Professeur Sorbonne Université
ENS – Département de chimie
24 rue Lhomond, 75005 Paris
Email: eric.labbe@ens.psl.eu
Phone: 0144322433
Office: E010
Short bio
Eric Labbé is an analytical electrochemist interested in the understanding of reactivity and transport issues related to biological molecules. He started studying electrosynthetic and electrocatalytic sequences in the group of Jacques Périchon at Université Paris Est (UPEC) until 2005. Since 2006, he is Professor at Sorbonne Université (SU) and his research topics focus on the exploration of drug metabolism as well as biomolecule distribution accross lipid membranes, through the electrochemical switching ON/OFF of fluorescent probes.
Education and professional experience
- Since 2006 Professor, Sorbonne Université
- 1992 – 2005 Maître de Conférences, IUFM de Créteil
- 1991 – 1992 Postdoc, Université Pierre et Marie Curie
- 1988 – 1991 PhD, Université Pierre et Marie Curie
Research interests
- Keywords : electrochemistry ; mechanisms ; metabolism ; transport
The journey of a biomolecule (drug, peptide,…) throughout a living organism from its generation -or administration- to its elimination encompasses namely metabolic processes and transport steps accross barriers. Eric Labbé is interested in delineating the metabolism of such molecules and the dynamics of their passage through lipid membranes, which are central considerations for both the identification of the active metabolites and the evaluation of their bio-availability. Within this topic, his research concerns the development of electrochemically switchable dual redox/fluorescent probes.
Teaching
- Engaged in the training and graduation of French middle and high-school teachers in physics & chemistry (Master MEEF) at ESPE de Paris.
- Engaged in the lifelong formation of chemistry teachers at Sorbonne Université
- Teaching Electrochemistry at École Normale Supérieure
Significant publications
- “The Fundamental Input of Analytical Electrochemistry in the Determination of Intermediates and Reaction Mechanisms in Electrosynthetic Processes.” ChemElectroChem Minireview, 2019, 6, 4118.
- “Redox switchable rhodamine-ferrocene dyad: Exploring imaging possibilities in cells” Electrochemistry Communications, 2018, 97, 46.
- “Selective Electrochemical Bleaching of the Outer Leaflet of Fluorescently Labelled Giant Liposomes” Chem. Eur.J., 2017, 23, 6781
- “Electrochemical Behavior of Plutonium in n-TriButylPhosphate” Dalton Trans., 2017, 46, 4943.
- “Monitoring and Quantifying the Passive Transport of Molecules Through Patch–Clamp Suspended Real and Model Cell Membranes “ Angew. Chem. Int Ed. , 2014, 53, 3192. Key Scientific Article of the Global Medical Discovery newsfeed.
Publications accessible from Open Access platforms /
- HAL Archive @ École Normale Supérieure
- HAL Archive @ Sorbonne Université
Publications ( full record)
2024 |
Electrochemical Behavior of Quinones Classically Used for Bioenergetical Applications: Considerations and Insights about the Anodic Side Article de journal ChemElectroChem, 11 (5), p. e202300542, 2024. |
Electrochemiluminescent imaging of a NADH-based enzymatic reaction confined within giant liposomes Article de journal Analytical and Bioanalytical Chemistry, p. 1–10, 2024. |
Interplay Between Molecular Electrochemistry and Light in Mechanistic Investigations Article de journal Current Opinion in Electrochemistry, p. 101613, 2024. |
Shadow electrochemiluminescence imaging of giant liposomes opening at polarized electrodes Article de journal Analyst, 2024. |
2023 |
Electrochemiluminescence imaging of liposome permeabilization by an antimicrobial peptide: melittin Article de journal Chemical & Biomedical Imaging, 1 (1), p. 58–65, 2023. |
Monitoring and Assessing Iridium-Promoted Photoredox Catalysis by Electrochemistry Article de journal ACS Catalysis, 13 (22), p. 14894–14906, 2023. |
2022 |
Dynamic electrochemiluminescence imaging of single giant liposome opening at polarized electrodes Article de journal Analytical Chemistry, 94 (3), p. 1686–1696, 2022. |
Electrode-supported and free-standing bilayer lipid membranes: Formation and uses in molecular electrochemistry Article de journal Electrochemical Science Advances, 2 (6), p. e2100170, 2022. |
Synthesis, Electrochemical and Fluorescence Properties of the First Fluorescent Member of the Ferrocifen Family and of Its Oxidized Derivatives Article de journal Molecules, 27 (19), p. 6690, 2022. |
2021 |
Electrochemical fluorescence switch of organic fluorescent or fluorogenic molecules Article de journal The Chemical Record, 21 (9), p. 2193–2202, 2021. |
Interaction of Redox Probes and Ferrocene-labelled Peptides with Lipid Bilayers Observed at Lipid Bilayer-Modified Electrodes Article de journal ChemElectroChem, 8 (13), p. 2556–2563, 2021. |
2020 |
Disclosing the redox metabolism of drugs: the essential role of electrochemistry Article de journal Current Opinion in Electrochemistry, 24 , p. 63–68, 2020. |
2019 |
A fluorescent false neurotransmitter as a dual electrofluorescent probe for secretory cell models Article de journal ChemPlusChem, 84 (10), p. 1578–1586, 2019. |
Cover Feature: Fundamental Input of Analytical Electrochemistry in the Determination of Intermediates and Reaction Mechanisms in Electrosynthetic Processes (ChemElectroChem 16/2019). Article de journal ChemElectroChem, 6 (16), 2019. |
Diverting photosynthetic electrons from suspensions of Chlamydomonas reinhardtii algae-New insights using an electrochemical well device Article de journal Electrochimica Acta, 304 , p. 465–473, 2019. |