Directeur de recherche (DR1 CNRS)

ENS – Département de chimie
24 rue Lhomond, 75005 Paris

Email: yong.chen@ens.psl.eu
Phone: +33 144322241
Office: E108

Understanding and regulating the natural systems at cellular levels is of particular interesting for disease modeling, drug screening, diagnosis and regenerative medicine. By developing consistently artificial basement membranes, microfluidic and pluripotent stem cell technologies, advanced in-vitro models of human tissues/organoids can be created, which mimic our sophisticated in-vivo systems.

Short bio

He received a B.S. degree in condensed matter physics from Wuhan University (1982) and  both M.S. and Ph.D. degrees from the University of Montpelier (1983 and 1986). After spent three years at the Scuola Normale Superiorie di Pisa and Peking University, he joined the Centre National de Recherche Scientifique (CNRS) as Chargé de Recherche (1st class) in 1990 to work at the Laboratoire  de Microstructures et de Microélectronique (L2M). In 1998, he became a Directeur de Recherche (2nd class) of CNRS. In 2003, he moved to the Ecole Normale Supérieure (ENS) as Professor and he is now Directeur de Recherche (1st class) of CNRS and head of the ENS team for microfluidics. In the past, he also served as Adjunct Professor at the Institute for Integrated Cell-Material Sciences (iCeMS) of Kyoto University, Changjiang Chair Professor of Peking University, Distinguished Chair Professor of Hong Kong Polytechnic University and Guess professor of Jianghan University.

Research interests

He has been worked in different fields, including semiconductor quantum heterostructures, photonic crystals, scanning near field optical microscopy, magnetic nanostructures, synchrotron based X-ray lithography, thermal and UV nanoimprint lithography, microfluidics, etc. His current interests are mainly in the field of biomedical research and applications such as cancer diagnosis and stem cell devices for in-vitro modeling of cardiac,  neural and alveolar systems.

He has contributed to more than 500 scientific publications (peer-reviewed journals, book chapters and proceeding articles) and a large number of European and national research projects/networks. He is member of several international or national committees and reviewer of a number of journals. In total, he has supervised more than 50 Ph.D and post-doc studies.


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Light-controlled drug releasing polymer films combining LbL self-assembly and host-guest interactions Article de journal

J Li; L He; J Wang; Z T Zhang; J Shi; X Z Zhang; Y P Cao; Y Chen

Express Polymer Letters, 8 (3), p. 143–153, 2014.

Multi-responsive drug release from hydrogen-bonding multilayers containing PEGylated nanoparticles and azobenzenes Article de journal

J Li; X Zhang; S Chen; Q You; R He; J Shi; Y Cao; Y Chen

Journal of Materials Chemistry B, 2 (28), p. 4422–4425, 2014.

Simultaneous and multisite tumor rapid-target bioimaging through in vivo biosynthesis of fluorescent gold nanoclusters Article de journal

J Wang; J Ye; H Jiang; S Gao; W Ge; Y Chen; C Liu; C Amatore; X Wang

RSC Advances, 4 (71), p. 37790–37795, 2014.

Ultraviolet-Induced Fluorescence of Polydopamine-Coated Emulsion Droplets Article de journal

S Quignard; M D'Ischia; Y Chen; J Fattaccioli

ChemPlusChem, 79 (9), p. 1254–1257, 2014.

Spatially-controlled protein crystallization in microfluidic chambers Article de journal

C Longuet; A Yamada; Y Chen; D Baigl; J Fattaccioli

Journal of Crystal Growth, 386 , p. 179–182, 2014.


Shape memory supramolecular networks for the photoregulated adsorption and release of model molecules Article de journal

J Li; Y Cao; Q You; Y Zhang; H Shi; Z Yang; L He; J Wang; C Ni; Y Chen; Z Qian

Materials Express, 3 (4), p. 310–318, 2013.


Double "plug and play" templates technology for photo controllable drug release polyelectrolyte multilayers Article de journal

M Wu; Y Cao; X Zhang; Y Zhang; Y Chen; L He; Z Qian

Chemical Communications, 48 (79), p. 9846–9848, 2012.


Fabrication of nano-scaled patterns on ceramic thin films and silicon substrates by soft ultraviolet nanoimprint lithography Article de journal

K L Jim; F K Lee; J Z Xin; C W Leung; H L W Chan; Y Chen

Microelectronic Engineering, 87 (5-8), p. 959–962, 2010.


All-optical switching in 2D silicon photonic crystals with low loss waveguides and optical cavities Article de journal

M Belotti; J F Galisteo-López; S De Angelis; M Galli; I Maksymov; L C Andreani; D Peyrade; Y Chen

Optics Express, 16 (15), p. 11624–11636, 2008.

Local nanofluidic light sources in silicon photonic crystal microcavities Article de journal

S Vignolini; F Riboli; F Intonti; M Belotti; M Gurioli; Y Chen; M Colocci; L C Andreani; D S Wiersma

Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, 78 (4), 2008.


Electrochemical detection in a microfluidic device of oxidative stress generated by macrophage cells Article de journal

C Amatore; S Arbault; Y Chen; C Crozatier; I Tapsoba

Lab on a Chip, 7 (2), p. 233–238, 2007.


Coupling of electrochemistry and fluorescence microscopy at indium tin oxide microelectrodes for the analysis of single exocytotic events Article de journal

C Amatore; S Arbault; Y Chen; C Crozatier; F Lemaître; Y Verchier

Angewandte Chemie - International Edition, 45 (24), p. 4000–4003, 2006.

Strong enhancement of Er3+ emission at room temperature in silicon-on-insulator photonic crystal waveguides Article de journal

M Galli; A Politi; M Belotti; D Gerace; M Liscidini; M Patrini; L C Andreani; M Miritello; A Irrera; F Priolo; Y Chen

Applied Physics Letters, 88 (25), 2006.

Synthesis of water-soluble 2-alkylcyclodextrin-C60 conjugates and their inclusion complexation in aqueous solution Article de journal

Y Chen; Y Wang; A Rassat; P Sinaÿ; Y Zhao; Y Zhang

Tetrahedron, 62 (9), p. 2045–2049, 2006.

Thermal radiation scanning tunnelling microscopy Article de journal

Y De Wilde; F Formanek; R Carminati; B Gralak; P -A Lemoine; K Joulain; J -P Mulet; Y Chen; J -J Greffet

Nature, 444 (7120), p. 740–743, 2006.

The direct, in situ, measurement of the flow velocity inside microfluidic devices via electrochemical coupling between two parallel microband electrodes Article de journal

C Amatore; Y Chen; C Sella; L Thouin

Houille Blanche, (2), p. 60–64, 2006.


Enhanced third harmonic reflection and diffraction in Silicon on Insulator photonic waveguides Article de journal

C Comaschi; G Vecchi; A M Malvezzi; M Patrini; G Guizzetti; M Liscidini; L C Andreani; D Peyrade; Y Chen

Applied Physics B: Lasers and Optics, 81 (2-3), p. 305–311, 2005.

Single-mode versus multimode behavior in silicon photonic crystal waveguides measured by attenuated total reflectance Article de journal

M Galli; D Bajoni; M Patrini; G Guizzetti; D Gerace; L C Andreani; M Belotti; Y Chen

Physical Review B - Condensed Matter and Materials Physics, 72 (12), 2005.

Regioselective one-step synthesis of hexahydroxy permethylated β-cyclodextrin and unambiguous NMR analysis Article de journal

Y Chen; J G Huber; Y Zhang; P Sinaÿ

Comptes Rendus Chimie, 8 (1), p. 27–30, 2005.


Diisobutylaluminum hydride as a molecular scalpel: The regioselective stripping of four methyl groups from permethylated β-cyclodextrin Article de journal

X Luo; Y Chen; J G Huber; Y Zhang; P Sinaÿ

Comptes Rendus Chimie, 7 (1), p. 25–28, 2004.

Excitation of radiative and evanescent defect modes in linear photonic crystal waveguides Article de journal

M Galli; M Belotti; D Bajoni; M Patrini; G Guizzetti; D Gerace; M Agio; L C Andreani; Y Chen

Physical Review B - Condensed Matter and Materials Physics, 70 (8), p. 081307–1–081307–4, 2004.

Using electrochemical coupling between parallel microbands for in situ monitoring of flow rates in microfluidic channels Article de journal

C Amatore; M Belotti; Y Chen; E Roy; C Sella; L Thouin

Journal of Electroanalytical Chemistry, 573 (2), p. 333–343, 2004.

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