Yong CHEN

Directeur de recherche (DR1 CNRS)

ENS – Département de chimie
24 rue Lhomond, 75005 Paris

Email: yong.chen@ens.psl.eu
Phone: +33 144322241
Office: E108

Understanding and regulating the natural systems at cellular levels is of particular interesting for disease modeling, drug screening, diagnosis and regenerative medicine. By developing consistently artificial basement membranes, microfluidic and pluripotent stem cell technologies, advanced in-vitro models of human tissues/organoids can be created, which mimic our sophisticated in-vivo systems.

Short bio

He received a B.S. degree in condensed matter physics from Wuhan University (1982) and  both M.S. and Ph.D. degrees from the University of Montpelier (1983 and 1986). After spent three years at the Scuola Normale Superiorie di Pisa and Peking University, he joined the Centre National de Recherche Scientifique (CNRS) as Chargé de Recherche (1st class) in 1990 to work at the Laboratoire  de Microstructures et de Microélectronique (L2M). In 1998, he became a Directeur de Recherche (2nd class) of CNRS. In 2003, he moved to the Ecole Normale Supérieure (ENS) as Professor and he is now Directeur de Recherche (1st class) of CNRS and head of the ENS team for microfluidics. In the past, he also served as Adjunct Professor at the Institute for Integrated Cell-Material Sciences (iCeMS) of Kyoto University, Changjiang Chair Professor of Peking University, Distinguished Chair Professor of Hong Kong Polytechnic University and Guess professor of Jianghan University.

Research interests

He has been worked in different fields, including semiconductor quantum heterostructures, photonic crystals, scanning near field optical microscopy, magnetic nanostructures, synchrotron based X-ray lithography, thermal and UV nanoimprint lithography, microfluidics, etc. His current interests are mainly in the field of biomedical research and applications such as cancer diagnosis and stem cell devices for in-vitro modeling of cardiac,  neural and alveolar systems.

He has contributed to more than 500 scientific publications (peer-reviewed journals, book chapters and proceeding articles) and a large number of European and national research projects/networks. He is member of several international or national committees and reviewer of a number of journals. In total, he has supervised more than 50 Ph.D and post-doc studies.

Publications

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2015

PDMS micropillar-based microchip for efficient cancer cell capture Article de journal

J Xiao; W He; Z Zhang; W Zhang; Y Cao; R He; Y Chen

RSC Advances, 5 (64), p. 52161–52166, 2015.

Phagocytosis of immunoglobulin-coated emulsion droplets Article de journal

K Ben M'Barek; D Molino; S Quignard; M -A Plamont; Y Chen; P Chavrier; J Fattaccioli

Biomaterials, 51 , p. 270–277, 2015.

One-step electroplating 3D template with gradient height to enhance micromixing in microfluidic chips Article de journal

W He; J Xiao; Z Zhang; W Zhang; Y Cao; R He; Y Chen

Microfluidics and Nanofluidics, 19 (4), p. 829–836, 2015.

Effect of microfluidic electrolyte on the photovoltaic performance of ZnO-nanowire-based dye-sensitised solar cells Article de journal

Z Han; J Dong; X Pan; Y Chen

Journal Materials Research Innovations, 19 , p. 435–440, 2015.

2014

Fluorescent microparticles fabricated through chemical coating of O/W emulsion droplets with a thin metallic film Article de journal

G M Nocera; K Ben M'Barek; D G Bazzoli; G Fraux; M Bontems-Van Heijenoort; J Chokki; S Georgeault; Y Chen; J Fattaccioli

RSC Advances, 4 (23), p. 11564–11568, 2014.

Light-controlled drug releasing polymer films combining LbL self-assembly and host-guest interactions Article de journal

J Li; L He; J Wang; Z T Zhang; J Shi; X Z Zhang; Y P Cao; Y Chen

Express Polymer Letters, 8 (3), p. 143–153, 2014.

Multi-responsive drug release from hydrogen-bonding multilayers containing PEGylated nanoparticles and azobenzenes Article de journal

J Li; X Zhang; S Chen; Q You; R He; J Shi; Y Cao; Y Chen

Journal of Materials Chemistry B, 2 (28), p. 4422–4425, 2014.

Simultaneous and multisite tumor rapid-target bioimaging through in vivo biosynthesis of fluorescent gold nanoclusters Article de journal

J Wang; J Ye; H Jiang; S Gao; W Ge; Y Chen; C Liu; C Amatore; X Wang

RSC Advances, 4 (71), p. 37790–37795, 2014.

Ultraviolet-Induced Fluorescence of Polydopamine-Coated Emulsion Droplets Article de journal

S Quignard; M D'Ischia; Y Chen; J Fattaccioli

ChemPlusChem, 79 (9), p. 1254–1257, 2014.

Light-controlled drug releasing polymer films combining LbL self-assembly and host-guest interactions Article de journal

J Li; L He; J Wang; Z T Zhang; J Shi; Y P Cao; Y Chen

Express Polymer Letters, p. doi–org, 2014.

Spatially-controlled protein crystallization in microfluidic chambers Article de journal

C Longuet; A Yamada; Y Chen; D Baigl; J Fattaccioli

Journal of Crystal Growth, 386 , p. 179–182, 2014.

2013

Upside and downside views of adherent cells on patterned substrates: three-dimensional image reconstruction Article de journal

JJ Li; XT Zhou; J Shi; F Zhang; X Li; LM Jiang; Y Chen

Microelectronic engineering, 110 , p. 365–368, 2013.

Multi-electrode monitoring of guided excitation in patterned cardiomyocytes Article de journal

L Wang; L Liu; X Li; N Magome; K Agladze; Y Chen

Microelectronic engineering, 111 , p. 267–271, 2013.

Microfluidic capture of endothelial progenitor cells in human blood samples Article de journal

JJ Li; D Broqueres-You; ZT Han; WT He; SS Li; LM Jiang; BI Levy; J Shi; Y Chen

Microelectronic engineering, 111 , p. 262–266, 2013.

Influence of patterned topographic features on the formation of cardiac cell clusters and their rhythmic activities Article de journal

L Wang; L Liu; N Magome; K Agladze; Y Chen

Biofabrication, 5 (3), p. 035013, 2013.

Shape memory supramolecular networks for the photoregulated adsorption and release of model molecules Article de journal

J Li; Y Cao; Q You; Y Zhang; H Shi; Z Yang; L He; J Wang; C Ni; Y Chen; Z Qian

Materials Express, 3 (4), p. 310–318, 2013.

Growth and attachment of embryonic stem cell colonies on single nanofibers Article de journal

L Liu; J Shi; Q H Yuan; L Wang; Y Chen

Micro and Nanosystems, 5 (4), p. 269–273, 2013.

Geometric friction directs cell migration Article de journal

M Le Berre; Yan-Jun Liu; J Hu; Paolo Maiuri; O Bénichou; R Voituriez; Y Chen; M Piel

Physical review letters, 111 (19), p. 198101, 2013.

Fabrication of gelatin nanopatterns for cell culture studies Article de journal

SS Li; J Shi; L Liu; JJ Li; LM Jiang; CX Luo; K Kamei; Y Chen

Microelectronic engineering, 110 , p. 70–74, 2013.

2012

Double "plug and play" templates technology for photo controllable drug release polyelectrolyte multilayers Article de journal

M Wu; Y Cao; X Zhang; Y Zhang; Y Chen; L He; Z Qian

Chemical Communications, 48 (79), p. 9846–9848, 2012.

2011

Online impedance monitoring of yeast cell culture behaviors Article de journal

JJ Liu; H Li; F Zhang; X Li; L Wang; Y Chen

Microelectronic engineering, 88 (8), p. 1711–1713, 2011.

Milliseconds mixing in microfluidic channel using focused surface acoustic wave Article de journal

Q Zeng; F Guo; L Yao; HW Zhu; L Zheng; ZX Guo; W Liu; Y Chen; SS Guo; XZ Zhao

Sensors and Actuators B: Chemical, 160 (1), p. 1552–1556, 2011.

Fabrication of high density metallic nanowires and nanotubes for cell culture studies Article de journal

JH Tian; J Hu; F Zhang; X Li; J Shi; J Liu; ZQ Tian; Y Chen

Microelectronic engineering, 88 (8), p. 1702–1706, 2011.

Cell culture on AAO nanoporous substrates with and without geometry constrains Article de journal

J Hu; JH Tian; J Shi; F Zhang; DL He; L Liu; DJ Jung; JB Bai; Y Chen

Microelectronic Engineering, 88 (8), p. 1714–1717, 2011.

A comparative study of preparation methods of nanoporous TiO2 films for microfluidic photocatalysis Article de journal

N Wang; L Lei; XM Zhang; YH Tsang; Y Chen; Helen LW Chan

Microelectronic engineering, 88 (8), p. 2797–2799, 2011.

2010

Cell imprinting and AFM imaging of cells cultured on nanoline patterns Article de journal

XT Zhou; F Zhang; J Hu; X Li; XM Ma; Y Chen

Microelectronic engineering, 87 (5-8), p. 1439–1443, 2010.

Micro-pressure sensor made of conductive PDMS for microfluidic applications Article de journal

H Li; CX Luo; H Ji; Qi Ouyang; Y Chen

Microelectronic engineering, 87 (5-8), p. 1266–1269, 2010.

High resolution and hybrid patterning for single cell attachment Article de journal

J Hu; J Shi; F Zhang; L Lei; X Li; L Wang; L Liu; Y Chen

Microelectronic engineering, 87 (5-8), p. 726–729, 2010.

Laser emission from dye doped microspheres produced on a chip Article de journal

H Li; L Lei; Q Zeng; J Shi; CX Luo; H Ji; Q Ouyang; Y Chen

Sensors and Actuators B: Chemical, 145 (1), p. 570–574, 2010.

Flow field effect transistors with polarisable interface for EOF tunable microfluidic separation devices Article de journal

A Plecis; J Tazid; A Pallandre; P Martinhon; C Deslouis; Y Chen; AM Haghiri-Gosnet

Lab on a Chip, 10 (10), p. 1245–1253, 2010.

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