Photosensitive Surfactants with Various Hydrophobic Tail Lengths for the Photocontrol of Genomic DNA Conformation with Improved Efficiency

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TitrePhotosensitive Surfactants with Various Hydrophobic Tail Lengths for the Photocontrol of Genomic DNA Conformation with Improved Efficiency
Type de publicationJournal Article
Nouvelles publications2010
AuteursDiguet, A, Mani NK, Geoffroy M, Sollogoub M, Baigl D
JournalChemistry-a European Journal
Volume16
Fascicule39
Pagination11890-11896
Numéro0947-6539
Accession NumberISI:000283834500019
Résumé

We report the synthesis and characterisation of photosensitive cationic surfactants with various hydrophobic tail lengths. These molecules, called AzoCx, are used as photosensitive nucleic acid binders (pNABs) and are applied to the photocontrol of DNA conformation. All these molecules induce DNA compaction in a photodependent way, originating in the photodependent polarity of their hydrophobic tails. We show that increasing hydrophobicity strongly enhancesthe compaction efficiencies of these molecules, but reduces the possibility of reversible photocontrol of a DNA conformation. Optimal performance was achieved with AzoC5, which allowed reversible control of DNA conformation with light at a concentration seven times smaller than previously reported.

URL<Go to ISI>://000283834500019
DOI10.1002/chem.201001579
Importer un fichierPhotosensitive Surfactants with Various Hydrophobic Tail Lengths for the Photocontrol of Genomic DNA Conformation with Improved Efficiency
Unité de rattachement: 
UMR 8640