Juan WANG

@article{Zheng:2017,
title = {Visible-light-controllable drug release from multilayer-coated microneedles},
author = {Z Zheng and H Ye and J Wang and T Zhang and Q You and H Li and R He and Y Chen and W Zhang and Y Cao},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028619823&doi=10.1039%2fc7tb01546a&partnerID=40&md5=608c3752c37c46977e3ffea74c7f9eda},
doi = {10.1039/c7tb01546a},
year = {2017},
date = {2017-01-01},
journal = {Journal of Materials Chemistry B},
volume = {5},
number = {34},
pages = {7014--7017},
abstract = {A method for the generation of visible-light-controllable drug release polyelectrolyte multilayers on poly(l-lactide) (PLLA) microneedles is developed by host-guest chemistry. In response to visible light irradiation, model drugs encapsulated on polyelectrolyte multilayers transfer into the skin following brief microneedle application. © 2017 The Royal Society of Chemistry.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{Wang:2015,
title = {A bottom-up approach to dual shape-memory effects},
author = {J Wang and J Li and N Li and X Guo and L He and X Cao and W Zhang and R He and Z Qian and Y Cao and Y Chen},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84927729697&doi=10.1021%2fcm504527w&partnerID=40&md5=71f6dc3d2ae2c2da788715bf0d155038},
doi = {10.1021/cm504527w},
year = {2015},
date = {2015-01-01},
journal = {Chemistry of Materials},
volume = {27},
number = {7},
pages = {2439--2448},
abstract = {This study demonstrates how to successfully bridge the gap between nanoscale shape-memory function and macroscale motion using a bottom-up approach. This was achieved by first fabricating a photoswitchable surface-molecular-imprinted layer-by-layer (LbL) film capable of memorizing the shape and size of template molecules when illuminated. This photoswitch was built on the fundamental supramolecular interaction between an α-cyclodextrin-modified template acting as a photosocket and an azobenzene-modified poly(acrylic acid) photoplug. Corresponding patterns applied by cover-printing and wet photolithography were used to illustrate the stability of the binding sites; a simple and clean method was developed for removing the template-dye by UV irradiation. A functional fusion of nanoimprints and macroscopic materials was subsequently established by applying LbL coating technology to poly(d,l-lactic acid) (PDLLA) modified to have a shape-memory effect. Macroscopic changes in shape were found to cause deformation of recognition cavities in terms of their shape and size, thereby enabling us to visualize the effect of the specific adsorption behavior toward template-dye on a patterned PDLLA sheet. The rapid swelling and surface erosion of PDLLA also revealed that an increase in the number of deposited layers can significantly affect the interfacial properties of both the substrate and LbL film. It is believed that such novel designs and methods should prove useful for the development of multifunctional biomaterials. © 2015 American Chemical Society.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{Li:2014a,
title = {Light-controlled drug releasing polymer films combining LbL self-assembly and host-guest interactions},
author = {J Li and L He and J Wang and Z T Zhang and J Shi and X Z Zhang and Y P Cao and Y Chen},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84891682763&doi=10.3144%2fexpresspolymlett.2014.18&partnerID=40&md5=5e618576e240449ecb3e98d7a68e34a6},
doi = {10.3144/expresspolymlett.2014.18},
year = {2014},
date = {2014-01-01},
journal = {Express Polymer Letters},
volume = {8},
number = {3},
pages = {143--153},
abstract = {By combining LbL (layer-by-layer) self-assembly approach and host-guest interactions, a unique multilayer film was constructed and employed for a light-controlled drug release system. The drug molecules can be loaded and released into the resulting polyelectrolyte multilayers containing azobenzene (Azo) function groups by using the irradiation of visible light and UV light alternately. The photo-sensitivity of the multilayer films was studied through UV-vis spectrum, fluorescence spectrum and confocal microscopy. The target molecules could be rapidly released from the multilayers after 300 W UV light irradiation for 20 minutes. Moreover, they could be readsorbed into the multilayers uniformly when illuminated under the 300 W visible light for 10 minutes confirmed by the observation of confocal microscopy, and the readsorption ratio exceeds 100% evidenced from UV-vis spectroscopy. After several cycles of the above-mentioned process, the multilayer films show good fatigue resistance. All these results indicate the photo-sensitivity and high-efficiency of the multilayer films, which have great potential in controlled drug delivery platform and biomedical applications. © BME-PT.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{Wang:2014,
title = {Simultaneous and multisite tumor rapid-target bioimaging through in vivo biosynthesis of fluorescent gold nanoclusters},
author = {J Wang and J Ye and H Jiang and S Gao and W Ge and Y Chen and C Liu and C Amatore and X Wang},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84906860811&doi=10.1039%2fc4ra05021e&partnerID=40&md5=b05e251117af875be68b9a3a457fb3c1},
doi = {10.1039/c4ra05021e},
year = {2014},
date = {2014-01-01},
journal = {RSC Advances},
volume = {4},
number = {71},
pages = {37790--37795},
abstract = {Simultaneous and multisite tumor rapid-target bioimaging has been realized in this contribution through in vivo biosynthesis of fluorescent gold nanoclusters (GNCs). The selectively biosynthesized fluorescent GNCs in cancer cells or tumor tissues by systemic bio-administration of gold precursors via tail vein injection in tumor bearing mice were found to exhibit a highly efficient tumor targeting effect. Intracellular fluorescence studies demonstrate that in vivo biosynthesized GNCs from cancer cells could efficiently label and image target cells with bright photostable fluorescence, which could be readily exploited for the rapid imaging in vivo of the biodistribution of GNCs in mice and thus efficiently determine the precise target sites of fluorescent GNCs specifically biosynthesized in tumor tissues with high spatiotemporal resolution. Moreover, histopathologic analyses of H&E-stained tissue sections indicate that no side effects for mice treated with gold precursors are found during the process of systemic bio-administration for gold precursors. This raises the possibility of utilizing the in vivo biosynthesized GNCs through intravenous administration of biocompatible gold precursors as promising and effective biomarkers for rapid tumor diagnosis and precise surgical intervention. © the Partner Organisations 2014.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{li2014light,
title = {Light-controlled drug releasing polymer films combining LbL self-assembly and host-guest interactions},
author = {J Li and L He and J Wang and Z T Zhang and J Shi and Y P Cao and Y Chen},
year = {2014},
date = {2014-01-01},
journal = {Express Polymer Letters},
pages = {doi--org},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{Wang:2013,
title = {In vivo self-bio-imaging of tumors through in situ biosynthesized fluorescent gold nanoclusters},
author = {J Wang and G Zhang and Q Li and H Jiang and C Liu and C Amatore and X Wang},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84879960552&doi=10.1038%2fsrep01157&partnerID=40&md5=55ab21e798ba6d60581c151e9972abeb},
doi = {10.1038/srep01157},
year = {2013},
date = {2013-01-01},
journal = {Scientific Reports},
volume = {3},
abstract = {Fluorescence imaging in vivo allows non-invasive tumor diagnostic thus permitting a direct monitoring of cancer therapies progresses. It is established herein that fluorescent gold nanoclusters are spontaneously biosynthesized by cancerous cell (i.e., HepG2, human hepatocarcinoma cell line; K562, leukemia cell line) incubated with micromolar chloroauric acid solutions, a biocompatible molecular Au(III) species. Gold nanoparticles form by Au(III) reduction inside cells cytoplasms and ultimately concentrate around their nucleoli, thus affording precise cell imaging. Importantly, this does not occur in non-cancerous cells, as evidenced with human embryo liver cells (L02) used as controls. This dichotomy is exploited for a new strategy for in vivo self-bio-imaging of tumors. Subcutaneous injections of millimolar chloroauric acid solution near xenograft tumors of the nude mouse model of hepatocellular carcinoma or chronic myeloid leukemia led to efficient biosynthesis of fluorescent gold nanoclusters without significant dissemination to the surrounding normal tissues, hence allowing specific fluorescent self-bio-marking of the tumors.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{Li:2013b,
title = {Shape memory supramolecular networks for the photoregulated adsorption and release of model molecules},
author = {J Li and Y Cao and Q You and Y Zhang and H Shi and Z Yang and L He and J Wang and C Ni and Y Chen and Z Qian},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84887692839&doi=10.1166%2fmex.2013.1128&partnerID=40&md5=822e7135d63186c461e38cda16db1e78},
doi = {10.1166/mex.2013.1128},
year = {2013},
date = {2013-01-01},
journal = {Materials Express},
volume = {3},
number = {4},
pages = {310--318},
abstract = {Multifunctional semi-interpenetrating polymer network (semi-IPN) constituted of poly(methacrylic acid-co-4-phenylazomaleinanil) (MAA-AzoMI) and Pluronic was designed and prepared, which is stabilized by hydrogenbonding interactions between PMAA carboxylic protons and Pluronic ether group. The characteristics of the materials were investigated by FTIR spectra, DSC, DMA and swelling measurements. Because of a large difference in storage modulus below and above the glass transition temperature, the semi-IPN material shows excellent shape memory effect with a recovery ratio of nearly 98%. For this system, the fixing phase is the MAA-AzoMI network, while the reversible phase is the PMAA-Pluronic complex phase. Meanwhile, by introducing azobenzene side group, this supramolecular network is sensitive to UV and visible light. The photoinduced trans → cis isomerization of azobenzene chromophores in the semi-IPN material leads to a transition from hydrophilicity to hydrophobicity of the polymer network. Therefore, UV light can induce a rapid autoloading of drug molecules into the network, and then the bound model molecules can be released under visible light. © 2013 by American Scientific Publishers All rights reserved.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{Wang:2007a,
title = {Lewis X oligosaccharides targeting to DC-SIGN enhanced antigen-specific immune response},
author = {J Wang and Y Zhang and J Wei and X Zhang and B Zhang and Z Zhu and W Zou and Y Wang and Z Mou and B Ni and Y Wu},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-34247515189&doi=10.1111%2fj.1365-2567.2007.02554.x&partnerID=40&md5=3966579c064dbe366ba1e6d4ca3d58e9},
doi = {10.1111/j.1365-2567.2007.02554.x},
year = {2007},
date = {2007-01-01},
journal = {Immunology},
volume = {121},
number = {2},
pages = {174--182},
abstract = {Dendritic cell-specific intercellular-adhesion-molecule-grabbing non-integrin (DC-SIGN) is a potential target receptor for vaccination purposes. In the present study, we employed Lewis X (Lex) oligosaccharides, which mimic natural ligands, to target ovalbumin (OVA) to human dendritic cells (DCs) via DC-SIGN, to investigate the effect of this DC-SIGN-targeting strategy on the OVA-specific immune response. We demonstrated that Lex oligosaccharides could enhance the OVA-specific immune response as determined by enzyme-linked immunospot assay (ELISPOT), intracellular interferon-γ staining and 51Cr-release assay. An almost 300-fold lower dose of Lex-OVA induced balanced interferon-γ-secreting cells compared to OVA alone. Furthermore, secretion of interleukin-10, a reported mediator of immune suppression related to DC-SIGN, was not increased by Lex-OVA, either alone or together with sCD40L-stimulated groups. A blocking antibody against DC-SIGN (12507) reduced the numbers of interferon-γ-secreting cells during Lex-OVA stimulation, yet it did not prevent Le x oligosaccharides from promoting the secretion of interleukin-10 that was induced by ultra-pure lipopolysaccharide. These results suggested that the strategy of DC-SIGN targeting mediated by Lex oligosaccharides could promote a T-cell response. This DC-targeting may imply a novel vaccination strategy. © 2007 Blackwell Publishing Ltd.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{Xu:2004,
title = {Metabolites from mangrove endophytic fungus Dothiorella sp},
author = {Q Xu and J Wang and Y Huang and Z Zheng and S Song and Y Zhang and W Su},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-8644242110&partnerID=40&md5=da748d5a558385ef7b3c77ca7b3cb76a},
year = {2004},
date = {2004-01-01},
journal = {Acta Oceanologica Sinica},
volume = {23},
number = {3},
pages = {541--547},
abstract = {Mangroves are special woody plant communities in the intertidal zone of tropical and subtropical coasts. They prove to be a natural microorganisms and new metabolites storage. In the study of mangrove endophytic fungi metabolites, four new compounds, Compounds 1, 2, 3 and 4, as well as a known octaketide, cytosporone B (5), are isolated from an endophytic fungus, Dothiorella sp., HTF3. They all show cytotoxic activities. The elucidation of these structures is mainly based on 1D/ 2D NMR and ESI-MS spectral analyses.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}