Yong CHEN

Directeur de recherche (DR1 CNRS)

ENS – Département de chimie
24 rue Lhomond, 75005 Paris

Email: yong.chen@ens.psl.eu
Phone: +33 144322241
Office: E108

Understanding and regulating the natural systems at cellular levels is of particular interesting for disease modeling, drug screening, diagnosis and regenerative medicine. By developing consistently artificial basement membranes, microfluidic and pluripotent stem cell technologies, advanced in-vitro models of human tissues/organoids can be created, which mimic our sophisticated in-vivo systems.

Short bio

He received a B.S. degree in condensed matter physics from Wuhan University (1982) and  both M.S. and Ph.D. degrees from the University of Montpelier (1983 and 1986). After spent three years at the Scuola Normale Superiorie di Pisa and Peking University, he joined the Centre National de Recherche Scientifique (CNRS) as Chargé de Recherche (1st class) in 1990 to work at the Laboratoire  de Microstructures et de Microélectronique (L2M). In 1998, he became a Directeur de Recherche (2nd class) of CNRS. In 2003, he moved to the Ecole Normale Supérieure (ENS) as Professor and he is now Directeur de Recherche (1st class) of CNRS and head of the ENS team for microfluidics. In the past, he also served as Adjunct Professor at the Institute for Integrated Cell-Material Sciences (iCeMS) of Kyoto University, Changjiang Chair Professor of Peking University, Distinguished Chair Professor of Hong Kong Polytechnic University and Guess professor of Jianghan University.

Research interests

He has been worked in different fields, including semiconductor quantum heterostructures, photonic crystals, scanning near field optical microscopy, magnetic nanostructures, synchrotron based X-ray lithography, thermal and UV nanoimprint lithography, microfluidics, etc. His current interests are mainly in the field of biomedical research and applications such as cancer diagnosis and stem cell devices for in-vitro modeling of cardiac,  neural and alveolar systems.

He has contributed to more than 500 scientific publications (peer-reviewed journals, book chapters and proceeding articles) and a large number of European and national research projects/networks. He is member of several international or national committees and reviewer of a number of journals. In total, he has supervised more than 50 Ph.D and post-doc studies.

Publications

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2010

High resolution and hybrid patterning for single cell attachment Article de journal

J Hu; J Shi; F Zhang; L Lei; X Li; L Wang; L Liu; Y Chen

Microelectronic engineering, 87 (5-8), p. 726–729, 2010.

Laser emission from dye doped microspheres produced on a chip Article de journal

H Li; L Lei; Q Zeng; J Shi; CX Luo; H Ji; Q Ouyang; Y Chen

Sensors and Actuators B: Chemical, 145 (1), p. 570–574, 2010.

Micro-pressure sensor made of conductive PDMS for microfluidic applications Article de journal

H Li; CX Luo; H Ji; Qi Ouyang; Y Chen

Microelectronic engineering, 87 (5-8), p. 1266–1269, 2010.

2009

Patterning bio-molecules for cell attachment at single cell levels in PDMS microfluidic chips Article de journal

L Wang; L Lei; XF Ni; J Shi; Y Chen

Microelectronic engineering, 86 (4-6), p. 1462–1464, 2009.

Osteogenic differentiation of human mesenchymal stem cells on chip: A comparison between two nutrient feeding methods Article de journal

F Zhang; Luc Sensébé; YL Zhou; CJ Lin; Y Chen

Microelectronic engineering, 86 (4-6), p. 1459–1461, 2009.

Microcontact printing and lithographic patterning of electrospun nanofibers Article de journal

J Shi; L Wang; Y Chen

Langmuir, 25 (11), p. 6015–6018, 2009.

Bilayer transparent molds for high resolution soft UV nanoimprint lithography Article de journal

D Decanini; J Shi; J Chen; E Cambril; Y Chen; A Haghiri-gosnet

Scanning Electrone Microsc, p. 3–4, 2009.

Fabrication of metallic nanocavities by soft UV nanoimprint lithography Article de journal

J Shi; J Chen; D Decanini; Y Chen; A-M Haghiri-Gosnet

Microelectronic engineering, 86 (4-6), p. 596–599, 2009.

Generation of Janus alginate hydrogel particles with magnetic anisotropy for cell encapsulation Article de journal

LB Zhao; L Pan; K Zhang; SS Guo; W Liu; Y Wang; Y Chen; XZ Zhao; HLW Chan

Lab on a Chip, 9 (20), p. 2981–2986, 2009.

Hydrodynamic focusing controlled microfluidic laser emission Article de journal

L Lei; YL Zhou; Y Chen

Microelectronic engineering, 86 (4-6), p. 1358–1360, 2009.

2008

On-chip differentiation of human mesenchymal stem cells into adipocytes Article de journal

XF Ni; C Crozatier; L Sensebe; A Langonne; L Wang; Y Fan; PG He; Y Chen

Microelectronic Engineering, 85 (5-6), p. 1330–1333, 2008.

All-optical switching in 2D silicon photonic crystals with low loss waveguides and optical cavities Article de journal

M Belotti; J F Galisteo-López; S De Angelis; M Galli; I Maksymov; L C Andreani; D Peyrade; Y Chen

Optics Express, 16 (15), p. 11624–11636, 2008.

Multi-reflection based on chip label free molecules detection Article de journal

L Billot; A Plecis; Y Chen

Microelectronic engineering, 85 (5-6), p. 1269–1271, 2008.

Microfluidic devices for optical determination of ethanol concentration Article de journal

L Lei; IL Mattos; Y Chen

Microelectronic engineering, 85 (5-6), p. 1318–1320, 2008.

Magnetization reversal and vortex chirality correlation in ferromagnetic dot arrays Article de journal

M Natali; Y Chen

Electromagnetic, Magnetostatic, and Exchange-interaction Vortices in Confined Magnetic Structures (ISBN 9788178953731), 2008.

Local nanofluidic light sources in silicon photonic crystal microcavities Article de journal

S Vignolini; F Riboli; F Intonti; M Belotti; M Gurioli; Y Chen; M Colocci; L C Andreani; D S Wiersma

Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, 78 (4), 2008.

Integration of ultrasonic transducers in fast prototyping microfluidic devices Article de journal

SS Guo; Sien Ting Lau; KH Lam; YL Deng; XZ Zhao; Y Chen; Helen LW Chan

Journal of applied physics, 103 (9), p. 094701, 2008.

Integrating whole transcriptome assays on a lab-on-a-chip for single cell gene profiling Article de journal

N Bontoux; L Dauphinot; T Vitalis; V Studer; Y Chen; J Rossier; MC Potier

Lab on a Chip, 8 (3), p. 443–450, 2008.

Glass-based nanofluidic device for biomolecule preconcentration study Article de journal

P Svarnas; A Plecis; C Nanteuil; D Duong; C David; M Muller; Y Chen

The European Physical Journal Applied Physics, 44 (3), p. 245–253, 2008.

Ultrasonic particle trapping in microfluidic devices using soft lithography Article de journal

SS Guo; LB Zhao; K Zhang; KH Lam; Sien Ting Lau; XZ Zhao; Yu Wang; Helen LW Chan; Y Chen; D Baigl

Applied physics letters, 92 (21), p. 213901, 2008.

2007

Characterization of microfluidic fuel cell based on multiple laminar flow Article de journal

MH Sun; Velve G Casquillas; SS Guo; J Shi; H Ji; Q Ouyang; Y Chen

Microelectronic Engineering, 84 (5-8), p. 1182–1185, 2007.

Micro-aspiration assisted lithography Article de journal

M Le Berre; J Shi; C Crozatier; Velve G Casquillas; Y Chen

Microelectronic engineering, 84 (5-8), p. 864–867, 2007.

Patterning of hydrophilic micro arrays with superhydrophobic surrounding zones Article de journal

SS Guo; MH Sun; J Shi; YJ Liu; WH Huang; C Combellas; Y Chen

Microelectronic engineering, 84 (5-8), p. 1673–1676, 2007.

Patterning biomolecules with a water-soluble release and protection interlayer Article de journal

J Shi; XF Ni; Y Chen

Langmuir, 23 (23), p. 11377–11380, 2007.

Microlitre hot strip devices for thermal characterization of nanofluids Article de journal

Velve G Casquillas; M Le Berre; C Peroz; Y Chen; Jean-Jacques Greffet

Microelectronic engineering, 84 (5-8), p. 1194–1197, 2007.

Microfluidic cooling of semiconductor light emission diodes Article de journal

ZM Wang; K Bao; LP Xu; CX Luo; B Zhang; H Ji; Q Ouyang; Y Chen

Microelectronic engineering, 84 (5-8), p. 1223–1226, 2007.

Highly parallel mix-and-match fabrication of nanopillar arrays integrated in microfluidic channels for long DNA molecule separation Article de journal

J Shi; AP Fang; L Malaquin; A Pepin; D Decanini; JL Viovy; Y Chen

Applied Physics Letters, 91 (15), p. 153114, 2007.

Fabrication and surface functionalization of high aspect ratio plastic nanostructures Article de journal

J Shi; C Peroz; Velve G Casquillas; A Pepin; M Belotti; LP Xu; D Peyrade; Y Chen

Microelectronic engineering, 84 (5-8), p. 1724–1728, 2007.

Fabrication of integrated patterns using lithography and particles assembling techniques Article de journal

J Shi; SS Guo; MH Sun; D Baigl; Y Chen

Microelectronic engineering, 84 (5-8), p. 1471–1475, 2007.

Reactive ion etching of high optical quality GaN/ sapphire photonic crystal slab using CH 4--H 2 chemistry Article de journal

S Bouchoule; S Boubanga-Tombet; L Le Gratiet; M Le Vassor d’Yerville; J Torres; Y Chen; D Coquillat

Journal of applied physics, 101 (4), p. 043103, 2007.

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