ENS – Département de chimie
24 rue Lhomond, 75005 Paris

Phone: 0144323641
Office: E154


Short bio

Frédéric Lemaître did a joint thesis between the Université de Bourgogne (France) and the Université de Sherbrooke (Canada). He received a double Ph. D. degree in 2003. His Ph. D. research dealt with electrochemistry of palladium clusters and their reactivity towards alkyl- and acyl halides. After doing postdoctoral research in the electrochemistry group at the Ecole Normale Supérieure de Paris (palladium catalysis – Heck reaction), he has been obtained an Assistant Professor position (Maître de Conférences) at the Université Pierre et Marie Curie – Sorbonne Université in September 2004. His research works concern bioelectrochemistry and especially the detection of secretion processes at the single cell level. He is also interested in the production of bioelectricity by using photosynthesis.

Education and professional experience

  • 2000-2003: joint thesis between Université de Bourgogne, France (Ph. D. Physical Chemistry) and Université de Sherbrooke, Canada (Ph. D Molecular Chemistry)
  • 2004-2020: associate professor in Université Pierre et Marie Curie, France (now Sorbonne Université)
  • 2012: habilitation thesis (May), Université Pierre et Marie Curie
  • since 2020: professor in Faculté des Sciences et Ingénierie, Sorbonne Université

Research interests

  • Bioelectrochemistry, Photosynthesis, Ultramicroelectrodes, Biophysics, Oxidative Stress, Analytical Chemistry, Microsystems, Fluorescence.

Awards and distinctions

  • Early Career Electrochemistry Prize from Société Française de Chimie (2015)
  • Member of ISE (International Society of Electrochemistry)
  • Member of BES (Bioelectrochemical Society)
  • Member of GFB (French Group of Bioelectrochemistry)
  • Member of SFC (Société Française de Chimie)

Supervised students and post-doctorants

  • Currents and formers (not yet available)


  • Teacher at Sorbonne Université (lectures, tutorials and practical works) : General Chemistry , Organic Chemistry, Electrochemistry, Kinetics, Thermodynamics
  • Teacher at CEPAC (Centre de Préparation de l’Agrégation de Chimie) in Electrochemistry
  • Chemistry academic book « Maxi-Fiches de Chimie Générale » (2008, Ed. Dunod, ISBN 978-2-10-051778-7)
  • Electrochemistry academic book« De l’Oxydo-Réduction à l’Electrochimie » (2006, Ed. Ellipses, ISBN 978-2-7298-3072-4)

Significant publications

  1. H.-Y. Fu, D. Picot, Y. Choquet, G. Longatte, A. Sayegh, J. Delacotte, M. Guille-Collignon, F. Lemaître, F. Rappaport, F.-A. Wollman Nat. Commun. 2017, 8, 15274. Redesigning the QA binding site of PSII allows reduction of exogenous quinones
  2. G. Longatte, F. Rappaport, F.-A. Wollman, M. Guille-Collignon, F. Lemaître Electrochim. Acta 2017, 236, 337-342. Electrochemical Harvesting of Photosynthetic Electrons from Unicellular Algae Population at the Preparative Scale by Using 2,6-dichlorobenzoquinone
  3. X. Liu, A. Savy, S. Maurin, L. Grimaud, F. Darchen, D. Quinton, E. Labbé, O. Buriez, J. Delacotte, F. Lemaître, M. Guille-Collignon Angew. Chem. Int. Ed. 2017, 56, 2366-2370. Coupling electrochemistry and TIRF-microscopy with the fluorescent false neurotransmitter FFN102 supports the fluorescence signals during single vesicle exocytosis detection
  4. G. Longatte, A. Sayegh, J. Delacotte, F. Rappaport, F. A. Wollman, M. Guille-Collignon, F. Lemaître Chem. Sci. 2018, 9, 8271-8281. Investigation of Photocurrents Resulting from Living Unicellular Algae Suspension with Quinones over Time
  5. L. Beauzamy, J. Delacotte, B. Bailleul, K. Tanaka, S. Nakanishi, F.-A. Wollman, F. Lemaître Anal. Chem. 2020, 92, 7532-7539.Mediator-Microorganism Interaction in Microbial Solar Cell: a Fluoro-Electrochemical Insight
  6. M. Guille-Collignon, F. Lemaître Trends Anal. Chem. 2020, 132, 116005. Overview and Outlook of the Strategies devoted to Electrofluorescence Surveys: Application to Single Cell Secretion Analysis


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Striking Inflammation from Both Sides: Manganese(II) Pentaazamacrocyclic SOD Mimics Act Also as Nitric Oxide Dismutases: A Single-Cell Study Article de journal

Milos R Filipovic; Alaric C W Koh; Stephane Arbault; Vesna Niketic; Andrea Debus; Ulrike Schleicher; Christian Bogdan; Manon Guille; Frederic Lemaitre; Christian Amatore; Ivana Ivanovic-Burmazovic

Angewandte Chemie-International Edition, 49 (25), p. 4228-4232, 2010, ISSN: 1433-7851.


Invariance of exocytotic events detected by amperometry as a function of the carbon fiber microelectrode diameter Article de journal

C Amatore; S Arbault; Y Bouret; M Guille; F Lemaître; Y Verchier

Analytical Chemistry, 81 (8), p. 3087–3093, 2009.


Electrochemical monitoring of single cell secretion: Vesicular exocytosis and oxidative stress Article de journal

C Amatore; S Arbault; M Guille; F Lemaître

Chemical Reviews, 108 (7), p. 2585–2621, 2008.


Comparison of apex and bottom secretion efficiency at chromaffin cells as measured by amperometry Article de journal

C Amatore; S Arbault; F Lemaître; Y Verchier

Biophysical Chemistry, 127 (3), p. 165–171, 2007.

Rate and mechanism of the Heck reactions of arylpalladium complexes ligated by a bidentate P,P ligand with an electron-rich alkene (isobutyl vinyl ether) Article de journal

C Amatore; B Godin; A Jutand; F Lemaître

Organometallics, 26 (7), p. 1757–1761, 2007.

Rate and mechanism of the reaction of alkenes with aryl palladium complexes ligated by a bidentate P,P ligand in heck reactions Article de journal

C Amatore; B Godin; A Jutand; F Lemaître

Chemistry - A European Journal, 13 (7), p. 2002–2011, 2007.

Relationship between amperometric pre-spike feet and secretion granule composition in Chromaffin cells: An overview Article de journal

C Amatore; S Arbault; I Bonifas; M Guille; F Lemaître; Y Verchier

Biophysical Chemistry, 129 (2-3), p. 181–189, 2007.

The Nature and Efficiency of Neurotransmitter Exocytosis Also Depend on Physicochemical Parameters Article de journal

Christian Amatore; Stephane Arbault; Manon Guille; Frederic Lemaitre

Chemphyschem, 8 (11), p. 1597-1605, 2007, ISSN: 1439-4235.

Vesicular exocytosis under hypotonic conditions shows two distinct populations of dense core vesicles in bovine chromaffin cells Article de journal

C Amatore; S Arbault; I Bonifas; F Lemaître; Y Verchier

ChemPhysChem, 8 (4), p. 578–585, 2007.


Coupling of electrochemistry and fluorescence microscopy at indium tin oxide microelectrodes for the analysis of single exocytotic events Article de journal

C Amatore; S Arbault; Y Chen; C Crozatier; F Lemaître; Y Verchier

Angewandte Chemie - International Edition, 45 (24), p. 4000–4003, 2006.

Regulation of exocytosis in chromaffin cells by Trans-insertion of lysophosphatidylcholine and arachidonic acid into the outer leaflet of the cell membrane Article de journal

C Amatore; S Arbault; Y Bouret; M Guille; F Lemaître; Y Verchier

ChemBioChem, 7 (12), p. 1998–2003, 2006.


Formation of anionic palladium(0) complexes ligated by the trifluoroacetate ion and their reactivity in oxidative addition Article de journal

C Amatore; A Jutand; F Lemaître; J L Ricard; S Kozuch; S Shaik

Journal of Organometallic Chemistry, 689 (23), p. 3728–3734, 2004.

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