Professor, Ecole Normale Supérieure, PSL université Paris
Dean of the studies at the department of chemistry of ENS
Deputy director of the Laboratoire des BioMolécules (LBM), UMR7203, CNRS-PSL-SU
Scientific deputy director of the Institute of chemistry at CNRS (DAS-INC-CNRS), in charge of interdisciplinarity
ENS – Département de chimie
24 rue Lhomond, 75005 Paris, France
Phone: +33 144322424
Clotilde Policar was trained in organic, inorganic and physical chemistry and she then specialized in bio-inorganic chemistry. After a Ph.D. under the supervision of Dr. Daniel Mansuy and Dr. Isabelle Artaud at Paris-Sud 11 and Paris 5 universities on mimics of a metalloprotein (manganese peroxidase), she worked as a post-doctoral fellow on high-field electron paramagnetic resonance to characterize complexes mimicking the Mn cluster from the oxygen evolving center in the photosystem II with Dr. Sun Un and Dr. William Rutherford. She was then appointed assistant professor at Paris-Sud 11, where she dedicated her work to the development of Mn-complexes reproducing the activity of superoxide-dismutase (SOD). The initial focus was the spectroscopic characterization of Mn-OO adducts involved in the catalytic cycle for superoxide dismutation. She became an associate professor in 2005. Because the metalloproteins SODs are involved in the cellular protection against oxidative stress, the next step she took was to study these compounds in cellular models of oxidative stress. Since 2008, she has a professorship at the Ecole Normale Supérieure—Paris Sciences et Lettres, where she has set up a thematic group in bioinorganic chemistry or more precisely in inorganic biological and cellular chemistry. This emerging thematic is dedicated to the direct study of inorganic compounds in biological environments. Her main current interests focus, on the one hand, on the design of manganese-based anti-oxidants and their evaluation in cells. On the other, her group has initiated a new topic with the development of metal-based probes, including metal–carbonyl as multimodal bioprobes and that they validated as efficient IR-probe for bio-imaging.
Education and professional experience
- Short CV
- Detailed CV
- Since 2019 (Sept) Responsible of the two-year master programme in Chemistry and Life Science (parcours CSDV du master de chimie de Paris Centre)
Since 2017 Member of the editorial board of Journal of Inorganic Biochemistry
Since 2016 Deputy director of the Institut de Chimie du CNRS in charge of interdisciplinarity (Directrice adjointe science DAS-INC)
2015-2017 Member of the advisory board of Inorganic Chemistry (ACS)
Since 2015 Deputy chair of the FrenchBIC (French network in BioInorganic Chemistry, network of 25 laboratories)
Since 2014 (Sept) Dean of the studies, co-responsible for the international relationships
Since 2014 (Jan) Deputy director of the Research Unit LBM
2008 Nomination as a professor at the ENS
2005-2008 Associate professor, Paris-Sud 11 university
2005 (nov.) Habilitation thesis, Paris-Sud 11 university
1996-2005 Assistant professor, Paris-Sud 11 university
Institut de Chimie Moléculaire et des Matériaux d’Orsay
- Bioinorganic chemistry
- Superoxide dismutase mimics, superoxide, cellular models of oxidative stress, metal-based anti-oxidants
- Metal-carbonyls as multimodal probes for imaging: IR-spectromicroscopy, micro X-ray fluorescence and classical fluorescence
- Metals in biology: intracellular detection, metal imaging
Awards, distinctions, scientific societies membership, and contracts
- Elected member of the international council of the SBIC in October 2019.
- Member of the Société chimique de France and of the FrenchBIC
- Research contracts since 2008:
-Research contract from FRM as PI (Fédération pour la recherche médicale, Appels Pionniers de la recherche Etudes Physico-chimiques innovantes pour la biologie et la médecine- 2016-2020)
-Research fellowship from the Association François Aupetit (inflammatory bowel disease patients) obtained in 2015
-ANR contracts (National Funding Agency) : one as a PI (MAGIC, 2015-2020) ; three ANR contracts as a partner (Take Care, PI M. Robert, 2011-13 ; Metabact, PI I. Artaud, 2011-13, and MnHFPELDOR, PI L. Tabares, 2012-2015,)
-Paris-Sciences-Lettres research contract (PI, 2014-15)
-CNRS-contract Interdisciplinary work (interface chemistry-physic-biology), support for risky research (2009)
-Young researcher grant (ACI jeune chercheur) (2005-08)
-Since 2008: more than 10 projects selected on synchrotron beamlines (SOLEIL, APS, Alladin).
- 1997: first prize “Creation” for the French Ministry of Research for the project Le ticket d’Archimède (posters of popularisation of science in the Parisian Metro), project directed by C. Policar from 1995 to 1998.
Supervised students and post-doctorants
- Formers (not available)
-Martha Zoumpoulaki, PhD since October 2017
-Koudedja Coulibaly, PhD since October 2017
-Antoine Hoste, PhD since October 2017
- Bioinorganic chemistry: M1-ENS and Sorbonne université; master de chimie de Paris Centre, parcours chemistry and life science
- Metals in biology: M2-master de chimie de Paris Centre, parcours chimie moléculaire
- History of Sciences: organisation of the annual conference day « Journée Bram »
Graftable SCoMPIs enable the labeling and X-Ray fluorescence imaging of proteins, Sarah Hostachy, Marie Masuda, Takayuki Miki, Itaru Hamachi, Sandrine Sagan, Olivier Lequin, Kadda Medjoubi, Andrea Somogyi, Nicolas Delsuc and Clotilde Policar*, Chem. Sci. 2018 9, 4483-4487, doi 10.1039/C8SC00886H
A cell penetrant manganese SOD-mimic is able to complement MnSOD and exerts an anti-inflammatory effect on cellular and animal models of inflammatory bowel diseases, Emilie Mathieu, Anne-Sophie Bernard, Nicolas Delsuc, Elodie Quévrain, Géraldine Gazzah, Barry Lai, Florian Chain, Philippe Langella, Maria Bachelet, Joelle Masliah, Philippe Seksik, and Clotilde Policar*, Inorg Chem. 2017, 56, 2545-2555, IF 4.82 (2016), doi: dx.doi.org/10.1021/acs.inorgchem.6b02695
Entasis Through Hook-and-Loop Fastening in a Glycoligand with Cumulative Weak Forces Stabilizing CuI, Ludivine Garcia, Federico Cisnetti, Natacha Gillet, Régis Guillot, Magali Aumont-Niciase, Jean-Philip Piquemal, Michel Desmadril, François Lambert, Clotilde Policar*, J. Am. Chem. Soc., 2015, 137, 1141−1146, DOI: 10.1021/ja510259p,
A Rhenium tris-Carbonyl Derivative as a Single Core Multimodal Probe for Imaging (SCoMPI) Combining Infrared and Luminescent Properties, Sylvain Clède, François Lambert, Christophe Sandt, Zoher Gueroui, Matthieu Réfrégiers, Marie-Aude Plamont, Paul Dumas, Anne Vessières, Clotilde Policar*, Chem. Commun., 2012, 48, 7729–7731, doi : 10.1039/C2CC32163G,
Subcellular Imaging in the Mid-IR of a Metal-Carbonyl Moiety using Photothermal Induced Resonance, Clotilde Policar*, Jenny-Birgitta Waern, Marie-Aude Plamont, Sylvain Clède, Céline Mayet, Rui Prazeres, Jean-Michel Ortega, Anne Vessières, Alexandre Dazzi, Angew. Chem., Int. Ed., 2011, 50, 860-864; doi : 10.1002/anie.201003161, Highlighted with an inside cover.
Inorganic Chemistry, 53 (12), p. 6204–6223, 2014.
Applied Spectroscopy, 68 (1), p. 113–117, 2014.
Journal of Biological Inorganic Chemistry, 19 , p. S182-S182, 2014, ISSN: 0949-8257.
Analyst, 138 (19), p. 5610–5618, 2013.
Sensors and Actuators, B: Chemical, 185 , p. 762–770, 2013.
Biotechnology Advances, 31 (3), p. 393–395, 2013.
New Journal of Chemistry, 37 (10), p. 3030–3034, 2013.
Detection of an estrogen derivative in two breast cancer cell lines using a single core multimodal probe for imaging (SCoMPI) imaged by a panel of luminescent and vibrational techniques Article de journal
Analyst, 138 (19), p. 5627–5638, 2013.
Chemical Communications, 48 (62), p. 7729–7731, 2012.
Dalton Transactions, 41 (21), p. 6399–6403, 2012.
Journal of Inorganic Biochemistry, 112 , p. 59–67, 2012.
Applied Spectroscopy Reviews, 47 (7), p. 531–549, 2012.
Applied Spectroscopy Reviews, 47 (8), p. 620–632, 2012.
European Journal of Inorganic Chemistry, (20), p. 3308–3319, 2012.
Angewandte Chemie - International Edition, 50 (4), p. 860–864, 2011.
Faraday Discussions, 148 , p. 83–95, 2011.
Intrinsically fluorescent glycoligands to study metal selectivity Article de journal
Inorganic Chemistry, 50 (22), p. 11353–11362, 2011.
Inorganic Chemistry, 49 (16), p. 7282–7288, 2010.
European Journal of Inorganic Chemistry, (29-30), p. 4396–4400, 2009.