FRE IMAP 2000 : Institut des Matériaux Poreux de Paris

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Nanoparticles of Metal-Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

Adv. Mater. 2018, 1707365

 

In the past few years, numerous studies have demonstrated the great potential of nano particles of metal-organic frameworks (nanoMOFs) at the preclinical level for biomedical applications. Many of them were reported very recently based on their bioactive composition, anticancer application, or from a general drug delivery/theranostic perspective. In this review, the authors aim at providing a global view of the studies that evaluated MOFs’ biomedical applications at the preclinical stage, when in vivo tests are described either for pharmacological applications or for toxicity evaluation. The authors first describe the current surface engineering approaches that are crucial to understand the in vivo behavior of the nanoMOFs. Finally, after a detailed and comprehensive analysis of the in vivo studies reported with MOFs so far, and considering the general evolution of the drug delivery science, the authors suggest new directions for future research in the use of nanoMOFs for biomedical applications.

 

A phase transformable ultrastable titanium-carboxylate framework for photoconduction

Nature Communications9, 1660 (2018)

 

Porous titanium oxide materials are attractive for energy-related applications. However, many suffer from poor stability and crystallinity. Here we present a robust nanoporous metal–organic framework (MOF), comprising a Ti12O15 oxocluster and a tetracarboxylate ligand, achieved through a scalable synthesis. This material undergoes an unusual irreversible thermally induced phase transformation that generates a highly crystalline porous product with an infinite inorganic moiety of a very high condensation degree. Preliminary photophysical experiments indicate that the product after phase transformation exhibits photoconductive behavior, highlighting the impact of inorganic unit dimensionality on the alteration of physical properties. Introduction of a conductive polymer into its pores leads to a significant increase of the charge separation lifetime under irradiation. Additionally, the inorganic unit of this Ti-MOF can be easily modified via doping with other metal elements. The combined advantages of this compound make it a promising functional scaffold for practical applications.

 

Smart Metal-Organic-Framework Nanomaterial for Lung Targeting

Angew Chem Int Ed. 2017 Sep 28.

Despite high morbidity and mortality associated to lung diseases, addressing drugs towards lung tissue remains a pending task. Particle lung filtration has been proposed for passive lung targeting and drug delivery. However, toxic issues, derived from the long-term presence of the particles must be overcome. We show here that by exploiting some of the ignored properties of nanosized metal-organic frameworks it is possible to achieve impressive antitumoral effects on experimental lung tumours, even without the need to engineer the surface of the material. In fact, it was discovered that, based on unique pH-responsiveness and reversible aggregation behaviors, nanoMOF was capable to target the lung tissue. At the neutral pH of the blood, the nanoMOFs form aggregates with the adequate size to be retained within the lung capillaries. Then, within 24 h they disaggregate and release their drug payload. This phenomenon was compatible with lung tissue physiology.

 

Disparition de Gérard Ferey

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Selective nitrogen capture by porous hybrid materials containing accessible transition metal ion sites

Nature Materials, 19 décembre 2016

 

Selective dinitrogen binding to transition metal ions mainly covers two strategic domains: biological nitrogen fixation catalysed by metalloenzyme nitrogenases, and adsorptive purification of natural gas and air. Many transition metal–dinitrogen complexes have been envisaged for biomimetic nitrogen fixation to produce ammonia. Inspired by this concept, herewe report mesoporous metal–organic framework materials containing accessible Cr(III) sites, able to thermodynamically capture N2 over CH4 and O2. This fundamental study integrating advanced experimental and computational tools confirmed that the separation mechanism for both N2/CH4 and N2/O2 gas mixtures is driven by the presence of these unsaturated Cr(III) sites that allows a much stronger binding of N2 over the two other gases. Besides the potential breakthrough in adsorption-based technologies, this proof of concept could open newhorizons to address several challenges in chemistry, including the design of heterogeneous biomimetic catalysts through nitrogen