A combinatorial approach using a One-Bead-One-Compound method and a screening based on an SOD-activity assay was set up for the discovery of an efficient peptidyl copper complex. The complex exhibited good stability constants, suitable redox potentials and excellent intrinsic activity. This complex was further assayed in cells for its antioxidant properties and showed beneficial effect when cells were submitted to oxidative stress.
An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase
Amandine Vincent, Jennifer Rodon Fores, Elodie Tauziet, Elodie Quévrain, Ágnes Dancs, Amandine Conte-Daban, Anne-Sophie Bernard, Philippe Pelupessy, Koudedja Coulibaly, Philippe Seksik,Christelle Hureau, Katalin Selmeczi, Clotilde Policar* and Nicolas Delsuc*
Chem. Commun., 2019