IMAP 2021 Webinar series
29th of June 2021 at 2pm
Online on Zoom
Meeting ID: 843 1247 9733
Secret code: K3nwq9
Tuning Properties and Functionality in the Modulated Self-Assembly of Metal-Organic Frameworks
Prof. Ross S. Forgan
WestCHEM School of Chemistry, University of Glasgow
Metal-organic frameworks (MOFs) are network materials comprised of organic ligands connected by metal ion clusters into multidimensional structures that often have permanent porosity. Their chemically addressable structures, combined with their ability to store large quantities of small molecules within their pores, have led to applications in gas storage, heterogeneous catalysis, sensing, and drug delivery, amongst others. Coordination modulation, the addition of monomeric modulators to synthetic mixtures, can tune particle size from nanometres to centimetres, through capping of crystallites (decreasing size) or coordinative competition with ligands (increasing size).
The talk will cover the development of our own modulation techniques for a range of trivalent and tetravalent MOFs, describing the versatility of modulation in controlling physical properties such as interpenetration, defectivity, and porosity.1 Our techniques provide access to high quality single crystals of many different MOFs, allowing the subsequent characterisation of their mechanical properties,2 flexibility upon guest uptake,3 single-crystal to single-crystal postsynthetic modification,4 and development of fluorescent sensors.5 Additionally, we will show that protocols can be tuned to downsize materials, producing nanoparticles with fine control of surface chemistry, allowing the assembly of pH-responsive6 and organelle targeted7 drug delivery devices.
1Marshall, R. J. et al., J. Mater. Chem. A 2018, 6, 1181–1187.
2Hobday, C. L. et al., Angew. Chem. Int. Ed. 2016 55, 2401–2405.
3Marshall, R. J.; McGuire, J.; Wilson, C.; Forgan, R. S. Supramol. Chem. 2018, 30, 124–133.
4Marshall, R. J.; Griffin, S. L.; Wilson, C; Forgan, R. S. J. Am. Chem. Soc. 2015, 137, 9527–9530.
5Marshall, R. J. et al., J. Am. Chem. Soc. 2017, 139, 6253–6260; Sussardi, A. et al., Angew. Chem. Int. Ed. 2020, 59, 8118–8122
6Abánades Lázaro, I. et al., Chem 2017, 2, 561–578.
7Haddad, S. et al., J. Am. Chem. Soc. 2020, 142, 6661–6674.