Eric LABBE

Professeur Sorbonne Université

ENS – Département de chimie
24 rue Lhomond, 75005 Paris

Email: eric.labbe@ens.psl.eu
Phone: 0144322433
Office: E010

Short bio

Eric Labbé is an analytical electrochemist interested in the understanding of reactivity and transport issues related to biological molecules. He started studying  electrosynthetic and electrocatalytic sequences in the group of Jacques Périchon at Université Paris Est (UPEC) until 2005. Since 2006, he is Professor at Sorbonne Université (SU) and his research topics focus on the exploration of drug metabolism as well as biomolecule distribution accross lipid membranes, through the electrochemical switching ON/OFF of fluorescent probes.

 

Education and professional experience

  • Since 2006         Professor, Sorbonne Université
  • 1992 – 2005      Maître de Conférences, IUFM de Créteil
  • 1991 – 1992      Postdoc, Université Pierre et Marie Curie
  • 1988 – 1991      PhD, Université Pierre et Marie Curie

 

Research interests

  • Keywords : electrochemistry ; mechanisms ; metabolism ; transport

The journey of a biomolecule (drug, peptide,…) throughout a living organism from its generation -or administration- to its elimination encompasses namely metabolic processes and transport steps accross barriers. Eric Labbé is interested in delineating the metabolism of such molecules and the dynamics of their passage through lipid membranes, which are central considerations for both the identification of the active metabolites and the evaluation of their bio-availability. Within this topic, his research concerns the development of electrochemically switchable dual redox/fluorescent probes.

 

Teaching

 

Significant publications

 

  1.  “The Fundamental Input of Analytical Electrochemistry in the Determination of Intermediates and Reaction Mechanisms in Electrosynthetic Processes.” ChemElectroChem Minireview,  2019, 6, 4118.
  2. “Redox switchable rhodamine-ferrocene dyad: Exploring imaging possibilities in cells”  Electrochemistry Communications, 2018, 97,  46.
  3. “Selective Electrochemical Bleaching of the Outer Leaflet of Fluorescently Labelled Giant Liposomes”  Chem. Eur.J., 2017, 23, 6781
  4. “Electrochemical Behavior of Plutonium in n-TriButylPhosphate”  Dalton Trans., 2017, 46, 4943.
  5. “Monitoring and Quantifying the Passive Transport of Molecules Through Patch–Clamp Suspended Real and Model Cell Membranes “  Angew. Chem. Int Ed. , 2014, 53, 3192.  Key Scientific Article  of the Global Medical Discovery newsfeed.

 

Publications accessible from Open Access platforms   /

 

 

Publications ( full record)

  • Publons : click here
  • ORCID : click here
  • Google Scholar : click here
  • ResearchGate : click here
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2019

Eric Labbé; Olivier Buriez

Fundamental input of analytical electrochemistry in the determination of intermediates and reaction mechanisms in electrosynthetic processes Article de journal

ChemElectroChem, 6 (16), p. 4118–4125, 2019.

Hui Zhi Shirley Lee; François Chau; Siden Top; Gérard Jaouen; Anne Vessi`eres; Eric Labbé; Olivier Buriez

New mechanistic insights into osmium-based tamoxifen derivatives Article de journal

Electrochimica Acta, 302 , p. 130–136, 2019.

2018

Xiaoqing Liu; Lihui Hu; Na Pan; Laurence Grimaud; Eric Labbé; Olivier Buriez; Jér^ome Delacotte; Frédéric Lema^itre; Manon Guille-Collignon

Coupling electrochemistry and TIRF-microscopy with the fluorescent false neurotransmitter FFN102 supports the fluorescence signals during single vesicle exocytosis detection Article de journal

Biophysical chemistry, 235 , p. 48–55, 2018.

Martina Č'ižková; Laurent Cattiaux; Jean-Maurice Mallet; Eric Labbé; Olivier Buriez

Electrochemical switching fluorescence emission in rhodamine derivatives Article de journal

Electrochimica Acta, 260 , p. 589–597, 2018.

Louis Godeffroy; François Chau; Olivier Buriez; Eric Labbé

Fast and complete electrochemical conversion of solutes contained in micro-volume water droplets Article de journal

Electrochemistry Communications, 86 , p. 145–148, 2018.

Martina Č'ižková; Laurent Cattiaux; Justine Pandard; Manon Guille-Collignon; Frédéric Lema^itre; Jér^ome Delacotte; Jean-Maurice Mallet; Eric Labbé; Olivier Buriez

Redox switchable rhodamine-ferrocene dyad: Exploring imaging possibilities in cells Article de journal

Electrochemistry Communications, 97 , p. 46–50, 2018.

2017

Xiaoqing Liu; Alexandra Savy; Sylvie Maurin; Laurence Grimaud; François Darchen; Damien Quinton; Eric Labbé; Olivier Buriez; Jér^ome Delacotte; Frédéric Lema^itre; others

A dual functional electroactive and fluorescent probe for coupled measurements of vesicular exocytosis with high spatial and temporal resolution Article de journal

Angewandte Chemie International Edition, 56 (9), p. 2366–2370, 2017.

Mohamed Ali Bahri; Alexandre Ruas; Eric Labbé; Philippe Moisy

Electrochemical Characterization of Plutonium in n-Tributyl Phosphate Article de journal

Dalton Transactions, p. 4943-4949, 2017.

Raquel De Oliveira; Mathieu Durand; Lylian Challier; Pierluca Messina; Jean Marie Swiecicki; Margherita Di Pisa; Gérard Chassaing; Solange Lavielle; Olivier Buriez; Eric Labbé

Electrochemical quenching of the fluorescence produced by NBD-labelled cell penetrating peptides: A contribution to the study of their internalization in large unilamellar vesicles Article de journal

Journal of Electroanalytical Chemistry, 788 , p. 225–231, 2017.

Christian Amatore; Eric Labbé; Olivier Buriez

Molecular electrochemistry: A central method to understand the metabolic activation of therapeutic agents. The example of metallocifen anti-cancer drug candidates Article de journal

Current Opinion in Electrochemistry, 2 (1), p. 7–12, 2017.

Martina Č'ižková; Laurent Cattiaux; Jean-Maurice Mallet; Eric Labbé; Olivier Buriez

NBD-Ferrocene: A New Fluorescence Redox Molecular Switch Based on Photoinduced Electron Transfer Inproceedings

Electrochemical Society Meeting Abstracts 231, p. 1808–1808, The Electrochemical Society, Inc. 2017.

Martina Ä ~AÅ$3/4$kov~A; Laurent Cattiaux; Jean-Maurice Mallet; Eric Labbé; Olivier Buriez

NBD-Ferrocene: A New Fluorescence Redox Molecular Switch Based on Photoinduced Electron Transfer Inproceedings

231st ECS Meeting (May 28-June 1, 2017), ECS 2017.

Ana Isabel Perez Jimenez; Lylian Challier; Eric A"it-Yahiat`ene; Jér^ome Delacotte; Eric Labbé; Olivier Buriez

Selective electrochemical bleaching of the outer leaflet of fluorescently labeled giant liposomes Article de journal

Chemistry--A European Journal, 23 (28), p. 6781–6787, 2017.

Olivier Buriez; Ana Isabel Perez Jimenez; Lylian Challier; Eric Aït-Yahiatène; Jerome Delacotte; Eric Labbe

Selective Electrochemical Bleaching of the Outer Leaflet of Fluorescently Labelled Giant Liposomes Article de journal

Chemistry A European Journal, 23 , p. 6781-6787, 2017.

Christian Andre Amatore; Olivier Buriez; Eric Labbe

Understanding the Metabolic Activation of Therapeutic Agents with Molecular Electrochemistry: The Example of Metallocifen Anti-Cancer Drug Canditates Inproceedings

Electrochemical Society Meeting Abstracts 231, p. 1712–1712, The Electrochemical Society, Inc. 2017.

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