Post-doctorante
ENS – Département de chimie
24 rue Lhomond, 75005 Paris
Email: alison.tebo@ens.psl.eu
Phone: 0144322410
Office: ES129b
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Personal Website
Education and professional experience
- 2010 – B.S. UCLA, Biochemistry
- 2015 – Ph.D. University of Michigan, Chemical Biology
Research interests
- List of keywords and themes
Awards and distinctions
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Supervised students and post-doctorants
Significant publications
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Publications
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2015
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Variable Primary Coordination Environments of Cd(II) Binding to Three Helix Bundles Provide a Pathway for Rapid Metal Exchange. Article de journal Alison G Tebo; Lars Hemmingsen; Vincent L Pecoraro Metallomics, 7 (12), p. 1555-1561, 2015. @article{Tebo:2015,
title = {Variable Primary Coordination Environments of Cd(II) Binding to Three Helix Bundles Provide a Pathway for Rapid Metal Exchange.},
author = {Alison G Tebo and Lars Hemmingsen and Vincent L Pecoraro},
doi = {10.1039/c5mt00228a},
year = {2015},
date = {2015-01-01},
journal = {Metallomics},
volume = {7},
number = {12},
pages = {1555-1561},
abstract = {Members of the ArsR/SmtB family of transcriptional repressors, such as CadC, regulate the intracellular levels of heavy metals like Cd(II), Hg(II), and Pb(II). These metal sensing proteins bind their target metals with high specificity and affinity, however, a lack of structural information about these proteins makes defining the coordination sphere of the target metal difficult. Lingering questions as to the identity of Cd(II) coordination in CadC are addressed via protein design techniques. Two designed peptides with tetrathiolate metal binding sites were prepared and characterized, revealing fast exchange between CdS3O and CdS4 coordination spheres. Correlation of (111m)Cd PAC spectroscopy and (113)Cd NMR spectroscopy suggests that Cd(II) coordinated to CadC is in fast exchange between CdS3O and CdS4 forms, which may provide a mechanism for rapid sensing of heavy metal contaminants by this regulatory protein.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Members of the ArsR/SmtB family of transcriptional repressors, such as CadC, regulate the intracellular levels of heavy metals like Cd(II), Hg(II), and Pb(II). These metal sensing proteins bind their target metals with high specificity and affinity, however, a lack of structural information about these proteins makes defining the coordination sphere of the target metal difficult. Lingering questions as to the identity of Cd(II) coordination in CadC are addressed via protein design techniques. Two designed peptides with tetrathiolate metal binding sites were prepared and characterized, revealing fast exchange between CdS3O and CdS4 coordination spheres. Correlation of (111m)Cd PAC spectroscopy and (113)Cd NMR spectroscopy suggests that Cd(II) coordinated to CadC is in fast exchange between CdS3O and CdS4 forms, which may provide a mechanism for rapid sensing of heavy metal contaminants by this regulatory protein. |
2014
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Porphyrins and Metalloporphyrins at Components in Artificial Photosynthesis Research incollection A Tebo; C Herrero; A Aukauloo Kadish, Karl M; Smith, Kevin M; Guilard, Roger (Ed.): Handbook of Porphyrin Science, 34 , p. 196-233, World Scientific Pulishing, Singapore, 2014, ISBN: 978-981-4425-10-0. @incollection{Tebo:2014,
title = {Porphyrins and Metalloporphyrins at Components in Artificial Photosynthesis Research},
author = {A Tebo and C Herrero and A Aukauloo},
editor = {Karl M Kadish and Kevin M Smith and Roger Guilard},
doi = {10.1142/9789814417297_0016},
isbn = {978-981-4425-10-0},
year = {2014},
date = {2014-01-01},
booktitle = {Handbook of Porphyrin Science},
volume = {34},
pages = {196-233},
publisher = {World Scientific Pulishing},
address = {Singapore},
keywords = {},
pubstate = {published},
tppubtype = {incollection}
}
|
Protein Design: Toward Functional Metalloenzymes. Article de journal Fangting Yu; Virginia M Cangelosi; Melissa L Zastrow; Matteo Tegoni; Jefferson S Plegaria; Alison G Tebo; Catherine S Mocny; Leela Ruckthong; Hira Qayyum; Vincent L Pecoraro Chemical reviews, 114 (7), p. 3495-3578, 2014. @article{Yu:2014,
title = {Protein Design: Toward Functional Metalloenzymes.},
author = {Fangting Yu and Virginia M Cangelosi and Melissa L Zastrow and Matteo Tegoni and Jefferson S Plegaria and Alison G Tebo and Catherine S Mocny and Leela Ruckthong and Hira Qayyum and Vincent L Pecoraro},
doi = {10.1021/cr400458x},
year = {2014},
date = {2014-04-01},
journal = {Chemical reviews},
volume = {114},
number = {7},
pages = {3495-3578},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
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