Mathilde LEPOITEVIN

Assistant professor, École Normale Supérieure

ENS – Département de chimie
24 rue Lhomond, 75005 Paris

Email: mathilde.lepoitevin@ens.fr
Phone: +33 144.322.460
Office: E024

Short bio

    • Since September 2018, Mathilde Lepoitevin is an assistant professor in Chemistry at Ecole Normale Superieure, in the Porous Materials Institute of Paris.
      During her bachelor’s she began to work on proteins interaction with materials. Before finishing that degree, she was admitted to the Materials for Energy Storage and Conversion (MESC) Master with a scholarship. While working on her master’s thesis, she was granted a PhD fellowship by Montpellier University (Fr), under the supervision of Dr. Balme and Dr. Bechelany. Her PhD work consisted in developing and designing single solid state nanopores to mimic biological channels and to investigate either bio-macromolecules translocation or to functionalize the nanopore to mimic stimuli-dependent ion channels. During her PhD, she was the recipient of a travel grant from the “Chaire Total” for a short-term stay collaboration work with Dr. Dumee group at Deakin University (Australia).
      In January 2017, she started working as a postdoctoral research fellow, at Brown University (Providence (RI), USA), under the guidance of Pr. D. Stein. There, she developed and demonstrated a new kind of ion source capable of efficiently transferring single amino acid ions from liquid into a mass spectrometer. Her results indicate a feasible path to single-molecule protein sequencing through a combination of a single-ion source and mass spectrometry.She has co-authored more than 20 papers in peer-reviewed journals.[Google scholar] and her work has been presented in 15 international conferences and 8 invited seminars. She has been the recipient of best PhD award from the “pole chimie Balard” in 2017.

        My research at IMAP focuses on Metal Organic Frameworks for two types of biological applications, (i) nanoMOFs systems for controlled drug release, (ii) the design of hybrid biosensors. The main objective is to develop new tools for the biomedical field, based on nanoMOFs and their associated composites, in a variety of designs and shaping. Regardless the application, this requires the development of new methods for modifying the surface of nanoMOFs to improve their stability, but also to regulate biological material (protein, DNA, etc.) / material interactions.
        [LinkedIn]
        .

Education and professional experience

Research interests

  • Nanopore, Biosensor, Nano-electrochemistry, Material Science

Awards and distinctions

Supervised students and post-doctorants

      • 3 Postdoctoral fellows: Francesca GAMBASSI(2023-2024), Charlotte de BLOIS (2023-2024), Ben SLATER (2021), Javier PEREZ (2019-2021)
      • 4 PhD Students: Xiling SONG (2023-2027), Shaokang JIANG (2021), Zhihao YU (2020-2024), Xin MA (2018-2022)
      • 11 MSc Students: Ximena LUNA GONZALEZ (2024), Leyth SAGLIO (2023), Wouter NIJENHUIS (2023), Thomas MCCLYMONT (2023), Ana Laure CORIA GUTIERREZ (2022), Anna STEVENSON (2020-2021), Narjis EL AMRAOUI (2020), Yutong LI (2020), Andrea FELLONI (2019-2020), Hanna SZAPARY (2017-2018), Marie LEMOUEL (2014)
      • 7 BSc Students: Bilal LAKHRISSI (2023), Paul ROBERT (2022), Marie BILLAUD (2021), Louise DELAURENTI (2020), Gabriel GOUJON (2020), Alban SIMMONOT (2019), Charles BUI (2017-2018), Paulius GAIGALAS (2016), Bastien JAMILLOUX (2015)
      • Xin MA, Master Chemistry and Life Science, PSL, Nov. 2018 – Nov. 2022
      • My-An TRAN, Magistère de Physico-Chimie Moléculaire, Université Paris-Saclay Feb. 2019 – July 2019
      • Andrea FELLONI, M.S. in Nanostructured Materials Engineering, Politecnico di Milano, March 2019 – Feb 2020

Teaching

Significant publications

Publications

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2015

Biological Channel Confinement in Nanostructured Nanopore Article de journal

Sébastien Balme; Mathilde Lepoitevin; Adib Abou-Chayaa; Mikhael Bechelany; Jean-Marc Janot; Emmanuel Balanzat

Biophysical Journal, 108 (2), p. 484a, 2015, ISSN: 0006-3495.

Nanopore Functionalization for Biological Channel Mimicking Article de journal

Mathilde Lepoitevin; Mikhael Bechelany; Jean-Marc Janot; Sebastien Balme

Science Letters, 4 , p. 188, 2015.

Combining a sensor and a pH-gated nanopore based on an avidin--biotin system Article de journal

Mathilde Lepoitevin; Gael Nguyen; Mikhael Bechelany; Emmanuel Balanzat; Jean-Marc Janot; Sebastien Balme

Chemical Communications, 51 (27), p. 5994–5997, 2015.

Influence of nanopore surface charge and magnesium ion on polyadenosine translocation Article de journal

Mathilde Lepoitevin; Pierre Eug`ene Coulon; Mikhael Bechelany; Julien Cambedouzou; Jean-Marc Janot; Sebastien Balme

Nanotechnology, 26 (14), p. 144001, 2015.

Gold nanoparticles for the bare-eye based and spectrophotometric detection of proteins, polynucleotides and DNA Article de journal

Mathilde Lepoitevin; Marie Lemouel; Mikhael Bechelany; Jean-Marc Janot; Sebastien Balme

Microchimica Acta, 182 , p. 1223–1229, 2015.

Biological Channel Confinement in Nanostructured Nanopore Article de journal

Sébastien Balme; Mathilde Lepoitevin; Adib Abou-Chayaa; Mikhael Bechelany; Jean-Marc Janot; Emmanuel Balanzat

Biophysical Journal, 108 (2), p. 484a, 2015.

Nanopore Functionalization for biological channel mimicking Article de journal

Mathilde Lepoitevin; Mikhael Bechelany; Jean-Marc Janot; Sebastien Balme

Science Letters Journal, 4 , p. 188, 2015.

2014

BSA and Lysozyme Adsorption on Homoionic Montmorillonite: Influence of the Interlayer Cation Article de journal

Mathilde Lepoitevin; Maguy Jaber; Régis Guégan; Jean-Marc Janot; Philippe Dejardin; Francois Henn; Sébastien Balme

Applied Clay Science, 95 , p. 396-402, 2014, ISSN: 0169-1317.

Influence of Nanopore Surface Charge on Polycytosine Translocation. Physics, Chemistry and Applications of Nanostructures: Proceedings of International Conference Nanomeeting 2015 Article de journal

Mathilde Lepoitevin; Mikhael Bechelany; JM Janot; Sebastien Balme

2014.

Hybrid Biological/Artificial Nanopore Physics, Chemistry and Applications of Nanostructures: Proceedings of International Conference Nanomeeting 2015 Article de journal

Sebastien Balme; Mathilde Lepoitevin; Mikhael Bechelany; Jean-Marc Janot

2014.

BSA and lysozyme adsorption on homoionic montmorillonite: Influence of the interlayer cation Article de journal

Mathilde Lepoitevin; Maguy Jaber; Régis Guégan; Jean-Marc Janot; Philippe Dejardin; Francois Henn; Sébastien Balme

Applied Clay Science, 95 , p. 396–402, 2014.

2013

Structure, Orientation and Stability of Lysozyme Confined in Layered Materials Article de journal

Sébastien Balme; Régis Guégan; Jean-Marc Janot; Maguy Jaber; Mathilde Lepoitevin; Philippe Dejardin; Xavier Bourrat; Mikael Motelica-Heino

Soft Matter, 9 (11), p. 3188-3196, 2013.

Controlling Potassium Selectivity and Proton Blocking in a Hybrid Biological/Solid-State Polymer Nanoporous Membrane Article de journal

Sébastien Balme; Fabien Picaud; Sebastian Kraszewski; Philippe Déjardin; Jean Marc Janot; Mathilde Lepoitevin; Jhon Capomanes; Christophe Ramseyer; Franc cois Henn

Nanoscale, 5 (9), p. 3961-3968, 2013.

Structure, orientation and stability of lysozyme confined in layered materials Article de journal

Sébastien Balme; Régis Guégan; Jean-Marc Janot; Maguy Jaber; Mathilde Lepoitevin; Philippe Dejardin; Xavier Bourrat; Mikael Motelica-Heino

Soft Matter, 9 (11), p. 3188–3196, 2013.

Controlling potassium selectivity and proton blocking in a hybrid biological/solid-state polymer nanoporous membrane Article de journal

Sébastien Balme; Fabien Picaud; Sebastian Kraszewski; Philippe Déjardin; Jean Marc Janot; Mathilde Lepoitevin; Jhon Capomanes; Christophe Ramseyer; François Henn

Nanoscale, 5 (9), p. 3961–3968, 2013.

Controlling Ionic Selectivity in Bio-Inspired Systems: Potassium Selectivity and Proton Blocking in Hybrid Biological/Solid-State Polymer Nanopore Membrane Article de journal

Sébastien Balme; Fabien Picaud; S Kraszewski; P Dejardin; JM Janot; M Lepoitevin; J Campomanes; C Ramseyer; F Henn

Nanoscale, 5 , p. 3961-3968, 2013.

Controlling ionic selectivity in bio-inspired systems: Potassium selectivity and proton blocking in hybrid biological/solid-state polymer nanopore membrane Article de journal

Sébastien Balme; Fabien Picaud; S Kraszewski; P Dejardin; JM Janot; M Lepoitevin; J Campomanes; C Ramseyer; F Henn

Nanoscale, 5 , p. 3961–3968, 2013.

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Controlling Potassium Selectivity and Proton Blocking by Gramicidin A Confined inside Track-Etched Membrane Article de journal

M Lepoitevin; F Picaud; S Kraszewski; JM Janot; F Henn; S Balme

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Controlling potassium selectivity and proton blocking by Gramicidin A confined inside track-etched membrane Article de journal

M Lepoitevin; F Picaud; S Kraszewski; JM Janot; F Henn; S Balme

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Sodium Insertion-Extraction in the Olivine NaxFePO4 (0$łeq$ X$łeq$ 1) from First-Principles Calculations Article de journal

A Saracibar; J Carrascob; D Saurelb; M Galceranb; B Acebedob; H Anneb; M Lepoitevinb; T Rojoc; Casas M Cabanas

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Sodium insertion-extraction in the olivine NaxFePO4 (0≤ x≤ 1) from first-principles calculations Article de journal

A Saracibar; J Carrascob; D Saurelb; M Galceranb; B Acebedob; H Anneb; M Lepoitevinb; T Rojoc; Casas M Cabanas

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