Since infrared and luminescent spectroscopies are complementary for bio-detection and bio-imaging, such IR-luminescent SCoMPIs are of great potential and their multiple modalities open up wide prospects for cross correlative studies in biological media. Multimodal imaging is currently a fast expanding field. The elaboration of small molecule chemistry to target and image other organelles and biological macromolecules is likely to contribute substantially to our molecular-level understanding of chemical processes in cells.
Gut microbiota metabolises bile acids (BA). As dysbiosis has been reported in inflammatory bowel diseases (IBD), we aim to investigate the impact of IBD associated dysbiosis on BA metabolism and its influence on the epithelial cell inflammation response.
We designed Calcium Rubies, a family of functionalizable BAPTA-based red-fluorescent calcium (Ca2+) indicators as new tools for biological Ca2+ imaging.
Overlapping 13C or 15N solid-state NMR spectra from crystallographically different forms of L-arginine hydrochloride can be separated by exploiting differential proton T1 relaxation in conjunction with cross polarization.