Agathe ESPAGNE

Chargée de recherche CNRS – Maître de conférences attachée à l’ENS

ENS – Département de chimie
24 rue Lhomond, 75005 Paris

Email: agathe.espagne@ens.psl.eu
Phone: 0144322413
Office: E121

ORCID: 0000-0002-2333-0227 (link)

Research interests

  • Photochemical mechanisms in light-sensitive proteins and molecules: cis/trans photoisomerization, photoinduced electron and proton transfer…
  • Fluorescent proteins: photophysics, photochemistry, engineering, applications
  • Time-resolved spectroscopy: transient absorption, time-resolved fluorescence, femtosecond to millisecond timescales

Short bio

Agathe Espagne studied chemistry at ENS in Paris. She specialized in mechanistic photochemistry and femtosecond transient absorption spectroscopy as a graduate student in the group of Monique Martin, studying the cis/trans photoisomerization of photoactive protein PYP. She received her PhD degree in physical chemistry in 2005. She was then trained in femtosecond fluorescence spectroscopy in the group of Ahmed H. Zewail at Caltech, and in femtosecond IR spectroscopy in the group of Thomas Elsaesser at MBI Berlin. In 2006 she joined the group of Klaus Brettel at CEA-Saclay, where she investigated photoinduced electron transfer in flavoproteins with transient absorption spectroscopy on subnanosecond to millisecond timescales. She was recruited by CNRS as a permanent researcher in 2007 and focussed then her research on fluorescent proteins photophysics, photochemistry, engineering and applications. First member of LCP in Orsay, she moved to ENS in 2012.

Publications

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2011

Relationship between Homo-Oligomerization of a Mammalian Olfactory Receptor and Its Activation State Demonstrated by Bioluminescence Resonance Energy Transfer Article de journal

F Wade; A Espagne; M A Persuy; J Vidic; R Monnerie; F Merola; E Pajot-Augy; G Sanz

Journal of Biological Chemistry, 286 (17), p. 15252-15259, 2011, ISSN: 0021-9258.

2010

DNA Repair by Photolyase: A Novel Substrate with Low Background Absorption around 265 Nm for Transient Absorption Studies in the UV Article de journal

V Thiagarajan; S Villette; A Espagne; A P M Eker; K Brettel; M Byrdin

Biochemistry, 49 (2), p. 297-303, 2010, ISSN: 0006-2960.

2009

Use of Ruthenium Dyes for Subnanosecond Detector Fidelity Testing in Real Time Transient Absorption Article de journal

M Byrdin; V Thiagarajan; S Villette; A Espagne; K Brettel

Review of Scientific Instruments, 80 (4), p. 5, 2009, ISSN: 0034-6748.

Very Fast Product Release and Catalytic Turnover of DNA Photolyase Article de journal

A Espagne; M Byrdin; A P M Eker; K Brettel

Chembiochem, 10 (11), p. 1777-1780, 2009, ISSN: 1439-4227.

2008

Polarized Transient Absorption to Resolve Electron Transfer between Tryptophans in DNA Photolyase Article de journal

M Byrdin; S Villette; A Espagne; A P M Eker; K Brettel

Journal of Physical Chemistry B, 112 (22), p. 6866-6871, 2008, ISSN: 1520-6106.

Ultrafast photochemical processes: From the lab to natural photoactive systems Article de journal

M M Martin; P Plaza; P Changenet-Barret; A Espagne; M Mahet; C Ley; F Lacombat

Actualite Chimique, (320-321), p. 14–19, 2008.

2007

Photoinduced charge shift as the driving force for the excited-state relaxation of analogues of the Photoactive Yellow Protein chromophore in solution Article de journal

A Espagne; P Changenet-Barret; J -B Baudin; P Plaza; M M Martin

Journal of Photochemistry and Photobiology A: Chemistry, 185 (2-3), p. 245-252, 2007, ISSN: 1010-6030.

Ultrafast light-induced response of photoactive yellow protein chromophore analogues Article de journal

A Espagne; D H Paik; P Changenet-Barret; P Plaza; M M Martin; A H Zewail

Photochemical and Photobiological Sciences, 6 (7), p. 780–787, 2007.

Ultrafast Structural Dynamics of Water Induced by Dissipation of Vibrational Energy Article de journal

S Ashihara; N Huse; A Espagne; E T J Nibbering; T Elsaesser

Journal of Physical Chemistry A, 111 (5), p. 743-746, 2007, ISSN: 1089-5639.

2006

Excited-state dynamics of the PYP chromophore in solution. Environment and structure effects Inproceedings

A Espagne; P Changenet-Barret; J -B Baudin; P Plaza; M M Martin

Jr, Castleman A W; Kimble, M L (Ed.): VIIth International Conference on Femtochemistry, p. 204-214, Elsevier, 2006.

Solvent effect on the excited-state dynamics of analogues of the photoactive Yellow Protein chromophore Article de journal

A Espagne; P Changenet-Barret; P Plaza; M M Martin

Journal of Physical Chemistry A, 110 (10), p. 3393–3404, 2006.

Ultrafast photoisomerization of photoactive yellow protein chromophore analogues in solution: Influence of the protonation state Article de journal

A Espagne; D H Paik; P Changenet-Barret; M M Martin; A H Zewail

ChemPhysChem, 7 (8), p. 1717–1726, 2006.

Vibrational Couplings and Ultrafast Relaxation of the O-Ħ Bending Mode in Liquid H2O Article de journal

S Ashihara; N Huse; A Espagne; E T J Nibbering; T Elsaesser

Chemical Physics Letters, 424 (1-3), p. 66-70, 2006, ISSN: 0009-2614.

2005

Investigations of the primary events in a bacterial photoreceptor for photomotility: Photoactive yellow protein (PYP) Article de journal

P Changenet-Barret; A Espagne; P Plaza; K J Hellingwerf; M M Martin

New Journal of Chemistry, 29 (4), p. 527–534, 2005.

2004

Chemical structure effect on the excited-state relaxation dynamics of the PYP chromophore Inproceedings

A Espagne; P Changenet-Barret; S Charier; J -B Baudin; L Jullien; P Plaza; M M Martin

Martin, M M; Hynes, J T (Ed.): VIth International Conference on Femtochemistry, p. 421-424, Elsevier, 2004.

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