Catégorie d'actualités : UMR8004 IMAP

New article on photoaccumulation of long-lived electrons in a Ti-MOF

Check out IMAP new article entitled:

Photoaccumulation of Long-Lived Reactive Electrons in a Microporous Ti(IV) Oxocluster-Based Metal–Organic Framework for Light and Dark Photocatalysis

The microporous Ti12 oxocluster-based metal–organic framework (MOF) MIP-177(Ti)-LT exhibits excellent stability and photoactivity, making it highly promising for photocatalysis. Using transient and photoinduced absorption spectroscopies, the behavior of reactive electrons in MIP-177(Ti)-LT across femtosecond-to-second timescales is investigated. The framework shows efficient charge separation and slow decay kinetics, with photogenerated charges persisting into the microsecond-second (µs-s) range and displaying higher yields and slower recombination than benchmark MOFs MIL-125(Ti)-NH2 and UiO-66(Zr)-NH2. Photogenerated holes oxidize water with an O2 yield of 335 µmol g−1 h−1 in the presence of electron scavengers. Under continuous irradiation, long-lived electrons accumulate, further enhanced by a hole scavenger (methanol). Remarkably, these electrons persist over 48 h post-excitation under argon, accompanied by a reversible white-to-black color change. The stored electrons remain redox-active, efficiently reducing added O2 and methyl viologen. Dark addition of a Pt co-catalyst to photocharged MIP-177(Ti)-LT induces H2 evolution at ≈300 µmol g−1 (≈58 C g−1), corresponding to an accumulated electron density of one electron per 12 Ti atoms. These results highlight the photocharging properties of MIP-177(Ti)-LT and its potential for sustainable photocatalytic applications.

More info here: https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202517595

Seminar Pr. Gassensmith, 11am Dec. 4th

Thursday 4th of December we will receive the visit of Pr. Jeremiah Gassensmith, Associate Professor in Chemistry & Biochemistry at The University of Texas at Dallas. He will give a talk on  « Metal–Organic Frameworks as Dual-Function Platforms for Immunology and Therapeutics» it will be at 11 am, at ENS, in room R.

Metal–Organic Frameworks as Dual-Function Platforms for Immunology and Therapeutics

Prof. Jeremiah J Gassensmith, Ph.D.
The University of Texas at Dallas
Dept. of Chemistry & Biochemistry, 800 West Campbell Road, Mail stop: BS13, Richardson, TX 75080
Email: gassensmith@utdallas.edu
https://labs.utdallas.edu/gassensmith/
BlueSky: @Gassensmith

Abstract:
Metal–organic frameworks (MOFs) have rapidly evolved from chemical curiosities into functional materials for biomedical science. Their high porosity, tunable chemistry, and compatibility with biologics enable MOFs to act as protective cages for fragile payloads such as proteins, nucleic acids, and enzymes. In our work, we investigate how MOFs can transition from passive carriers to actively participate in immunology and therapeutic design. Zinc-based ZIFs offer both antigen stabilization and measurable adjuvant effects, capitalizing on the immunological activity of their constituent metals. By introducing manganese nodes, we further exploit the cGAS–STING pathway, showing how Mn-containing MOFs can synergize with cyclic dinucleotides to amplify dendritic cell activation and cytokine production. These dual functions—structural protection and immunological stimulation—enable the development of next-generation vaccine formulations that combine stability with innate immune activation. In parallel, we investigate MOFs as depots for enzymes that neutralize toxic organophosphates, where the crystalline scaffold prolongs enzyme lifetime in vivo and supports prophylactic applications. Together, these studies demonstrate how the rational design of MOFs can integrate materials science with immunology to address challenges ranging from infectious disease vaccination to chemical defense.

MOFs Workshop: Oct 30th – amphi IPPG

On the morning of October 30th, 2025, the Department of Chemistry at ENS and IMAP will host a workshop on Metal–Organic Frameworks for Energy, Environmental, and Biomedical Applications. This event will bring together internationally recognized experts, Patricia Horcajada, Hana Bunzen, Paolo Falcaro and Moises Pinto, to discuss recent advances in the design, characterization, and application of MOFs, from sustainable energy conversion and environmental remediation to innovative biomedical technologies. It will be in the IPGG amphitheater located at 6 Rue Jean Calvin.
More info and detailed program: HERE

Seminar Pr. S. Floquet, Oct. 9th, 11am

Thursday 9th of October we will receive the visit of Pr. Sebastien Floquet, from Institut Lavoisier de Versailles, Université Paris-Saclay.
He will give a talk on the « Use of Molybdenum complexes for the safeguard of the honeybees: from the beaker to the market.» it will be at 11 am, at ENS, in room R.

Use of Molybdenum complexes for the safeguard of the honeybees: from the beaker to the market.

Prof. Sébastien Floquet
Institut Lavoisier de Versailles, Université Paris-Saclay, UVSQ, CNRS, UMR 8180, 78000 Versailles, France.
Oligofeed SAS, Ferme du Moulon, 91190 Gif sur Yvette, France
sebastien.floquet@uvsq.fr

Bees are experiencing a worrying decline around the world. Beyond this decline, 20,000 species of plants are also affected by their disappearance and nearly 40% of our diet. Molybdenum is an essential trace element for life. Found in over fifty enzymes, Mo plays an important role in plants and in animals. For several years we are developing molecular complexes based on Mo for applications in biology.[1,2] In particular, very simple coordination complexes have proved to be very active in beekeeping[3-5]. Non-toxic, these molecules allow improving the honey bee health, enhance their productivity and decrease their mortality, especially in winter. A first part of this talk will be focused on the the effects obersved for one complex in beehives in different countries and different environment but in real operating conditions for professional beekeepers. A second part will be dedicated to understanding of the role played by these complexes within the bees’ organism, thanks to many techniques such as ICP-MS, X-Ray Fluorescence experiments performed on Synchrotron SOLEIL or XPS studies.


Localization of molybdenum within the head of a bee fed with a Mo-complex

[1] A. Fuior, A. Hijazi, O. Garbuz, V. Bulimaga, L. Zosim, D. Cebotari, M. Haouas, I. Toderas, A. Gulea and S. Floquet, Journal of Inorg. Biochem., 2022, 226, 111627.
[2] A. Fuior, D. Cebotari, M. Haouas, J. Marrot, G. Minguez Espallargas, V. Guérineau, D. Touboul, R. Rusnac, A. Gulea and S. Floquet, ACS Omega, 2022, https://doi.org/10.1021/acsomega.2c00705
[3] A. Fuior, S. Floquet, V. Cebotari, D. Cebotari, A. Gulea, I. Toderas. « Food supplement based on molybdenum for bees ». European patent EP4185594B1 (delivered on 04 dec. 2024). In progress for USA, Canada, Argentina, and China.
[4] A. Fuior et al. Feed supplementation with molybdenum complexes improves honey bee health. Inorganic Chemistry Frontiers 2025 https://doi.org/10.1039/D5QI00878F
[5] Benito-Murcia et al., Reducing Honey Bee Winter Mortality with Molybdenum Supplementation: Field Evidence Across Europe. 2025. Under revision for Reseach in Veterinary Science. Preprint sur BioRxiv. https://doi.org/10.1101/2025.07.23.666091

« Les métaux et la vie », « Pasteur au microscope » : représentations théâtrales à venir

La chimie s’invite au théâtre ! Venez découvrir :

Une belle occasion de découvrir que nous serions ni vivants, ni humains, sans les métaux, et la vie de Pasteur à quelques mètres de son ancien bureau à l’ENS !

A Novel Ti12-Based Metal-Organic Framework for Photocatalytic Hydrogen Evolution

Check out the latest paper from IMAP and colleagues here:
https://advanced.onlinelibrary.wiley.com/share/6ZQXKUNPZRHRNQ3JHRS2?target=10.1002/aenm.202500211

A new microporous titanium-based metal-organic framework (Ti-MOF), labeled as MIP-209(Ti) (MIP: Materials from Institute of Porous Materials of Paris), features nitro terephthalate ligands and Ti12O15 oxo-clusters, as revealed by continuous rotation electron diffraction (cRED). MIP-209(Ti) can be obtained using two different terephthalate (1, 4-BDC2−) derivatives such as NO2-BDC and 2Cl-BDC in an eco-friendly solvent, suggesting the isostructural versatility of Ti12-MOFs. Alternatively, its Ti-oxo-cluster can be tuned, similarly to MIP-177(Ti)-LT bearing the same Ti12O15 sub-unit. Typically, low percentage Cr3+ doping (≤5 at%) in MIP-209(Ti) favorably enhances the water stability. MIP-209(Ti-Cr)-NO2 shows a significant hydrogen production rate, with good reusability and stability under simulated solar light irradiation. Compared to the benchmark Ti-MOF IEF-11, the hydrogen production of MIP-209(Ti-Cr)-NO2 with 5 at% Cr doping has a fourfold enhancement in photocatalytic hydrogen evolution from water splitting reaction (HER) during 5 h in presence of methanol (5 812 µmol/gcat against 1 391 µmol/gcat), as well as, without any noble metal co-catalyst, a sixfold enhancement in overall water splitting reaction (OWS) (681 and 325 µmol/gcat of H2 and O2, respectively, against 94 and 53 µmol/gcat of H2 and O2, respectively). This work represents a leap forward in the synthesis of Ti-MOFs and their practical photocatalytic applications.

Une avancée pour purifier l’air intérieur : des matériaux prometteurs contre le formaldéhyde

Le formaldéhyde pollue l’air intérieur, car il est utilisé pour conserver le mobilier et les vêtements lors des longs voyages en bateau depuis leurs lieux de production. Il est très nocif pour la santé, mais les filtres à air le retiennent mal. De nouveaux matériaux, poreux à toute petite échelle, agissent comme des éponges et montrent une bonne efficacité de capture de ce polluant.

Le lien vers l’article complet

IMAP Seminar April 25th 11am, Prof. Matthias Thommes, @ESPCI (Boreau)

Friday 25th of April we will receive the visit of Pr. Matthias Thommes, from Friedrich-Alexander-University
he will give a talk on the « Recent Advances in the Adsorption Characterization of Nanoporous Materials »
it will be at 11 am, at ESPCI in amphitheater Boreau,

Abstract:

Recent Advances in the Adsorption Characterization of Nanoporous Materials

Matthias Thommes

Institute of Separation Science and Technology,
Department of Chemical and Bioengineering
Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, 91058, Germany
e-mail: matthias.thommes@fau.de

Nanoporous materials (e.g. carbons, zeolites, metal organic framework materials, ordered and hierarchically structured meso-macroporous oxides etc.) have been the subject of extensive research targeted towards a wide range of applications because of their unique textural properties such as increased surface area and the ability to customize the pore size and pore size distribution. In addition, unique nano-confinement effects, such as for instance enhancements in the adsorption capacity, reaction kinetics, ion selectivity and gas solubility can be observed within narrow nanopores. Moreover, confinement induces shifts in the phase diagram of pore fluids and alters their thermophysical properties. Hence, in order to utilize effects of nano-confinement in the various application areas (e.g.,separation, catalysis, gas-energy storage) a detailed understanding of the interplay between effective fluid-fluid and fluid-(pore) wall interactions on the one hand and the effects of confined pore space and pore geometry/pore network on the other hand is required. For this, a detailed characterization of the surface properties and pore network architecture is required.

Within this context, we focus on fundamental aspects associated with the adsorption-, phase- and wetting behavior of fluids in nanoporous materials and will link this with recent advances in the application of advanced and novel adsorption methodologies for assessing key aspects of their pore network characteristics and surface properties.

CV:


Matthias Thommes is Full Professor and Head of the Institute of Separation Science and Technology at the Department of Chemical and Biological Engineering at the Friedrich-Alexander Universität Erlangen-Nürnberg (FAU). He also served as Head of the Department for Chemical and Biological Engineering at FAU from 2021 to 2023.

Matthias obtained his Ph.D. in Physical Chemistry in 1993 at the Technical University Berlin. From 1992 to 1995 he was a project scientist at the EURECA mission of the European Space Agency (ESA). In 1996, he moved as an ESA fellow/research associate to the University of Maryland, College Park, USA. In 1998, Matthias joined Quantachrome Corp (Boynton Beach, FL, USA).and was prior to accepting the position at FAU Scientific Director at Quantachrome Corporation, Boynton Beach, USA (from 2001 to 2018). .In addition, he held Visiting Professor positions at the University of Edinburgh (UK) and the University of Lorraine (Epinal, Nancy, France) as well as prestigious leadership positions in a number of national and international boards, committees and authoritative bodies in the field of adsorption, nanoporous materials and their characterization. This includes the International Union for Pure and Applied Chemistry (IUPAC)), American Institute of Chemical Engineering (AIChE), International Zeolite Association (IZA), Facility of Adsorbent Testing and Characterization (FACT) at the National Institute of Standards (NIST, USA), International Adsorption Society (IAS), International Standard Organization (ISO).

Matthias Thommes’ work involves investigating the adsorption behavior of fluids in nanoporous materials, developing methodologies for application-specific nanoporous material characterization (both in the dry and wet phase) and conducting research in gas and energy storage. Within this framework, he examines the effects of nano-confinement on the adsorption, phase and wetting behavior of subcritical and supercritical fluids in nanopores. His research forms a link between the adsorption properties of adsorbents and their characteristics with the development of nanoporous materials and their use in various processes

He has received numerous recognitions for his work, among them the induction as a Fellow of the International Adsorption Society (IAS) in 2021.and most recently by the American Institute of Chemical Engineers (AIChE), where is was distinguished for his outstanding achievements in the area of fundamentals of adsorption and porous materials characterization. during a dedicated Honorary Session on October 28th in San Diego (USA) at the 2024 AIChE Annual Meeting.

Séminaire: 18 Mars Pr. S. Lecommandoux

Self-Assembly of Biohybrid Polymers:
from Smart Therapeutics to artificial cells

Tuesday March 18th at 10.30 am
Salle Emile BOREL
29 rue d’Ulm, 75005 Paris

Sébastien Lecommandoux
Université de Bordeaux, CNRS, Bordeaux INP, LCPO, UMR 5629, ENSCBP, 16 Avenue
Pey-Berland, Pessac F-33600, France
E-mail: sebastien.lecommandoux@u-bordeaux.fr

Our scientific approach is based on biomimicry, as we engineer synthetic mimics of natural macromolecules (such as proteins or glycoproteins), and explore their controlled and tunable self-assembly to form structures similar to those found in nature (such as virus or cell membranes). In this context, we develop polymer-based self-assembled nanoparticles, mostly polymeric vesicles, also named polymersomes, with high loading content of active pharmaceutical ingredients (e.g., anticancer drugs, peptides, proteins) and targeting ability. Our expertise includes the synthesis of precise, biocompatible polymers such as polypeptides (by chemical synthesis or recombinant DNA technology), polysaccharides, and their conjugates.
We present here an overview of the self-assembly of amphiphilic block copolymers and their contribution in nanomedicine. We pay particular attention to block copolymer vesicles based on polysaccharides, polypeptides and proteins especially based on Elastin Like Polypeptides (ELPs) and their modification with synthetic polypeptides [1], saccharides [2], polysaccharides [3] and lipids [4], aiming at mimicking both the structure and functionality of glycoproteins and lipoproteins. The ability of these systems for different biomedical applications, from bioprinting, drug-delivery to inhibitor, will be presented [5,6]. Finally, our most recent advances in the design of complex, compartmentalized and functional artificial cells will be presented [7-11]. These systems represent a first step towards the challenge of structural and functional mimicry of cells, which in future could act autonomously to detect and repair any biological deregulation in situ.

[1] M Badreldin et al. Biomacromolecules 25, 3033 (2024). P. Salas-Ambrosio J. Am. Chem. Soc.
143, 3697 (2021).
[2] LMM Bravo Anaya et al. Biomacromolecules 22, 1, 76–85 (2021)
[3] M. Levêque et al. Biomaterials Science 10, 6365-6376 (2022)
[4] V Ibrahimova et al. Angew. Chem. Int. Ed. 60, 15036-15040 (2021)
[5] M. Levêque et a. Biomacromolecules 25, 3011 (2024)
[6] H. Duan et al. Angew. Chem. Int. Ed. 132 (32), 13693-13698 (2020)
[7] H. Zhao et al. Angew. Chem. Int. Ed. 132 (27), 11121-11129 (2020)
[8] H. Zhao et al. Advanced Science 2102508 (2021)
[9] C. Schwartzman et al. Advanced Materials 17, 2301856 (2023)
[10] C.G. Palivan et al. Biomacromolecules 25(9), 5454−5467 (2024)
[11] E. Equy.et al. J. Am. Chem. Soc. in press (2025).

Sébastien Lecommandoux
Professor at University of Bordeaux
Bordeaux INP/CNRS
https://www.lcpo.fr/people/faculties/sebastien-lecommandoux

Short Biography
Sébastien Lecommandoux received his Ph.D. (1996) in Physical Chemistry from the University of Bordeaux. After a postdoctoral experience at the University of Illinois (UIUC, USA) in the group of Prof. Samuel I. Stupp, he started his academic career at the Laboratoire de Chimie des Polymères Organiques as Associate Professor in 1998 and was promoted to Full Professor at Bordeaux INP in 2005. He is currently Director of the Laboratoire de Chimie des Polymères Organiques (LCPO-CNRS) and is leading the group “Polymers Self-Assembly and Life Sciences”. His research interests include the design of bio-inspired polymers for biomaterials and pharmaceutical development, especially based on polypeptide, proteins and polysaccharide-based block copolymers self-assembly, the design of polymersomes for drug-delivery and theranostic, as well as biomimetic approaches toward design of synthetic viruses and artificial cells. He published over 235 publications in international journal, 6 book chapters and 15 patents (3 being licenced, 1 start-up created Doxanano). He is also co-director of the joint laboratory LCPO-L’OREAL. Sébastien Lecommandoux is recipient of the CNRS bronze medal (2004), Institut Universitaire de France Junior Chair (IUF 2007), Fellow of the Royal Society of Chemistry RSC (2017), French Academy of Science Chemistry Seqens Award (2019), Member of the Academia Europaea (2020), XingDa Lectureship Award from Peking University (2021). He currently holds the Chaire annuelle Innovation technologique Liliane Bettencourt, Collège de France (2024-2025). He is Editor-in-Chief of Biomacromolecules (ACS) since 2020 after serving as Associate Editor since 2013. He is also in the Editorial Advisory Board of several international journals, including Bioconjugate Chemistry (ACS), Polymer Chemistry (RSC), Biomaterials Science (RSC) and RSC Applied Polymers.