Bioinorganic Chemistry and Redox Homeostasis
Our website :
Metals in Biology and Redox Homeostasis
A new name for our research group: METROX
CONGRATULATIONS to our former PhD students:
Jean Bouvet for his selection to the MBA « collège des ingénieurs » (jan. 2024)
Paul Demay-Drouhard, who was appointed as a CNRS researcher (section 12, ICOA Orléans) in 2023
Martha Zoumpoulaki for her selection to the MBA « collège des ingénieurs » (oct. 2021) and her recruitment at Air Liquide in 2023.
Koudedja Coulibaly, who was recruited by Air Liquide in 2021
Emilie Mathieu, who was appointed as a CNRS researcher (section 16, LCC Toulouse) in 2021
Sarah Hostachy, who was appointed as a CEAEA researcher (LCBM, Grenoble) in 2020
Our personal webpages and resumes:
Alice Balfourier (ORCID: 0000-0002-4801-1388)
Hélène Bertrand (ORCID: 0000-0002-3841-022X)
Nicolas Delsuc (ORCID: 0000-0001-5570-8311)
Clotilde Policar (ORCID: 0000-0003-0255-1650)
Christine Rampon (ORCID: 0000-0002-1444-3166)
Michel Volovitch (ORCID: 0000-0002-7488-764X)
Sophie Vriz
Some news about our work:
About our work and equity in science (in French): https://www.youtube.com/watch?v=ZfyFIkh_G4k
https://www.inc.cnrs.fr/fr/cnrsinfo/des-complexes-bio-inspires-dans-le-vent
https://www.ens.psl.eu/actualites/des-catalyseurs-bio-inspires-pour-lutter-contre-le-stress-oxydant
Publications of the group:
((Go back to the publication page of the ens-bic website))
2011 |
Proton-coupled electron transfers in biomimetic water bound metal complexes. the electrochemical approach Article de journal E Anxolabéhère-Mallart; C Costentin; C Policar; M Robert; J -M Savéant; A -L Teillout Faraday Discussions, 148 , p. 83–95, 2011. @article{Anxolabehere-Mallart:2011, title = {Proton-coupled electron transfers in biomimetic water bound metal complexes. the electrochemical approach}, author = {E Anxolab\'{e}h\`{e}re-Mallart and C Costentin and C Policar and M Robert and J -M Sav\'{e}ant and A -L Teillout}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-79952268478&doi=10.1039%2fc004276e&partnerID=40&md5=24036168d6b9ca482d1b9f949b3a5995}, doi = {10.1039/c004276e}, year = {2011}, date = {2011-01-01}, journal = {Faraday Discussions}, volume = {148}, pages = {83--95}, abstract = {Water-bound metal (M) complexes play a central role in the catalytic centers of natural systems such as Photosystem II (PSII), superoxide dismutase, cytochrome c oxidase and others. In these systems, electron transfer reactions involving the metal center are coupled to proton transfers. Besides its fundamental interest, comprehension of these reactions and of possible bio-inspired catalytic devices is an additional motivation for studying the coupling between proton and electron transfer (proton-coupled electron transfers, PCET), starting with an aqua-MII/hydroxo-MIII couple, and going to higher oxidation degrees as in the case of PSII (hydroxo-MIII/oxo-MIV couple). Factors that determine the occurrence of the stepwise and concerted pathways are recalled from the illustrating example of a recently described mononuclear osmium complex, thus opening perspectives for further studies of the biomimicking complex. PCET in a mononuclear aqua/hydroxo manganese couple was then studied using the electrochemical approach. © 2011 The Royal Society of Chemistry.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Water-bound metal (M) complexes play a central role in the catalytic centers of natural systems such as Photosystem II (PSII), superoxide dismutase, cytochrome c oxidase and others. In these systems, electron transfer reactions involving the metal center are coupled to proton transfers. Besides its fundamental interest, comprehension of these reactions and of possible bio-inspired catalytic devices is an additional motivation for studying the coupling between proton and electron transfer (proton-coupled electron transfers, PCET), starting with an aqua-MII/hydroxo-MIII couple, and going to higher oxidation degrees as in the case of PSII (hydroxo-MIII/oxo-MIV couple). Factors that determine the occurrence of the stepwise and concerted pathways are recalled from the illustrating example of a recently described mononuclear osmium complex, thus opening perspectives for further studies of the biomimicking complex. PCET in a mononuclear aqua/hydroxo manganese couple was then studied using the electrochemical approach. © 2011 The Royal Society of Chemistry. |
Intrinsically fluorescent glycoligands to study metal selectivity Article de journal L Garcia; S Maisonneuve; J Oudinet-Sin Marcu; R Guillot; F Lambert; J Xie; C Policar Inorganic Chemistry, 50 (22), p. 11353–11362, 2011. @article{Garcia:2011, title = {Intrinsically fluorescent glycoligands to study metal selectivity}, author = {L Garcia and S Maisonneuve and J Oudinet-Sin Marcu and R Guillot and F Lambert and J Xie and C Policar}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-81255195281&doi=10.1021%2fic200897v&partnerID=40&md5=2d82616942d473b2774c71363fb8ff6a}, doi = {10.1021/ic200897v}, year = {2011}, date = {2011-01-01}, journal = {Inorganic Chemistry}, volume = {50}, number = {22}, pages = {11353--11362}, abstract = {Glycoligands are a versatile family of ligands centered on a sugar platform and functionalized by Lewis bases. In this article, pentofuranoses were appended with the fluoroionophores 4-(pyridin-2′-yl)-1,2,3-triazol-1-yl and 4-(2′,1′,3′-benzothiadiazol-4′-yl)-1,2,3-triazol-1- yl using the "click-like" cycloaddition [2 + 3] of Huisgen catalyzed by copper(I). Their fluorescence properties were used to study metal cation complexation. A possible selective functionalization of furanoscaffolds allows the synthesis of "mixed" glycoligands with the successive insertion of these different fluoroionophores. The metal selectivity and the chelating behavior of these six resulting intrinsically fluorescent glycoligands were investigated. The change in the configuration at the carbon C3 of furanose did not influence either the metal selectivity or the binding constants. However, different selectivities and binding constants were found to depend on the nature of the fluoroionophore moieties. Overall, the triazolylbenzothiadiazolyl chelating group was shown to be less efficient than the triazolylpyridyl claw for complexation. Interestingly enough, the triazolylbenzothiadiazolyl claw, which fluoresces in the visible range, did not interfere in the binding and selectivity of the more efficient triazolylpyridyl claw. This study suggests that the triazolylbenzothiadiazolyl moiety could be used as an adequate fluorescent reporter to qualitatively monitor complexation of other moieties. © 2011 American Chemical Society.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Glycoligands are a versatile family of ligands centered on a sugar platform and functionalized by Lewis bases. In this article, pentofuranoses were appended with the fluoroionophores 4-(pyridin-2′-yl)-1,2,3-triazol-1-yl and 4-(2′,1′,3′-benzothiadiazol-4′-yl)-1,2,3-triazol-1- yl using the "click-like" cycloaddition [2 + 3] of Huisgen catalyzed by copper(I). Their fluorescence properties were used to study metal cation complexation. A possible selective functionalization of furanoscaffolds allows the synthesis of "mixed" glycoligands with the successive insertion of these different fluoroionophores. The metal selectivity and the chelating behavior of these six resulting intrinsically fluorescent glycoligands were investigated. The change in the configuration at the carbon C3 of furanose did not influence either the metal selectivity or the binding constants. However, different selectivities and binding constants were found to depend on the nature of the fluoroionophore moieties. Overall, the triazolylbenzothiadiazolyl chelating group was shown to be less efficient than the triazolylpyridyl claw for complexation. Interestingly enough, the triazolylbenzothiadiazolyl claw, which fluoresces in the visible range, did not interfere in the binding and selectivity of the more efficient triazolylpyridyl claw. This study suggests that the triazolylbenzothiadiazolyl moiety could be used as an adequate fluorescent reporter to qualitatively monitor complexation of other moieties. © 2011 American Chemical Society. |
Relative helix-helix conformations in branched aromatic oligoamide foldamers Article de journal N Delsuc; S Massip; J -M Léger; B Kauffmann; I Huc Journal of the American Chemical Society, 133 (9), p. 3165–3172, 2011. @article{Delsuc:2011, title = {Relative helix-helix conformations in branched aromatic oligoamide foldamers}, author = {N Delsuc and S Massip and J -M L\'{e}ger and B Kauffmann and I Huc}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-79952263733&doi=10.1021%2fja110677a&partnerID=40&md5=36f1e84ade60bac4aee1c82b34b28b99}, doi = {10.1021/ja110677a}, year = {2011}, date = {2011-01-01}, journal = {Journal of the American Chemical Society}, volume = {133}, number = {9}, pages = {3165--3172}, abstract = {The de novo design and synthesis of large and well-organized, tertiary-like, α-peptidic folded architectures is difficult because it relies on multiple cooperative interactions within and between secondary folded motifs of relatively weak intrinsic stability. The very stable helical structures of oligoamides of 8-amino-2-quinoline carboxylic acid offer a way to circumvent this difficulty thanks to their ability to fold into predictable and stable secondary motifs. Branched architectures comprised of two pairs of tetrameric (1), pentameric (2), or octameric (3) oligomers connected via an ethylene glycol spacer were designed and synthesized. The short spacer holds two helices in close proximity, thus enabling interactions between them. Degrees of freedom allowed in the system are well-defined: the relative P or M handedness of the two helices; the relative orientation of the helix axes; and the gauche or anti conformation of the ethylene spacer. Investigating the structures of 1-3 in the solid state and in solution allowed a detailed picture to be drawn of their conformational preferences and dynamics. The high variability of the solid state structures provides many snapshots of possible solution conformations. Helix-helix handedness communication was evidenced and shown to depend both on solvent and on a defined set of side chains at the helix-helix interface. Interdigitation of the side chains was found to restrict free rotation about the ethylene spacer. One solid state structure shows a high level of symmetry and provides a firm basis to further design specific side chain/side chain directional interactions. © 2011 American Chemical Society.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The de novo design and synthesis of large and well-organized, tertiary-like, α-peptidic folded architectures is difficult because it relies on multiple cooperative interactions within and between secondary folded motifs of relatively weak intrinsic stability. The very stable helical structures of oligoamides of 8-amino-2-quinoline carboxylic acid offer a way to circumvent this difficulty thanks to their ability to fold into predictable and stable secondary motifs. Branched architectures comprised of two pairs of tetrameric (1), pentameric (2), or octameric (3) oligomers connected via an ethylene glycol spacer were designed and synthesized. The short spacer holds two helices in close proximity, thus enabling interactions between them. Degrees of freedom allowed in the system are well-defined: the relative P or M handedness of the two helices; the relative orientation of the helix axes; and the gauche or anti conformation of the ethylene spacer. Investigating the structures of 1-3 in the solid state and in solution allowed a detailed picture to be drawn of their conformational preferences and dynamics. The high variability of the solid state structures provides many snapshots of possible solution conformations. Helix-helix handedness communication was evidenced and shown to depend both on solvent and on a defined set of side chains at the helix-helix interface. Interdigitation of the side chains was found to restrict free rotation about the ethylene spacer. One solid state structure shows a high level of symmetry and provides a firm basis to further design specific side chain/side chain directional interactions. © 2011 American Chemical Society. |
Locking the free-rotation of a prochiral star-shaped guest molecule inside a two-dimensional nanoporous network by introduction of chlorine atoms Article de journal Hélène Bertrand; Fabien Silly; Marie-Paule Teulade-Fichou; Ludovic Tortech; Denis Fichou Chemical Communications, 47 (36), p. 10091–10093, 2011, ISSN: 1359-7345. @article{Bertrand2011, title = {Locking the free-rotation of a prochiral star-shaped guest molecule inside a two-dimensional nanoporous network by introduction of chlorine atoms}, author = {H\'{e}l{\`{e}}ne Bertrand and Fabien Silly and Marie-Paule Teulade-Fichou and Ludovic Tortech and Denis Fichou}, url = {http://dx.doi.org/10.1039/C1CC12951A}, doi = {10.1039/C1CC12951A}, issn = {1359-7345}, year = {2011}, date = {2011-01-01}, journal = {Chemical Communications}, volume = {47}, number = {36}, pages = {10091--10093}, publisher = {The Royal Society of Chemistry}, abstract = {Two star-shaped triazatrinaphthylene (TrisK) derivatives form highly-organized nanoporous honeycomb networks when adsorbed at the n-tetradecane/HOPG interface. STM reveals that replacing three H-atoms by three Cl-atoms in the chemical structure of the TrisK skeleton results in locking the free-rotation of the guest molecules inside the pore of the host network as a result of symmetry breaking.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Two star-shaped triazatrinaphthylene (TrisK) derivatives form highly-organized nanoporous honeycomb networks when adsorbed at the n-tetradecane/HOPG interface. STM reveals that replacing three H-atoms by three Cl-atoms in the chemical structure of the TrisK skeleton results in locking the free-rotation of the guest molecules inside the pore of the host network as a result of symmetry breaking. |
2010 |
Sugars to control ligand shape in metal complexes: Conformationally constrained glycoligands with a predetermination of stereochemistry and a structural control Article de journal L Garcia; S Maisonneuve; J Xie; R Guillot; P Dorlet; E Rivière; M Desmadril; F Lambert; C Policar Inorganic Chemistry, 49 (16), p. 7282–7288, 2010. @article{Garcia:2010, title = {Sugars to control ligand shape in metal complexes: Conformationally constrained glycoligands with a predetermination of stereochemistry and a structural control}, author = {L Garcia and S Maisonneuve and J Xie and R Guillot and P Dorlet and E Rivi\`{e}re and M Desmadril and F Lambert and C Policar}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-77955475481&doi=10.1021%2fic1002379&partnerID=40&md5=d7e719000261dc5be94c8bbf72ce40ca}, doi = {10.1021/ic1002379}, year = {2010}, date = {2010-01-01}, journal = {Inorganic Chemistry}, volume = {49}, number = {16}, pages = {7282--7288}, abstract = {In coordination chemistry, ligand shape can be used to tune properties, such as metal selectivity, coordination number, electronic structure, redox potential, and metal center stereochemistry including coordination helicates formation, and also to generate cavities for encapsulation. The results presented in this article indicate that two epimeric glycoligands (3 and 4) based on the conformationally restrained xylo-and ribo-1,2-O- isopropylidenefurano scaffolds are preorganized in water through π-π stacking due to hydrophobic interactions, as evidenced from excimer observation. The structure obtained in the solid state for one of the Cu(II) complexes (5) is chiral, with an original helical chirality arising from the coiling of the two ligands around the Cu-Cu axis. It shows an unusual double-deck type structure, with π-π interaction between two triazoyl-pyridyl rings and with a small cavity between the two Cu(II) ions able to host a bridging water molecule, as suggested by electron paramagnetic resonance. The Cu(II) complex from the epimeric ligand (6) shows similar properties with a mirror-image CD spectrum in the d-d region of the Cu(II). There is a predetermination of chirality at the metal center by the glycoligand induced by the C3 configuration, 6 and 5 being pseudoenantiomers. Interestingly, the stereochemistry at the metal center is here controlled by the combination of π-stacking and chiral backbone. © 2010 American Chemical Society.}, keywords = {}, pubstate = {published}, tppubtype = {article} } In coordination chemistry, ligand shape can be used to tune properties, such as metal selectivity, coordination number, electronic structure, redox potential, and metal center stereochemistry including coordination helicates formation, and also to generate cavities for encapsulation. The results presented in this article indicate that two epimeric glycoligands (3 and 4) based on the conformationally restrained xylo-and ribo-1,2-O- isopropylidenefurano scaffolds are preorganized in water through π-π stacking due to hydrophobic interactions, as evidenced from excimer observation. The structure obtained in the solid state for one of the Cu(II) complexes (5) is chiral, with an original helical chirality arising from the coiling of the two ligands around the Cu-Cu axis. It shows an unusual double-deck type structure, with π-π interaction between two triazoyl-pyridyl rings and with a small cavity between the two Cu(II) ions able to host a bridging water molecule, as suggested by electron paramagnetic resonance. The Cu(II) complex from the epimeric ligand (6) shows similar properties with a mirror-image CD spectrum in the d-d region of the Cu(II). There is a predetermination of chirality at the metal center by the glycoligand induced by the C3 configuration, 6 and 5 being pseudoenantiomers. Interestingly, the stereochemistry at the metal center is here controlled by the combination of π-stacking and chiral backbone. © 2010 American Chemical Society. |
Photocontrol of protein activity in cultured cells and zebrafish with one- and two-photon illumination Article de journal D K Sinha; P Neveu; N Gagey; I Aujard; C Benbrahim-Bouzidi; T Le Saux; C Rampon; C Gauron; B Goetz; S Dubruille; M Baaden; M Volovitch; D Bensimon; S Vriz; L Jullien ChemBioChem, 11 (5), p. 653–663, 2010. @article{Sinha:2010, title = {Photocontrol of protein activity in cultured cells and zebrafish with one- and two-photon illumination}, author = {D K Sinha and P Neveu and N Gagey and I Aujard and C Benbrahim-Bouzidi and T Le Saux and C Rampon and C Gauron and B Goetz and S Dubruille and M Baaden and M Volovitch and D Bensimon and S Vriz and L Jullien}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-77949823382&doi=10.1002%2fcbic.201000008&partnerID=40&md5=4ac50ebf9ae4f10b80cc91f729b23969}, doi = {10.1002/cbic.201000008}, year = {2010}, date = {2010-01-01}, journal = {ChemBioChem}, volume = {11}, number = {5}, pages = {653--663}, abstract = {We have implemented a noninvasive optical method for the fast control of protein activity in a live zebrafish embryo. It relies on releasing a protein fused to a modified estrogen receptor ligand binding domain from its complex with cytoplasmic chaperones, upon the local photoactivation of a nonendogenous caged inducer. Molecular dynamics simulations were used to design cyclofen-OH, a photochemically stable inducer of the receptor specific for 4-hydroxy-tamoxifen (ERT2). Cyclofen-OH was easily synthesized in two steps with good yields. At submicromolar concentrations, it activates proteins fused to the ERT2 receptor. This was shown in cultured cells and in zebrafish embryos through emission properties and subcellular localization of properly engineered fluorescent proteins. Cyclofen-OH was successfully caged with various photolabile protecting groups. One particular caged compound was efficient in photoinducing the nuclear translocation of fluorescent proteins either globally (with 365 nm UV illumination) or locally (with a focused UV laser or with two-photon illumination at 750 nm). The present method for photocontrol of protein activity could be used more generally to investigate important physiological processes (e.g., in embryogenesis, organ regeneration and carcinogenesis) with high spatiotemporal resolution. © 2010 Wiley-VCH Verlag GmbH& Co. KGaA.}, keywords = {}, pubstate = {published}, tppubtype = {article} } We have implemented a noninvasive optical method for the fast control of protein activity in a live zebrafish embryo. It relies on releasing a protein fused to a modified estrogen receptor ligand binding domain from its complex with cytoplasmic chaperones, upon the local photoactivation of a nonendogenous caged inducer. Molecular dynamics simulations were used to design cyclofen-OH, a photochemically stable inducer of the receptor specific for 4-hydroxy-tamoxifen (ERT2). Cyclofen-OH was easily synthesized in two steps with good yields. At submicromolar concentrations, it activates proteins fused to the ERT2 receptor. This was shown in cultured cells and in zebrafish embryos through emission properties and subcellular localization of properly engineered fluorescent proteins. Cyclofen-OH was successfully caged with various photolabile protecting groups. One particular caged compound was efficient in photoinducing the nuclear translocation of fluorescent proteins either globally (with 365 nm UV illumination) or locally (with a focused UV laser or with two-photon illumination at 750 nm). The present method for photocontrol of protein activity could be used more generally to investigate important physiological processes (e.g., in embryogenesis, organ regeneration and carcinogenesis) with high spatiotemporal resolution. © 2010 Wiley-VCH Verlag GmbH& Co. KGaA. |
Photoactivation of the CreERT2 recombinase for conditional site-specific recombination with high spatiotemporal resolution Article de journal D K Sinha; P Neveu; N Gagey; I Aujard; T Le Saux; C Rampon; C Gauron; K Kawakami; C Leucht; L Bally-Cuif; M Volovitch; D Bensimon; L Jullien; S Vriz Zebrafish, 7 (2), p. 199–204, 2010. @article{Sinha:2010a, title = {Photoactivation of the CreERT2 recombinase for conditional site-specific recombination with high spatiotemporal resolution}, author = {D K Sinha and P Neveu and N Gagey and I Aujard and T Le Saux and C Rampon and C Gauron and K Kawakami and C Leucht and L Bally-Cuif and M Volovitch and D Bensimon and L Jullien and S Vriz}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-77953623529&doi=10.1089%2fzeb.2009.0632&partnerID=40&md5=e5fb039a397abb6510140bcd6b2b258b}, doi = {10.1089/zeb.2009.0632}, year = {2010}, date = {2010-01-01}, journal = {Zebrafish}, volume = {7}, number = {2}, pages = {199--204}, abstract = {We implemented a noninvasive optical method for the fast control of Cre recombinase in single cells of a live zebrafish embryo. Optical uncaging of the caged precursor of a nonendogeneous steroid by one- or two-photon illumination was used to restore Cre activity of the CreERT2 fusion protein in specific target cells. This method labels single cells irreversibly by inducing recombination in an appropriate reporter transgenic animal and thereby can achieve high spatiotemporal resolution in the control of gene expression. This technique could be used more generally to investigate important physiological processes (e.g., in embryogenesis, organ regeneration, or carcinogenesis) with high spatiotemporal resolution (single cell and 10-min scales). © Copyright 2010, Mary Ann Liebert, Inc.}, keywords = {}, pubstate = {published}, tppubtype = {article} } We implemented a noninvasive optical method for the fast control of Cre recombinase in single cells of a live zebrafish embryo. Optical uncaging of the caged precursor of a nonendogeneous steroid by one- or two-photon illumination was used to restore Cre activity of the CreERT2 fusion protein in specific target cells. This method labels single cells irreversibly by inducing recombination in an appropriate reporter transgenic animal and thereby can achieve high spatiotemporal resolution in the control of gene expression. This technique could be used more generally to investigate important physiological processes (e.g., in embryogenesis, organ regeneration, or carcinogenesis) with high spatiotemporal resolution (single cell and 10-min scales). © Copyright 2010, Mary Ann Liebert, Inc. |
Cascading transformations within a dynamic self-assembled system Article de journal Victoria E Campbell; Xavier de Hatten; Nicolas Delsuc; Brice Kauffmann; Ivan Huc; Jonathan R Nitschke Nature Chemistry, 2 (8), p. 684–687, 2010, ISSN: 1755-4349. @article{campbell_cascading_2010, title = {Cascading transformations within a dynamic self-assembled system}, author = {Victoria E Campbell and Xavier de Hatten and Nicolas Delsuc and Brice Kauffmann and Ivan Huc and Jonathan R Nitschke}, url = {https://www.nature.com/articles/nchem.693}, doi = {10.1038/nchem.693}, issn = {1755-4349}, year = {2010}, date = {2010-01-01}, urldate = {2018-03-06}, journal = {Nature Chemistry}, volume = {2}, number = {8}, pages = {684--687}, abstract = {Molecular subcomponents such as phosphate groups are often passed between biomolecules during complex signalling cascades, the flow of which define the motion of the machinery of life. Here, we show how an abiological system consisting of organic subcomponents knitted together by metal-ion coordination can respond to simple signals in complex ways. A CuI3 helicate transformed into its ZnII2CuI analogue following the addition of zinc(II), and the ejected copper(I) went on to induce the self-assembly of a CuI2 helicate from other free subcomponents present in solution. The addition of an additional subcomponent, 8-aminoquinoline, resulted in the formation of a third, more stable CuI3 helicate, requiring the destruction of both the ZnII2CuI and CuI2 helicates to scavenge sufficient CuI for the new structure. This system thus demonstrates two examples in which the application of one signal provokes two distinct responses involving the creation or destruction of complex assemblies as the system seeks thermodynamic equilibrium following perturbation.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Molecular subcomponents such as phosphate groups are often passed between biomolecules during complex signalling cascades, the flow of which define the motion of the machinery of life. Here, we show how an abiological system consisting of organic subcomponents knitted together by metal-ion coordination can respond to simple signals in complex ways. A CuI3 helicate transformed into its ZnII2CuI analogue following the addition of zinc(II), and the ejected copper(I) went on to induce the self-assembly of a CuI2 helicate from other free subcomponents present in solution. The addition of an additional subcomponent, 8-aminoquinoline, resulted in the formation of a third, more stable CuI3 helicate, requiring the destruction of both the ZnII2CuI and CuI2 helicates to scavenge sufficient CuI for the new structure. This system thus demonstrates two examples in which the application of one signal provokes two distinct responses involving the creation or destruction of complex assemblies as the system seeks thermodynamic equilibrium following perturbation. |
2009 |
Design, self-assembly, and molecular structures of 3D copper(II) capsules templated by BF4 - guest anions Article de journal C Desmarets; C Policar; L -M Chamoreau; H Amouri European Journal of Inorganic Chemistry, (29-30), p. 4396–4400, 2009. @article{Desmarets:2009, title = {Design, self-assembly, and molecular structures of 3D copper(II) capsules templated by BF4 - guest anions}, author = {C Desmarets and C Policar and L -M Chamoreau and H Amouri}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-70350150888&doi=10.1002%2fejic.200900606&partnerID=40&md5=a0e5525563850dda7c2083f3b040390c}, doi = {10.1002/ejic.200900606}, year = {2009}, date = {2009-01-01}, journal = {European Journal of Inorganic Chemistry}, number = {29-30}, pages = {4396--4400}, abstract = {The synthesis of two 3D M2L4 copper(II) capsules, [BF4C(CH3CN)2Cu2(L 1)4][BF4]3 (1) and ([BF 4C(BF4J2Cu2(L1) 4][BF4]) (2), by using l,3-(benzimidazol-l-ylmethyl)-2, 5dimethoxy-4,6-dimethylbenzene (L1) as a semirigid exobidentate ligand and [Cu(CH3CN)4][BF4]2 as a metallobrick is reported. Single-crystal X-ray diffraction studies show the encapsulation of a BF4 - anion in 1 and 2. Moreover, 2 dis-played three coordinated BF4 - anions, which is rare in supramolecular coordination host-guest chemistry. Remarkably, in both metallocages the weakly coordinated BF4 - anion acts as a template and interacts with the metal center through a weak Cu⋯F contact. © Wiley-VCH Verlag GmbH & Co. KGaA.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The synthesis of two 3D M2L4 copper(II) capsules, [BF4C(CH3CN)2Cu2(L 1)4][BF4]3 (1) and ([BF 4C(BF4J2Cu2(L1) 4][BF4]) (2), by using l,3-(benzimidazol-l-ylmethyl)-2, 5dimethoxy-4,6-dimethylbenzene (L1) as a semirigid exobidentate ligand and [Cu(CH3CN)4][BF4]2 as a metallobrick is reported. Single-crystal X-ray diffraction studies show the encapsulation of a BF4 - anion in 1 and 2. Moreover, 2 dis-played three coordinated BF4 - anions, which is rare in supramolecular coordination host-guest chemistry. Remarkably, in both metallocages the weakly coordinated BF4 - anion acts as a template and interacts with the metal center through a weak Cu⋯F contact. © Wiley-VCH Verlag GmbH & Co. KGaA. |
Exclusive platination of loop adenines in the human telomeric G-quadruplex Article de journal Hélène Bertrand; Sophie Bombard; David Monchaud; Eric Talbot; Aurore Guédin; Jean-Louis Mergny; Renate Grünert; Patrick J Bednarski; Marie-Paule Teulade-Fichou Organic & Biomolecular Chemistry, 7 (14), p. 2864–2871, 2009, ISSN: 1477-0520. @article{Bertrand2009, title = {Exclusive platination of loop adenines in the human telomeric G-quadruplex}, author = {H\'{e}l{\`{e}}ne Bertrand and Sophie Bombard and David Monchaud and Eric Talbot and Aurore Gu\'{e}din and Jean-Louis Mergny and Renate Gr\"{u}nert and Patrick J Bednarski and Marie-Paule Teulade-Fichou}, url = {http://dx.doi.org/10.1039/B904599F}, doi = {10.1039/B904599F}, issn = {1477-0520}, year = {2009}, date = {2009-01-01}, journal = {Organic & Biomolecular Chemistry}, volume = {7}, number = {14}, pages = {2864--2871}, publisher = {The Royal Society of Chemistry}, abstract = {The present article reports on the platination of the human telomeric G-quadruplex by three Pt-terpyridine complexes. It is shown that extension of the aromatic surface of the terpyridine moiety surrounding the platinum atom influences both the binding affinity and the platination activity. Remarkably, the most strongly bound complex Pt-ttpy coordinates exclusively the adenine nucleobases present in the loop of the G-quadruplex. This exclusive single-site platination reflects the interaction of the compound with both the G-tetrad and the loop residues. In addition Pt-ttpy showed promising antiproliferative activity on a panel of cancer cell lines in a parallel study using cisplatin derivatives currently in clinical use.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The present article reports on the platination of the human telomeric G-quadruplex by three Pt-terpyridine complexes. It is shown that extension of the aromatic surface of the terpyridine moiety surrounding the platinum atom influences both the binding affinity and the platination activity. Remarkably, the most strongly bound complex Pt-ttpy coordinates exclusively the adenine nucleobases present in the loop of the G-quadruplex. This exclusive single-site platination reflects the interaction of the compound with both the G-tetrad and the loop residues. In addition Pt-ttpy showed promising antiproliferative activity on a panel of cancer cell lines in a parallel study using cisplatin derivatives currently in clinical use. |
Interplay of Interactions Governing the Dynamic Conversions of Acyclic and Macrocyclic Helicates Article de journal Victoria E. Campbell; Xavier de Hatten; Nicolas Delsuc; Brice Kauffmann; Ivan Huc; Jonathan R. Nitschke Chemistry - A European Journal, 15 (25), p. 6138–6142, 2009, ISSN: 09476539, 15213765. @article{campbell_interplay_2009, title = {Interplay of Interactions Governing the Dynamic Conversions of Acyclic and Macrocyclic Helicates}, author = {Victoria E. Campbell and Xavier de Hatten and Nicolas Delsuc and Brice Kauffmann and Ivan Huc and Jonathan R. Nitschke}, url = {http://doi.wiley.com/10.1002/chem.200900693}, doi = {10.1002/chem.200900693}, issn = {09476539, 15213765}, year = {2009}, date = {2009-01-01}, urldate = {2018-02-18}, journal = {Chemistry - A European Journal}, volume = {15}, number = {25}, pages = {6138--6142}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Helical Aromatic Oligoamide Foldamers as Organizational Scaffolds for Photoinduced Charge Transfer Article de journal Martin Wolffs; Nicolas Delsuc; Dirk Veldman; Nguyễn Vân Anh; René M Williams; Stefan C J Meskers; René A J Janssen; Ivan Huc; Albertus P H J Schenning Journal of the American Chemical Society, 131 (13), p. 4819–4829, 2009, ISSN: 0002-7863, 1520-5126. @article{wolffs_helical_2009, title = {Helical Aromatic Oligoamide Foldamers as Organizational Scaffolds for Photoinduced Charge Transfer}, author = {Martin Wolffs and Nicolas Delsuc and Dirk Veldman and Nguyễn V\^{a}n Anh and Ren\'{e} M Williams and Stefan C J Meskers and Ren\'{e} A J Janssen and Ivan Huc and Albertus P H J Schenning}, url = {http://pubs.acs.org/doi/abs/10.1021/ja809367u}, doi = {10.1021/ja809367u}, issn = {0002-7863, 1520-5126}, year = {2009}, date = {2009-01-01}, urldate = {2018-02-18}, journal = {Journal of the American Chemical Society}, volume = {131}, number = {13}, pages = {4819--4829}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
2008 |
Plasmodium Telomeric Sequences: Structure, Stability and Quadruplex Targeting by Small Compounds Article de journal Anne De Cian; Philippe Grellier; Elisabeth Mouray; Delphine Depoix; Hélène Bertrand; David Monchaud; Marie-Paule Teulade-Fichou; Jean-Louis Mergny; Patrizia Alberti ChemBioChem, 9 (16), p. 2730–2739, 2008, ISSN: 1439-4227. @article{DeCian2008, title = {Plasmodium Telomeric Sequences: Structure, Stability and Quadruplex Targeting by Small Compounds}, author = {Anne {De Cian} and Philippe Grellier and Elisabeth Mouray and Delphine Depoix and H\'{e}l{\`{e}}ne Bertrand and David Monchaud and Marie-Paule Teulade-Fichou and Jean-Louis Mergny and Patrizia Alberti}, url = {https://doi.org/10.1002/cbic.200800330}, doi = {10.1002/cbic.200800330}, issn = {1439-4227}, year = {2008}, date = {2008-11-01}, journal = {ChemBioChem}, volume = {9}, number = {16}, pages = {2730--2739}, publisher = {John Wiley & Sons, Ltd}, abstract = {Abstract The increasing resistance of Plasmodium falciparum to the most commonly used antimalarial drugs makes it necessary to identify new therapeutic targets. The telomeres of the parasite could constitute an attractive target. They are composed of repetitions of a degenerate motif (5?GGGTTYA3?, where Y is T or C), different from the human one (5?GGGTTA3?). In this report we investigate the possibility of targeting Plasmodium telomeres with G-quadruplex ligands. Through solution hybridisation assays we provide evidence of the existence of a telomeric 3? G-overhang in P. falciparum genomic DNA. Through UV spectroscopy studies we demonstrate that stable G-quadruplex structures are formed at physiological temperature by sequences composed of the degenerate Plasmodium telomeric motif. Through a FRET melting assay we show stabilisation of Plasmodium telomeric G-quadruplexes by a variety of ligands. Many of the tested ligands display strong quadruplex versus duplex selectivity, but show little discrimination between human and Plasmodium telomeric quadruplexes.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Abstract The increasing resistance of Plasmodium falciparum to the most commonly used antimalarial drugs makes it necessary to identify new therapeutic targets. The telomeres of the parasite could constitute an attractive target. They are composed of repetitions of a degenerate motif (5?GGGTTYA3?, where Y is T or C), different from the human one (5?GGGTTA3?). In this report we investigate the possibility of targeting Plasmodium telomeres with G-quadruplex ligands. Through solution hybridisation assays we provide evidence of the existence of a telomeric 3? G-overhang in P. falciparum genomic DNA. Through UV spectroscopy studies we demonstrate that stable G-quadruplex structures are formed at physiological temperature by sequences composed of the degenerate Plasmodium telomeric motif. Through a FRET melting assay we show stabilisation of Plasmodium telomeric G-quadruplexes by a variety of ligands. Many of the tested ligands display strong quadruplex versus duplex selectivity, but show little discrimination between human and Plasmodium telomeric quadruplexes. |
New platinum(II) complexes targeting the loops of the human telomeric G-quadruplex. Article de journal Hélène Bertrand; Sophie Bombard; David Monchaud; Marie-Paule Teulade-Fichou Nucleic Acids Symposium Series, 52 (1), p. 163–164, 2008, ISSN: 0261-3166. @article{Bertrand2008, title = {New platinum(II) complexes targeting the loops of the human telomeric G-quadruplex.}, author = {H\'{e}l{\`{e}}ne Bertrand and Sophie Bombard and David Monchaud and Marie-Paule Teulade-Fichou}, url = {https://doi.org/10.1093/nass/nrn083}, doi = {10.1093/nass/nrn083}, issn = {0261-3166}, year = {2008}, date = {2008-09-01}, journal = {Nucleic Acids Symposium Series}, volume = {52}, number = {1}, pages = {163--164}, abstract = {Two novel series of platinum(II) complexes have been designed and shown to interact with the human telomeric G-quadruplex-DNA via different binding modes: i- terpyridine-platinum (Pt-tpy) complexes covalently interact with quadruplex-DNA via selective platination of adenine residues of the loops, their interaction being driven by the aromatic surface of the ligand; ii- platinum-quinacridine hybrid (Pt-MPQ) interacts with quadruplex-DNA via a dual noncovalent/covalent binding mode, targeting preferentially guanines constitutive of external G-quartets. Therefore, platinum complexes presented herein constitute potential agents for irreversible trapping of G-quadruplex. DNA.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Two novel series of platinum(II) complexes have been designed and shown to interact with the human telomeric G-quadruplex-DNA via different binding modes: i- terpyridine-platinum (Pt-tpy) complexes covalently interact with quadruplex-DNA via selective platination of adenine residues of the loops, their interaction being driven by the aromatic surface of the ligand; ii- platinum-quinacridine hybrid (Pt-MPQ) interacts with quadruplex-DNA via a dual noncovalent/covalent binding mode, targeting preferentially guanines constitutive of external G-quartets. Therefore, platinum complexes presented herein constitute potential agents for irreversible trapping of G-quadruplex. DNA. |
A caged retinoic acid for one- and two-photon excitation in zebrafish embryos Article de journal P Neveu; I Aujard; C Benbrahim; T Le Saux; J -F Allemand; S Vriz; D Bensimon; L Jullien Angewandte Chemie - International Edition, 47 (20), p. 3744–3746, 2008. @article{Neveu:2008, title = {A caged retinoic acid for one- and two-photon excitation in zebrafish embryos}, author = {P Neveu and I Aujard and C Benbrahim and T Le Saux and J -F Allemand and S Vriz and D Bensimon and L Jullien}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-45549089482&doi=10.1002%2fanie.200800037&partnerID=40&md5=320b837fbef96180278af6d16a13797a}, doi = {10.1002/anie.200800037}, year = {2008}, date = {2008-01-01}, journal = {Angewandte Chemie - International Edition}, volume = {47}, number = {20}, pages = {3744--3746}, abstract = {(Chemical Equation Presented) Escaping the cage: Retinoic acid (RA), a crucial signaling molecule for the embryogenesis of vertebrates, can be photoreleased from a simple caged derivative (cRA) upon illumination. In zebrafish embryos, cRA causes RA-induced phenotypes with one- and two-photon excitation (see picture), which opens a route to the noninvasive generation of controlled RA concentration patterns in vivo. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.}, keywords = {}, pubstate = {published}, tppubtype = {article} } (Chemical Equation Presented) Escaping the cage: Retinoic acid (RA), a crucial signaling molecule for the embryogenesis of vertebrates, can be photoreleased from a simple caged derivative (cRA) upon illumination. In zebrafish embryos, cRA causes RA-induced phenotypes with one- and two-photon excitation (see picture), which opens a route to the noninvasive generation of controlled RA concentration patterns in vivo. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA. |
Metal-Directed Dynamic Formation of Tertiary Structure in Foldamer Assemblies: Orienting Helices at an Angle Article de journal Nicolas Delsuc; Marie Hutin; Victoria E. Campbell; Brice Kauffmann; Jonathan R. Nitschke; Ivan Huc Chemistry - A European Journal, 14 (24), p. 7140–7143, 2008, ISSN: 09476539, 15213765. @article{delsuc_metal-directed_2008, title = {Metal-Directed Dynamic Formation of Tertiary Structure in Foldamer Assemblies: Orienting Helices at an Angle}, author = {Nicolas Delsuc and Marie Hutin and Victoria E. Campbell and Brice Kauffmann and Jonathan R. Nitschke and Ivan Huc}, url = {http://doi.wiley.com/10.1002/chem.200800988}, doi = {10.1002/chem.200800988}, issn = {09476539, 15213765}, year = {2008}, date = {2008-01-01}, urldate = {2018-02-18}, journal = {Chemistry - A European Journal}, volume = {14}, number = {24}, pages = {7140--7143}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Kinetics of Helix-Handedness Inversion: Folding and Unfolding in Aromatic Amide Oligomers Article de journal Nicolas Delsuc; Takahiro Kawanami; Julien Lefeuvre; Atsuomi Shundo; Hirotaka Ihara; Makoto Takafuji; Ivan Huc ChemPhysChem, 9 (13), p. 1882–1890, 2008, ISSN: 14394235, 14397641. @article{delsuc_kinetics_2008, title = {Kinetics of Helix-Handedness Inversion: Folding and Unfolding in Aromatic Amide Oligomers}, author = {Nicolas Delsuc and Takahiro Kawanami and Julien Lefeuvre and Atsuomi Shundo and Hirotaka Ihara and Makoto Takafuji and Ivan Huc}, url = {http://doi.wiley.com/10.1002/cphc.200800310}, doi = {10.1002/cphc.200800310}, issn = {14394235, 14397641}, year = {2008}, date = {2008-01-01}, urldate = {2018-02-18}, journal = {ChemPhysChem}, volume = {9}, number = {13}, pages = {1882--1890}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
2007 |
The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes Article de journal Hélène Bertrand; David Monchaud; Anne De Cian; Régis Guillot; Jean-Louis Mergny; Marie-Paule Teulade-Fichou Organic & Biomolecular Chemistry, 5 (16), p. 2555–2559, 2007, ISSN: 1477-0520. @article{Bertrand2007, title = {The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes}, author = {H\'{e}l{\`{e}}ne Bertrand and David Monchaud and Anne {De Cian} and R\'{e}gis Guillot and Jean-Louis Mergny and Marie-Paule Teulade-Fichou}, url = {http://dx.doi.org/10.1039/B708635K}, doi = {10.1039/B708635K}, issn = {1477-0520}, year = {2007}, date = {2007-01-01}, journal = {Organic & Biomolecular Chemistry}, volume = {5}, number = {16}, pages = {2555--2559}, publisher = {The Royal Society of Chemistry}, abstract = {A family of terpyridine metallo-organic complexes has been designed and its recognition properties of G-quadruplex-DNA investigated. The series combines easy synthetic access and good affinity\textendashselectivity ratio for quadruplex-DNA. Our study also highlights that the geometry of the metal center strongly governs the ability of the compounds to discriminate quadruplex from duplex-DNA.}, keywords = {}, pubstate = {published}, tppubtype = {article} } A family of terpyridine metallo-organic complexes has been designed and its recognition properties of G-quadruplex-DNA investigated. The series combines easy synthetic access and good affinity–selectivity ratio for quadruplex-DNA. Our study also highlights that the geometry of the metal center strongly governs the ability of the compounds to discriminate quadruplex from duplex-DNA. |
A platinum–quinacridine hybrid as a G-quadruplex ligand Article de journal Hélène Bertrand; Sophie Bombard; David Monchaud; Marie-Paule Teulade-Fichou JBIC Journal of Biological Inorganic Chemistry, 12 (7), p. 1003–1014, 2007, ISSN: 1432-1327. @article{Bertrand2007a, title = {A platinum\textendashquinacridine hybrid as a G-quadruplex ligand}, author = {H\'{e}l{\`{e}}ne Bertrand and Sophie Bombard and David Monchaud and Marie-Paule Teulade-Fichou}, url = {https://doi.org/10.1007/s00775-007-0273-3}, doi = {10.1007/s00775-007-0273-3}, issn = {1432-1327}, year = {2007}, date = {2007-01-01}, journal = {JBIC Journal of Biological Inorganic Chemistry}, volume = {12}, number = {7}, pages = {1003--1014}, abstract = {A novel platinum\textendashquinacridine hybrid, comprising a monofunctional Pt moiety and a G-quadruplex ligand (mono-para-quinacridine or MPQ), has been synthesized and shown to interact with quadruplex DNA via a dual noncovalent/covalent binding mode. Denaturing gel electrophoresis was used to separate the various platination products of 22AG (an oligonucleotide that mimics the human telomeric repeat) by Pt-MPQ, and it was shown that two platinated adducts are highly stable quadruplex structures. Dimethylsulfate/piperidine treatment and 3′-exonuclease digestion of the isolated adducts allowed us to precisely determine the platination pattern of 22AG by Pt-MPQ, which displays three main sites G2, G10 and G22. Data presented herein support the hypothesis that Pt-MPQ traps preferentially the antiparallel structure of the 22AG quadruplex. Finally, the kinetics of Pt-MPQ platination using a construct containing both quadruplex DNA and a duplex DNA parts provide the first insights into the Pt-MPQ preference for quadruplex DNA over duplex DNA.}, keywords = {}, pubstate = {published}, tppubtype = {article} } A novel platinum–quinacridine hybrid, comprising a monofunctional Pt moiety and a G-quadruplex ligand (mono-para-quinacridine or MPQ), has been synthesized and shown to interact with quadruplex DNA via a dual noncovalent/covalent binding mode. Denaturing gel electrophoresis was used to separate the various platination products of 22AG (an oligonucleotide that mimics the human telomeric repeat) by Pt-MPQ, and it was shown that two platinated adducts are highly stable quadruplex structures. Dimethylsulfate/piperidine treatment and 3′-exonuclease digestion of the isolated adducts allowed us to precisely determine the platination pattern of 22AG by Pt-MPQ, which displays three main sites G2, G10 and G22. Data presented herein support the hypothesis that Pt-MPQ traps preferentially the antiparallel structure of the 22AG quadruplex. Finally, the kinetics of Pt-MPQ platination using a construct containing both quadruplex DNA and a duplex DNA parts provide the first insights into the Pt-MPQ preference for quadruplex DNA over duplex DNA. |
Proteomorphous Objects from Abiotic Backbones Article de journal Nicolas Delsuc; Jean-Michel Léger; Stéphane Massip; Ivan Huc Angewandte Chemie International Edition, 46 (1-2), p. 214–217, 2007, ISSN: 14337851, 15213773. @article{delsuc_proteomorphous_2007, title = {Proteomorphous Objects from Abiotic Backbones}, author = {Nicolas Delsuc and Jean-Michel L\'{e}ger and St\'{e}phane Massip and Ivan Huc}, url = {http://doi.wiley.com/10.1002/anie.200603390}, doi = {10.1002/anie.200603390}, issn = {14337851, 15213773}, year = {2007}, date = {2007-01-01}, urldate = {2018-02-18}, journal = {Angewandte Chemie International Edition}, volume = {46}, number = {1-2}, pages = {214--217}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
The Herringbone Helix: A Noncanonical Folding in Aromatic−Aliphatic Peptides Article de journal Nicolas Delsuc; Frédéric Godde; Brice Kauffmann; Jean-Michel Léger; Ivan Huc Journal of the American Chemical Society, 129 (37), p. 11348–11349, 2007, ISSN: 0002-7863, 1520-5126. @article{delsuc_herringbone_2007, title = {The Herringbone Helix: A Noncanonical Folding in Aromatic−Aliphatic Peptides}, author = {Nicolas Delsuc and Fr\'{e}d\'{e}ric Godde and Brice Kauffmann and Jean-Michel L\'{e}ger and Ivan Huc}, url = {http://pubs.acs.org/doi/abs/10.1021/ja074285s}, doi = {10.1021/ja074285s}, issn = {0002-7863, 1520-5126}, year = {2007}, date = {2007-01-01}, urldate = {2018-02-18}, journal = {Journal of the American Chemical Society}, volume = {129}, number = {37}, pages = {11348--11349}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
2006 |
Improved Synthesis of Quinacridine Derivatives Article de journal Rémy Lartia; Hélène Bertrand; Marie-Paule Teulade-Fichou Synlett, 2006 (04), p. 610–614, 2006, ISSN: 0936-5214. @article{Lartia2006, title = {Improved Synthesis of Quinacridine Derivatives}, author = {R\'{e}my Lartia and H\'{e}l{\`{e}}ne Bertrand and Marie-Paule Teulade-Fichou}, doi = {10.1055/s-2006-932465}, issn = {0936-5214}, year = {2006}, date = {2006-01-01}, journal = {Synlett}, volume = {2006}, number = {04}, pages = {610--614}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Vibrational circular dichroism and ab initio structure elucidation of an aromatic foldamer Article de journal Thierry Buffeteau; Laurent Ducasse; Legiso Poniman; Nicolas Delsuc; Ivan Huc Chemical Communications, (25), p. 2714, 2006, ISSN: 1359-7345, 1364-548X. @article{buffeteau_vibrational_2006, title = {Vibrational circular dichroism and ab initio structure elucidation of an aromatic foldamer}, author = {Thierry Buffeteau and Laurent Ducasse and Legiso Poniman and Nicolas Delsuc and Ivan Huc}, url = {http://xlink.rsc.org/?DOI=b604462j}, doi = {10.1039/b604462j}, issn = {1359-7345, 1364-548X}, year = {2006}, date = {2006-01-01}, urldate = {2018-02-18}, journal = {Chemical Communications}, number = {25}, pages = {2714}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
2005 |
Probing helix propensity of monomers within a helical oligomer Article de journal Christel Dolain; Jean-Michel Léger; Nicolas Delsuc; Heinz Gornitzka; Ivan Huc Proceedings of the National Academy of Sciences of the United States of America, 102 (45), p. 16146–16151, 2005. @article{dolain_probing_2005, title = {Probing helix propensity of monomers within a helical oligomer}, author = {Christel Dolain and Jean-Michel L\'{e}ger and Nicolas Delsuc and Heinz Gornitzka and Ivan Huc}, year = {2005}, date = {2005-01-01}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, volume = {102}, number = {45}, pages = {16146--16151}, keywords = {}, pubstate = {published}, tppubtype = {article} } |