Synthesis and functionalization of nanoparticulate vectors for evaluating the toxicity of xenobiotics using the nematode Caenorhabditis elegans

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Type d'offre: 
Stage post-doctoral
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Celescreen, a French biotechnology start-up, is looking for a post-doc or an engineer specialized in synthesis and / or functionalization of nanoparticulate vectors

Keywords: Caenorhabditis elegans, toxicity, nanoparticles, functionnalisation, MOFs

Starting date : January or February 2019. 1 Year position

Celescreen is developing a patented method for evaluating the toxicity of xenobiotics using the nematode Caenorhabditis elegans, a well-known model for medical research. The method uses a nanoparticle vector to facilitate the ingestion of xenobiotics by C. elegans. The team of Dr. Christian Serre at the Institut des Matériaux Poreux de Paris (IMAP, a joint Ecole Normale Supérieure, ESPCI research unit; http://www.chimie.ens.fr/?q=en/en-fre-imap-2000) has a renown expertise in the synthesis of biocompatible metal-organic frameworks (MOF) for biomedical applications. NanoMOFs are non toxic hybrid nanoparticles built up from metal subunits (e.g. Fe…) coordinated with organic ligands (e.g. carboxylates…) exhibiting  ordered micro or mesoporous architectures, associated to unprecedented drug loading capacities and controlled releases of a wide range of active drugs.

The mission: to develop and evaluate biocompatible metal-organic frameworks (MOF)-based compounds by playing on the MOF structure/composition, its surface functionalization, the conditions of implementation, one will have to improve the palatability of C. elegans, to put the process of synthesis under control, to control the release.

Celescreen is based at Lariboisière Hospital (Paris). The project will be carried out in strong collaboration with the IMAP (Paris).

After the one year post-doc or research engineer position, in case of success, there will be the possibility for the fellow to become a permanent staff member of Celescreen. It is co-financed by Respore, the Ile-de-France network in porous solids sciences.

Contacts: Luc Lenglet (lllenglet@gmail.com), Christian Serre (christian.serre@ens.fr)

Unit: 
FRE IMAP 2000