Eur. J., 2011, 17 (16), 4529-4539   – DOI: 10.1002/chem.201002810
  • Bertrand H., Bombard S., Monchaud D., Talbot E., Guédin A., Mergny J.-L., Grünert R., Bednarsky P.J., Teulade-Fichou M.-P. Exclusive platination of loop adenines in the human telomeric G-quadruplex. Org. Biomol. Chem. 2009, 7, 2864-2871 – DOI: 10.1039/b904599f
  • Monchaud D., Allain C., Bertrand H., Smargiasso N., Rosu F., Gabelica V., De Cian A., Mergny J.-L., Teulade-Fichou M.-P. Ligands playing musical chairs with G-quadruplex DNA: A rapid and simple displacement assay for identifying selective G-quadruplex binders. Biochimie 2008, 90, 1207-1223 – DOI: 10.1016/j.biochi.2008.02.019
  • De Cian A., Grellier P., Mouray E., Depoix D., Bertrand H., Monchaud D., Teulade-Fichou M.-P., Mergny J.-L., Alberti P. Plasmodium Telomeric Sequences: Structure, Stability and Quadruplex Targeting by Small Compounds. ChemBioChem 2008, 9, 2730–2739 – DOI: 10.1002/cbic.200800330
  • Bertrand H., Bombard S., Monchaud D., Teulade-Fichou, M.-P. A platinum-quinacridine hybrid as a G-quadruplex ligand. J. Biol. Inorg. Chem. 2007, 12 (7), 1003-1014 – DOI: 10.1007/s00775-007-0273-3
  • Bertrand H., Monchaud D., de Cian A., Mergny J.-L., Teulade-Fichou, M.-P. The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes. Org. Biomol. Chem. 2007, 5 (16), 2555-2559 – DOI: 10.1039/B708635K
  • Lartia R., Bertrand H., Teulade-Fichou M.-P. Improved synthesis of quinacridine derivatives. Synlett 2006, 4, 610-614 – DOI: 10.1055/s-2006-932465

Proceedings:

Bertrand H., Bombard S., Monchaud D., Teulade-Fichou M.-P. New platinum(II) complexes targeting the loops of the human telomeric G-quadruplex. Nucleic Acids Symposium Series, 2008, 52, 163-164 – DOI: 10.1093/nass/nrn083

Patents:

Slama-Schowk A., Delmas B., Quideau S., Bertrand H., Tarus B., Antiviral compositions directed against the influenza virus nucleoprotein. 13/12/2012, WO2012143141 A3

Policar C., Delsuc N., Lambert F., Bertrand H., Bernard A. S., Hostachy, S. Functionalizable molecular probe for X-ray fluorescence spectroscopy and multimodal imaging, 06/07/2015, application number 15175553.5 – 1408

e-book chapter:

Biochemical assays and biophysical tools for inhibitor identification and validation. Fowkes A., Bertrand H., Wells G. In: Understanding and Exploiting Protein–Protein Interactions as Drug Targets, Unitec House, 2 Albert Place, London N3 1QB, UK (Future Science Ltd) 2013, Pages 104-116 eBook ISBN: 978-1-909453-46-3

Publications

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2011

Locking the free-rotation of a prochiral star-shaped guest molecule inside a two-dimensional nanoporous network by introduction of chlorine atoms Article de journal

Hélène Bertrand; Fabien Silly; Marie-Paule Teulade-Fichou; Ludovic Tortech; Denis Fichou

Chemical Communications, 47 (36), p. 10091–10093, 2011, ISSN: 1359-7345.

2009

Exclusive platination of loop adenines in the human telomeric G-quadruplex Article de journal

Hélène Bertrand; Sophie Bombard; David Monchaud; Eric Talbot; Aurore Guédin; Jean-Louis Mergny; Renate Grünert; Patrick J Bednarski; Marie-Paule Teulade-Fichou

Organic & Biomolecular Chemistry, 7 (14), p. 2864–2871, 2009, ISSN: 1477-0520.

2008

Plasmodium Telomeric Sequences: Structure, Stability and Quadruplex Targeting by Small Compounds Article de journal

Anne De Cian; Philippe Grellier; Elisabeth Mouray; Delphine Depoix; Hélène Bertrand; David Monchaud; Marie-Paule Teulade-Fichou; Jean-Louis Mergny; Patrizia Alberti

ChemBioChem, 9 (16), p. 2730–2739, 2008, ISSN: 1439-4227.

New platinum(II) complexes targeting the loops of the human telomeric G-quadruplex. Article de journal

Hélène Bertrand; Sophie Bombard; David Monchaud; Marie-Paule Teulade-Fichou

Nucleic Acids Symposium Series, 52 (1), p. 163–164, 2008, ISSN: 0261-3166.

2007

A platinum–quinacridine hybrid as a G-quadruplex ligand Article de journal

Hélène Bertrand; Sophie Bombard; David Monchaud; Marie-Paule Teulade-Fichou

JBIC Journal of Biological Inorganic Chemistry, 12 (7), p. 1003–1014, 2007, ISSN: 1432-1327.

The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes Article de journal

Hélène Bertrand; David Monchaud; Anne De Cian; Régis Guillot; Jean-Louis Mergny; Marie-Paule Teulade-Fichou

Organic & Biomolecular Chemistry, 5 (16), p. 2555–2559, 2007, ISSN: 1477-0520.

2006

Improved Synthesis of Quinacridine Derivatives Article de journal

Rémy Lartia; Hélène Bertrand; Marie-Paule Teulade-Fichou

Synlett, 2006 (04), p. 610–614, 2006, ISSN: 0936-5214.

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