Professeur Sorbonne Université
ENS – Département de chimie
24 rue Lhomond, 75005 Paris
Email: eric.labbe@ens.psl.eu
Phone: 0144322433
Office: E010
Short bio
Eric Labbé is an analytical electrochemist interested in the understanding of reactivity and transport issues related to biological molecules. He started studying electrosynthetic and electrocatalytic sequences in the group of Jacques Périchon at Université Paris Est (UPEC) until 2005. Since 2006, he is Professor at Sorbonne Université (SU) and his research topics focus on the exploration of drug metabolism as well as biomolecule distribution accross lipid membranes, through the electrochemical switching ON/OFF of fluorescent probes.
Education and professional experience
- Since 2006 Professor, Sorbonne Université
- 1992 – 2005 Maître de Conférences, IUFM de Créteil
- 1991 – 1992 Postdoc, Université Pierre et Marie Curie
- 1988 – 1991 PhD, Université Pierre et Marie Curie
Research interests
- Keywords : electrochemistry ; mechanisms ; metabolism ; transport
The journey of a biomolecule (drug, peptide,…) throughout a living organism from its generation -or administration- to its elimination encompasses namely metabolic processes and transport steps accross barriers. Eric Labbé is interested in delineating the metabolism of such molecules and the dynamics of their passage through lipid membranes, which are central considerations for both the identification of the active metabolites and the evaluation of their bio-availability. Within this topic, his research concerns the development of electrochemically switchable dual redox/fluorescent probes.
Teaching
- Engaged in the training and graduation of French middle and high-school teachers in physics & chemistry (Master MEEF) at ESPE de Paris.
- Engaged in the lifelong formation of chemistry teachers at Sorbonne Université
- Teaching Electrochemistry at École Normale Supérieure
Significant publications
- “The Fundamental Input of Analytical Electrochemistry in the Determination of Intermediates and Reaction Mechanisms in Electrosynthetic Processes.” ChemElectroChem Minireview, 2019, 6, 4118.
- “Redox switchable rhodamine-ferrocene dyad: Exploring imaging possibilities in cells” Electrochemistry Communications, 2018, 97, 46.
- “Selective Electrochemical Bleaching of the Outer Leaflet of Fluorescently Labelled Giant Liposomes” Chem. Eur.J., 2017, 23, 6781
- “Electrochemical Behavior of Plutonium in n-TriButylPhosphate” Dalton Trans., 2017, 46, 4943.
- “Monitoring and Quantifying the Passive Transport of Molecules Through Patch–Clamp Suspended Real and Model Cell Membranes “ Angew. Chem. Int Ed. , 2014, 53, 3192. Key Scientific Article of the Global Medical Discovery newsfeed.
Publications accessible from Open Access platforms /
- HAL Archive @ École Normale Supérieure
- HAL Archive @ Sorbonne Université
Publications ( full record)
2002 |
Preparation of alternating $pi$-conjugated copolymers involving electrochemically generated aryldizinc intermediates Article de journal New Journal of Chemistry, 26 (6), p. 787–790, 2002. |
Synthesis of unsymmetrical biaryls by electroreductive cobalt-catalyzed cross-coupling of aryl halides Article de journal Tetrahedron, 58 (42), p. 8417–8424, 2002. |
2001 |
New and efficient access to 3-substituted 2, 5-dibromothiophenes. Consecutive nickel-catalyzed electrochemical conversion to thienylzinc species Article de journal New Journal of Chemistry, 25 (2), p. 318–321, 2001. |
2000 |
Electrochemical Studies on the Nickel-Catalyzed O- C (allyl) Bond Cleavage of Allyl Ethers Article de journal Organometallics, 19 (14), p. 2798–2804, 2000. |
1999 |
100 Q.C.M. corrigés de Biologie, physique, chimie : Concours d'entrée kiné, sage-femme, ergothérapeutes, techniciens en analyse biomédicale, manipulateurs d'électroradiologie médicale Livre 1999, ISBN: 2224025653. |
1996 |
Nickel-catalyzed electrochemical homocoupling of alkenyl halides: rates and mechanisms Article de journal Journal of Electroanalytical Chemistry, 412 (1-2), p. 85–93, 1996. |
1994 |
ELECTROCHEMICAL ACTIVATION OF BROMOTRIFLUOROMETHANE : A NEW METHOD TO PREPARE TRIFLUOROMETHYLATED COMPOUNDS Inproceedings Torii, Sigeru (Ed.): Novel trends in electroorganic synthesis - proceedings of the Second International Symposium on Electroorganic Synthesis, Kurashiki, September 27 - 30, 1994 and Pre-Symposium on Novel Aspects of Electrogenerated Active Species, Okayama, September 24 - 25. 1994, p. 99-102, Tokyo, 1994. |
Electrochemical Activation of Bromotrifluoromethane Using Various Reactive Electrodes. Synthetic Applications Article de journal Denki Kagaku oyobi Kogyo Butsuri Kagaku, 62 (12), p. 1129–1138, 1994. |
1991 |
Electrooxidative polymerization of cobalt, nickel and manganese salen complexes in acetonitrile solution Article de journal Journal of electroanalytical chemistry and interfacial electrochemistry, 301 (1-2), p. 267–274, 1991. |
1989 |
New stable modified electrodes coated by electroactive films of~ l~~ ole nickel (II)-biplane complex Article de journal J. Electroanal. Chem, 274 , p. 271–279, 1989. |
1988 |
Ligand-directed reaction products in the nickel-catalyzed electrochemical carboxylation of terminal alkynes Article de journal Journal of organometallic chemistry, 353 (3), p. C51–C56, 1988. |
0000 |
Molecular Electrochemistry as a Central Method to Determine the Metabolism of Therapeutic Agents: the Example of Metallocifen Anti-Cancer Drug Canditates Article de journal 0000. |
Reactivity and Vectorisation of Ferrocenyl-Tamoxifen Adducts, a New Class of Breast Cancer Drug Candidates. Article de journal 0000. |
Reactivity, Solubilisation, and Vectorisation of “Ferroccifen” Anticancer Drug Candidates. Article de journal 0000. |