2015
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PDMS micropillar-based microchip for efficient cancer cell capture Article de journal J Xiao; W He; Z Zhang; W Zhang; Y Cao; R He; Y Chen RSC Advances, 5 (64), p. 52161–52166, 2015. @article{Xiao:2015,
title = {PDMS micropillar-based microchip for efficient cancer cell capture},
author = {J Xiao and W He and Z Zhang and W Zhang and Y Cao and R He and Y Chen},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84934994300&doi=10.1039%2fc5ra04353k&partnerID=40&md5=5ec3cf585d43549d8144c5bc9928a633},
doi = {10.1039/c5ra04353k},
year = {2015},
date = {2015-01-01},
journal = {RSC Advances},
volume = {5},
number = {64},
pages = {52161--52166},
abstract = {We introduce a micropillar-based microfluidic device for efficient and rapid cancer cell capture. The microfluidic chip consists of two linear arrays of micropillars integrated with a herringbones flow-derived microstructure, and the separation distance between two adjacent micropillars is similar to the size of tumor cells. Cancer cells can be forced to come into contact with the micro-columns and are then captured by specific immune antibody-antigen interactions. Both previously published data and new available experimental data confirm the superiority of the proposed device. Different cancer cell lines were utilized to investigate the capture efficiency of our microfluidic device. MCF-7 cancer cells spiked into DMEM culture medium can be captured from a suspension with over 90% efficiency. The results of the present work provide a promising method for separation of rare cells, such as circulating tumor or fetal cells. © The Royal Society of Chemistry.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
We introduce a micropillar-based microfluidic device for efficient and rapid cancer cell capture. The microfluidic chip consists of two linear arrays of micropillars integrated with a herringbones flow-derived microstructure, and the separation distance between two adjacent micropillars is similar to the size of tumor cells. Cancer cells can be forced to come into contact with the micro-columns and are then captured by specific immune antibody-antigen interactions. Both previously published data and new available experimental data confirm the superiority of the proposed device. Different cancer cell lines were utilized to investigate the capture efficiency of our microfluidic device. MCF-7 cancer cells spiked into DMEM culture medium can be captured from a suspension with over 90% efficiency. The results of the present work provide a promising method for separation of rare cells, such as circulating tumor or fetal cells. © The Royal Society of Chemistry. |
Phagocytosis of immunoglobulin-coated emulsion droplets Article de journal K Ben M'Barek; D Molino; S Quignard; M -A Plamont; Y Chen; P Chavrier; J Fattaccioli Biomaterials, 51 , p. 270–277, 2015. @article{BenMBarek:2015,
title = {Phagocytosis of immunoglobulin-coated emulsion droplets},
author = {K Ben M'Barek and D Molino and S Quignard and M -A Plamont and Y Chen and P Chavrier and J Fattaccioli},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84924916623&doi=10.1016%2fj.biomaterials.2015.02.030&partnerID=40&md5=94df848ca153367029941c2f412fd8bf},
doi = {10.1016/j.biomaterials.2015.02.030},
year = {2015},
date = {2015-01-01},
journal = {Biomaterials},
volume = {51},
pages = {270--277},
abstract = {Phagocytosis by macrophages represents a fundamental process essential for both immunity and tissue homeostasis. The size of targets to be eliminated ranges from small particles as bacteria to large objects as cancerous or senescent cells. Most of our current quantitative knowledge on phagocytosis is based on the use of solid polymer microparticles as model targets that are well adapted to the study of phagocytosis mechanisms that do not involve any lateral mobility of the ligands, despite the relevance of this parameter in the immunological context. Herein we designed monodisperse, IgG-coated emulsion droplets that are efficiently and specifically internalized by macrophages through in-vitro FcγR-mediated phagocytosis. We show that, contrary to solid polymeric beads, droplet uptake is efficient even for low IgG densities, and is accompagnied by the clustering of the opsonins in the zone of contact with the macrophage during the adhesion step. Beyond the sole interest in the design of the material, our results suggest that lateral mobility of proteins at the interface of a target greatly enhances the phagocytic uptake. © 2015 Elsevier Ltd.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Phagocytosis by macrophages represents a fundamental process essential for both immunity and tissue homeostasis. The size of targets to be eliminated ranges from small particles as bacteria to large objects as cancerous or senescent cells. Most of our current quantitative knowledge on phagocytosis is based on the use of solid polymer microparticles as model targets that are well adapted to the study of phagocytosis mechanisms that do not involve any lateral mobility of the ligands, despite the relevance of this parameter in the immunological context. Herein we designed monodisperse, IgG-coated emulsion droplets that are efficiently and specifically internalized by macrophages through in-vitro FcγR-mediated phagocytosis. We show that, contrary to solid polymeric beads, droplet uptake is efficient even for low IgG densities, and is accompagnied by the clustering of the opsonins in the zone of contact with the macrophage during the adhesion step. Beyond the sole interest in the design of the material, our results suggest that lateral mobility of proteins at the interface of a target greatly enhances the phagocytic uptake. © 2015 Elsevier Ltd. |
One-step electroplating 3D template with gradient height to enhance micromixing in microfluidic chips Article de journal W He; J Xiao; Z Zhang; W Zhang; Y Cao; R He; Y Chen Microfluidics and Nanofluidics, 19 (4), p. 829–836, 2015. @article{He:2015,
title = {One-step electroplating 3D template with gradient height to enhance micromixing in microfluidic chips},
author = {W He and J Xiao and Z Zhang and W Zhang and Y Cao and R He and Y Chen},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84942982402&doi=10.1007%2fs10404-015-1607-z&partnerID=40&md5=8c49a05eae58ea4957e3dcdf4666e6f3},
doi = {10.1007/s10404-015-1607-z},
year = {2015},
date = {2015-01-01},
journal = {Microfluidics and Nanofluidics},
volume = {19},
number = {4},
pages = {829--836},
abstract = {A cost-effective method that used electroplating to fabricate a 3D polydimethylsiloxane (PDMS) passive micromixer was developed in this work. The mixer fabrication process characteristics were as follows: The chip design was transferred to indium tin oxide (ITO) glass via photolithography; the ITO glass was vertically immersed in a nickel electroplating solution; and the ITO glass was raised up by controlling by the syringe pump, while electroplating was in progress. In this method, the height of the mixing structure could increase gradient from 15 to 30 μm. Compared with a flat structure, this structure could increase mixing efficiency by at least 10 %. The mixing efficiency with this 3D microstructure can reach more than 80 %. This 3D microstructure fabrication method can be easily integrated with other PDMS functional structures for future point-of-care diagnostic applications because of the advantages of this technique. © 2015, Springer-Verlag Berlin Heidelberg.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
A cost-effective method that used electroplating to fabricate a 3D polydimethylsiloxane (PDMS) passive micromixer was developed in this work. The mixer fabrication process characteristics were as follows: The chip design was transferred to indium tin oxide (ITO) glass via photolithography; the ITO glass was vertically immersed in a nickel electroplating solution; and the ITO glass was raised up by controlling by the syringe pump, while electroplating was in progress. In this method, the height of the mixing structure could increase gradient from 15 to 30 μm. Compared with a flat structure, this structure could increase mixing efficiency by at least 10 %. The mixing efficiency with this 3D microstructure can reach more than 80 %. This 3D microstructure fabrication method can be easily integrated with other PDMS functional structures for future point-of-care diagnostic applications because of the advantages of this technique. © 2015, Springer-Verlag Berlin Heidelberg. |
Effect of microfluidic electrolyte on the photovoltaic performance of ZnO-nanowire-based dye-sensitised solar cells Article de journal Z Han; J Dong; X Pan; Y Chen Journal Materials Research Innovations, 19 , p. 435–440, 2015. @article{han2015effect,
title = {Effect of microfluidic electrolyte on the photovoltaic performance of ZnO-nanowire-based dye-sensitised solar cells},
author = {Z Han and J Dong and X Pan and Y Chen},
year = {2015},
date = {2015-01-01},
journal = {Journal Materials Research Innovations},
volume = {19},
pages = {435--440},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
2014
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Fluorescent microparticles fabricated through chemical coating of O/W emulsion droplets with a thin metallic film Article de journal G M Nocera; K Ben M'Barek; D G Bazzoli; G Fraux; M Bontems-Van Heijenoort; J Chokki; S Georgeault; Y Chen; J Fattaccioli RSC Advances, 4 (23), p. 11564–11568, 2014. @article{Nocera:2014,
title = {Fluorescent microparticles fabricated through chemical coating of O/W emulsion droplets with a thin metallic film},
author = {G M Nocera and K Ben M'Barek and D G Bazzoli and G Fraux and M Bontems-Van Heijenoort and J Chokki and S Georgeault and Y Chen and J Fattaccioli},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84897724004&doi=10.1039%2fc3ra47063f&partnerID=40&md5=a03f0a9c595313d8e80db24330c46286},
doi = {10.1039/c3ra47063f},
year = {2014},
date = {2014-01-01},
journal = {RSC Advances},
volume = {4},
number = {23},
pages = {11564--11568},
abstract = {We have developed a simple fabrication process for fluorescent silver-coated liquid particles. The synthesis involves the encapsulation of quasi-monodisperse micronic soybean oil-in-water emulsion droplets in a polydopamine shell followed by an electroless silver plating of the surface. Due to the presence of the thin silver layer, the droplets exhibit a broad range fluorescence that shows no photobleaching upon illumination. The method shows that multimodal colloidal microparticles can be produced via a high-yield method from sustainable, off-the-shelf products with mild synthesis routes in aqueous conditions. © The Royal Society of Chemistry 2014.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
We have developed a simple fabrication process for fluorescent silver-coated liquid particles. The synthesis involves the encapsulation of quasi-monodisperse micronic soybean oil-in-water emulsion droplets in a polydopamine shell followed by an electroless silver plating of the surface. Due to the presence of the thin silver layer, the droplets exhibit a broad range fluorescence that shows no photobleaching upon illumination. The method shows that multimodal colloidal microparticles can be produced via a high-yield method from sustainable, off-the-shelf products with mild synthesis routes in aqueous conditions. © The Royal Society of Chemistry 2014. |
Light-controlled drug releasing polymer films combining LbL self-assembly and host-guest interactions Article de journal J Li; L He; J Wang; Z T Zhang; J Shi; X Z Zhang; Y P Cao; Y Chen Express Polymer Letters, 8 (3), p. 143–153, 2014. @article{Li:2014a,
title = {Light-controlled drug releasing polymer films combining LbL self-assembly and host-guest interactions},
author = {J Li and L He and J Wang and Z T Zhang and J Shi and X Z Zhang and Y P Cao and Y Chen},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84891682763&doi=10.3144%2fexpresspolymlett.2014.18&partnerID=40&md5=5e618576e240449ecb3e98d7a68e34a6},
doi = {10.3144/expresspolymlett.2014.18},
year = {2014},
date = {2014-01-01},
journal = {Express Polymer Letters},
volume = {8},
number = {3},
pages = {143--153},
abstract = {By combining LbL (layer-by-layer) self-assembly approach and host-guest interactions, a unique multilayer film was constructed and employed for a light-controlled drug release system. The drug molecules can be loaded and released into the resulting polyelectrolyte multilayers containing azobenzene (Azo) function groups by using the irradiation of visible light and UV light alternately. The photo-sensitivity of the multilayer films was studied through UV-vis spectrum, fluorescence spectrum and confocal microscopy. The target molecules could be rapidly released from the multilayers after 300 W UV light irradiation for 20 minutes. Moreover, they could be readsorbed into the multilayers uniformly when illuminated under the 300 W visible light for 10 minutes confirmed by the observation of confocal microscopy, and the readsorption ratio exceeds 100% evidenced from UV-vis spectroscopy. After several cycles of the above-mentioned process, the multilayer films show good fatigue resistance. All these results indicate the photo-sensitivity and high-efficiency of the multilayer films, which have great potential in controlled drug delivery platform and biomedical applications. © BME-PT.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
By combining LbL (layer-by-layer) self-assembly approach and host-guest interactions, a unique multilayer film was constructed and employed for a light-controlled drug release system. The drug molecules can be loaded and released into the resulting polyelectrolyte multilayers containing azobenzene (Azo) function groups by using the irradiation of visible light and UV light alternately. The photo-sensitivity of the multilayer films was studied through UV-vis spectrum, fluorescence spectrum and confocal microscopy. The target molecules could be rapidly released from the multilayers after 300 W UV light irradiation for 20 minutes. Moreover, they could be readsorbed into the multilayers uniformly when illuminated under the 300 W visible light for 10 minutes confirmed by the observation of confocal microscopy, and the readsorption ratio exceeds 100% evidenced from UV-vis spectroscopy. After several cycles of the above-mentioned process, the multilayer films show good fatigue resistance. All these results indicate the photo-sensitivity and high-efficiency of the multilayer films, which have great potential in controlled drug delivery platform and biomedical applications. © BME-PT. |
Multi-responsive drug release from hydrogen-bonding multilayers containing PEGylated nanoparticles and azobenzenes Article de journal J Li; X Zhang; S Chen; Q You; R He; J Shi; Y Cao; Y Chen Journal of Materials Chemistry B, 2 (28), p. 4422–4425, 2014. @article{Li:2014c,
title = {Multi-responsive drug release from hydrogen-bonding multilayers containing PEGylated nanoparticles and azobenzenes},
author = {J Li and X Zhang and S Chen and Q You and R He and J Shi and Y Cao and Y Chen},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84903450793&doi=10.1039%2fc3tb21651a&partnerID=40&md5=5dff6b400ae6f8e77119fd17d8b4da23},
doi = {10.1039/c3tb21651a},
year = {2014},
date = {2014-01-01},
journal = {Journal of Materials Chemistry B},
volume = {2},
number = {28},
pages = {4422--4425},
abstract = {Using PEGylated nanoparticles and light-sensitive azobenzenes, a multicolor fluorescence layer-by-layer film loading drug has been constructed based on hydrogen bonding. The multilayer film exhibited multi-responsive drug release properties. This journal is © the Partner Organisations 2014.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Using PEGylated nanoparticles and light-sensitive azobenzenes, a multicolor fluorescence layer-by-layer film loading drug has been constructed based on hydrogen bonding. The multilayer film exhibited multi-responsive drug release properties. This journal is © the Partner Organisations 2014. |
Simultaneous and multisite tumor rapid-target bioimaging through in vivo biosynthesis of fluorescent gold nanoclusters Article de journal J Wang; J Ye; H Jiang; S Gao; W Ge; Y Chen; C Liu; C Amatore; X Wang RSC Advances, 4 (71), p. 37790–37795, 2014. @article{Wang:2014,
title = {Simultaneous and multisite tumor rapid-target bioimaging through in vivo biosynthesis of fluorescent gold nanoclusters},
author = {J Wang and J Ye and H Jiang and S Gao and W Ge and Y Chen and C Liu and C Amatore and X Wang},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84906860811&doi=10.1039%2fc4ra05021e&partnerID=40&md5=b05e251117af875be68b9a3a457fb3c1},
doi = {10.1039/c4ra05021e},
year = {2014},
date = {2014-01-01},
journal = {RSC Advances},
volume = {4},
number = {71},
pages = {37790--37795},
abstract = {Simultaneous and multisite tumor rapid-target bioimaging has been realized in this contribution through in vivo biosynthesis of fluorescent gold nanoclusters (GNCs). The selectively biosynthesized fluorescent GNCs in cancer cells or tumor tissues by systemic bio-administration of gold precursors via tail vein injection in tumor bearing mice were found to exhibit a highly efficient tumor targeting effect. Intracellular fluorescence studies demonstrate that in vivo biosynthesized GNCs from cancer cells could efficiently label and image target cells with bright photostable fluorescence, which could be readily exploited for the rapid imaging in vivo of the biodistribution of GNCs in mice and thus efficiently determine the precise target sites of fluorescent GNCs specifically biosynthesized in tumor tissues with high spatiotemporal resolution. Moreover, histopathologic analyses of H&E-stained tissue sections indicate that no side effects for mice treated with gold precursors are found during the process of systemic bio-administration for gold precursors. This raises the possibility of utilizing the in vivo biosynthesized GNCs through intravenous administration of biocompatible gold precursors as promising and effective biomarkers for rapid tumor diagnosis and precise surgical intervention. © the Partner Organisations 2014.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Simultaneous and multisite tumor rapid-target bioimaging has been realized in this contribution through in vivo biosynthesis of fluorescent gold nanoclusters (GNCs). The selectively biosynthesized fluorescent GNCs in cancer cells or tumor tissues by systemic bio-administration of gold precursors via tail vein injection in tumor bearing mice were found to exhibit a highly efficient tumor targeting effect. Intracellular fluorescence studies demonstrate that in vivo biosynthesized GNCs from cancer cells could efficiently label and image target cells with bright photostable fluorescence, which could be readily exploited for the rapid imaging in vivo of the biodistribution of GNCs in mice and thus efficiently determine the precise target sites of fluorescent GNCs specifically biosynthesized in tumor tissues with high spatiotemporal resolution. Moreover, histopathologic analyses of H&E-stained tissue sections indicate that no side effects for mice treated with gold precursors are found during the process of systemic bio-administration for gold precursors. This raises the possibility of utilizing the in vivo biosynthesized GNCs through intravenous administration of biocompatible gold precursors as promising and effective biomarkers for rapid tumor diagnosis and precise surgical intervention. © the Partner Organisations 2014. |
Ultraviolet-Induced Fluorescence of Polydopamine-Coated Emulsion Droplets Article de journal S Quignard; M D'Ischia; Y Chen; J Fattaccioli ChemPlusChem, 79 (9), p. 1254–1257, 2014. @article{Quignard:2014,
title = {Ultraviolet-Induced Fluorescence of Polydopamine-Coated Emulsion Droplets},
author = {S Quignard and M D'Ischia and Y Chen and J Fattaccioli},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84941027883&doi=10.1002%2fcplu.201402157&partnerID=40&md5=f4641b55e2507d63b3ff08772d48eaa8},
doi = {10.1002/cplu.201402157},
year = {2014},
date = {2014-01-01},
journal = {ChemPlusChem},
volume = {79},
number = {9},
pages = {1254--1257},
abstract = {Polydopamine (PDA), a multifunctional biomaterial with strong adhesion and coating properties, exhibits melanin-like optoelectronic properties but is virtually devoid of intrinsic fluorescence. Herein we disclose the first PDA-based system that can develop fluorescence without chemical manipulation. The polymerization of dopamine in the presence of oil microdroplets results in the formation of smooth PDA-coated core-shell droplets, which develop a bright and persistent fluorescence upon UVA illumination. The fluorescence induction depends on the excitation wavelength, the nature of the oil, and oxidation and buffer conditions, suggesting photo-oxidation of PDA components within the oil matrix, which shields the developing fluorophores from water quenching. Peroxyl radical scavengers enhance the fluorescence, whereas hydrogen peroxide induces quenching. The new system holds potential interest for imaging and tocopherol sensing applications. Fluorescent droplets: The first polydopamine-based system that can develop fluorescence without chemical manipulation is disclosed. The polymerization of dopamine in the presence of oil microdroplets results in the formation of smooth PDA-coated core-shell droplets, which develop a bright and persistent fluorescence upon UVA illumination (see figure). © 2014 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Polydopamine (PDA), a multifunctional biomaterial with strong adhesion and coating properties, exhibits melanin-like optoelectronic properties but is virtually devoid of intrinsic fluorescence. Herein we disclose the first PDA-based system that can develop fluorescence without chemical manipulation. The polymerization of dopamine in the presence of oil microdroplets results in the formation of smooth PDA-coated core-shell droplets, which develop a bright and persistent fluorescence upon UVA illumination. The fluorescence induction depends on the excitation wavelength, the nature of the oil, and oxidation and buffer conditions, suggesting photo-oxidation of PDA components within the oil matrix, which shields the developing fluorophores from water quenching. Peroxyl radical scavengers enhance the fluorescence, whereas hydrogen peroxide induces quenching. The new system holds potential interest for imaging and tocopherol sensing applications. Fluorescent droplets: The first polydopamine-based system that can develop fluorescence without chemical manipulation is disclosed. The polymerization of dopamine in the presence of oil microdroplets results in the formation of smooth PDA-coated core-shell droplets, which develop a bright and persistent fluorescence upon UVA illumination (see figure). © 2014 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim. |
Light-controlled drug releasing polymer films combining LbL self-assembly and host-guest interactions Article de journal J Li; L He; J Wang; Z T Zhang; J Shi; Y P Cao; Y Chen Express Polymer Letters, p. doi–org, 2014. @article{li2014light,
title = {Light-controlled drug releasing polymer films combining LbL self-assembly and host-guest interactions},
author = {J Li and L He and J Wang and Z T Zhang and J Shi and Y P Cao and Y Chen},
year = {2014},
date = {2014-01-01},
journal = {Express Polymer Letters},
pages = {doi--org},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Spatially-controlled protein crystallization in microfluidic chambers Article de journal C Longuet; A Yamada; Y Chen; D Baigl; J Fattaccioli Journal of Crystal Growth, 386 , p. 179–182, 2014. @article{Longuet:2014,
title = {Spatially-controlled protein crystallization in microfluidic chambers},
author = {C Longuet and A Yamada and Y Chen and D Baigl and J Fattaccioli},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84887030786&doi=10.1016%2fj.jcrysgro.2013.10.011&partnerID=40&md5=2d3429038a1597df1adbfc9e7fccaf9d},
doi = {10.1016/j.jcrysgro.2013.10.011},
year = {2014},
date = {2014-01-01},
journal = {Journal of Crystal Growth},
volume = {386},
pages = {179--182},
abstract = {We present a simple microfluidic device able to trigger the nucleation of the crystals at specific locations on the microchip for the statistical study of protein crystallization. The microsystem is an array of independent PDMS microchambers connected to a fluid-dispensing channel. The chambers are filled with a crystallizing aqueous protein solution and then sealed with a fluorinated oil phase. Each chamber presents a small oil/water interface at the connection with the main channel. The crystals most likely grow near the interface, allowing a microscopic observation of the nucleation events at specific positions on the chip. For the sake of demonstration, the method is applied to the crystallization of HEW lysozyme. © 2013 Elsevier B.V.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
We present a simple microfluidic device able to trigger the nucleation of the crystals at specific locations on the microchip for the statistical study of protein crystallization. The microsystem is an array of independent PDMS microchambers connected to a fluid-dispensing channel. The chambers are filled with a crystallizing aqueous protein solution and then sealed with a fluorinated oil phase. Each chamber presents a small oil/water interface at the connection with the main channel. The crystals most likely grow near the interface, allowing a microscopic observation of the nucleation events at specific positions on the chip. For the sake of demonstration, the method is applied to the crystallization of HEW lysozyme. © 2013 Elsevier B.V. |
2013
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Upside and downside views of adherent cells on patterned substrates: three-dimensional image reconstruction Article de journal JJ Li; XT Zhou; J Shi; F Zhang; X Li; LM Jiang; Y Chen Microelectronic engineering, 110 , p. 365–368, 2013. @article{li2013upside,
title = {Upside and downside views of adherent cells on patterned substrates: three-dimensional image reconstruction},
author = {JJ Li and XT Zhou and J Shi and F Zhang and X Li and LM Jiang and Y Chen},
year = {2013},
date = {2013-01-01},
journal = {Microelectronic engineering},
volume = {110},
pages = {365--368},
publisher = {Elsevier},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Multi-electrode monitoring of guided excitation in patterned cardiomyocytes Article de journal L Wang; L Liu; X Li; N Magome; K Agladze; Y Chen Microelectronic engineering, 111 , p. 267–271, 2013. @article{wang2013multi,
title = {Multi-electrode monitoring of guided excitation in patterned cardiomyocytes},
author = {L Wang and L Liu and X Li and N Magome and K Agladze and Y Chen},
year = {2013},
date = {2013-01-01},
journal = {Microelectronic engineering},
volume = {111},
pages = {267--271},
publisher = {Elsevier},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Microfluidic capture of endothelial progenitor cells in human blood samples Article de journal JJ Li; D Broqueres-You; ZT Han; WT He; SS Li; LM Jiang; BI Levy; J Shi; Y Chen Microelectronic engineering, 111 , p. 262–266, 2013. @article{li2013microfluidic,
title = {Microfluidic capture of endothelial progenitor cells in human blood samples},
author = {JJ Li and D Broqueres-You and ZT Han and WT He and SS Li and LM Jiang and BI Levy and J Shi and Y Chen},
year = {2013},
date = {2013-01-01},
journal = {Microelectronic engineering},
volume = {111},
pages = {262--266},
publisher = {Elsevier},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Influence of patterned topographic features on the formation of cardiac cell clusters and their rhythmic activities Article de journal L Wang; L Liu; N Magome; K Agladze; Y Chen Biofabrication, 5 (3), p. 035013, 2013. @article{wang2013influence,
title = {Influence of patterned topographic features on the formation of cardiac cell clusters and their rhythmic activities},
author = {L Wang and L Liu and N Magome and K Agladze and Y Chen},
year = {2013},
date = {2013-01-01},
journal = {Biofabrication},
volume = {5},
number = {3},
pages = {035013},
publisher = {IOP Publishing},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
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Shape memory supramolecular networks for the photoregulated adsorption and release of model molecules Article de journal J Li; Y Cao; Q You; Y Zhang; H Shi; Z Yang; L He; J Wang; C Ni; Y Chen; Z Qian Materials Express, 3 (4), p. 310–318, 2013. @article{Li:2013b,
title = {Shape memory supramolecular networks for the photoregulated adsorption and release of model molecules},
author = {J Li and Y Cao and Q You and Y Zhang and H Shi and Z Yang and L He and J Wang and C Ni and Y Chen and Z Qian},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84887692839&doi=10.1166%2fmex.2013.1128&partnerID=40&md5=822e7135d63186c461e38cda16db1e78},
doi = {10.1166/mex.2013.1128},
year = {2013},
date = {2013-01-01},
journal = {Materials Express},
volume = {3},
number = {4},
pages = {310--318},
abstract = {Multifunctional semi-interpenetrating polymer network (semi-IPN) constituted of poly(methacrylic acid-co-4-phenylazomaleinanil) (MAA-AzoMI) and Pluronic was designed and prepared, which is stabilized by hydrogenbonding interactions between PMAA carboxylic protons and Pluronic ether group. The characteristics of the materials were investigated by FTIR spectra, DSC, DMA and swelling measurements. Because of a large difference in storage modulus below and above the glass transition temperature, the semi-IPN material shows excellent shape memory effect with a recovery ratio of nearly 98%. For this system, the fixing phase is the MAA-AzoMI network, while the reversible phase is the PMAA-Pluronic complex phase. Meanwhile, by introducing azobenzene side group, this supramolecular network is sensitive to UV and visible light. The photoinduced trans → cis isomerization of azobenzene chromophores in the semi-IPN material leads to a transition from hydrophilicity to hydrophobicity of the polymer network. Therefore, UV light can induce a rapid autoloading of drug molecules into the network, and then the bound model molecules can be released under visible light. © 2013 by American Scientific Publishers All rights reserved.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Multifunctional semi-interpenetrating polymer network (semi-IPN) constituted of poly(methacrylic acid-co-4-phenylazomaleinanil) (MAA-AzoMI) and Pluronic was designed and prepared, which is stabilized by hydrogenbonding interactions between PMAA carboxylic protons and Pluronic ether group. The characteristics of the materials were investigated by FTIR spectra, DSC, DMA and swelling measurements. Because of a large difference in storage modulus below and above the glass transition temperature, the semi-IPN material shows excellent shape memory effect with a recovery ratio of nearly 98%. For this system, the fixing phase is the MAA-AzoMI network, while the reversible phase is the PMAA-Pluronic complex phase. Meanwhile, by introducing azobenzene side group, this supramolecular network is sensitive to UV and visible light. The photoinduced trans → cis isomerization of azobenzene chromophores in the semi-IPN material leads to a transition from hydrophilicity to hydrophobicity of the polymer network. Therefore, UV light can induce a rapid autoloading of drug molecules into the network, and then the bound model molecules can be released under visible light. © 2013 by American Scientific Publishers All rights reserved. |
Growth and attachment of embryonic stem cell colonies on single nanofibers Article de journal L Liu; J Shi; Q H Yuan; L Wang; Y Chen Micro and Nanosystems, 5 (4), p. 269–273, 2013. @article{liu2013growth,
title = {Growth and attachment of embryonic stem cell colonies on single nanofibers},
author = {L Liu and J Shi and Q H Yuan and L Wang and Y Chen},
year = {2013},
date = {2013-01-01},
journal = {Micro and Nanosystems},
volume = {5},
number = {4},
pages = {269--273},
publisher = {Bentham Science Publishers},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Geometric friction directs cell migration Article de journal M Le Berre; Yan-Jun Liu; J Hu; Paolo Maiuri; O Bénichou; R Voituriez; Y Chen; M Piel Physical review letters, 111 (19), p. 198101, 2013. @article{le2013geometric,
title = {Geometric friction directs cell migration},
author = {M Le Berre and Yan-Jun Liu and J Hu and Paolo Maiuri and O B\'{e}nichou and R Voituriez and Y Chen and M Piel},
year = {2013},
date = {2013-01-01},
journal = {Physical review letters},
volume = {111},
number = {19},
pages = {198101},
publisher = {APS},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Fabrication of gelatin nanopatterns for cell culture studies Article de journal SS Li; J Shi; L Liu; JJ Li; LM Jiang; CX Luo; K Kamei; Y Chen Microelectronic engineering, 110 , p. 70–74, 2013. @article{li2013fabrication,
title = {Fabrication of gelatin nanopatterns for cell culture studies},
author = {SS Li and J Shi and L Liu and JJ Li and LM Jiang and CX Luo and K Kamei and Y Chen},
year = {2013},
date = {2013-01-01},
journal = {Microelectronic engineering},
volume = {110},
pages = {70--74},
publisher = {Elsevier},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
2012
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Double "plug and play" templates technology for photo controllable drug release polyelectrolyte multilayers Article de journal M Wu; Y Cao; X Zhang; Y Zhang; Y Chen; L He; Z Qian Chemical Communications, 48 (79), p. 9846–9848, 2012. @article{Wu:2012,
title = {Double "plug and play" templates technology for photo controllable drug release polyelectrolyte multilayers},
author = {M Wu and Y Cao and X Zhang and Y Zhang and Y Chen and L He and Z Qian},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84866233519&doi=10.1039%2fc2cc35274e&partnerID=40&md5=1ba4f071183888e608f8c48b0745c5ec},
doi = {10.1039/c2cc35274e},
year = {2012},
date = {2012-01-01},
journal = {Chemical Communications},
volume = {48},
number = {79},
pages = {9846--9848},
abstract = {An approach for the generation of photo controllable drug release polyelectrolyte multilayers is developed by combining double "plug and play" (PnP) templates technology and host-guest chemistry. These multilayers exhibited a reversible drug loading and release achieved by the photoinduced isomerization. © The Royal Society of Chemistry 2012.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
An approach for the generation of photo controllable drug release polyelectrolyte multilayers is developed by combining double "plug and play" (PnP) templates technology and host-guest chemistry. These multilayers exhibited a reversible drug loading and release achieved by the photoinduced isomerization. © The Royal Society of Chemistry 2012. |
2011
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Online impedance monitoring of yeast cell culture behaviors Article de journal JJ Liu; H Li; F Zhang; X Li; L Wang; Y Chen Microelectronic engineering, 88 (8), p. 1711–1713, 2011. @article{liu2011online,
title = {Online impedance monitoring of yeast cell culture behaviors},
author = {JJ Liu and H Li and F Zhang and X Li and L Wang and Y Chen},
year = {2011},
date = {2011-01-01},
journal = {Microelectronic engineering},
volume = {88},
number = {8},
pages = {1711--1713},
publisher = {Elsevier},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Milliseconds mixing in microfluidic channel using focused surface acoustic wave Article de journal Q Zeng; F Guo; L Yao; HW Zhu; L Zheng; ZX Guo; W Liu; Y Chen; SS Guo; XZ Zhao Sensors and Actuators B: Chemical, 160 (1), p. 1552–1556, 2011. @article{zeng2011milliseconds,
title = {Milliseconds mixing in microfluidic channel using focused surface acoustic wave},
author = {Q Zeng and F Guo and L Yao and HW Zhu and L Zheng and ZX Guo and W Liu and Y Chen and SS Guo and XZ Zhao},
year = {2011},
date = {2011-01-01},
journal = {Sensors and Actuators B: Chemical},
volume = {160},
number = {1},
pages = {1552--1556},
publisher = {Elsevier},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Fabrication of high density metallic nanowires and nanotubes for cell culture studies Article de journal JH Tian; J Hu; F Zhang; X Li; J Shi; J Liu; ZQ Tian; Y Chen Microelectronic engineering, 88 (8), p. 1702–1706, 2011. @article{tian2011fabrication,
title = {Fabrication of high density metallic nanowires and nanotubes for cell culture studies},
author = {JH Tian and J Hu and F Zhang and X Li and J Shi and J Liu and ZQ Tian and Y Chen},
year = {2011},
date = {2011-01-01},
journal = {Microelectronic engineering},
volume = {88},
number = {8},
pages = {1702--1706},
publisher = {Elsevier},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Cell culture on AAO nanoporous substrates with and without geometry constrains Article de journal J Hu; JH Tian; J Shi; F Zhang; DL He; L Liu; DJ Jung; JB Bai; Y Chen Microelectronic Engineering, 88 (8), p. 1714–1717, 2011. @article{hu2011cell,
title = {Cell culture on AAO nanoporous substrates with and without geometry constrains},
author = {J Hu and JH Tian and J Shi and F Zhang and DL He and L Liu and DJ Jung and JB Bai and Y Chen},
year = {2011},
date = {2011-01-01},
journal = {Microelectronic Engineering},
volume = {88},
number = {8},
pages = {1714--1717},
publisher = {Elsevier},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
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A comparative study of preparation methods of nanoporous TiO2 films for microfluidic photocatalysis Article de journal N Wang; L Lei; XM Zhang; YH Tsang; Y Chen; Helen LW Chan Microelectronic engineering, 88 (8), p. 2797–2799, 2011. @article{wang2011comparative,
title = {A comparative study of preparation methods of nanoporous TiO2 films for microfluidic photocatalysis},
author = {N Wang and L Lei and XM Zhang and YH Tsang and Y Chen and Helen LW Chan},
year = {2011},
date = {2011-01-01},
journal = {Microelectronic engineering},
volume = {88},
number = {8},
pages = {2797--2799},
publisher = {Elsevier},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
2010
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Cell imprinting and AFM imaging of cells cultured on nanoline patterns Article de journal XT Zhou; F Zhang; J Hu; X Li; XM Ma; Y Chen Microelectronic engineering, 87 (5-8), p. 1439–1443, 2010. @article{zhou2010cell,
title = {Cell imprinting and AFM imaging of cells cultured on nanoline patterns},
author = {XT Zhou and F Zhang and J Hu and X Li and XM Ma and Y Chen},
year = {2010},
date = {2010-01-01},
journal = {Microelectronic engineering},
volume = {87},
number = {5-8},
pages = {1439--1443},
publisher = {Elsevier},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Micro-pressure sensor made of conductive PDMS for microfluidic applications Article de journal H Li; CX Luo; H Ji; Qi Ouyang; Y Chen Microelectronic engineering, 87 (5-8), p. 1266–1269, 2010. @article{li2010micro,
title = {Micro-pressure sensor made of conductive PDMS for microfluidic applications},
author = {H Li and CX Luo and H Ji and Qi Ouyang and Y Chen},
year = {2010},
date = {2010-01-01},
journal = {Microelectronic engineering},
volume = {87},
number = {5-8},
pages = {1266--1269},
publisher = {Elsevier},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
High resolution and hybrid patterning for single cell attachment Article de journal J Hu; J Shi; F Zhang; L Lei; X Li; L Wang; L Liu; Y Chen Microelectronic engineering, 87 (5-8), p. 726–729, 2010. @article{hu2010high,
title = {High resolution and hybrid patterning for single cell attachment},
author = {J Hu and J Shi and F Zhang and L Lei and X Li and L Wang and L Liu and Y Chen},
year = {2010},
date = {2010-01-01},
journal = {Microelectronic engineering},
volume = {87},
number = {5-8},
pages = {726--729},
publisher = {Elsevier},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Laser emission from dye doped microspheres produced on a chip Article de journal H Li; L Lei; Q Zeng; J Shi; CX Luo; H Ji; Q Ouyang; Y Chen Sensors and Actuators B: Chemical, 145 (1), p. 570–574, 2010. @article{li2010laser,
title = {Laser emission from dye doped microspheres produced on a chip},
author = {H Li and L Lei and Q Zeng and J Shi and CX Luo and H Ji and Q Ouyang and Y Chen},
year = {2010},
date = {2010-01-01},
journal = {Sensors and Actuators B: Chemical},
volume = {145},
number = {1},
pages = {570--574},
publisher = {Elsevier},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Flow field effect transistors with polarisable interface for EOF tunable microfluidic separation devices Article de journal A Plecis; J Tazid; A Pallandre; P Martinhon; C Deslouis; Y Chen; AM Haghiri-Gosnet Lab on a Chip, 10 (10), p. 1245–1253, 2010. @article{plecis2010flow,
title = {Flow field effect transistors with polarisable interface for EOF tunable microfluidic separation devices},
author = {A Plecis and J Tazid and A Pallandre and P Martinhon and C Deslouis and Y Chen and AM Haghiri-Gosnet},
year = {2010},
date = {2010-01-01},
journal = {Lab on a Chip},
volume = {10},
number = {10},
pages = {1245--1253},
publisher = {Royal Society of Chemistry},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
