UMR 7203 Laboratoire des Biomolécules (LBM)1,2,3
Sorbonne Université, Faculté des Sciences, Tour 33-23, 4 place Jussieu, 75005 Paris
1Sorbonne Université
2École Normale Supérieure – PSL Université

Short bio

Graduated from the École Normale Supérieure of Lyon, I specialized in Chemical Biology in the labs of Prof. Kai Johnsson at the École Polytechnique Fédérale de Lausanne, and Prof. Jason Chin at the MRC Laboratory of Molecular Biology in Cambridge UK. After starting my independent career as Assistant Professor at the École Normale Supérieure in Paris, I joined Sorbonne University in Paris as Full Professor in Chemistry. My lab aims at developing Chemical Biology tools to push the frontiers of biological imaging.

Academic positions

2019 – now Professor of Chemistry at Sorbonne University (Paris, France), and Investigator in the Laboratory of Biomolecules (UMR 7203)
2010 – 2019 Assistant Professor of Chemistry at École Normale Supérieure – PSL University (Paris, France), and Investigator in the Laboratory PASTEUR (UMR 8640)
2009 – 2010 Postdoc, MRC Laboratory of Molecular Biology
2006 – 2009 Postdoc, École Polytechnique Fédérale de Lausanne


2016 Habilitation (HDR) in Chemistry, École Normale Supérieure
2005 PhD in Chemistry, École Normale Supérieure de Lyon
2002 Master in Chemistry, École Normale Supérieure de Lyon /Université Lyon 1 Claude Bernard

Research interests

Cells and organisms are complex machines driven by a set of dynamic biological events tightly orchestrated in space and time. Our understanding of their inner workings is intricately related to our ability to observe how their constituents organize and interact. Despite spectacular developments in biological imaging and probe design, many biologically relevant molecules and processes remain invisible. Arnaud Gautier is interested in inventing new tools for observing biomolecules and dynamic biochemical events in live cells and tissues. These tools can allow biologists to address questions ranging from fundamental mechanisms to the causes of disease and the development of novel therapeutics.

Awards and distinctions

2018 Junior Member of the Institut Universitaire de France (IUF)
2017 CNRS Bronze Medal
2016 ERC Consolidator Laureate
2011 FEBS Distinguished Young Investigator Award


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Nitric oxide-triggered remodeling of chloroplast bioenergetics and thylakoid proteins upon nitrogen starvation in Chlamydomonas reinhardtii Article de journal

L Wei; B Derrien; A Gautier; L Houille-Vernes; A Boulouis; D Saint-Marcoux; A Malnoë; F Rappaport; C de Vitry; O Vallon; Y Choquet; F -A Wollman

Plant Cell, 26 (1), p. 353–372, 2014.


Photochemical properties of Spinach and its use in selective imaging Article de journal

P Wang; J Querard; S Maurin; S S Nath; T Le Saux; A Gautier; L Jullien

Chemical Science, 4 (7), p. 2865–2873, 2013.


"Self-immolative" spacer for uncaging with fluorescence reporting Article de journal

R Labruère; A Alouane; T Le Saux; I Aujard; P Pelupessy; A Gautier; S Dubruille; F Schmidt; L Jullien

Angewandte Chemie - International Edition, 51 (37), p. 9344–9347, 2012.

Modification-Free Photocontrol of $beta$-Lactam Conversion with Spatiotemporal Resolution Article de journal

Anna Venancio-Marques; Yan-Jun Liu; Antoine Diguet; Thomas di Maio; Arnaud Gautier; Damien Baigl

ACS Synthetic Biology, 1 (11), p. 526-531, 2012.


Light-Activated Kinases Enable Temporal Dissection of Signaling Networks in Living Cells Article de journal

Arnaud Gautier; Alexander Deiters; Jason W Chin

Journal of the American Chemical Society, 133 (7), p. 2124-2127, 2011, ISSN: 0002-7863.


Genetically Encoded Photocontrol of Protein Localization in Mammalian Cells Article de journal

Arnaud Gautier; Duy P Nguyen; Hrvoje Lusic; Wenlin An; Alexander Deiters; Jason W Chin

Journal of the American Chemical Society, 132 (12), p. 4086-4088, 2010, ISSN: 0002-7863.


Selective Cross-Linking of Interacting Proteins Using Self-Labeling Tags Article de journal

Arnaud Gautier; Eiji Nakata; Grav zvydas Lukinaviv cius; Kui-Thong Tan; Kai Johnsson

Journal of the American Chemical Society, 131 (49), p. 17954-17962, 2009, ISSN: 0002-7863.


AGT/SNAP-Tag: A Versatile Tag for Covalent Protein Labeling Article de journal

Arnaud Gautier; Kai Johnsson; Helen O'Hare

Probes and Tags to Study Biomolecular Function, 2008, ISSN: 9783527623099.

An Engineered Protein Tag for Multiprotein Labeling in Living Cells Article de journal

Arnaud Gautier; Alexandre Juillerat; Christian Heinis; Ivan Reis Corr^ea; Maik Kindermann; Florent Beaufils; Kai Johnsson

Chemistry & Biology, 15 (2), p. 128-136, 2008, ISSN: 1074-5521.


Chemical Probes Shed Light on Protein Function Article de journal

Helen M O'Hare; Kai Johnsson; Arnaud Gautier

Current Opinion in Structural Biology, 17 (4), p. 488-494, 2007, ISSN: 0959-440X.


An Unusual Functional Group Interaction and Its Potential to Reproduce Steric and Electrostatic Features of the Transition States of Peptidolysis Article de journal

Arnaud Gautier; Delphine Pitrat; Jens Hasserodt

Bioorganic & Medicinal Chemistry, 14 (11), p. 3835-3847, 2006, ISSN: 0968-0896.


Chiral Trialkanolamine-Based Hemicryptophanes: Synthesis and Oxovanadium Complex Article de journal

A Gautier; J C Mulatier; J Crassous; J P Dutasta

Organic Letters, 7 (7), p. 1207-1210, 2005, ISSN: 1523-7060.

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