CNRS researcher (CRCN)

ENS – Département de chimie
24 rue Lhomond, 75005 Paris

Email: ayako.yamada@ens.psl.eu
Phone: +33 1 44 32 32 64
Office: E110


Short bio

I wish to decipher the emergent self-organization underlying fundamental mechanisms of life. To this end, I am following bottom-up approaches using reconstituted systems, reprogrammed cells and/or microfluidics. I am currently focusing on brain-on-chip development for both fundamentally understanding how brain works and exploring solutions to heal it.

Education and professional experience

2017 Oct.-present  CNRS researcher at Pôle NBMS, UMR 8640 PASTEUR, Department of Chemistry, Ecole Normale Supérieure

2013-2017  Postdoctoral fellow at Institut Curie (UMR 168) and Institut Pierre-Gilles de Gennes pour la Microfluidique, France (supervisors: Drs. Jean-Louis Viovy, Catherine Villard, and Stéphanie Descroix)

2010-2013  Postdoctoral fellow at Institut Curie (UMR 168 & 144), France (supervisors: Drs. Patricia Bassereau and Evelyne Coudrier)

2008-2009  Postdoctoral fellow at Department of Chemistry, Ecole Normale Supérieure (UMR 8640 PASTEUR), France (supervisors: Prof. Damien Baigl and Dr. Yong Chen)

2005-2008  Ph.D. at Department of Physics, Graduate School of Science, Kyoto University, Japan (supervisor: Prof. Kenichi Yoshikawa)

2003-2005  M. Sc. at Department of Physics, Graduate School of Science, Kyoto University, Japan (supervisor: Prof. Kenichi Yoshikawa)

2003     Graduate from Faculty of Science, Kyoto University, Japan

Research interests

  • Microfluidics
  • Brain-on-chip
  • Reconstituted systems
  • Biophysics
  • Organs-on-chips

Fellowships, Awards and Grants

  • DIM ELICIT EQUIPMENT 2018 from Île-de-France, 2019
  • Postdoctoral Fellowship for Research Abroad from the Japan Society for the Promotion of Science, 2008-2009
  • Research Fellowship for Young Scientists (DC2) from the Japan Society for the Promotion of Science, 2006-2008
  • Sasakawa Scientific Research Grant, 2005-2006
  • Kyoto University Venture Business Laboratory Research Grant for undergraduate and graduate students, 2004-2005

Supervised students and post-doctorants

  • Boxin HUANG (Ph.D. candidate, co-supervision with Dr. Yong CHEN)
  • Chloé PAKA (M1)

Selected publications

  • Transient microfluidic compartmentalization using actionable microfilaments for biochemical assays, cell culture and organs-on-chip
    A. Yamada*, R. Renault, A. Chikina, B. Venzac, I. Pereiro, S. Coscoy, M. Verhulsel, M. C. Parrini, C. Villard, J.-L. Viovy, S. Descroix*
    Lab on a Chip, 16, 4691-4701 (2016)
  • In-mold patterning and actionable axo-somatic compartmentalization for on-chip neuron culture
    A. Yamada, M. Vignes, C. Bureau, A. Mamane, B. Venzac, S. Descroix, J.-L. Viovy, C. Villard, J.-M. Peyrin, L. Malaquin
    Lab on a Chip, 16, 2059-2068 (2016)
  • Trapping and release of giant unilamellar vesicles in microfluidic wells
    A. Yamada, S. Lee, P. Bassereau, C. N. Baroud
    Soft Matter, 10, 5878-5885 (2014)
  • Catch-bond behaviour facilitates membrane tubulation by non-processive myosin 1b
    A. Yamada, A. Mamane, J. Lee-Tin-Wah, A. Di Cicco, C. Prévost, D. Lévy, J.-F. Joanny, E. Coudrier, P. Bassereau
    Nature Communications, 5, 3624 (2014)
  • Myosin 1b promotes the formation of post-Golgi carriers by regulating actin assembly and membrane remodelling at the trans-Golgi network
    C. G. Almeida, A. Yamada, D. Tenza, D. Louvard, G. Raposo, E. Coudrier
    Nature Cell Biology, 13, 779-789 (2011)
  • Oil micro-sealing: a robust micro-compartmentalization method for on-chip chemical and biological assays
    A. Yamada, F. Barbaud, L. Cinque, L. Wang, Q. Zeng, Y. Chen, D. Baigl
    Small, 6, 2169-2175 (2010)
  • Spontaneous transfer of phospholipid-coated oil-in-oil and water-in-oil micro-droplets through an oil/water Interface
    A. Yamada, T. Yamanaka, T. Hamada, M. Hase, K. Yoshikawa, D. Baigl
    Langmuir, 22, 9824-9828 (2006)
  • All-or-none switching on transcriptional activity of individual DNA molecules through discrete conformational transition
    A. Yamada, K. Kubo, T. Nakai, K. Tsumoto, K. Yoshikawa
    Applied Physics Letters, 86, 223901 (2005)