UMR 7203 Laboratoire des Biomolécules (LBM)1,2,3
Sorbonne Université, Faculté des Sciences, Tour 33-23, 4 place Jussieu, 75005 Paris
1Sorbonne Université
2École Normale Supérieure – PSL Université

Short bio

Graduated from the École Normale Supérieure of Lyon, I specialized in Chemical Biology in the labs of Prof. Kai Johnsson at the École Polytechnique Fédérale de Lausanne, and Prof. Jason Chin at the MRC Laboratory of Molecular Biology in Cambridge UK. After starting my independent career as Assistant Professor at the École Normale Supérieure in Paris, I joined Sorbonne University in Paris as Full Professor in Chemistry. My lab aims at developing Chemical Biology tools to push the frontiers of biological imaging.

Academic positions

2019 – now Professor of Chemistry at Sorbonne University (Paris, France), and Investigator in the Laboratory of Biomolecules (UMR 7203)
2010 – 2019 Assistant Professor of Chemistry at École Normale Supérieure – PSL University (Paris, France), and Investigator in the Laboratory PASTEUR (UMR 8640)
2009 – 2010 Postdoc, MRC Laboratory of Molecular Biology
2006 – 2009 Postdoc, École Polytechnique Fédérale de Lausanne


2016 Habilitation (HDR) in Chemistry, École Normale Supérieure
2005 PhD in Chemistry, École Normale Supérieure de Lyon
2002 Master in Chemistry, École Normale Supérieure de Lyon /Université Lyon 1 Claude Bernard

Research interests

Cells and organisms are complex machines driven by a set of dynamic biological events tightly orchestrated in space and time. Our understanding of their inner workings is intricately related to our ability to observe how their constituents organize and interact. Despite spectacular developments in biological imaging and probe design, many biologically relevant molecules and processes remain invisible. Arnaud Gautier is interested in inventing new tools for observing biomolecules and dynamic biochemical events in live cells and tissues. These tools can allow biologists to address questions ranging from fundamental mechanisms to the causes of disease and the development of novel therapeutics.

Awards and distinctions

2018 Junior Member of the Institut Universitaire de France (IUF)
2017 CNRS Bronze Medal
2016 ERC Consolidator Laureate
2011 FEBS Distinguished Young Investigator Award


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An expanded palette of fluorogenic HaloTag probes with enhanced contrast for targeted cellular imaging Article de journal

Sylvestre P J T Bachollet; Yuriy Shpinov; Fanny Broch; Hela Benaissa; Arnaud Gautier; Nicolas Pietrancosta; Jean-Maurice Mallet; Blaise Dumat

Organic & Biomolecular Chemistry, 20 (17), p. 3619 - 3628, 2022, ISSN: 1477-0520.

Reciprocal Regulation of Shh Trafficking and H2O2 Levels via a Noncanonical BOC-Rac1 Pathway Article de journal

Marion Thauvin; Irène Amblard; Christine Rampon; Aurélien Mourton; Isabelle Queguiner; Chenge Li; Arnaud Gautier; Alain Joliot; Michel Volovitch; Sophie Vriz

Antioxidants (Basel, Switzerland), 11 (4), p. 718, 2022, ISSN: 2076-3921.


Orthogonal fluorescent chemogenetic reporters for multicolor imaging Article de journal

Alison G Tebo; Benjamien Moeyaert; Marion Thauvin; Irene Carlon-Andres; Dorothea Böken; Michel Volovitch; Sergi Padilla-Parra; Peter Dedecker; Sophie Vriz; Arnaud Gautier

Nature Chemical Biology, 17 (1), p. 30–38, 2021, ISSN: 1552-4469.

Versatile On-Demand Fluorescent Labeling of Fusion Proteins Using Fluorescence-Activating and Absorption-Shifting Tag (FAST) Livre

Arnaud Gautier; Ludovic Jullien; Chenge Li; Marie-Aude Plamont; Alison G Tebo; Marion Thauvin; Michel Volovitch; Sophie Vriz

Springer US, New York, NY, 2021, ISBN: 978-1-07-161593-5.


A Far-Red Emitting Fluorescent Chemogenetic Reporter for In Vivo Molecular Imaging Article de journal

Chenge Li; Alison G Tebo; Marion Thauvin; Marie-Aude Plamont; Michel Volovitch; Xavier Morin; Sophie Vriz; Arnaud Gautier

Angewandte Chemie International Edition, 59 (41), p. 17917–17923, 2020, ISSN: 1521-3773, (_eprint:


A split fluorescent reporter with rapid and reversible complementation Article de journal

Alison G Tebo; Arnaud Gautier

Nature Communications, 10 (1), p. 2822, 2019, ISSN: 2041-1723.

Live Cell Super Resolution Imaging by Radial Fluctuations Using Fluorogen Binding Tags Article de journal

Muthukumaran Venkatachalapathy; Vivek Belapurkar; Mini Jose; Arnaud Gautier; Deepak Nair

Nanoscale, 11 (8), p. 3626-3632, 2019, ISSN: 2040-3364.

Single-Molecule Localization Microscopy with the Fluorescence-Activating and Absorption-Shifting Tag (FAST) System Article de journal

Elizabeth M Smith; Arnaud Gautier; Elias M Puchner

ACS Chemical Biology, 14 (6), p. 1115-1120, 2019, ISSN: 1554-8929.

The Glowing Panoply of Fluorogen-based Markers for Advanced Bioimaging Book Chapter

A Gautier

The Glowing Panoply of Fluorogen-based Markers for Advanced Bioimaging, Chapitre 3, 2019.


Circularly Permuted Fluorogenic Proteins for the Design of Modular Biosensors Article de journal

A G Tebo; F M Pimenta; M Zoumpoulaki; C Kikuti; H Sirkia; M -A Plamont; A Houdusse; A Gautier

ACS Chemical Biology, 13 (9), p. 2392–2397, 2018.

Fluorogenic Probing of Membrane Protein Trafficking Article de journal

C Li; A Mourton; M -A Plamont; V Rodrigues; I Aujard; M Volovitch; T Le Saux; F Perez; S Vriz; L Jullien; A Joliot; A Gautier

Bioconjugate Chemistry, 29 (6), p. 1823–1828, 2018.

Fluorogenic Protein-Based Strategies for Detection, Actuation, and Sensing Article de journal

A Gautier; A G Tebo

BioEssays, 40 (10), 2018.

Improved Chemical-Genetic Fluorescent Markers for Live Cell Microscopy Article de journal

A G Tebo; F M Pimenta; Y Zhang; A Gautier

Biochemistry, 57 (39), p. 5648–5653, 2018.

Macroscale fluorescence imaging against autofluorescence under ambient light Article de journal

R Zhang; R Chouket; M -A Plamont; Z Kelemen; A Espagne; A G Tebo; A Gautier; L Gissot; J -D Faure; L Jullien; V Croquette; T Le Saux

Light: Science and Applications, 7 (1), 2018.

Spying on cells with chemical-genetic hybrids Article de journal

A Gautier

Actualite Chimique, (435), p. 31–35, 2018.

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