Professeur Sorbonne Université
ENS – Département de chimie
24 rue Lhomond, 75005 Paris
Email: eric.labbe@ens.psl.eu
Phone: 0144322433
Office: E010
Short bio
Eric Labbé is an analytical electrochemist interested in the understanding of reactivity and transport issues related to biological molecules. He started studying electrosynthetic and electrocatalytic sequences in the group of Jacques Périchon at Université Paris Est (UPEC) until 2005. Since 2006, he is Professor at Sorbonne Université (SU) and his research topics focus on the exploration of drug metabolism as well as biomolecule distribution accross lipid membranes, through the electrochemical switching ON/OFF of fluorescent probes.
Education and professional experience
- Since 2006 Professor, Sorbonne Université
- 1992 – 2005 Maître de Conférences, IUFM de Créteil
- 1991 – 1992 Postdoc, Université Pierre et Marie Curie
- 1988 – 1991 PhD, Université Pierre et Marie Curie
Research interests
- Keywords : electrochemistry ; mechanisms ; metabolism ; transport
The journey of a biomolecule (drug, peptide,…) throughout a living organism from its generation -or administration- to its elimination encompasses namely metabolic processes and transport steps accross barriers. Eric Labbé is interested in delineating the metabolism of such molecules and the dynamics of their passage through lipid membranes, which are central considerations for both the identification of the active metabolites and the evaluation of their bio-availability. Within this topic, his research concerns the development of electrochemically switchable dual redox/fluorescent probes.
Teaching
- Engaged in the training and graduation of French middle and high-school teachers in physics & chemistry (Master MEEF) at ESPE de Paris.
- Engaged in the lifelong formation of chemistry teachers at Sorbonne Université
- Teaching Electrochemistry at École Normale Supérieure
Significant publications
- “The Fundamental Input of Analytical Electrochemistry in the Determination of Intermediates and Reaction Mechanisms in Electrosynthetic Processes.” ChemElectroChem Minireview, 2019, 6, 4118.
- “Redox switchable rhodamine-ferrocene dyad: Exploring imaging possibilities in cells” Electrochemistry Communications, 2018, 97, 46.
- “Selective Electrochemical Bleaching of the Outer Leaflet of Fluorescently Labelled Giant Liposomes” Chem. Eur.J., 2017, 23, 6781
- “Electrochemical Behavior of Plutonium in n-TriButylPhosphate” Dalton Trans., 2017, 46, 4943.
- “Monitoring and Quantifying the Passive Transport of Molecules Through Patch–Clamp Suspended Real and Model Cell Membranes “ Angew. Chem. Int Ed. , 2014, 53, 3192. Key Scientific Article of the Global Medical Discovery newsfeed.
Publications accessible from Open Access platforms /
- HAL Archive @ École Normale Supérieure
- HAL Archive @ Sorbonne Université
Publications ( full record)
2009 |
Design and electrochemical characterization of a new cobalt(II)-cyclodextrin complex. Evidence for a supramolecular stabilization of the Co(I) state Article de journal Electrochemistry Communications, 11 (1), p. 114-117, 2009. |
Exploring the first steps of an electrochemically-triggered controlled polymerization sequence: Activation of alkyl- and benzyl halide initiators by an electrogenerated Fe(II)Salen complex Article de journal Journal of Electroanalytical Chemistry, 633 (1), p. 99-105, 2009. |
Further insights into hydrophobic interactions between ferrocenyl-tamoxifen drugs and non-polar molecular architectures at electrode surfaces Article de journal Journal of Electroanalytical Chemistry, 635 (1), p. 13-19, 2009. |
The replacement of a phenol group by an aniline or acetanilide group enhances the cytotoxicity of 2-ferrocenyl-1,1-diphenyl-but-1-ene compounds against breast cancer cells Article de journal Journal of Organometallic Chemistry, 694 (6), p. 895-901, 2009. |
2008 |
Electrochemical attachment of a conjugated amino-ferrocifen complex onto carbon and metal surfaces Article de journal Journal of Electroanalytical Chemistry, 619 , p. 169-175, 2008. |
Reactivity and Antiproliferative Activity of Ferrocenyl-Tamoxifen Adducts with Cyclodextrins against Hormone-Independent Breast-Cancer Cell Lines Article de journal Chemistry-a European Journal, 14 (27), p. 8195-8203, 2008. |
Supramolecular effects of cyclodextrins on the electrochemical reduction and reactivity of aromatic carbonyl compounds Article de journal Journal of Electroanalytical Chemistry, 621 (2), p. 134-145, 2008. |
2007 |
Activation of 1-halonaphthalenes by electrogenerated Co-I-salen (-) Article de journal Journal of Electroanalytical Chemistry, 600 (2), p. 359-363, 2007. |
2006 |
Unexpected stabilization of a simple cobalt(I) salt in acetonitrile at a glassy carbon electrode Article de journal Journal of Electroanalytical Chemistry, 593 (1-2), p. 99-104, 2006. |
1999 |
100 Q.C.M. corrigés de Biologie, physique, chimie : Concours d'entrée kiné, sage-femme, ergothérapeutes, techniciens en analyse biomédicale, manipulateurs d'électroradiologie médicale Livre 1999, ISBN: 2224025653. |
1994 |
ELECTROCHEMICAL ACTIVATION OF BROMOTRIFLUOROMETHANE : A NEW METHOD TO PREPARE TRIFLUOROMETHYLATED COMPOUNDS Inproceedings Torii, Sigeru (Ed.): Novel trends in electroorganic synthesis - proceedings of the Second International Symposium on Electroorganic Synthesis, Kurashiki, September 27 - 30, 1994 and Pre-Symposium on Novel Aspects of Electrogenerated Active Species, Okayama, September 24 - 25. 1994, p. 99-102, Tokyo, 1994. |