D-Amino Acid Detection in Peptides by MALDI-TOF-TOF

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TitreD-Amino Acid Detection in Peptides by MALDI-TOF-TOF
Type de publicationJournal Article
Nouvelles publications2009
AuteursSachon, E, Clodic G, Galanth C, Amiche M, Ollivaux C, Soyez D, Bolbach G
JournalAnalytical Chemistry
Année de publicationJun
Accession NumberISI:000266601800032

Detection of a D-amino acid residue in natural peptides by mass spectrometry remains a challenging task, as this post-translational modification does not induce any change in molecular mass. To our knowledge, the present article is the first report using matrix-assisted laser desorption/ionization (MALDI) for the discrimination and the quantification of peptide isomers. In this work, we used synthetic hepta- and decapeptides of biological relevance and their isomers. All-L sequences and some isomers containing a D-residue in various positions were analyzed.

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Importer un fichierD-Amino Acid Detection in Peptides by MALDI-TOF-TOF
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