UMR 7203 Laboratoire des Biomolécules (LBM)1,2,3
Sorbonne Université, Faculté des Sciences, Tour 33-23, 4 place Jussieu, 75005 Paris
1Sorbonne Université
2École Normale Supérieure – PSL Université

Short bio

Graduated from the École Normale Supérieure of Lyon, I specialized in Chemical Biology in the labs of Prof. Kai Johnsson at the École Polytechnique Fédérale de Lausanne, and Prof. Jason Chin at the MRC Laboratory of Molecular Biology in Cambridge UK. After starting my independent career as Assistant Professor at the École Normale Supérieure in Paris, I joined Sorbonne University in Paris as Full Professor in Chemistry. My lab aims at developing Chemical Biology tools to push the frontiers of biological imaging.

Academic positions

2019 – now Professor of Chemistry at Sorbonne University (Paris, France), and Investigator in the Laboratory of Biomolecules (UMR 7203)
2010 – 2019 Assistant Professor of Chemistry at École Normale Supérieure – PSL University (Paris, France), and Investigator in the Laboratory PASTEUR (UMR 8640)
2009 – 2010 Postdoc, MRC Laboratory of Molecular Biology
2006 – 2009 Postdoc, École Polytechnique Fédérale de Lausanne


2016 Habilitation (HDR) in Chemistry, École Normale Supérieure
2005 PhD in Chemistry, École Normale Supérieure de Lyon
2002 Master in Chemistry, École Normale Supérieure de Lyon /Université Lyon 1 Claude Bernard

Research interests

Cells and organisms are complex machines driven by a set of dynamic biological events tightly orchestrated in space and time. Our understanding of their inner workings is intricately related to our ability to observe how their constituents organize and interact. Despite spectacular developments in biological imaging and probe design, many biologically relevant molecules and processes remain invisible. Arnaud Gautier is interested in inventing new tools for observing biomolecules and dynamic biochemical events in live cells and tissues. These tools can allow biologists to address questions ranging from fundamental mechanisms to the causes of disease and the development of novel therapeutics.

Awards and distinctions

2018 Junior Member of the Institut Universitaire de France (IUF)
2017 CNRS Bronze Medal
2016 ERC Consolidator Laureate
2011 FEBS Distinguished Young Investigator Award


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Fluorogenic labeling strategies for biological imaging Article de journal

C Li; A G Tebo; A Gautier

International Journal of Molecular Sciences, 18 (7), 2017.

Hybrid fluorescent probes for imaging cellular proteins on demand Article de journal

L Jullien; A Gautier

Medecine/Sciences, 33 (6-7), p. 576–578, 2017.

Resonant out-of-phase fluorescence microscopy and remote imaging overcome spectral limitations Article de journal

J Quérard; R Zhang; Z Kelemen; M -A Plamont; X Xie; R Chouket; I Roemgens; Y Korepina; S Albright; E Ipendey; M Volovitch; H L Sladitschek; P Neveu; L Gissot; A Gautier; J -D Faure; V Croquette; T Le Saux; L Jullien

Nature Communications, 8 (1), 2017.


Design and characterization of red fluorogenic push-pull chromophores holding great potential for bioimaging and biosensing Article de journal

C Li; M -A Plamont; I Aujard; T Le Saux; L Jullien; A Gautier

Organic and Biomolecular Chemistry, 14 (39), p. 9253–9261, 2016.

Kinetics of Reactive Modules Adds Discriminative Dimensions for Selective Cell Imaging Article de journal

J Quérard; T Le Saux; A Gautier; D Alcor; V Croquette; A Lemarchand; C Gosse; L Jullien

ChemPhysChem, 17 (10), p. 1396–1413, 2016.

Small Fluorescence-Activating and Absorption-Shifting Tag for Tunable Protein Imaging in Vivo Article de journal

Marie-Aude Plamont; Emmanuelle Billon-Denis; Sylvie Maurin; Carole Gauron; Frederico M Pimenta; Christian G Specht; Jian Shi; Jérôme Querard; Buyan Pan; Julien Rossignol; Karine Moncoq; Nelly Morellet; Michel Volovitch; Ewen Lescop; Yong Chen; Antoine Triller; Sophie Vriz; Thomas Le Saux; Ludovic Jullien; Arnaud Gautier

Proceedings of the National Academy of Sciences, 113 (3), p. 497, 2016.


Expanding discriminative dimensions for analysis and imaging Article de journal

J Querard; A Gautier; T Le Saux; L Jullien

Chemical Science, 6 (5), p. 2968–2978, 2015.

Fluorogen-Based Reporters for Fluorescence Imaging: A Review Article de journal

Ludovic Jullien; Arnaud Gautier

Methods and Applications in Fluorescence, 3 (4), p. 042007, 2015, ISSN: 2050-6120.

Light-Activated Proteolysis for the Spatiotemporal Control of Proteins Article de journal

Quentin Delacour; Chenge Li; Marie-Aude Plamont; Emmanuelle Billon-Denis; Isabelle Aujard; Thomas Le Saux; Ludovic Jullien; Arnaud Gautier

ACS Chemical Biology, 10 (7), p. 1643-1647, 2015, ISSN: 1554-8929.

Photoswitching Kinetics and Phase-Sensitive Detection Add Discriminative Dimensions for Selective Fluorescence Imaging Article de journal

Jérôme Querard; Tal-Zvi Markus; Marie-Aude Plamont; Carole Gauron; Pengcheng Wang; Agathe Espagne; Michel Volovitch; Sophie Vriz; Vincent Croquette; Arnaud Gautier; Thomas Le Saux; Ludovic Jullien

Angewandte Chemie International Edition, 54 (9), p. 2633-2637, 2015, ISSN: 1433-7851.


How to Control Proteins with Light in Living Systems Article de journal

Arnaud Gautier; Carole Gauron; Michel Volovitch; David Bensimon; Ludovic Jullien; Sophie Vriz

Nature Chemical Biology, 10 , p. 533, 2014.

Nitric oxide-triggered remodeling of chloroplast bioenergetics and thylakoid proteins upon nitrogen starvation in Chlamydomonas reinhardtii Article de journal

L Wei; B Derrien; A Gautier; L Houille-Vernes; A Boulouis; D Saint-Marcoux; A Malnoë; F Rappaport; C de Vitry; O Vallon; Y Choquet; F -A Wollman

Plant Cell, 26 (1), p. 353–372, 2014.


Photochemical properties of Spinach and its use in selective imaging Article de journal

P Wang; J Querard; S Maurin; S S Nath; T Le Saux; A Gautier; L Jullien

Chemical Science, 4 (7), p. 2865–2873, 2013.


"Self-immolative" spacer for uncaging with fluorescence reporting Article de journal

R Labruère; A Alouane; T Le Saux; I Aujard; P Pelupessy; A Gautier; S Dubruille; F Schmidt; L Jullien

Angewandte Chemie - International Edition, 51 (37), p. 9344–9347, 2012.

Modification-Free Photocontrol of $beta$-Lactam Conversion with Spatiotemporal Resolution Article de journal

Anna Venancio-Marques; Yan-Jun Liu; Antoine Diguet; Thomas di Maio; Arnaud Gautier; Damien Baigl

ACS Synthetic Biology, 1 (11), p. 526-531, 2012.

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