Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

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What is already known on this subject
▸ Microbiota impacts on gut homeostasis.
▸ Dysbiosis is involved in inflammatory bowel diseases (IBD) pathophysiology.
▸ Bile acids (BAs) metabolism depends of gut microbiota activity.
▸ BAs exerts anti-inflammatory effects on macrophages.

Résumé: 

Gut microbiota metabolises bile acids (BA). As dysbiosis has been reported in inflammatory bowel diseases (IBD), we aim to investigate the impact of IBD associated dysbiosis on BA metabolism and its influence on the epithelial cell inflammation response.

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Equipe 4
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Références: 

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

H Duboc, S Rajca, D Rainteau, Benarous D, M Maubert, E Quevrain, G Thomas, V Barbu, L Humbert, G Despras, C Bridonneau, F Dumetz, J-P Grill, J Masliah, L Beaugerie, J Cosnes , O Chazouillères, R Poupon, C Wolf, J-M Mallet; P Langella, G Trugnan, H Sokol, P Seksik
Gut 2012
, on line 19 sept 2012
doi:10.1136/gutjnl-2012-302578