Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins

06 July 2018

Bio-imaging techniques alternative to fluorescence microscopy are gaining increasing interest as complementary tools to visualize and analyze biological systems. Among them, X-ray fluorescence microspectroscopy provides information on the local content and distribution of heavy elements (Z > 14) in cells or biological samples. In this context, similar tools to those developed for fluorescence microscopy are desired, including chemical probes or tags. In this work, we study rhenium complexes as a convenient and sensitive probe for X-ray fluorescence microspectroscopy. We demonstrate their ability to label and sense exogenously incubated or endogenous proteins inside cells.

Pour plus d’informations, consultez le communiqué de presse associé à cet article : Des complexes de rhénium pour cartographier le vivant !

References:
Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins
Sarah Hostachy, Marie Masuda, Takayuki Miki, Itaru Hamachi, Sandrine Sagan, Olivier Lequin, Kadda Medjoubi, Andrea Somogyi, Nicolas Delsuc and Clotilde Policar
Chem. Sci., 2018, 9, 4483-4487
DOI : 10.1039/c8sc00886h

Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins