Blaise DUMAT

Chargé de Recherche CNRS – CNRS Research Associate

Laboratoire des Biomolécules
UMR7203
ENS – Département de chimie
24 rue Lhomond, 75005 Paris

Email: blaise.dumat@ens.psl.eu
Phone: +33 144323335
Office: E045

Education and professional experience

  • Since 2017: CNRS research associate in the Laboratoire des Biomolécules UMR7203 at the ENS chemistry department
  • 2015 – 2016: Assistant Professor (ATER) at University Paris Descartes
  • 2013 – 2015: Postdoctoral researcher in the group of Pr. Marcus Wilhelmsson at Chalmers University (Gothenburg, Sweden)
  • 2012: PhD in Chemistry from University Paris Sud under the supervision of Dr. Marie-Paule Teulade-Fichou and Dr. Florence Mahuteau-Betzer at Institut Curie
  • 2008: MSc and chemical engineering degree from Chimie Paristech

Research projects

My research aims at developing new fluorescent probes as tools to study biological processes. To that end, we develop functional probes whose emission can be specifically triggered by biological analytes or proteins. The research work combines organic synthesis, biochemistry (interaction studies) and biophysics (optical spectroscopies, microscopy).

  • Hybrid chemogenetic probes and sensors (ANR JCJC DIPimaging 2019-2022)
  • Targeted fluorescent lipid mircroparticles for probing phagocytosis (in collaboration with Jean-Maurice Mallet (LBM), Jacques Fattaccioli (PASTEUR lab UMR8640) and Florence Niedergang (Institut Cochin))

Supervised students and post-doctoral researchers

Current
Manon Wittwer (PhD student ; since Sept. 2023)
Dr. Carolina Chieffo (Postdoc; since Jan. 2023)
Justine Coïs (PhD student ; since Oct. 2021) in co-supervision with J-M Mallet (LBM) and Vincent Vialou (Neurosciences Paris Seine, UMR8246)
Sophie Michelis (PhD student ; since Oct. 2021) in co-supervision with J-M Mallet (LBM)

Past
Manon Wittwer (M2 intern; Feb. – June 2023)
Louis Sanchez (M2 intern ; Feb. – June 2022)
Dr. Sylvestre Bachollet (postdoc ANR ; Dec. 2018- May 2021)
Yuriy Shpinov (M2 intern ; February – June 2020)
Charles-Henri Buffet (M2 intern ; February – June 2020) in co-supervision with JM Mallet
Nadjib Khene (M1 intern ; April – July 2019)

Publications

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2016

Mitochondria-Targeted Triphenylamine Derivatives Activatable by Two-Photon Excitation for Triggering and Imaging Cell Apoptosis Article de journal

Rahima Chennoufi; Houcine Bougherara; Nathalie Gagey-Eilstein; Blaise Dumat; Etienne Henry; Frédéric Subra; Stéphanie Bury-Moné; Florence Mahuteau-Betzer; Patrick Tauc; Marie-Paule Teulade-Fichou; Eric Deprez

Scientific Reports, 6 (January), p. 21458-21458, 2016.

2015

Development of Bright Fluorescent Quadracyclic Adenine Analogues: TDDFT-Calculation Supported Rational Design Article de journal

Anders Foller Larsen; Blaise Dumat; Moa S Wranne; Christopher P Lawson; Søren Preus; Mattias Bood; Henrik Gradén; L Marcus Wilhelmsson; Morten Grøtli

Scientific Reports, 5 , p. 12653-12653, 2015.

Second-Generation Fluorescent Quadracyclic Adenine Analogues: Environment-Responsive Probes with Enhanced Brightness Article de journal

Blaise Dumat; Mattias Bood; Moa S Wranne; Christopher P Lawson; Anders Foller Larsen; Søren Preus; Jens Streling; Henrik Gradén; Eric Wellner; Morten Grøtli; Marcus L Wilhelmsson

Chemistry - A European Journal, 21 (10), p. 4039-4048, 2015.

Differential Behaviour of Cationic Triphenylamine Derivatives in Fixed and Living Cells: Triggering and Imaging Cell Death Article de journal

R Chennoufi; H Bougherara; N Gagey-Eilstein; B Dumat; E Henry; F Subra; F Mahuteau-Betzer; P Tauc; M -P Teulade-Fichou; E Deprez

Chemical Communications, 51 (80), p. 14881-14884, 2015.

2013

DNA Switches on the Two-Photon Efficiency of an Ultrabright Triphenylamine Fluorescent Probe Specific of AT Regions Article de journal

Blaise Dumat; Guillaume Bordeau; Elodie Faurel-Paul; Florence Mahuteau-Betzer; Nicolas Saettel; Germain Metge; Céline Fiorini-Debuisschert; Fabrice Charra; Marie-Paule Teulade-Fichou

Journal of the American Chemical Society, 135 (34), p. 12697-12706, 2013.

2012

Vinyl-Triphenylamine Dyes, a New Family of Switchable Fluorescent Probes for Targeted Two-Photon Cellular Imaging: From DNA to Protein Labeling Article de journal

Blaise Dumat; Guillaume Bordeau; Ana I Aranda; Florence Mahuteau-Betzer; Yara El Harfouch; Germain Metgé; Fabrice Charra; Céline Fiorini-Debuisschert; Marie-Paule Teulade-Fichou

Organic & Biomolecular Chemistry, 10 (30), p. 6054-6054, 2012.

2011

N-Phenyl-Carbazole-Based Two-Photon Fluorescent Probes: Strong Sequence Dependence of the Duplex vs Quadruplex Selectivity Article de journal

B Dumat; G Bordeau; E Faurel-Paul; F Mahuteau-Betzer; N Saettel; M Bombled; G Metgé; F Charra; C Fiorini-Debuisschert; M-P Teulade-Fichou

Biochimie, 93 (8), p. 1209-1218, 2011.

2009

Synthesis of N-Functionalized 2,2$'$-Dipyridylamine Ligands, Complexation to Ruthenium (II) and Anchoring of Complexes to Papain from Papaya Latex Article de journal

Pierre Haquette; Blaise Dumat; Barisa Talbi; Shararé Arbabi; Jean-Luc Renaud; Gérard Jaouen; Mich`ele Salmain

Journal of Organometallic Chemistry, 694 (6), p. 937-941, 2009.

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