Catégorie d'actualités : UMR8004 IMAP

IMAP Seminar April 25th 11am, Prof. Matthias Thommes, @ESPCI (Boreau)

Friday 25th of April we will receive the visit of Pr. Matthias Thommes, from Friedrich-Alexander-University
he will give a talk on the « Recent Advances in the Adsorption Characterization of Nanoporous Materials »
it will be at 11 am, at ESPCI in amphitheater Boreau,

Abstract:

Recent Advances in the Adsorption Characterization of Nanoporous Materials

Matthias Thommes

Institute of Separation Science and Technology,
Department of Chemical and Bioengineering
Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, 91058, Germany
e-mail: matthias.thommes@fau.de

Nanoporous materials (e.g. carbons, zeolites, metal organic framework materials, ordered and hierarchically structured meso-macroporous oxides etc.) have been the subject of extensive research targeted towards a wide range of applications because of their unique textural properties such as increased surface area and the ability to customize the pore size and pore size distribution. In addition, unique nano-confinement effects, such as for instance enhancements in the adsorption capacity, reaction kinetics, ion selectivity and gas solubility can be observed within narrow nanopores. Moreover, confinement induces shifts in the phase diagram of pore fluids and alters their thermophysical properties. Hence, in order to utilize effects of nano-confinement in the various application areas (e.g.,separation, catalysis, gas-energy storage) a detailed understanding of the interplay between effective fluid-fluid and fluid-(pore) wall interactions on the one hand and the effects of confined pore space and pore geometry/pore network on the other hand is required. For this, a detailed characterization of the surface properties and pore network architecture is required.

Within this context, we focus on fundamental aspects associated with the adsorption-, phase- and wetting behavior of fluids in nanoporous materials and will link this with recent advances in the application of advanced and novel adsorption methodologies for assessing key aspects of their pore network characteristics and surface properties.

CV:


Matthias Thommes is Full Professor and Head of the Institute of Separation Science and Technology at the Department of Chemical and Biological Engineering at the Friedrich-Alexander Universität Erlangen-Nürnberg (FAU). He also served as Head of the Department for Chemical and Biological Engineering at FAU from 2021 to 2023.

Matthias obtained his Ph.D. in Physical Chemistry in 1993 at the Technical University Berlin. From 1992 to 1995 he was a project scientist at the EURECA mission of the European Space Agency (ESA). In 1996, he moved as an ESA fellow/research associate to the University of Maryland, College Park, USA. In 1998, Matthias joined Quantachrome Corp (Boynton Beach, FL, USA).and was prior to accepting the position at FAU Scientific Director at Quantachrome Corporation, Boynton Beach, USA (from 2001 to 2018). .In addition, he held Visiting Professor positions at the University of Edinburgh (UK) and the University of Lorraine (Epinal, Nancy, France) as well as prestigious leadership positions in a number of national and international boards, committees and authoritative bodies in the field of adsorption, nanoporous materials and their characterization. This includes the International Union for Pure and Applied Chemistry (IUPAC)), American Institute of Chemical Engineering (AIChE), International Zeolite Association (IZA), Facility of Adsorbent Testing and Characterization (FACT) at the National Institute of Standards (NIST, USA), International Adsorption Society (IAS), International Standard Organization (ISO).

Matthias Thommes’ work involves investigating the adsorption behavior of fluids in nanoporous materials, developing methodologies for application-specific nanoporous material characterization (both in the dry and wet phase) and conducting research in gas and energy storage. Within this framework, he examines the effects of nano-confinement on the adsorption, phase and wetting behavior of subcritical and supercritical fluids in nanopores. His research forms a link between the adsorption properties of adsorbents and their characteristics with the development of nanoporous materials and their use in various processes

He has received numerous recognitions for his work, among them the induction as a Fellow of the International Adsorption Society (IAS) in 2021.and most recently by the American Institute of Chemical Engineers (AIChE), where is was distinguished for his outstanding achievements in the area of fundamentals of adsorption and porous materials characterization. during a dedicated Honorary Session on October 28th in San Diego (USA) at the 2024 AIChE Annual Meeting.

Séminaire: 18 Mars Pr. S. Lecommandoux

Self-Assembly of Biohybrid Polymers:
from Smart Therapeutics to artificial cells

Tuesday March 18th at 10.30 am
Salle Emile BOREL
29 rue d’Ulm, 75005 Paris

Sébastien Lecommandoux
Université de Bordeaux, CNRS, Bordeaux INP, LCPO, UMR 5629, ENSCBP, 16 Avenue
Pey-Berland, Pessac F-33600, France
E-mail: sebastien.lecommandoux@u-bordeaux.fr

Our scientific approach is based on biomimicry, as we engineer synthetic mimics of natural macromolecules (such as proteins or glycoproteins), and explore their controlled and tunable self-assembly to form structures similar to those found in nature (such as virus or cell membranes). In this context, we develop polymer-based self-assembled nanoparticles, mostly polymeric vesicles, also named polymersomes, with high loading content of active pharmaceutical ingredients (e.g., anticancer drugs, peptides, proteins) and targeting ability. Our expertise includes the synthesis of precise, biocompatible polymers such as polypeptides (by chemical synthesis or recombinant DNA technology), polysaccharides, and their conjugates.
We present here an overview of the self-assembly of amphiphilic block copolymers and their contribution in nanomedicine. We pay particular attention to block copolymer vesicles based on polysaccharides, polypeptides and proteins especially based on Elastin Like Polypeptides (ELPs) and their modification with synthetic polypeptides [1], saccharides [2], polysaccharides [3] and lipids [4], aiming at mimicking both the structure and functionality of glycoproteins and lipoproteins. The ability of these systems for different biomedical applications, from bioprinting, drug-delivery to inhibitor, will be presented [5,6]. Finally, our most recent advances in the design of complex, compartmentalized and functional artificial cells will be presented [7-11]. These systems represent a first step towards the challenge of structural and functional mimicry of cells, which in future could act autonomously to detect and repair any biological deregulation in situ.

[1] M Badreldin et al. Biomacromolecules 25, 3033 (2024). P. Salas-Ambrosio J. Am. Chem. Soc.
143, 3697 (2021).
[2] LMM Bravo Anaya et al. Biomacromolecules 22, 1, 76–85 (2021)
[3] M. Levêque et al. Biomaterials Science 10, 6365-6376 (2022)
[4] V Ibrahimova et al. Angew. Chem. Int. Ed. 60, 15036-15040 (2021)
[5] M. Levêque et a. Biomacromolecules 25, 3011 (2024)
[6] H. Duan et al. Angew. Chem. Int. Ed. 132 (32), 13693-13698 (2020)
[7] H. Zhao et al. Angew. Chem. Int. Ed. 132 (27), 11121-11129 (2020)
[8] H. Zhao et al. Advanced Science 2102508 (2021)
[9] C. Schwartzman et al. Advanced Materials 17, 2301856 (2023)
[10] C.G. Palivan et al. Biomacromolecules 25(9), 5454−5467 (2024)
[11] E. Equy.et al. J. Am. Chem. Soc. in press (2025).

Sébastien Lecommandoux
Professor at University of Bordeaux
Bordeaux INP/CNRS
https://www.lcpo.fr/people/faculties/sebastien-lecommandoux

Short Biography
Sébastien Lecommandoux received his Ph.D. (1996) in Physical Chemistry from the University of Bordeaux. After a postdoctoral experience at the University of Illinois (UIUC, USA) in the group of Prof. Samuel I. Stupp, he started his academic career at the Laboratoire de Chimie des Polymères Organiques as Associate Professor in 1998 and was promoted to Full Professor at Bordeaux INP in 2005. He is currently Director of the Laboratoire de Chimie des Polymères Organiques (LCPO-CNRS) and is leading the group “Polymers Self-Assembly and Life Sciences”. His research interests include the design of bio-inspired polymers for biomaterials and pharmaceutical development, especially based on polypeptide, proteins and polysaccharide-based block copolymers self-assembly, the design of polymersomes for drug-delivery and theranostic, as well as biomimetic approaches toward design of synthetic viruses and artificial cells. He published over 235 publications in international journal, 6 book chapters and 15 patents (3 being licenced, 1 start-up created Doxanano). He is also co-director of the joint laboratory LCPO-L’OREAL. Sébastien Lecommandoux is recipient of the CNRS bronze medal (2004), Institut Universitaire de France Junior Chair (IUF 2007), Fellow of the Royal Society of Chemistry RSC (2017), French Academy of Science Chemistry Seqens Award (2019), Member of the Academia Europaea (2020), XingDa Lectureship Award from Peking University (2021). He currently holds the Chaire annuelle Innovation technologique Liliane Bettencourt, Collège de France (2024-2025). He is Editor-in-Chief of Biomacromolecules (ACS) since 2020 after serving as Associate Editor since 2013. He is also in the Editorial Advisory Board of several international journals, including Bioconjugate Chemistry (ACS), Polymer Chemistry (RSC), Biomaterials Science (RSC) and RSC Applied Polymers.

Séminaire du département: 13 Mars Prof. Tatjana N. Parac-Vogt

“Artificial enzymes based on metal oxo-clusters:
from discrete species to extended materials”

Thursday March 13th at 11 am
Department of Chemistry of ENS, Salle des Eléments (E012)
24, rue Lhomond, 75005 Paris

Prof. Tatjana N. Parac-Vogt
Department of Chemistry, KU Leuven, 3001 Leuven, Belgium

Effective catalysts for the controlled transformation of large and complex biomolecules are rare and challenging to develop. In particular, selective hydrolysis of proteins by non-enzymatic catalysis is difficult to achieve, yet it is crucial for many modern applications in biotechnology and proteomics. In recent years we developed conceptually new way for selectively cleaving proteins by combining the enzyme-like molecular recognition ability of polyoxometalates (POM), a large group of soluble metal-oxo clusters, with the hydrolytic activity of a strong Lewis acid metal cations (Zr, Hf, Ce) imbedded into the POM structure. Selective cleavage has been demonstrated in a range of proteins differing in structure, size, and charge. More recently, we have shown that metal-organic frameworks (MOFs) based on {Zr6O8} clusters act as very effective heterogeneous catalysts for the hydrolysis of the peptide bond. The catalytic activity of MOFs was shown to be excellent through a broad pH range, resulting in large rate accelerations compared to the uncatalyzed reaction. In addition, UiO-66 Zr-MOF has been found to effectively catalyze intramolecular and intermolecular peptide bond formation without any signs of epimerization. The potential of metal-oxo clusters as nanozymes for protein hydrolysis has been further demonstrated on the example of discrete {Zr6O8} cluster which showed excellent selectivity in the hydrolysis of myoglobin, cleaving the protein only at six solvent accessible Asp residues among 154 residues.Ultimately, these findings indicate that materials based on Zr(IV)-oxo clusters have a large potential to be developed as a novel class of nanozymes for peptide bond formation and hydrolysis.

Key References:
[1] Ly, H.G.T. et.al. J. Am. Chem. Soc. 2018,140, 6325. [2] Moons, J. et.al. Angew. Chem. Int. Ed. 2020, 59, 9094. [3] de Azambuja F., et.al. Acc. Chem. Res., 2021, 54, 1673. [4] de Azambuja, F.; ACS Catal., 2021, 11, 7647. [5] Wang, S. et.al. Nat. Commun. 2022, 13, 1284. [6] S. A. M. Abdelhameed, et.al. Nat. Commun., 2023, 14, 486. [7] K. Declerck, et al. J. Am. Chem. Soc., 2024, 146,11400. [8] S. Dai, et. al. Nat. Commun., 2024, 15, 3434.

Short Biography
Tatjana N. Parac-Vogt is a full professor and head of the laboratory of bioinorganic chemistry at KU Leuven, where she is pursuing interdisciplinary research at the interface of inorganic chemistry, biochemistry, materials science and catalysis. Her main research lines are the development of metal cluster-based complexes and materials such as polyoxometalates (POMs) and metal-organic frameworks (MOFs) for biologically inspired reactions with biomolecules and model systems. The group is also creating new hybrid structures based on polyoxometalates using principles of biomolecular recognition and supramolecular chemistry. Tatjana is the recipient of IUPAC 2023 Distinguished Women in Chemistry and Chemical Engineering award. She is a Fellow of the Royal Society of Chemistry and has been elected as a Chemistry Europe Fellow (Class 2020/2021), the highest award given by an association of European Chemical Societies. Tatjana is a member of AcademiaNet, a global portal of outstanding female scientists, and she is currently the Vice-President of the European Rare-Earth and Actinide Society. She serves on the Editorial Board of Chemical Society Reviews and is a member of the Advisory Board of Inorganic Chemistry.

web: https://lbc.chem.kuleuven.be

MOF-Enhanced Phototherapeutic Wound Dressings Against Drug-Resistant Bacteria

Full article HERE!!
And you can also check out his very exhaustive review on Iron-MOFs for Biomedical Applications

Abstract MOF-Enhanced Phototherapeutic Wound Dressings Against Drug-Resistant Bacteria:
Phototherapy is a low-risk alternative to traditional antibiotics against drug-resistant bacterial infections. However, optimizing phototherapy agents, refining treatment conditions, and addressing misuse of agents, remain a formidable challenge. This study introduces a novel concept leveraging the unique customizability of metal–organic frameworks (MOFs) to house size-matched dye molecules in “single rooms”. The mesoporous iron(III) carboxylate nanoMOF, MIL-100(Fe), and the hydrophobic heptamethine cyanine photothermal dye (Cy7), IR775, are selected as model systems. Their combination is predicted to minimize dye–dye interactions, leading to exceptional photostability and efficient light-to-heat conversion. Furthermore, MIL-100(Fe) preserves the antimicrobial nature of hydrophobic IR775, enabling it to disrupt bacterial cell envelopes. Through electrospinning, MIL-100(Fe)@IR775 nanoparticles are shaped into a gelatin-based film dressing for the treatment of skin wounds infected by Methicillin-resistant Staphylococcus aureus (MRSA). Activation of the dressing requires only a portable near-infrared light-emitting diode (NIR LED) and induces both low-dose photodynamic therapy (LPDT) and mild-temperature photothermal therapy (MPTT). Combined with the antimicrobial properties of IR775 and ferroptosis-like lipid peroxidation induced by MIL-100(Fe), the photoactive dressing eradicates MRSA and the healing is as quick as the uninfected wounds. This safe, cost-effective, and multifunctional therapeutic wound dressing offers a promising solution to overcome the current bottleneck in phototherapy.

Une journaliste du Monde des Grandes Ecoles visite l’IMAP

Le point commun entre la capture du CO2, la libération contrôlée de médicaments et la détection des composés organovolatils ?
L’utilisation et la synthétisation de molécules dont l’Institut des Matériaux Poreux de Paris a fait sa spécialité. L’Université PSL nous a ouvert les portes de ce laboratoire universitaire unique en son genre.
L’article du Monde des Grandes Ecoles vient d’être publié.
Voici le lien vers la version web : https://www.mondedesgrandesecoles.fr/reportage-plongee-dans-les-coulisses-dun-laboratoire-de-luniversite-psl/ et un aperçu de la version print : https://drive.google.com/file/d/1JCVnJ6ppdo2RpQK4Vq8Z7U9bJNrIbLEx/view?usp=sharing

A holistic platform for accelerating sorbent-based carbon capture

Find more about the latest IMAP’s collaborative work here:
https://www.nature.com/articles/s41586-024-07683-8

Abstract:
Reducing carbon dioxide (CO2) emissions urgently requires the large-scale deployment of carbon-capture technologies. These technologies must separate CO2 from various sources and deliver it to different sinks1,2. The quest for optimal solutions for specific source–sink pairs is a complex, multi-objective challenge involving multiple stakeholders and depends on social, economic and regional contexts. Currently, research follows a sequential approach: chemists focus on materials design3 and engineers on optimizing processes4,5, which are then operated at a scale that impacts the economy and the environment. Assessing these impacts, such as the greenhouse gas emissions over the plant’s lifetime, is typically one of the final steps6. Here we introduce the PrISMa (Process-Informed design of tailor-made Sorbent Materials) platform, which integrates materials, process design, techno-economics and life-cycle assessment. We compare more than 60 case studies capturing CO2 from various sources in 5 global regions using different technologies. The platform simultaneously informs various stakeholders about the cost-effectiveness of technologies, process configurations and locations, reveals the molecular characteristics of the top-performing sorbents, and provides insights on environmental impacts, co-benefits and trade-offs. By uniting stakeholders at an early research stage, PrISMa accelerates carbon-capture technology development during this critical period as we aim for a net-zero world.

New article: Room Temperature Reduction of Nitrogen Oxide on Iron Metal-Organic Frameworks

Nitrogen oxides represent one of the main threats for the environment. Despite decades of intensive research efforts, a sustainable solution for NOx removal under environmental conditions is still undefined. Using theoretical modelling, material design, state-of-the-art investigation methods and mimicking enzymes, we have found that selected porous hybrid iron(II/III) based MOF material are able to decompose NOx, at room temperature, in the presence of water and oxygen, into N2 and O2 and without reducing agents. This paves the way to the development of new highly sustainable heterogeneous catalysts to improve air quality.

https://onlinelibrary.wiley.com/doi/10.1002/adma.202403053

New IMAP paper on scalable & cost-effective MOF for CO2 capture

A Scalable Robust Microporous Al-MOF for Post-Combustion Carbon Capture

Bingbing Chen, Dong Fan, Rosana V. Pinto, Iurii Dovgaliuk, Shyamapada Nandi, Debanjan Chakraborty,…, Farid Nouar, Guillaume Maurin, Georges Mouchaham, Christian Serre

First published: 25 March 2024 https://doi.org/10.1002/advs.202401070

Herein, a robust microporous aluminum tetracarboxylate framework, MIL-120(Al)-AP, (MIL, AP: Institute Lavoisier and Ambient Pressure synthesis, respectively) is reported, which exhibits high CO2 uptake (1.9 mmol g−1 at 0.1 bar, 298 K). In situ Synchrotron X-ray diffraction measurements together with Monte Carlo simulations reveal that this structure offers a favorable CO2 capture configuration with the pores being decorated with a high density of µ2-OH groups and accessible aromatic rings. Meanwhile, based on calculations and experimental evidence, moderate host-guest interactions Qst (CO2) value of MIL-120(Al)-AP (−40 kJ mol−1) is deduced, suggesting a relatively low energy penalty for full regeneration. Moreover, an environmentally friendly ambient pressure green route, relying on inexpensive raw materials, is developed to prepare MIL-120(Al)-AP at the kilogram scale with a high yield while the Metal- Organic Framework (MOF) is further shaped with inorganic binders as millimeter-sized mechanically stable beads. First evidences of its efficient CO2/N2 separation ability are validated by breakthrough experiments while operando IR experiments indicate a kinetically favorable CO2 adsorption over water. Finally, a techno-economic analysis gives an estimated production cost of ≈ 13 $ kg−1, significantly lower than for other benchmark MOFs. These advancements make MIL-120(Al)-AP an excellent candidate as an adsorbent for industrial-scale CO2 capture processes.

A microporous multi-cage metal-organic framework for an effective one-step separation of branched alkanes feeds

The improvement of the Total Isomerization Process (TIP) for the production of high-quality gasoline with the ultimate goal of reaching a Research Octane Number (RON) higher than 92 requires the use of specific sorbents to separate pentane and hexane isomers into classes of linear, mono- and di-branched isomers. Herein we report the design of a new multi-cage microporous Fe(III)-MOF (referred to as MIP-214, MIP stands for materials of the Institute of Porous Materials of Paris) with a flu-e topology, incorporating an asymmetric heterofunctional ditopic ligand, 4-pyrazolecarboxylic acid, that exhibits an appropriate microporous structure for a thermodynamic-controlled separation of hydrocarbon isomers. This MOF produced via a direct, scalable, and mild synthesis route was proven to encompass a unique separation of C5/C6 isomers by classes of low RON over high RON alkanes with a sorption hierarchy: (n-hexane >> n-pentane ≈ 2-methylpentane > 3-methylpentane)low RON>>(2,3-dimethylbutane ≈ i-pentane ≈ 2,2-dimethylbutane)high RON following the adsorption enthalpy sequence. We reveal for the first time that a single sorbent can efficiently separate such a complex mixture of high RON di-branched hexane and mono-branched pentane isomers from their low RON counterparts, which is a major achievement reported so far.

First published in Angewandte Chemie on 15 February 2024, here: https://doi.org/10.1002/anie.202320008
by Lin Zhou, Pedro Brantuas, Adriano Henrique, Helge Reinsch, Mohammad Wahiduzzaman, Jean-Marc Grenèche, Alirio Rodrigues, José Silva, Guillaume Maurin, Christian Serre