MOFs’ hydrolytic stability together with high versatility and modularity has promoted them as highly promising candidates for water-related applications of high societal interest and other emerging fields. S-shaped water isotherms and the finely tuned hydrophilic character of MOFs are key parameters for heat reallocation and water harvesting applications, while increased hydrophobicity is expected for separation occurring under wet conditions. Bearing suitable functional groups (e.g., –SO3H, –COOH, –NH2) that are geometrically precisely distributed, MOFs can show high proton conductivity outperforming benchmark materials. https://doi.org/10.1016/j.trechm.2020.09.004
Catégorie d'actualités : UMR8004 IMAP
New pre-print on MedRXiv: SARS-CoV-2 Inactivation Potential of Metal Organic Framework Induced Photocatalysis
https://doi.org/10.1101/2020.10.01.20204214
As the world recovers from the lockdown imposed by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic, returning to shared indoor spaces is considered a formidable risk. It is now clear that transmission of SARS-CoV-2 is driven by respiratory microdroplets expelled by infected persons, which can become suspended in the air. Several layering technologies are being explored to mitigate indoor transmission in the hopes of re-opening business, schools and transportation systems. Here we coupled the water adsorptive and photocatalytic capacity of novel Metal Organic Frameworks (MOFs) to demonstrate the capture and inactivation of SARS-CoV-2. Discussion is given on the methods of analysis and the differences between the photocatalytic activity of several MOFs, and the difference between MOF induced photocatalysis and ultra violet photolysis of SARS-CoV-2. Our results are intended to provide support to industry looking for alternative methods secure indoor spaces.
Faraday Discussion on MOFs for energy and environmental applications
Angelika Mielcarek Defense
Surface engineered hybrid nanocarriers for cancer treatment
Par Angelika Maria MIELCAREK, jeu. 14 mai 2020 14:00 – 18:00 (CEST)
Thèse de doctorat de PSL Research University préparée à l’École Normale Supérieure de Paris et à l’Université Paris-Sud
ÉCOLE DOCTORALE 397, spécialité: Chimie Matériaux et Sciences pharmaceutiques
Metal-Organic Frameworks nanoparticles (nanoMOFs) are porous crystalline materials of interest for biomedicine applications. Particularly attractive ones are MIL-100(Fe) iron carboxylate nanoparticles (NPs). Despite many advantages, these NPs tend to aggregate in physiological media and accumulate in organs after intravenous administration. In this work, we investigated the impact of different surface modifications route (covalent and non-covalent) on the colloidal stability of MIL-100(Fe) NPs in physiological media and the ability of the coatings to tune the in vivo biodistribution and pharmacokinetics of NPs. We also investigated different synthesis route to decrease the size of the NPs, in a view of reducing the macrophage recognition. Finally, we studied the encapsulation and release of anticancer drug, Methotrexate (MTX), into magnetic core-shell nanoMOFs-iron oxide NPs and the toxicity evaluation of molecules based on C.elegans worms.
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Tuning Cellular Biological Functions Through the Controlled Release of NO from a Porous Ti-MOF
Materials for the controlled release of nitric oxide (NO) are of interest for therapeutic applications. However, to date, many suffer from toxicity and stability issues, as well as poor performance. Herein, we propose a new NO adsorption/release mechanism through the formation of nitrites on the skeleton of a titanium-based Metal-Organic Framework (MOF) that we have named MIP-177, featuring a suitable set of properties for such applications: (i) high NO storage capacity (3 μmol mg-1solid), (ii) excellent biocompatibility at therapeutic relevant concentrations (no cytotoxicity at 90 μg/mL for wound healing) due to its high stability in biological media (< 9% degradation in 72 hours) and (iii) slow NO release in biological media (⁓2 hours for 90% release). The prospective application of MIP-177 is demonstrated through the NO-driven control of mitochondrial respiration in cells and the stimulation of cell migration, paving the way for the design of new NO delivery systems for wound healing therapy.
Presse Release (in french): Un MOF à base de titane prometteur pour la cicatrisation !
References:
Tuning Cellular Biological Functions Through the Controlled Release of NO from a Porous Ti-MOF
Rosana V. Pinto, Sujing Wang, Sergio R. Tavares, João Pires, Fernando Antunes, Alexandre Vimont, Guillaume Clet, Marco Daturi, Guillaume Maurin, Christian Serre and Moisés L. Pinto
Angew. Chem. Int. Ed. 2020
DOI: 10.1002/anie.201913135
Toward a Rational Design of Titanium Metal-Organic Frameworks
The complexity of Ti chemistry in solution not only leads to the difficulty of isolating crystalline titanium metal-organic frameworks (Ti-MOFs) but also brings the challenge of controlled assembly of the crystal structure. We report here the first example of a controlled synthesis of a Ti-MOF structure through a linker-exchange strategy directly from a preformed Ti-O cluster. A Ti8O8 cluster precursor with terminal formate and acetate ligands (Ti8AF) was reacted with tri- mesic acid (BTC) under green and mild conditions, generating a microporous Ti-MOF (MIP-207) while preserving the connection and configuration of the Ti8O8 core. In addition, due to the ditopic meta-positional connection mode of the linker, the chemical environment and functionality of the structural voids could be easily tuned by substituting trimesate moieties with isophthalate-type linkers via concise one-pot reactions. This finally resulted in an adjustable per- formance in CO2 capture over N2.
References:
Toward a Rational Design of Titanium Metal-Organic Frameworks
Sujing Wang, Helge Reinsch, Nicolas Heymans, Mohammad Wahiduzzaman, Charlotte Martineau-Corcos, Guy De Weireld, Guillaume Maurin, and Christian Serre
Matter 2, 1–11, 2020
DOI: 10.1016/j.matt.2019.11.002
Engineering Structural Dynamics of Zirconium Metal–Organic Frameworks Based on Natural C4 Linkers
Engineering the structural flexibility of metal–organic framework (MOF) materials for separation-related applications remains a great challenge. We present here a strategy of mixing rigid and soft linkers in a MOF structure to achieve tunable structural flexibility, as exemplified in a series of stable isostructural Zr-MOFs built with natural C4 linkers (fumaric acid, succinic acid, and malic acid). As shown by the differences in linker bond stretching and bending freedom, these MOFs display distinct responsive dynamics to external stimuli, namely, changes in temperature or guest molecule type. Comprehensive in situ characterizations reveal a clear correlation between linker character and MOF dynamic behavior, which leads to the discovery of a multivariate flexible MOF. It shows an optimal combination of both good working capacity and significantly enhanced selectivity for CO2/N2 separation. In principle, it provides a new avenue for potentially improving the ability of microporous MOFs to separate other gaseous and liquid mixtures.
References:
Engineering Structural Dynamics of Zirconium Metal–Organic Frameworks Based on Natural C4 Linkers
Sujing Wang, Nertil Xhaferaj, Mohammad Wahiduzzaman, Kolade Oyekan, Xiao Li, Kevin Wei, Bin Zheng, Antoine Tissot, Jérôme Marrot, William Shepard, Charlotte Martineau-Corcos, Yaroslav Filinchuk, Kui Tan, Guillaume Maurin, Christian Serre
J. Am. Chem. Soc. 2019, 141, 43, 17207-17216
DOI: 10.1021/jacs.9b07816
A Robust Zirconium Amino Acid Metal-Organic Framework for Proton Conduction
Proton conductive materials are of significant importance and highly desired for clean energy-related applications. Discovery of practical metal-organic frameworks (MOFs) with high proton conduction remains a challenge due to the use of toxic chemicals, inconvenient ligand preparation and complication of production at scale for the state-of-the-art candidates. Herein, we report a zirconium-MOF, MIP-202(Zr), constructed from natural α-amino acid showing a high and steady proton conductivity of 0.011 S cm−1 at 363 K and under 95% relative humidity. This MOF features a cost-effective, green and scalable preparation with a very high space-time yield above 7000 kg m−3 day−1. It exhibits a good chemical stability under various conditions, including solutions of wide pH range and boiling water. Finally, a comprehensive molecular simulation was carried out to shed light on the proton conduction mechanism. All together these features make MIP-202(Zr) one of the most promising candidates to approach the commercial benchmark Nafion.
Pour plus d’informations, consultez notre communiqué de presse : Produire de l’énergie « verte » avec un matériau hybride à base d’acide aminé naturel !
References:
A Robust Zirconium Amino Acid Metal-Organic Framework for Proton Conduction
Sujing Wang, Mohammad Wahiduzzaman, Louisa Davis, Antoine Tissot, William Shepard, Jérôme Marrot, Charlotte Martineau-Corcos, Djemel Hamdane, Guillaume Maurin, Sabine Devautour-Vinot and Christian Serre
Nature Communications volume 9, Article number: 4937 (2018)
DOI: 10.1038/s41467-018-07414-4
A Robust Energy-Efficient Metal-Organic Framework Adsorbent for Refrigeration
The discovery of more-efficient and stable water adsorbents for adsorption-driven chillers for cooling applications remains a challenge due to the low working capacity of water sorption, high regeneration temperature, low energy efficiency under given operating conditions and the toxicity risk of harmful working fluids for the state-of-the-art sorbents. Here we report the water-sorption properties of a porous zirconium carboxylate metal–organic framework, MIP-200, which features S-shaped sorption isotherms, a high water uptake of 0.39 g g−1below P/P0 = 0.25, facile regeneration and stable cycling, and most importantly a notably high coefficient of performance of 0.78 for refrigeration at a low driving temperature (below 70 °C). A joint computational–experimental approach supports that MIP-200 may be a practical alternative to the current commercially available adsorbents for refrigeration when its water adsorption performance is combined with advantages such as the exceptional chemical and mechanical stability and the scalable synthesis that involves simple, cheap and green chemicals.
Consultez le communiqué de presse associé à cet article : Un solide nanoporeux pour une réfrigération plus efficace
References :
A Robust Energy-Efficient Metal-Organic Framework Adsorbent for Refrigeration
Sujing Wang, Ji Sun Lee, Mohammad Wahiduzzaman, Jaedeuk Park, Mégane Muschi, Charlotte Martineau-Corcos, Antoine Tissot, Kyung Ho Cho, Jérôme Marrot, William Shepard, Guillaume Maurin*, Jong-San Chang*, and Christian Serre*
Nature Energy 2018
DOI: 10.1038/s41560-018-0261-6
3rd International Conference on Metal Organic Frameworks and Porous Polymers
3rd International Conference on Metal Organic Frameworks and Porous Polymers
October 27th – October 30th 2019 – Paris, France
More information: https://euromof2019.sciencesconf.org/
Based on the success of the two previous EuroMOF conferences organized in Postdam (2015) and Delft (2017), more than 450 researchers in the field of MOFs, COFs and porous polymers from all over the world are expected to join us for a new edition of the EuroMOFs 2019 conference. The conference will be held in Paris (France) the 27th-30th of October 2019.
Internationally renown speakers have already accepted to give a Plenary or Keynote lecture which will certainly make this event a great success.
A young investigator symposium will be organized before the EuroMOFs conference while an industrial workshop will be held right after the conference.
Chairs : Dr. Christian Serre and Prof. Guillaume Maurin.