Directeur de recherche (DR1 CNRS)

ENS – Département de chimie
24 rue Lhomond, 75005 Paris

Email: yong.chen@ens.psl.eu
Phone: +33 144322241
Office: E108

Understanding and regulating the natural systems at cellular levels is of particular interesting for disease modeling, drug screening, diagnosis and regenerative medicine. By developing consistently artificial basement membranes, microfluidic and pluripotent stem cell technologies, advanced in-vitro models of human tissues/organoids can be created, which mimic our sophisticated in-vivo systems.

Short bio

He received a B.S. degree in condensed matter physics from Wuhan University (1982) and  both M.S. and Ph.D. degrees from the University of Montpelier (1983 and 1986). After spent three years at the Scuola Normale Superiorie di Pisa and Peking University, he joined the Centre National de Recherche Scientifique (CNRS) as Chargé de Recherche (1st class) in 1990 to work at the Laboratoire  de Microstructures et de Microélectronique (L2M). In 1998, he became a Directeur de Recherche (2nd class) of CNRS. In 2003, he moved to the Ecole Normale Supérieure (ENS) as Professor and he is now Directeur de Recherche (1st class) of CNRS and head of the ENS team for microfluidics. In the past, he also served as Adjunct Professor at the Institute for Integrated Cell-Material Sciences (iCeMS) of Kyoto University, Changjiang Chair Professor of Peking University, Distinguished Chair Professor of Hong Kong Polytechnic University and Guess professor of Jianghan University.

Research interests

He has been worked in different fields, including semiconductor quantum heterostructures, photonic crystals, scanning near field optical microscopy, magnetic nanostructures, synchrotron based X-ray lithography, thermal and UV nanoimprint lithography, microfluidics, etc. His current interests are mainly in the field of biomedical research and applications such as cancer diagnosis and stem cell devices for in-vitro modeling of cardiac,  neural and alveolar systems.

He has contributed to more than 500 scientific publications (peer-reviewed journals, book chapters and proceeding articles) and a large number of European and national research projects/networks. He is member of several international or national committees and reviewer of a number of journals. In total, he has supervised more than 50 Ph.D and post-doc studies.


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Substrate elasticity dependent colony formation and cardiac differentiation of human induced pluripotent stem cells Article de journal

B Wang; X Tu; J Wei; L Wang; Y Chen

Biofabrication, 11 (1), 2019.

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Fabrication of spaced monolayers of electrospun nanofibers for three-dimensional cell infiltration and proliferation Article de journal

B Wang; L Wang; Y Tang; J Shi; J Wei; X Tu; Y Chen

Microelectronic Engineering, 198 , p. 73–77, 2018.

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Electro-capture of heavy metal ions with carbon cloth integrated microfluidic devices Article de journal

F -M Allioux; P Kapruwan; N Milne; L Kong; J Fattaccioli; Y Chen; L F Dumée

Separation and Purification Technology, 194 , p. 26–32, 2018.

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Highly sensitive and ultra-fast gas sensor based on CeO2-loaded In2O3 hollow spheres for ppb-level hydrogen detection Article de journal

J Hu; Y Sun; Y Xue; M Zhang; P Li; K Lian; S Zhuiykov; W Zhang; Y Chen

Sensors and Actuators, B: Chemical, 257 , p. 124–135, 2018.

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Fluorescent Determination of Glucose Using Silicon Nanodots Article de journal

C Chen; Y Zhang; Z Zhang; R He; Y Chen

Analytical Letters, 51 (18), p. 2895–2905, 2018.

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Improved neuron culture using scaffolds made of three-dimensional PDMS micro-lattices Article de journal

S Li; F P U Severino; J Ban; L Wang; G Pinato; V Torre; Y Chen

Biomedical Materials (Bristol), 13 (3), 2018.

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TiO2 Nanorod Arrays with Mesoscopic Micro-Nano Interfaces for in Situ Regulation of Cell Morphology and Nucleus Deformation Article de journal

H Liu; M Ruan; J Xiao; Z Zhang; C Chen; W Zhang; Y Cao; R He; Y Liu; Y Chen

ACS Applied Materials and Interfaces, 10 (1), p. 66–74, 2018.

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Synthesis and gas sensing properties of NiO/SnO2 hierarchical structures toward ppb-level acetone detection Article de journal

J Hu; J Yang; W Wang; Y Xue; Y Sun; P Li; K Lian; W Zhang; L Chen; J Shi; Y Chen

Materials Research Bulletin, 102 , p. 294–303, 2018.

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Fabrication of PLGA nanofibers on PDMS micropillars for neuron culture studies Article de journal

J Wei; D Pozzi; F P Ulloa Severino; V Torre; Y Chen

Microelectronic Engineering, 175 , p. 67–72, 2017.

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Integrated heart/cancer on a chip to reproduce the side effects of anti-cancer drugs: In vitro Article de journal

K -I Kamei; Y Kato; Y Hirai; S Ito; J Satoh; A Oka; T Tsuchiya; Y Chen; O Tabata

RSC Advances, 7 (58), p. 36777–36786, 2017.

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Human Pluripotent Stem Cell-Derived Cardiac Tissue-like Constructs for Repairing the Infarcted Myocardium Article de journal

J Li; I Minami; M Shiozaki; L Yu; S Yajima; S Miyagawa; Y Shiba; N Morone; S Fukushima; M Yoshioka; S Li; J Qiao; X Li; L Wang; H Kotera; N Nakatsuji; Y Sawa; Y Chen; L Liu

Stem Cell Reports, 9 (5), p. 1546–1559, 2017.

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Patterned parylene C for cell adhesion, spreading and alignment studies Article de journal

X Tu; J Wei; B Wang; Y Tang; J Shi; Y Chen

Microelectronic Engineering, 175 , p. 56–60, 2017.

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Patch method for culture of primary hippocampal neurons Article de journal

Y Tang; F P Ulloa Severino; F Iseppon; V Torre; Y Chen

Microelectronic Engineering, 175 , p. 61–66, 2017.

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Visible-light-controllable drug release from multilayer-coated microneedles Article de journal

Z Zheng; H Ye; J Wang; T Zhang; Q You; H Li; R He; Y Chen; W Zhang; Y Cao

Journal of Materials Chemistry B, 5 (34), p. 7014–7017, 2017.

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Synthesis and gas sensing properties of molybdenum oxide modified tungsten oxide microstructures for ppb-level hydrogen sulphide detection Article de journal

J Hu; Y Sun; X Wang; L Chen; W Zhang; Y Chen

RSC Advances, 7 (45), p. 28542–28547, 2017.

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Artificial honeycomb-inspired TiO2 nanorod arrays with tunable nano/micro interfaces for improving poly(dimethylsiloxane) surface hydrophobicity Article de journal

R He; J Xiao; M Zhang; Z Zhang; W Zhang; Y Cao; Y Liu; Y Chen

Journal of Materials Science, 51 (6), p. 2935–2941, 2016.

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Agarose multi-wells for tumour spheroid formation and anti-cancer drug test Article de journal

Y Tang; J Liu; Y Chen

Microelectronic Engineering, 158 , p. 41–45, 2016.

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3D printed PEGDA microstructures for gelatin scaffold integration and neuron differentiation Article de journal

X Tu; L Wang; J Wei; B Wang; Y Tang; J Shi; Z Zhang; Y Chen

Microelectronic Engineering, 158 , p. 30–34, 2016.

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Fabrication of adjacent micropillar arrays with different heights for cell studies Article de journal

J Wei; J Shi; B Wang; Y Tang; X Tu; E Roy; B Ladoux; Y Chen

Microelectronic Engineering, 158 , p. 22–25, 2016.

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Effective motor neuron differentiation of hiPSCs on a patch made of crosslinked monolayer gelatin nanofibers Article de journal

Y Tang; L Liu; J Li; L Yu; F P U Severino; L Wang; J Shi; X Tu; V Torre; Y Chen

Journal of Materials Chemistry B, 4 (19), p. 3305–3312, 2016.

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Induction and differentiation of human induced pluripotent stem cells into functional cardiomyocytes on a compartmented monolayer of gelatin nanofibers Article de journal

Y Tang; L Liu; J Li; L Yu; L Wang; J Shi; Y Chen

Nanoscale, 8 (30), p. 14530–14540, 2016.

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Luminescent and absorptive metal-coated emulsions for micro-velocimetry Article de journal

O Mesdjian; Y Chen; J Fattaccioli

Microelectronic Engineering, 158 , p. 69–74, 2016.

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Nanometric emulsions encapsulating solid particles as alternative carriers for intracellular delivery Article de journal

S Quignard; G Frébourg; Y Chen; J Fattaccioli

Nanomedicine, 11 (16), p. 2059–2072, 2016.

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On-chip quantitative measurement of mechanical stresses during cell migration with emulsion droplets Article de journal

D Molino; S Quignard; C Gruget; F Pincet; Y Chen; M Piel; J Fattaccioli

Scientific Reports, 6 , 2016.

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A bottom-up approach to dual shape-memory effects Article de journal

J Wang; J Li; N Li; X Guo; L He; X Cao; W Zhang; R He; Z Qian; Y Cao; Y Chen

Chemistry of Materials, 27 (7), p. 2439–2448, 2015.

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Fabrication of cardiac patch by using electrospun collagen fibers Article de journal

M Kitsara; P Joanne; S E Boitard; I Ben Dhiab; B Poinard; P Menasché; C Gagnieu; P Forest; O Agbulut; Y Chen

Microelectronic Engineering, 144 , p. 46–50, 2015.

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PDMS micropillar-based microchip for efficient cancer cell capture Article de journal

J Xiao; W He; Z Zhang; W Zhang; Y Cao; R He; Y Chen

RSC Advances, 5 (64), p. 52161–52166, 2015.

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Phagocytosis of immunoglobulin-coated emulsion droplets Article de journal

K Ben M'Barek; D Molino; S Quignard; M -A Plamont; Y Chen; P Chavrier; J Fattaccioli

Biomaterials, 51 , p. 270–277, 2015.

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One-step electroplating 3D template with gradient height to enhance micromixing in microfluidic chips Article de journal

W He; J Xiao; Z Zhang; W Zhang; Y Cao; R He; Y Chen

Microfluidics and Nanofluidics, 19 (4), p. 829–836, 2015.

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Fluorescent microparticles fabricated through chemical coating of O/W emulsion droplets with a thin metallic film Article de journal

G M Nocera; K Ben M'Barek; D G Bazzoli; G Fraux; M Bontems-Van Heijenoort; J Chokki; S Georgeault; Y Chen; J Fattaccioli

RSC Advances, 4 (23), p. 11564–11568, 2014.

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