UMR 7203 : Micro-organismes et physiopathologie intestinale ERL U1057 INSERM

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Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

Gut microbiota metabolises bile acids (BA). As dysbiosis has been reported in inflammatory bowel diseases (IBD), we aim to investigate the impact of IBD associated dysbiosis on BA metabolism and its influence on the epithelial cell inflammation response.

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Mapping molecules inside cells is a contemporary challenge that requires both high sensitivity and sub-micrometric resolution. IR-spectroscopy is valuable for chemical imaging.