CNRS Research Director (DR2)
Laboratoire des Biomolécules – UMR7203
École Normale Supérieure
PSL University, Sorbonne University
Email: ORCID iD icon
  Contact Details
École Normale Supérieure Chemistry Department – Office E023 24 rue Lhomond, 75005 Paris Tel: +33 (1) 44 32 38 72
  Research Interests
Metal catalysis, Mechanistic studies, Electrosynthesis, Isocyanide-based multicomponent processes
  Education / Scientific Experiences
2019Research Director at CNRS (DR 2) at ENS Paris – UMR 7203
2016Research Director at CNRS (DR 2) at ENS Paris – UMR 8640
2012Researcher at CNRS (CR 1) at ENS Paris – UMR 8640
2010Researcher at CNRS (CR 1) at Ecole Polytechnique – UMR 7652
2006Habilitation à diriger des recherches (HDR, Paris XI)
1999-2010Assistant Professeur at ENSTA with Prof. Laurent El Kaïm
1996-1999Ph. D. in Organic Chemistry at Ecole Polytechnique (supervision: Dr J. Prunet)


119. A DFT Protocol for the Prediction of 31P NMR Chemical Shifts of Phosphine Ligands in First-Row Transition Metal Complexes. Payard, P. A.; Perego, L. P.; Grimaud, L.; Ciofini, I. Organometallics 2020,  39, 17, 3121–3130. DOI: 10.1021/acs.organomet.0c00309

118. Reversing reactivity: stereoselective desulfurative β-O-glycosylation of anomeric thiosugars with carboxylic acids under copper or cobalt catalysis. Bennai, N.; Chabrier, A.; Fatthalla, M.; Tran, C.; Yen-Pon, E. Belkadi, M.; Alami, M.; Grimaud, L.; Messaoudi, S. J. Org. Chem. 2020, 85, 8893-8909.

117. Rational Design of Lewis-Acid Catalysts for Direct Alcohol Amination, Part 2 – Titanium Triflimide as New Active Catalyst. Payard, P. A.; Finidori, C.; Guichard, L.; Cartigny,D.; Corbet, M.; Khrouz, L.; Bonneviot, L.; Wischert, R.; Grimaud, L.; Pera-Titus, M. Eur. J. Org. Chem. 2020, 3225-3228. DOI: 10.1002/ejoc.202000413.

116. Rational Optimization of Lewis-Acid Catalysts for the Direct Amination of Alcohols, Part 1 – Activity Descriptors for Metal Triflates and Triflimides. Payard, P. A.; Finidori, C.; Guichard, L.; Cartigny,D.; Corbet, M.; Khrouz, L.; Bonneviot, L.; Wischert, R.; Grimaud, L.; Pera-Titus, M. Eur. J. Org. Chem. 2020, 3219-3224. DOI: 10.1002/ejoc.202000229R1.

115. Iron Triflate Salts as Highly Active Catalysts for the Solvent-Free Oxidation of Cyclohexane. Payard, P. A.; Zheng, Y. -T.; Zhou, W. -J.; Khrouz, L.; Bonneviot, L.; Wischert, R.; Grimaud, L.; Pera-Titus, M. Eur. J. O. C. 2020, 3552–3559. DOI: 10.1002/ejoc.202000263.

114. Copper Reactivity Can Be Tuned to Catalyze the Stereoselective Synthesis of 2‑Deoxyglycosides from Glycals. Palo-Nieto, C.; Sau, A.; Jeanneret, R; Payard, P.A.; Salamé, A.; Braga Martins-Teixeira, M.; Carvalho, I.; Grimaud, L.; Galan, M. C. Org. Lett. 2020, 22, 1991–1996. DOI: 10.1021/acs.orglett.9b04525.


113. 108. Copper-Catalysed Hydroamination of N-Allenyl Sulfonamides: The Key Role of Ancillary Coordinating Groups. Blieck, R.; Perego, L. A.; Ciofini, I.; Grimaud, L.; Taillefer, M.; Monnier Synthesis 201951, 1225-1234.

112. Formation and Reactivity of XPhos-Ligated Palladium(0) Complexes in Oxidative Additions. Wagschal, S.; Perego, L. A.; Simon, A.; Franco-Espejo, A.; Tocqueville, C.; Albaneze-Walker, J.; Jutand, A.; Grimaud, L. Chem. Eur. J. 201925, 6980-6987. (DOI: 10.1002/chem.201900451)

111. Electroactive fluorescent false neurotransmitter FFN102 partially replaces dopamine in PC12 cell vesicles. Hu, L.; Savy, A.; Grimaud, L.; Guille-Collignon, M.; Lemaître, F.; Amatore, C.; Delacotte, J. Biophys. Chem. 2019, 245, 1-5. (DOI: 10.1016/j.bpc.2018.11.001)

110. Metformin reveals a mitochondrial copper addiction of mesenchymal cancer cells. Müller, S.; Versini, A.; Sindikubwabo, F.; Belthier, G.; Niyomchon, S.; Pannequin, J.; Grimaud, L.; Cañeque, T.; Rodriguez R.  PLOS ONE 2018, 13, e020676, (DOI: 10.1371/journal.pone.0206764)

109. From Benzofurans to Indoles: Palladium-Catalyzed Reductive Ring-Opening and Closure via β-Phenoxide Elimination. Perego, L. A.; Wagschal, S.; Grüber, R.; Fleurat-Lessard, P.; El Kaïm, L.; Grimaud, L. Adv. Synth. Cat. 2019361, 151-159(DOI 10.1002/adsc.201801225).


108. Direct Amination of Alcohols Catalyzed by Aluminum Triflate: an Experimental and Computational Study. Payard, P. A.; Gu, Q.; Guo, W.; Wang, Q.; Corbet, M.; Michel, C.; Sautet, P.; Grimaud, L.; Wischert, R.; Pera‐Titus, M. Chem. Eur. J. 201853, 14146-14153 (DOI 10.1002/chem.201801492).

107. Taming Nickel-Catalyzed Suzuki-Miyaura Coupling: a Mechanistic Focus on Boron-to-Nickel Transmetalation. Payard, P. A.; Perego, L. A.; Ciofini, I.; Grimaud, L. ACS catal. 20188, 4812-4823. DOI: 10.1021/acscatal.8b00933

106. 4-Aminopyrimidine Libraries from the Ugi-Smiles Reaction of Thiouracil. Ait Sidhoum, M.; El Kaïm, L.; Grimaud, L. Tetrahedron 2018acceptedDOI: 10.1016/j.tet.2018.04.058

105. Coupling electrochemistry and TIRF-microscopy with the fluorescent false neurotransmitter FFN102 supports the fluorescence signals during single vesicle exocytosis detection. Liu, X.; Hu, L.; Pan, N.; Grimaud, L.; Labbé, E. ; Buriez, O.; Delacotte, J.; Lemaître, F.; Guille-Collignon, M. Biophys. Chem. 2018235, 48-55.DOI: 10.1021/acs.bioconjchem.7b00825

104. Labelling of hyaluronic acids with a Re-tricarbonyl tag and percutaneous penetration into human skin studied by multimodal imaging. Henry, L.; Delsuc, N.; Laugel, C.; Lambert, F.; Sandt, C.; Hostachy, S.; Bernard, A. S.; Bertrand, H. C.; Grimaud, L.; Baillet-Guffroy, A.; Policar, C. Bioconjugate Chem. 2018, 29, 987-991.

103. Evidence for a Cooperative Mechanism Involving two Palladium(0) Centers in the Oxidative Addition of Iodoarenes. Perego, L. A.; Payard, P. A.; Haddou, B.; Ciofini, I.; Grimaud, L. Chem. Eur. J. 201824, 2192-2199. DOI: 10.1002/chem.201704899

102. TiCl4-mediated synthesis of 3,4-hetero-disubstituted isocoumarins by means of isocyanide insertion reactions. Ponra, S.; Nyadanu, A.; Maurin, S.; El Kaïm, L.; Grimaud, L.; Vitale, M. R. Synthesis201850, 1331–1342DOI: 10.1055/s-0036-1591733


101. Copper-Catalyzed Hydroamination of N-Allenylazoles: Access to Amino-Substituted N-Vinylazoles. Perego, L. A.; Blieck, R.; Michel, J.; Ciofini, I.; Grimaud, L.; Taillefer, M.; Monnier, F. Adv. Synth. Cat. 2017359, 4388–4392. DOI: 10.1002/adsc.201700965

100. Copper-Catalyzed Hydroamination of Allenes: from Mechanistic Understanding to Methodology Development. Perego, L. A.; Blieck, R.; Groué, A.; Monnier, F.; Taillefer, M.; Ciofini, I.; Grimaud, L. ACS Catal20177, 4253−4264. DOI: 10.1021/acscatal.7b00911

99. Stereoselective access to trisubstituted fluorinated alkenyl thioethers. Fabre, I.; Poisson, T.; Pannecoucke, X.; Gillaizeau, I.; Ciofini, I.; Grimaud, L. Catal. Sci. Technol. 20177, 1921-1927.DOI: 10.1039/C7CY00076F

98. N-N bond formation in Ugi Processes: from nitric acid to libraries of Nitramines. Mercalli, V.; Nyadanu, A.; Cordier, C.; Tron, G. C.; Grimaud, L.; El Kaim, L. Chem. Comm. 201753, 2118-2121.DOI: 10.1039/C6CC10288C

97. A dual functional electroactive and fluorescent probe for coupled measurements of vesicular exocytosis with high spatial and temporal resolution. Liu, X.; Savy, A.; Maurin, S.; Grimaud, L.; Labbé, E.; Buriez, O.; Delacotte, J.; Amatore, C.; Lemaître, F.; Guille-Collignon, M. Angew. Chem. Int. Ed. 2017, 2366-2370.

96. Ugi-Smiles couplings of purine derivatives. Ben Abdessalem, A.; Abderrahim, R.; Dos Santos, A.; El Kaïm, L.; Grimaud, L. Synlett 201728, 691–694. DOI 10.1055/s-0036-1588117


95. Review: Role of Fluoride Ions in Palladium-Catalyzed Cross-Coupling Reactions. Jutand, A.; Grimaud, L. Synthesis 201649, 1182-1189.

94. Benzoxazinone syntheses through Passerini-Smiles couplings. Martinand-Lurin, E.; Dos Santos, A.; Robineau, E.; Retailleau, P.; Dauban, P.; Grimaud, L.; El Kaïm, L. Molecules 201616, 1257-1270. DOI: 10.1016/j.tetlet.2014.07.088

93. TiCl4-Mediated Preparation of Thiophtalide Derivatives via Formal Thio-Passerini Reactions. Ponra, S.; Nyadanu, A.; El Kaïm, L.; Grimaud, L.; Vitale, M. R. Org. Lett. 201618, 4060–4063. DOI: 10.1021/acs.orglett.6b01937

92. Multiple Roles of Isocyanides in Imidoylative Palladium-Catalyzed Couplings – A Mechanistic Study. Perego, L. A.; Fleurat-Lessard, P.; El Kaïm, L.; Ciofini, I.; Grimaud, L. Chem. Eur J. 201622, 15491-15500. DOI: 10.1002/chem.201602913

91. Antagonist Effect of Acetates in C-N bond formation with in situ generated diazonium salts: a combined theoretical and experimental study. Fabre, I.; Perego, L. A.; Bergès, J.; Ciofini, I.; Grimaud, L.; Taillefer, M. Eur J. Org. Chem. 2016, 5887–5896DOI: 10.1002/ejoc.201600891

90. Mechanistic Studies on the Pd-Catalyzed Direct C5 Arylation of Imidazoles: the Fundamental Role of the Azole as a Ligand for Pd. Perego, L. A.; Grimaud, L.; Bellina, F. Adv. Synth. Cat. 2016358, 597-609. DOI: 10.1002/adsc.201500888


89. Hypervalent iodine-mediated synthesis of 1,2-dispirodienones: experimental and theoretical investigations. Hromjakova, T.; Retailleau, P.; Grimaud, L.; Gandon, V.; Chabaud, L.; Guillou, C. Eur. J. Org. Chem. 2015, 7494-7503.

88. Transition-Metal-Free alpha-Arylation of Enolizable Aryl Ketones and Mechanistic Evidence for a Radical Process. Pichette-Drapeau, M.; Fabre, I.; Grimaud, L.; Ciofini, I.; Ollevier, T.; Taillefer, M. Angew. Chem. Int. Ed. 201554, 10587-10591DOI: 10.1002/anie.201502332


87. Review: The Ugi-Smiles and Passerini-Smiles couplings: a story about phenols in Isocyanide based Multicomponent Reactions El Kaïm, L.; Grimaud, L. Eur. J. Org. Chem. 2014, 7749–7762.

86. Benzoxazinone synthesis via Passerini-Smiles couplings. Martinand-Lurin, E.; El Kaïm, L.; Grimaud, L. Tetrahedron Lett. 201455, 5144-5146.

85. Kinetic Data on the Synergetic Role of Amines and Water in the Reduction of Phosphine Ligated-Palladium(II) to Palladium(0). Amatore, C.; El Kaïm, L.; Grimaud, L.; Jutand, A.; Meigné, A.; Romanov, G., Eur. J.O.C 2014, 4709-4713. DOI : 10.1002/ejoc.201402519

84. Three Roles for Fluoride Ions in Palladium-Catalyzed Hiyama Reactions: Transmetallation of ArPdFL2 by Ar’Si(OR)3. Amatore, C.; Grimaud, L.; Le Duc, G.; Jutand, A, Angew. Chem. Int. Ed. 201453, 6982–6985. DOI: 10.1002/anie.201400956

83. Copper-Catalyzed Olefinic C-H Difluoroacetylation of Enamides. Caillot, G.; Dufour, J.; Belhomme, M. C.; Poisson, T.; Grimaud, L.; Pannecoucke, X.; Gillaizeau, I. Chem. Commun. 201450, 5887-5890.

82. Nitrile synthesis through catalyzed cascades involving acid-nitrile exchange reaction. Cartigny,D.; El Kaïm, L.; Grimaud, L.; Marion, P; Jacquot, R. Synthesis 201446, 1802-1806.

81. Double Smiles rearrangement of Passerini adducts towards benzoxazinones. Martinand-Lurin, E.; Dos Santos, A.; El Kaïm, L.; Grimaud, L.; Retailleau, P. Chem. Comm. 201450, 2214-2217DOI: 10.1039/C3CC49022J


80. Pyrrolo[2,3-d]pyrimidine synthesis through activation of N-benzyl groups by distal amides. El Kaïm, L.; Grimaud, L.; Wagschal, S. Org. Biomol. Chem. 201311, 6883-6885.

79. Substituent Effects in Ugi-Smiles Reactions. Chéron, N.; Ramozzi, R.; El Kaïm, L.; Grimaud, L.; Fleurat-Lessard, P. J. Phys. Chem. A 2013, 117, 8035−8042.

78. Lewis acid mediated fragmentation of tetrazoles towards triazoles. El Kaïm, L.; Grimaud, L.; Pravin, P. Eur. J. Org. Chem 201322, 4752–4755.

77. Three-Component Metal-Free Arylation of Isocyanides. Basavanag, U. M. V.; Dos Santos, A.; El Kaïm, L.; Gamez-Montano, R.; Grimaud, L. Angew. Chem. Int. Ed. 201352, 7194-7197. DOI: 10.1002/anie.201302659

76. Metal-free aerobic oxidation of benzazole derivatives. Dos Santos, A.; El Kaïm, L. ; Grimaud, L. Org. Biomol. Chem. 201311, 3282-3287.


75. Oxazole synthesis from isocyanides. El Kaïm, L.; Grimaud, L.; Pravin, P. Synlett 2012, 1361-1363.

74. Palladium catalyzed ring-opening of aminocyclopropyl Ugi adducts. Dos Santos, A.; El Kaïm, L.; Grimaud, L.; Ramozzi, R. Synlett 2012, 438-442.

73. Four-component synthesis of indazole through Ugi-azide coupling. El Kaïm, L.; Grimaud, L.; Purumandla, S. R. Synlett 2012, 295-297.

72. Challenging 50 years of established views on Ugi reaction: a theoretical approach. Chéron, N.; Ramozzi, R.; El Kaïm, L.; Grimaud, L.; Fleurat-Lessard, P. J. Org. Chem. 201277, 1361–1366.

71. Ugi-Smiles coupling of thiouracil derivatives towards 2,4-diamino pyrimidines. Ait Sidhoum, M.; El Kaïm, L. ; Grimaud, L. Synlett 2012, 632-636.

70. Ugi-Smiles couplings of 4-substituted pyridine derivatives: a fast access to chloroquine analogues. El Kaïm, L.; Grimaud, L.; Pravin, P. Org. Lett. 201214, 476-478.


69. Xanthate Based Radical Cascade Toward Multicomponent Formation of Pyrrolopyrimidines. El Kaïm, L.; Grimaud, L.; Pravin, P. Molecules 2011, 16, 9261-9273.

68. Copper-triggered oxidative cascade as Ugi post-condensation towards pyrazoles. El Kaïm, L.; Grimaud, L.; Ronsseray, C. Beilstein J. Chem. 20117, 1310-1314.

67.Straightforward four-component access to spiroindolines. El Kaïm, L.; Grimaud, L.; Le Goff, X. –F.; Menes-Arzate, M.; Miranda, L. D. Chem. Commun. 201147, 8145-8147. DOI:

66. Evidences for the Key-Role of Hydrogen Bonds in SNAr. Chéron, N.;El Kaïm, L.; Grimaud, L.; Fleurat-Lessard, P.  Chem. Eur. J. 201117, 14929–14934.

65. A Density Functional Theory Study of the Nef-Isocyanide Reaction: Mechanism, Influence of Parameters and Scope. Chéron, N. ; El Kaïm, L. ; Grimaud, L. ; Fleurat-Lessard, P. J. Phys. Chem. A2011, 115, 10106-10112.

64. Phosphite mediated synthesis of benzimidazoles: a one-pot four-component approach from nitrophenols. El Kaïm, L.; Grimaud, L. ; Purumandla, S. P. Eur. J. Org. Chem. 201131, 6177–6180.

63. Three-component strategy towards 5-membered heterocycles from isocyanide dibromides. El Kaïm, L.; Grimaud, L.; Pravin, P. Org. Lett. 201113, 1261–1263. DOI: 10.1021/ol200003u

62. Copper catalyzed aerobic oxidative cyclization of hydrazones to pyrazolinones. Dos Santos, A.; El Kaïm, L.; Grimaud, L.; Ronsseray, C. Eur. J. Org. Chem. 2011, 3117–3121.

61. Allyl and Benzyl Dance under Basic Conditions. El Kaïm, L.; Grimaud, L.; Purumandla, S. R. Synlett 2011, 1816-1820.

60Multicomponent Synthesis of Fused Benzimidazolopiperazines. El Kaïm, L.; Grimaud, L.; Purumandla, S. P. J. Org. Chem. 201176, 4728-4733.

59.  A new multicomponent reaction for the synthesis of pyridines via cycloaddition of azadienes and ketenimines. Coffinier, D.; El Kaïm, L.; Grimaud, L.; Ruijter, E.; Orru, R. V. A. Tetrahedron Lett. 201152, 3023-3025.

58. Palladium catalyzed ring opening of furans as a route to a,b-unsaturated aldehydes. El Kaïm, L.; Grimaud, L.; Wagschal, S. Chem. Comm. 2011, 47, 1887-1889DOI: 10.1039/C0CC04164E

57. Smiles cascades towards heterocyclic scaffolds. El Kaïm, L.; Le Goff, X. -F.; Grimaud, L.; Schiltz, A. Org. Lett. 201113, 534-536. DOI: 10.1021/ol1028817


56. Review: Ugi–Smiles couplings: new entries to N-aryl carboxamide Derivatives. El Kaïm, L. ; Grimaud, L. Mol. Div. 201014, 855-867.

55. New pyridine synthesis from hydrazone. Coffinier, D.; El Kaïm, L.; Grimaud, L.; Hadrot, S.  Tetrahedron Lett. 201051, 6186-6188.

54. Ammonia in Ugi-Smiles couplings. Barthelon, A.; El Kaïm, L.; Gizzi, M.; Grimaud, L. Synlett 2010, 2784-2788.

53. Ugi-Smiles reactions in water. El Kaïm, L.; Grimaud, L.; Purumandla, S. R. Tetrahedron Lett. 201051, 4962-4964.

52. Three-Component Fischer Indole Synthesis. El Kaïm, L.; Grimaud, L.; Ronsseray, C. Synlett 2010, 2296-2298.

51. Nef/Perkow access to indolizine derivatives. Coffinier, D.; El Kaïm, L. ; Grimaud, L. Synlett 2010, 2474-2476.

50. 1,2,4-Triazole synthesis via amidrazones. El Kaïm, L.; Gizzi, M.; Grimaud, L. Synlett 2010, 1771-1774.

49. Towards new pyrrolo[2,3-d]pyrimidines scaffolds. El Kaïm, L.; Grimaud, L.; Wagschal, S.  J. Org. Chem. 201075, 5343–5346. DOI: 10.1021/jo100759b

48. New xanthate-based radical cyclization onto alkynes. El Kaïm, L.; Grimaud, L.; Miranda, L. D.; Vieu, E.; Cano-Herrera, M. A.; Perez-Labrada, K. Chem. Commun. 201046, 2489 – 2491.

47. Four-component Synthesis of Imidazolinium-fused Heterocycles from Ugi-Smiles Couplings. Barthelon, A.; Legoff, X.-F.; El Kaïm, L.; Grimaud, L. Synlett 2010, 153-157.


46. Review: Beyond the Ugi reaction: less conventional interactions between isocyanides and iminium species (sur invitation du Pr W. B. Motherwell). El Kaïm, L.; Grimaud, L. Tetrahedron 200965, 2153-2171.

45. Isocyanide-based multicomponent reaction ‘without’ isocyanides. El Kaïm, L.; Grimaud, L.; Schiltz, A. Synlett 2009, 1401-1404.

44. One-pot synthesis of oxazoles using isocyanide surrogates. El Kaïm, L.; Grimaud, L.; Schiltz. A. Tetrahedron Lett. 200950, 5235-5237.

43. Unconventional oxazole formation from isocyanides. Dos Santos, A.; El Kaïm, L.; Grimaud, L.; Ronsseray, C. Chem. Commun. 2009, 3907-3909.

42. Isocyanide-free Ugi reactions. El Kaïm, L.; Grimaud, L.; Schiltz, A. Org. Biomol. Chem. 20097, 3024-3026.

41. Three-component Nef/Huisgen access to 1,2,4-triazoles. El Kaïm, L.; Grimaud, L.; Wagschal, S. Synlett 2009, 1315-1317.

40. Isocyanide-Based Two-Step Three-Component Keteneimine Formation. Coffinier, D.; El Kaïm, L.; Grimaud, L. Org. Lett. 200911, 1825-1827.DOI: 10.1021/ol9004432

39. Three component Ugi-Smiles couplings of cyclic imines. El Kaïm, L.; Grimaud, L.; Oble, J. Wagschal, S. Tetrahedron Lett. 200950, 1741-1743.

38. New benzotriazole and benzimidazole scaffolds from Ugi-Smiles couplings of isocyanides. Coffinier, D.; El Kaïm, L.; Grimaud, L. Org. Lett. 200911, 995-997. DOI: 10.1021/ol8029438


37. Thiols in Ugi- and Passerini-Smiles-type couplings. Barthelon, A.; El Kaïm, L.; Gizolme, M.; Grimaud, L. European J. Org. Chem. 2008, 35, 5974-5987. DOI: 10.1002/ejoc.200800859

36. New MCR-Heck-Isomerization Cascade toward Indoles. El Kaïm, L.; Gizzi, M.; Grimaud, L. Org. Lett200810; 3417-3419. DOI: 10.1021/ol801217a

35. Intramolecular Kulinkovitch-de Mejeire reactions of various disubstituted alkenes bearing amide groups. Madelaine, C.; Ouhamou, N.; Chiaroni, A.; Vedrenne, E.; Grimaud, L.; Six, Y. Tetrahedron 2008 64, 8878-8898.

34. Ugi-Smiles access to pyrazine scaffolds. Barthelon, A.; Dos Santos, A.; El Kaïm, L.; Grimaud, L. Tetrahedron Lett 200849, 3208-3211.

33. Isocyanide addition to acylphosphonates: A formal Passerini reaction of acyl chlorides. Coffinier, D.; El Kaïm, L.; Grimaud, L. Synlett 2008, 1133-1136

32. New Pd catalyzed aerobic oxidative cleavage and cyclization of N-aryl peptid derivatives. El Kaïm, L.; Grimaud, L.; Ibarra, T.; Montano-Gamez, R. Chem. Comm. 200811, 1350-1352. DOI: 10.1039/B716849G


31. From simple Ugi adducts to indanes and amidomalonates: new manganese (III) induced radical cascades. El Kaïm, L.; Grimaud, L.; Vieu, E. Org. Lett., 20079, 4171-4173. DOI: 10.1021/ol701678d

30. Ugi-Smiles access to quinoxaline derivatives. Oble, J.; El Kaïm, L.; Gizzi, M.; Grimaud, L. Heterocycles200773, 503-517.

29. New Ugi-Smiles-metathesis strategy towards the synthesis of pyrimido azepines. El Kaïm, L.; Gizolme, M.; Grimaud, L.; Oble, J. J. Org. Chem200772, 5835-5838. DOI: 10.1021/jo070706c

28. Smiles rearrangements in Ugi and Passerini type couplings: new multicomponent accesses to O– and N‑aryl amides. El Kaïm, L.; Gizolme, M.; Grimaud, L.; Oble, J. J. Org. Chem200772, 4169-4180. DOI: 10.1021/jo070202e

27. New benzothiazole and benzoxazole scaffolds from the Ugi–Smiles couplings of heterocyclic thiols. El Kaïm, L.; Gizolme, M.; Grimaud, L.; Oble, J. Synlett 2007, 465-469.

26. New Ugi/Pictet–Spengler multicomponent formation of polycyclic diketopiperazines from isocyanides and α-keto acids. El Kaïm, L. ; Gageat, M.; Gaultier, L.; Grimaud, L. Synlett 2007, 500-502.

25. New indolizines template from the Ugi reaction. El Kaïm, L.; Gizolme, M.; Grimaud, L. Synlett 2007, 227-230.


24. O-Arylative Passerini reactions. El Kaïm, L.; Gizolme, M.; Grimaud, L. Org. Lett. 20068, 5021-5023. DOI: 10.1021/ol0617502

23. Direct access to heterocyclic scaffolds by new multicomponent Ugi-Smiles couplings. El Kaïm, L.; Gizolme, M.; Grimaud, L.; Oble, J. Org. Lett. 20068, 4019-4021. DOI: 10.1021/ol061605o

22. Ugi /xanthate cyclizations as a radical route to lactam scaffolds. El Kaïm, L.; Grimaud, L.; Miranda, L.; Vieu, E. Tetrahedron Lett. 2006, 47, 8259-8261.

21. New ortho-quinone methide formation: application to three component coupling of isocyanide, aldehyde and phenol. El Kaïm, L.; Grimaud, L.; Oble, J. Organic Biomol. Chem. 20064, 3410-3413.

20. Solvent-free preparation of amidophosphonates from isocyanides. El Kaïm, L.; Grimaud, L.; Hadrot, S. Tetrahedron Lett. 2006, 47, 3945-3947.


19. Phenol Ugi-Smiles systems: Strategies for the multicomponent of N-arylation of primary amines with isocyanides, aldehydes and phenols. El Kaïm, L.; Grimaud, L.; Oble, J. Angew. Chem. Int. Ed. 200544, 7961-7964. DOI: 10.1002/anie.200502636

18. Towards the Synthesis of Paulitin: New Insights into Enyne-Metathesis Mechanism. Vedrenne, E.; Royer, F.; Oble, J.; El Kaïm, L.; Grimaud, L. Synlett 200515, 2379-2381.

17. Formation of new phosphates from aldehydes by a DBU-catalysed phospha-Brook rearrangement in a polar solvent. El Kaïm, L.; Gaultier, L.; Grimaud, L.; Dos Santos, A. Synlett 200515, 2335-2336.

16. Dramatic effect of boron-based Lewis acid in cross-metathesis reactions. Vedrenne, E.; Dupont, H.; Oualef, S.; El Kaïm, L.; Grimaud, L. Synlett 20054, 670-672.


15. New access to fluorinated ketoglycolic acid derivatives from trifluoropyruvamides. Colin, T.; El Kaïm, L.; Gaultier, L.; Grimaud, L.; Gatay, L. Tetrahedron Lett200445, 5611-5613.

14. From isocyanides to trichloropyruvamides : Application to new preparation of Oxamide derivatives. El Kaïm, L.; Gaultier, L.; Grimaud, L.; Vieu, E. Tetrahedron Lett. 200445, 8047-8048.

13. First Carbamates Conversion to Amides by Simple Alkyl Group Transfer from Trialkylalanes. El Kaïm, L.; Grimaud, L.; Perroux, Y.; Tirla, C. Org. Lett. 2004, 6, 381-383.

12. Condensation of ɤ-hydroxy sulfones and vinyl sulfones with aldehydes and ketones using phenyllithium as base. Rotulo-Sims, D.; Grimaud, L.; Prunet, J. Comptes Rendus, 2004, 941-944.


11. New insight into the azaenamine behavior of N-Arylhydrazones: first Aldol and improved Mannich reactions with unactivated aldehydes. El Kaïm, L.; Gautier, L.; Grimaud, L.; Michaut, V. Synlett200312, 1844-1846.

10. The Mannich Reaction of Hydrazones: Improved Reactivity under Solvent-free Conditions. El Kaïm, L.; Gautier, L.; Grimaud, L.; M. Harwood, L.; Michaut, V. Green Chem. 20035, 477-479.

9. New trimethylaluminum induced Mannich type reaction of hydrazones. El Kaïm, L.; Grimaud, L.; Perroux, Y.; Tirla, C. J. Org. Chem. 200368, 8733-8735.

8. Selective Domino Ring-Closing Metathesis-Cross-Metathesis Reactions between Enynes and Electron-deficient Alkenes. Royer, F.; Vilain, C.; El Kaïm, L; Grimaud, L. Org. Lett. 20035, 2007-2009.


7. Diastereoselective Synthesis of Protected syn 1,3-Diols: Preparation of the C16-C24 Portion of Dolabelides. Grimaud, L.; de Mesmay, R.; Prunet, J. Org. Lett20024; 419-421.

6. Amines addition to a-nitrohydrazones: application to amidrazones and triazoles formation. El Kaïm, L.; Grimaud, L.; Jana, N. K.; Mettetal, F.; Tirla, C. Tetrahedron Lett. 2002, 43, 8925-8927.

5. Studies towards the synthesis of Fipronil analogues: improved decarboxylation of a-hydrazonoacid derivatives. Ancel, J. E.; El Kaïm, L.; Gadras, A.; Grimaud, L.; Jana, N. K. Tetrahedron Lett. 200243, 8319-8321.

4. Synthesis of protected syn 1,3-diols by intramolecular conjugate addition to vinyl sulfones. Grimaud, L.; Rotulo, D., Ros-Perez, R.; Guitry-Azam, L.; Prunet, J. Tetrahedron Lett. 200243, 7477-7479.

3. a-Nitrohydrazones: versatile intermediates for phosphonate derivatives formation from primary nitro compounds. El Kaïm, L.; Grimaud, L.; Jana, N. K.; Tirla, C. Tetrahedron Lett. 2002, 43, 2037-2038.

2. The Mannich reaction of hydrazones amenable to solid phase synthesis: a powerful tool for heterocycle preparation. Atlan, V.; El Kaïm, L.; Grimaud, L.; Jana, N. K.; Majee, A. Synlett 20022, 352-354.

1. Diastereoselective intramolecular Diels-Alder reactions towards the synthesis of a taxol C-ring precursor. Grimaud, L.; Férézou, J.-P.; Prunet, J.; Lallemand, J. –Y. Tetrahedron 1997, 53, 9253-9268.

Chapters in collective international books

– Smiles rearrangement. Molecular Rearrangements in Organic Synthesis. El Kaïm, L.; Grimaud, L. Editor: Rojas, C. M., Wiley: 2015.

– Ugi-Smiles and Passerini-Smiles couplings. Multicomponent Reactions in Organic Synthesis. El Kaïm, L.; Grimaud, L. Editors : Zhu, J.; Wang, Q.; Wang, M.-X. Wiley: 2015.

– Ugi and Passerini Reactions with Carboxylic Acid Surrogates. Isocyanide Chemistry: Applications in Synthesis and Material Science. El Kaïm, L.; Grimaud, L. Editor : Nenadjenko, V. Wiley: 2012.

– Cross-Metathesis in Natural Products Synthesis. Prunet, J.; Grimaud, L. Editors : J. Cossy, S. Arseniyadis, C. Meyer, Wiley: 2010.

– One or More C=C Bond(s) Formed by Condensation: Condensation of Nonheteroatom Linked Functions, Halides, Chalcogen or Nitrogen Functions. Prunet, J.; Grimaud, L. Chapitre 1.15 du Comprehensive Organic Functional Group Transformations, 2e édition, editors: A. R. Katritzky et R. J. K. Taylor, Elsevier: 2005.